Fumonisin-induced tumor necrosis factor-alpha expression in a porcine kidney cell line is independent of sphingoid base accumulation induced by ceramide synthase inhibition.

abstract：:The embryotoxic and teratogenic potential of inhaled monochlorobenzene (MCB) was evaluated in rats and rabbits. Bred Fischer 344 rats and inseminated New Zealand White rabbits were exposed to 0, 75, 210, or 590 ppm of MCB via inhalation for 6 hr/day during the period of major organogenesis. Exposure to 590 ppm caused ...

journal_title：Toxicology and applied pharmacology

authors： John JA,Hayes WC,Hanley TR Jr,Johnson KA,Gushow TS,Rao KS

更新日期：1984-11-01 00:00:00

abstract：:Drinking water contaminated with arsenic, a human carcinogen, is a worldwide health issue. An understanding of cellular signaling events in response to arsenic exposure and rational designing of strategies to reduce arsenic damages by modulating signaling events are important to fight against arsenic-induced diseases....

journal_title：Toxicology and applied pharmacology

authors： Wang XJ,Sun Z,Chen W,Li Y,Villeneuve NF,Zhang DD

更新日期：2008-08-01 00:00:00

abstract：:To elucidate the underlying mechanisms in oxidative stress-related airway remodeling observed in chronic inflammatory pulmonary diseases such as asthma, we studied the effects of a thiol antioxidant, N-acetylcysteine (NAC), a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, AG-1478, and tyr...

journal_title：Toxicology and applied pharmacology

authors： Tsukagoshi H,Kawata T,Shimizu Y,Ishizuka T,Dobashi K,Mori M

更新日期：2002-11-01 00:00:00

abstract：:Ethylnitrosourea (ENU) is a proven animal teratogen, although the mechanism of its developmental toxicity is unknown. The micromass rat embryo midbrain (CNS) and limb bud (LB) cultures were used in an effort to determine potential mechanisms by which ENU may exert its teratogenic effect. When cultured at high cell den...

journal_title：Toxicology and applied pharmacology

authors： Ribeiro PL,Faustman EM

更新日期：1990-06-15 00:00:00

abstract：INTRODUCTION:Noncirrhotic portal fibrosis has been reported to occur in humans due to prolonged intake of arsenic contaminated water. Further, oxystress and hepatic fibrosis have been demonstrated by us in chronic arsenic induced hepatic damage in murine model. Cytokines like tumor necrosis factor alpha (TNF-alpha) and...

journal_title：Toxicology and applied pharmacology

authors： Das S,Santra A,Lahiri S,Guha Mazumder DN

更新日期：2005-04-01 00:00:00

abstract：:Polybrominated diphenyl ethers (PBDEs) have been used in a wide variety of consumer applications as additive flame retardants. In North America, scientists have noted continuing increases in the levels of PBDE congeners measured in human serum. Some recent studies have found that PBDEs are associated with adverse heal...

journal_title：Toxicology and applied pharmacology

authors： Emond C,Sanders JM,Wikoff D,Birnbaum LS

更新日期：2013-12-01 00:00:00

abstract：:The present study examined the activation of protein kinase C (PKC) and disruption of Ca2+ homeostasis as potential mechanisms underlying effects of the polychlorinated biphenyl (PCB) congener 2,2'-dichlorobiphenyl (DCB) on inositol phosphate (IP) signaling in cerebellar granule cells. DCB (100 microM) increased basal...

journal_title：Toxicology and applied pharmacology

authors： Shafer TJ,Mundy WR,Tilson HA,Kodavanti PR

更新日期：1996-12-01 00:00:00

abstract：:The toxic effects of dioxins, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), mainly through activation of the aryl hydrocarbon receptor (AhR) are well documented. Fibroblast growth factor (Fgf) 21 plays critical roles in metabolic adaptation to fasting by increasing lipid oxidation and ketogenesis in the liver. T...

journal_title：Toxicology and applied pharmacology

authors： Cheng X,Vispute SG,Liu J,Cheng C,Kharitonenkov A,Klaassen CD

更新日期：2014-07-01 00:00:00

abstract：:The physicochemical complexity of airborne particulate matter (PM) has hampered identifying a specific mechanism(s) for its toxicity. In this study, selected physicochemical characteristics (i.e., size, particle number, acidity, and surface charge) were measured on various field PM, derived from urban ambient (St. Lou...

journal_title：Toxicology and applied pharmacology

authors： Veronesi B,de Haar C,Lee L,Oortgiesen M

更新日期：2002-02-01 00:00:00

abstract：:p-Aminophenol causes necrosis of the pars recta of the proximal tubules in rats, and its nephrotoxicity may be due to glutathione-dependent bioactivation reactions. We have investigated the hepatic metabolism of p-aminophenol in Wistar rats and the cytotoxicity of formed glutathione S-conjugates in rat renal epithelia...

