Selective cytolysis by a protein toxin as a consequence of direct interaction with the lymphocyte plasma membrane.

abstract：:A comparative study was undertaken in order to assess the hematotoxic effects of hydroquinone (HQ), 1,4-benzoquinone (BQ), and doxorubicin (DX) on mouse and human bone marrow (BM) cells. Initial experiments indicated that the inhibitory effects of near-ambient pO2 and HQ on granulocyte/macrophage colony-stimulating fa...

journal_title：Toxicology and applied pharmacology

authors： Colinas RJ,Burkart PT,Lawrence DA

更新日期：1994-11-01 00:00:00

abstract：:Cannabinoid receptor (CB) expression was characterized in immunological cell and tissue preparations. Northern analysis revealed approximately 6-kb transcripts for CB1 (brain-type) in mouse spleen and brain and in rat cerebellum. CB1 was not detected in mouse thymus or rat spleen RNA by Northern analysis. CB2 (periphe...

journal_title：Toxicology and applied pharmacology

authors： Schatz AR,Lee M,Condie RB,Pulaski JT,Kaminski NE

更新日期：1997-02-01 00:00:00

abstract：:Previous studies in this laboratory have shown that polycyclic aromatic hydrocarbons (PAHs) alter Ca2+ homeostasis and inhibit activation of both B and T lymphocytes obtained from rodents and humans. In the present studies, we demonstrate that alpha-naphthoflavone (ANF), an inhibitor of cytochrome P4501A activity, red...

journal_title：Toxicology and applied pharmacology

authors： Romero DL,Mounho BJ,Lauer FT,Born JL,Burchiel SW

更新日期：1997-05-01 00:00:00

abstract：:Metabolism of methylene chloride, or dichloromethane (DCM), plays a key role in determining the kinetics and carcinogenicity of the halocarbon. The objectives of this study were: to evaluate and optimize the vial equilibration technique, originally described by Sato and Nakajima (1979a), in order to characterize the h...

journal_title：Toxicology and applied pharmacology

authors： Kim C,Manning RO,Brown RP,Bruckner JV

更新日期：1996-08-01 00:00:00

abstract：:Although insulin and atorvastatin have been shown to exert glycemic control and could improve brain function, the effects of atorvastatin or insulin as well as the combination of atorvastatin plus insulin on brain pathology in diabetes mellitus type 1 (T1DM) are unclear. Therefore, this study investigated the effect o...

journal_title：Toxicology and applied pharmacology

authors： Pratchayasakul W,Thongnak LO,Chattipakorn K,Lungaphin A,Pongchaidecha A,Satjaritanun P,Jaiwongkam T,Kerdphoo S,Chattipakorn SC

更新日期：2018-03-01 00:00:00

abstract：:The effects of oral exposure to 0, 5, and 25 mg/kg body wt vomitoxin (VT) on cytokine mRNA levels in spleen, Peyer's patches (PP), liver, kidney, and small intestine were evaluated in B6C3F1 mice at 2 and 4 hr postexposure using RT-PCR in conjunction with Southern hybridization analysis. The abundance of mRNAs for sev...

journal_title：Toxicology and applied pharmacology

authors： Azcona-Olivera JI,Ouyang Y,Murtha J,Chu FS,Pestka JJ

更新日期：1995-07-01 00:00:00

abstract：:Although the development of a therapeutic strategy for glioblastoma multiforme (GBM), the most aggressive type of brain tumor in adults, is in progress, the prognosis is still limited. In this study, we evaluated the anti-glioma effects of darapladib, a selective reversible inhibitor of lipoprotein-associated phosphol...

journal_title：Toxicology and applied pharmacology

authors： Wang YJ,Chang SB,Wang CY,Huang HT,Tzeng SF

更新日期：2020-09-01 00:00:00

abstract：UNLABELLED:Acetaminophen (APAP) overdose causes severe hepatotoxicity in animals and humans. However, the mechanisms underlying the gender differences in susceptibility to APAP overdose in mice have not been clarified. In our study, APAP (300mg/kg) caused severe liver injury in male mice but 69-77% lower injury in fema...

journal_title：Toxicology and applied pharmacology

authors： Du K,Williams CD,McGill MR,Jaeschke H

更新日期：2014-11-15 00:00:00

abstract：:Bisphenol A (BPA) is an important industrial chemical used in the manufacture of polycarbonate plastic products and epoxy resin-based food can liners. The presence of BPA metabolites in urine of >90% of Americans aged 6-60 suggests ubiquitous and frequent exposure in the range of 0.02-0.2μg/kgbw/d (25th-95th percentil...

journal_title：Toxicology and applied pharmacology

authors： Doerge DR,Twaddle NC,Vanlandingham M,Brown RP,Fisher JW

更新日期：2011-09-15 00:00:00

abstract：:Free gold nanoparticles easily aggregate when the environment conditions change. Here, gold nanoparticles (AuNPs) with average diameter of 3.7 nm were prepared and then modified with poly(ethylene glycol) (PEG) to improve stability. The gold nanoparticles were first surface-modified with 3-mercaptopropionic acid (MPA)...