journal_title：Toxicology and applied pharmacology

authors： Klos C,Koob M,Kramer C,Dekant W

更新日期：1992-07-01 00:00:00

abstract：:Benzene is a potent hematotoxin and has been shown to cause leukemia in man. Chronic toxicity studies indicate that B6C3F1 mice are more susceptible than F334/N rats to benzene toxicity. The purpose of the studies presented in this paper was to determine if there were metabolic differences between F344/N rats and B6C3...

journal_title：Toxicology and applied pharmacology

authors： Sabourin PJ,Bechtold WE,Birnbaum LS,Lucier G,Henderson RF

更新日期：1988-06-15 00:00:00

abstract：:We report that there is a time-related change in the phospholipase C (PLC) activities of rat brain cytosol and membrane fractions after iv injection of a soman-like or a sarin-like organophosphorous agent (bis(isopropyl methyl)phosphonate [BIMP] and bis(pinacolyl methyl)phosphonate [BPMP]). PLCgamma was activated in t...

journal_title：Toxicology and applied pharmacology

authors： Niijima H,Nagao M,Nakajima M,Takatori T,Matsuda Y,Iwase H,Kobayashi M

更新日期：1999-04-01 00:00:00

abstract：:Two lines of evidence support the concept that cardiotoxin from Naja naja siamensis interacts directly with the plasma membrane to produce selective cytolysis of lymphocytes. Toxin adsorbed to the wells of microtiter plates retained the ability to lyse murine T-lymphocytes, but lost the ability to destroy natural kill...

journal_title：Toxicology and applied pharmacology

authors： Hinman CL,Jiang XL,Tang HP

更新日期：1990-06-15 00:00:00

abstract：:The influence of carbon monoxide (CO) on the development of systemic hypertension was studied in Dahl rats selectively bred for susceptibility (DS) and resistance (DR) to NaCl-induced hypertension. This study was designed to examine the interactions among rat line (DS or DR), NaCl content of diet, and exposure to CO. ...

journal_title：Toxicology and applied pharmacology

authors： Shiotsuka RN,Drew RT,Wehner RW

更新日期：1984-11-01 00:00:00

abstract：:The disposition of polycyclic aromatic hydrocarbons (PAHs) in the respiratory tract of the Beagle dog was measured and presented in two previous papers. In this paper, the data were used to demonstrate that highly lipophilic toxicants, such as PAHs, were diffusion-limited during clearance from the respiratory tract. O...

journal_title：Toxicology and applied pharmacology

authors： Gerde P,Muggenburg BA,Henderson RF

更新日期：1993-08-01 00:00:00

abstract：:To evaluate the functional significance of bis(tri-n-butyltin)oxide (TBTO)-induced thymus atrophy, lymphocyte depletion in spleen and lymph nodes, lymphopenia, and increased serum IgM and decreased IgG concentrations, in vivo and in vitro function studies were performed for specific and nonspecific resistance. Weaned ...

journal_title：Toxicology and applied pharmacology

authors： Vos JG,de Klerk A,Krajnc EI,Kruizinga W,van Ommen B,Rozing J

更新日期：1984-09-30 00:00:00

abstract：:Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that stimulates transcription directed by xenobiotic response elements upstream of target genes. Recently, AhR ligands were reported to induce formation of an AhR-estrogen receptor (ER) complex, which can bind to estrogen response elements (ERE...

journal_title：Toxicology and applied pharmacology

authors： Shipley JM,Waxman DJ

更新日期：2006-06-01 00:00:00

abstract：:An in vitro model, the aggregating brain cell culture of fetal rat telencephalon, has been used to study the maturation-dependent sensitivity of brain cells to two organophosphorus pesticides (OPs), chlorpyrifos and parathion, and to their oxon derivatives. Immature (DIV 5-15) or differentiated (DIV 25-35) brain cells...

journal_title：Toxicology and applied pharmacology

authors： Monnet-Tschudi F,Zurich MG,Schilter B,Costa LG,Honegger P

更新日期：2000-06-15 00:00:00

abstract：:Accumulation, tissue distribution, and depuration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-derived 3H were examined in fingerling yellow perch fed a diet containing 494 ppt of [3H]TCDD for 13 weeks followed by the same diet without TCDD for 13 weeks. None of the TCDD-exposed perch showed any signs of overt toxici...

journal_title：Toxicology and applied pharmacology

authors： Kleeman JM,Olson JR,Chen SM,Peterson RE

更新日期：1986-05-01 00:00:00

abstract：:Deltamethrin, a widely used type II pyrethroid insecticide, is a relatively potent neurotoxicant. While the toxicity has been extensively examined, toxicokinetic studies of deltamethrin and most other pyrethroids are very limited. The aims of this study were to identify, characterize, and assess the relative contribut...

journal_title：Toxicology and applied pharmacology

authors： Anand SS,Bruckner JV,Haines WT,Muralidhara S,Fisher JW,Padilla S

更新日期：2006-04-15 00:00:00

abstract：:The metabolism of CCl(4) initiates the peroxidation of polyunsaturated fatty acids producing alpha,beta-unsaturated aldehydes, such as 4-hydroxynonenal (4-HNE) and malondialdehyde (MDA). The facile reactivity of these electrophilic aldehydic products suggests they play a role in the toxicity of compounds like CCl(4). ...

journal_title：Toxicology and applied pharmacology

authors： Hartley DP,Kolaja KL,Reichard J,Petersen DR

更新日期：1999-11-15 00:00:00

abstract：:Propiconazole is a mouse hepatotumorigenic fungicide designed to inhibit CYP51, a key enzyme in the biosynthesis of ergosterol in fungi and is widely used in agriculture to prevent fungal growth. Metabolomic studies in mice revealed that propiconazole increased levels of hepatic cholesterol metabolites and bile acids,...

journal_title：Toxicology and applied pharmacology

authors： Murphy LA,Moore T,Nesnow S

更新日期：2012-04-15 00:00:00

abstract：:Methyl palmitate (MP) has been shown earlier to inhibit Kupffer cells and rat peritoneal macrophages. To evaluate the potential of MP to inhibit the activation of other macrophages, RAW cells (macrophages of alveolar origin) were treated with varying concentrations of MP (0.25, 0.5, 1mM). Assessment of cytotoxicity us...

journal_title：Toxicology and applied pharmacology

authors： El-Demerdash E

更新日期：2011-08-01 00:00:00

abstract：:A comparative study was undertaken in order to assess the hematotoxic effects of hydroquinone (HQ), 1,4-benzoquinone (BQ), and doxorubicin (DX) on mouse and human bone marrow (BM) cells. Initial experiments indicated that the inhibitory effects of near-ambient pO2 and HQ on granulocyte/macrophage colony-stimulating fa...

journal_title：Toxicology and applied pharmacology

authors： Colinas RJ,Burkart PT,Lawrence DA

更新日期：1994-11-01 00:00:00

abstract：:2,3- and 3,4-Dichlorophenyl methyl sulfoxides and 2,3- and 3,4-dichlorophenyl methyl sulfones (2,3- and 3,4-DCPSO2Mes) were detected in the urine of rats administered o-dichlorobenzene (o-DCB). After administration of o-DCB to rats, swift decreases were observed in the concentrations of o-DCB in blood, liver, and kidn...

journal_title：Toxicology and applied pharmacology

authors： Kato Y,Kimura R

更新日期：1997-08-01 00:00:00

abstract：:Perinatal and juvenile oral treatment of rats with methoxychlor (MXC) only during development reduces testicular size and Sertoli cell number in those animals as adults. The objectives were to determine if MXC administered orally reduces numbers of spermatogonia and daily sperm production that parallel reduction in Se...

journal_title：Toxicology and applied pharmacology

authors： Staub C,Hardy VB,Chapin RE,Harris MW,Johnson L

更新日期：2002-04-15 00:00:00

abstract：:A series of naturally occurring cardenolides that exhibit potent anti-transmissible gastroenteritis virus (TGEV) activity in swine testicular (ST) cells has been identified. In an immunofluorescence assay, these cardenolides were found to diminish the expressions of TGEV nucleocapsid and spike protein, which was used ...

journal_title：Toxicology and applied pharmacology

authors： Yang CW,Chang HY,Hsu HY,Lee YZ,Chang HS,Chen IS,Lee SJ

更新日期：2017-10-01 00:00:00

abstract：:Epidermal growth factor receptor antibody (EGFRAb) conjugated silica nanorattles (SNs) were synthesized and used to develop receptor mediated endocytosis for targeted drug delivery strategies for cancer therapy. The present study determined that the rate of internalization of silica nanorattles was found to be high in...

journal_title：Toxicology and applied pharmacology

authors： Sundarraj S,Thangam R,Sujitha MV,Vimala K,Kannan S

更新日期：2014-03-15 00:00:00

abstract：:Acrolein is a highly toxic, volatile, unsaturated aldehyde generated during incomplete combustion as in tobacco smoke and indoor fires. Because the transient receptor potential ankyrin 1 (TRPA1) channel mediates tobacco smoke-induced lung injury, we assessed its role in high-level acrolein-induced toxicity in mice. Ac...

journal_title：Toxicology and applied pharmacology

authors： Conklin DJ,Haberzettl P,Jagatheesan G,Kong M,Hoyle GW

更新日期：2017-06-01 00:00:00

abstract：:Zinc oxide (ZnO) particle induced cytotoxicity was dependent on size, charge and solubility, factors which at sublethal concentrations may influence the activation of the human monocytic cell line THP1. ZnO nanoparticles (NP; average diameter 70nm) were more toxic than the bulk form (<44μm mesh) and a positive charge ...

journal_title：Toxicology and applied pharmacology

authors： Prach M,Stone V,Proudfoot L

更新日期：2013-01-01 00:00:00