journal_title：Toxicology and applied pharmacology

authors： Gu YJ,Cheng J,Lin CC,Lam YW,Cheng SH,Wong WT

更新日期：2009-06-01 00:00:00

abstract：:Epidermal growth factor receptor antibody (EGFRAb) conjugated silica nanorattles (SNs) were synthesized and used to develop receptor mediated endocytosis for targeted drug delivery strategies for cancer therapy. The present study determined that the rate of internalization of silica nanorattles was found to be high in...

journal_title：Toxicology and applied pharmacology

authors： Sundarraj S,Thangam R,Sujitha MV,Vimala K,Kannan S

更新日期：2014-03-15 00:00:00

abstract：:This study sought to investigate the effects of environmentally relevant gestational followed by continued chronic exposure to the herbicide, atrazine, on motor function, cognition, and neurochemical indices of nigrostriatal dopamine (DA) activity in male rats. Dams were treated with 100 μg/kg atrazine, 10mg/kg atrazi...

journal_title：Toxicology and applied pharmacology

authors： Walters JL,Lansdell TA,Lookingland KJ,Baker LE

更新日期：2015-12-01 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs) derived from fossil fuels are ubiquitous contaminants and occur in aquatic habitats as highly variable and complex mixtures of compounds containing 2 to 6 rings. For aquatic species, PAHs are generally accepted as acting through either of two modes of action: (1) "dioxin-like" t...

journal_title：Toxicology and applied pharmacology

authors： Incardona JP,Day HL,Collier TK,Scholz NL

更新日期：2006-12-15 00:00:00

abstract：:Various drugs have been shown to stimulate surfactant phospholipid metabolism. Particularly beta-adrenergic agonists play an important role under physiologic conditions. For the first time we have studied whether nitrogen dioxide (NO2) inhalation alters beta-adrenergic regulation of surfactant phospholipid metabolism ...

journal_title：Toxicology and applied pharmacology

authors： Mengel RG,Bernhard W,Barth P,von Wichert P,Müller B

更新日期：1993-06-01 00:00:00

abstract：:Over half of T cell acute lymphoblastic leukemia (T-ALL) patients have activating mutations in the Notch gene. Moreover, the contaminant 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) is a known carcinogen that mediates its toxicity through the aryl hydrocarbon receptor (AHR), and crosstalk between activated AHR and Notch...

journal_title：Toxicology and applied pharmacology

authors： Ahrenhoerster LS,Leuthner TC,Tate ER,Lakatos PA,Laiosa MD

更新日期：2015-03-01 00:00:00

abstract：:In many neuropathologies activated microglia and macrophages cause neurotoxicity and prolong the inflammatory response. We have previously characterized the glycosphingolipid Neurostatin (Nst), which potentially reduces these detrimental mechanisms. Nst, isolated from mammalian brain, is the GD1b ganglioside with O-ac...

journal_title：Toxicology and applied pharmacology

authors： Yanguas-Casás N,Ojalvo-Sanz AC,Martínez-Vázquez A,Goneau MF,Gilbert M,Nieto-Sampedro M,Romero-Ramírez L

更新日期：2019-08-15 00:00:00

abstract：:Ro 23-9223 is a highly lipophilic aromatic retinoid with antiproliferative and sebum supressive effects in preclinical disease models of acne. To investigate the relation between Ro 23-9223 developmental toxicity, drug distribution, and transplacental transfer, groups of pregnant hamsters were given oral doses of 50-5...

journal_title：Toxicology and applied pharmacology

authors： Willhite CC,Lovey A,Eckhoff C

更新日期：2000-04-15 00:00:00

abstract：:Polychlorinated biphenyl (PCB)126 and perfluorooctane sulfonic acid (PFOS) are halogenated organic pollutants of high concern. Exposure to these chemicals is ubiquitous, and can lead to potential synergistic adverse effects in individuals exposed to both classes of chemicals. The present study was designed to identify...

journal_title：Toxicology and applied pharmacology

authors： Deng P,Wang C,Wahlang B,Sexton T,Morris AJ,Hennig B

更新日期：2020-12-15 00:00:00

abstract：:Bropirimine is an immunomodulator with experimental antiviral and antitumor activities. This pyrimidinone has been found to be embryolethal at doses (200 and 400 mg/kg) that produce only transient maternal toxicity, when administered to pregnant Upj:TUC(SD)spf rats on specific days of gestation. Serum analyses carried...

journal_title：Toxicology and applied pharmacology

authors： Black DL,Marks TA,Branstetter DG,Kirton KT

更新日期：1991-03-15 00:00:00

abstract：:Acute exposure to Cd produces liver injury, whereas chronic exposure results in kidney injury. Tolerance to the hepatotoxicity is observed during chronic exposure to Cd due to the induction of metallothionein (MT). The nephrotoxicity produced by chronic Cd exposure purportedly results from renal uptake of Cd-metalloth...

journal_title：Toxicology and applied pharmacology

authors： Sendelbach LE,Klaassen CD

更新日期：1988-01-01 00:00:00

abstract：:Melatonin is a neuroendocrine hormone which is currently receiving considerable attention as a treatment for jet lag, a treatment for insomnia and, by some, a possible "magic bullet" for delaying the effects of aging and preventing cancer. Production of melatonin is focused primarily in the pineal gland with very wide...

journal_title：Toxicology and applied pharmacology

authors： Blumenthal GM,Kohn MC,Portier CJ

更新日期：1997-11-01 00:00:00

abstract：:Proton magnetic resonance imaging (MRI) and 31P magnetic resonance spectroscopy (MRS) have been used to study the response of the rat liver in situ to bromobenzene, a classic hepatotoxicant. A localized region of high proton signal intensity was seen in the perihilar region of the liver 24 hr after injection of a subl...

journal_title：Toxicology and applied pharmacology

authors： Locke SJ,Brauer M

更新日期：1991-09-15 00:00:00

abstract：:The immunoreactivity and pharmacokinetics of a new horse F(ab')2 scorpion antivenom and its effect on Buthus occitanus mardochei venom plasma disposition in the rabbit were studied. The scorpion venom-specific F(ab')2 affinity constant determined by immunoradiometric assay was 1.6 +/- 0.6 10(8) M-1. One group received...

journal_title：Toxicology and applied pharmacology

authors： Pépin-Covatta S,Lutsch C,Grandgeorge M,Lang J,Scherrmann JM

更新日期：1996-11-01 00:00:00

abstract：:A physiologically based model of lead absorption and disposition, previously developed and validated for adults, has been tested and calibrated for children. The model was modified to incorporate additional information on the age dependence of bone formation rate and to take into account increasing localization of bon...

journal_title：Toxicology and applied pharmacology

authors： O'Flaherty EJ

更新日期：1995-04-01 00:00:00

abstract：:The protective effect of ursodeoxycholic acid (UDCA), a biliary component found in bears, on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced testicular damage in mice was investigated. Fifty C57BL/6J mice were equally divided into five groups. The mice in the control group received the vehicle and standard chow. Th...

journal_title：Toxicology and applied pharmacology

authors： Kwon YI,Yeon JD,Oh SM,Chung KH

更新日期：2004-02-01 00:00:00

abstract：:The purpose of this study was to determine whether exposure to levels of sarin causing no overt clinical signs would cause more subtle, adverse health effects that persisted after the exposure ended. Inhalation exposures of male Fischer 344 rats to 0, 0.2, or 0.4 mg/m(3) of sarin for 1 h/day for 1, 5, or 10 days under...

journal_title：Toxicology and applied pharmacology

authors： Henderson RF,Barr EB,Blackwell WB,Clark CR,Conn CA,Kalra R,March TH,Sopori ML,Tesfaigzi Y,Ménache MG,Mash DC

更新日期：2002-10-15 00:00:00

abstract：:Ethyl carbamate (EC) is bioactivated by CYP2E1 through vinyl carbamate to its epoxide, a reactive electrophile. This carcinogen reacts with macromolecules, including hemoglobin (Hb). This report defines a method to examine levels of N-(2-oxoethyl) adduct on the N-terminal valine of Hb after EC treatment at carcinogeni...

journal_title：Toxicology and applied pharmacology

authors： Cai J,Myers SR,Hurst HE

更新日期：1995-03-01 00:00:00

abstract：:p,p'-DDT (1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane; 75 mg/kg) or corn oil was administered po to male Fischer 344N rats. Tremor was quantified 8 hr later by spectral analysis of whole body movements. The effect of sc injection of pharmacological challenges on the spectral profile of body movements was determined....

journal_title：Toxicology and applied pharmacology

authors： Herr DW,Tilson HA

更新日期：1987-11-01 00:00:00

abstract：:The number of neurons, astrocytes, reactive glia, oligodendrocytes, endothelia, and pericytes in the cortex of the calcarine sulcus of adult female Macaca fascicularis following long-term subclinical exposure to methyl mercury (MeHg) and mercuric chloride (inorganic mercury; IHg) has been estimated by use of the optic...

journal_title：Toxicology and applied pharmacology

authors： Charleston JS,Bolender RP,Mottet NK,Body RL,Vahter ME,Burbacher TM

更新日期：1994-12-01 00:00:00

abstract：:Recently, the FDA approved the medical use of oral pyridostigmine as prophylactic treatment of possible nerve agent exposure: the concept is to block the cholinesterase transitorily using the carbamate (pyridostigmine) in order to deny access to the active site of the enzyme to the irreversible inhibitor (nerve agent)...

journal_title：Toxicology and applied pharmacology

authors： Petroianu GA,Hasan MY,Nurulain SM,Arafat K,Sheen R,Nagelkerke N

更新日期：2007-03-01 00:00:00