Physiologically based models for bone-seeking elements. V. Lead absorption and disposition in childhood.

Abstract:

:A physiologically based model of lead absorption and disposition, previously developed and validated for adults, has been tested and calibrated for children. The model was modified to incorporate additional information on the age dependence of bone formation rate and to take into account increasing localization of bone modeling activity with age. A bone volume characterized by mature bone metabolic activity increases from zero at birth to the total bone volume by young adulthood. Bone formation rate is high from childhood through adolescence, with peaks at birth and around puberty. Bone resorption rate keeps pace at a rate that allows the orderly increase of bone mass. In general, the model reproduces childhood blood lead observations well, except in instances where lead is ingested at very high concentrations. Both bone and blood lead concentration are labile during early childhood because of the high rate of bone turnover. They respond rapidly to increases in lead exposure, and decrease almost as rapidly to near-preexposure concentrations when exposure returns to background levels. As the child grows, fractional bone formation and resorption rates decline and total bone lead turnover becomes more sluggish. From the time of peak bone mineralization rate in adolescence into early adulthood, the rate of bone turnover drops dramatically and the ability to reverse bone lead accumulation relatively rapidly is lost.

journal_name

Toxicol Appl Pharmacol

authors

O'Flaherty EJ

doi

10.1006/taap.1995.1072

subject

Has Abstract

pub_date

1995-04-01 00:00:00

pages

297-308

issue

2

eissn

0041-008X

issn

1096-0333

pii

S0041008X85710721

journal_volume

131

pub_type

杂志文章,评审
  • Reaction between metabolically activated acetaminophen and phosphorothioate oligonucleotides.

    abstract::Assessment of toxic or mutagenic risks associated with phosphorothioate oligonucleotides (PTO) is important. In vitro and in vivo data have shown that PTOs are nontoxic and nonmutagenic. However, these studies do not address interactions between PTOs and other compounds. The sulfur on PTOs may provide a novel reactive...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1006/taap.1995.1126

    authors: Copple BL,Gmeiner WM,Iversen PL

    更新日期:1995-07-01 00:00:00

  • Gene expression profiling reveals underlying molecular mechanisms of the early stages of tamoxifen-induced rat hepatocarcinogenesis.

    abstract::Tamoxifen is a widely used anti-estrogenic drug for chemotherapy and, more recently, for the chemoprevention of breast cancer. Despite the indisputable benefits of tamoxifen in preventing the occurrence and re-occurrence of breast cancer, the use of tamoxifen has been shown to induce non-alcoholic steatohepatitis, whi...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2007.07.001

    authors: Pogribny IP,Bagnyukova TV,Tryndyak VP,Muskhelishvili L,Rodriguez-Juarez R,Kovalchuk O,Han T,Fuscoe JC,Ross SA,Beland FA

    更新日期:2007-11-15 00:00:00

  • Biphasic hormonal responses to the adrenocorticolytic DDT metabolite 3-methylsulfonyl-DDE in human cells.

    abstract::The DDT metabolite 3-methylsulfonyl-DDE (3-MeSO(2)-DDE) has been proposed as a lead compound for an improved adrenocortical carcinoma (ACC) treatment. ACC is a rare malignant disorder with poor prognosis, and the current pharmacological therapy o,p'-DDD (mitotane) has limited efficacy and causes severe adverse effects...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2009.10.018

    authors: Asp V,Ullerås E,Lindström V,Bergström U,Oskarsson A,Brandt I

    更新日期:2010-02-01 00:00:00

  • Enlightened protein: Fhit tumor suppressor protein structure and function and its role in the toxicity of protoporphyrin IX-mediated photodynamic reaction.

    abstract::The Fhit tumor suppressor protein possesses Ap(3)A (diadenosine triphosphate - ApppA) hydrolytic activity in vitro and its gene is found inactive in many pre-malignant states due to gene inactivation. For several years Fhit has been a widely investigated protein as its cellular function still remains largely unsolved....

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.taap.2009.08.023

    authors: Zawacka-Pankau J,Ferens B

    更新日期:2009-12-01 00:00:00

  • Influence of iron and zinc status on cadmium accumulation in Bangladeshi women.

    abstract::Cadmium is a widespread environmental contaminant present in food. The absorption in the intestine increases in individuals with low iron stores, but the effect of zinc deficiency is not clear. The aim of the present study was to assess the influence of iron and zinc status on cadmium accumulation in pregnant Banglade...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2007.04.009

    authors: Kippler M,Ekström EC,Lönnerdal B,Goessler W,Akesson A,El Arifeen S,Persson LA,Vahter M

    更新日期:2007-07-15 00:00:00

  • Gender-specific impairment of in vitro sinoatrial node chronotropic responses and of myocardial ischemia tolerance in rats exposed prenatally to betamethasone.

    abstract::Excessive fetal glucocorticoid exposure has been linked to increased susceptibility to hypertension and cardiac diseases in the adult life, a process called fetal programming. The cardiac contribution to the hypertensive phenotype of glucocorticoid-programmed progeny is less known, therefore, we investigated in vitro ...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2017.09.002

    authors: Kiguti LRA,Borges CS,Mueller A,Silva KP,Polo CM,Rosa JL,Silva PV,Missassi G,Valencise L,Kempinas WG,Pupo AS

    更新日期:2017-11-01 00:00:00

  • Calcium homeostasis in pregnant rats treated with ethylene glycol monomethyl ether (EGME).

    abstract::The industrial solvent ethylene glycol monomethyl ether (EGME) is a known teratogen that has been reported to alter calcium metabolism in guinea pigs during chronic exposure. Because of the tremendous demand of reproduction on maternal calcium stores, the effects of EGME on calcium and vitamin D metabolism during gest...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/0041-008x(86)90050-5

    authors: Toraason M,Niemeier RW,Hardin BD

    更新日期:1986-11-01 00:00:00

  • HBCDD-induced sustained reduction in mitochondrial membrane potential, ATP and steroidogenesis in peripubertal rat Leydig cells.

    abstract::Hexabromocyclododecane (HBCDD), a brominated flame retardant added to various consumer products, is a ubiquitous environmental contaminant. We have previously shown that 6-hour exposure to HBCDD disturbs basal and human chorionic gonadotropin (hCG)-induced steroidogenesis in rat Leydig cells. Reduction in mitochondria...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2014.11.001

    authors: Fa S,Pogrmic-Majkic K,Samardzija D,Hrubik J,Glisic B,Kovacevic R,Andric N

    更新日期:2015-01-01 00:00:00

  • Influence of AS3MT polymorphisms on arsenic metabolism and liver injury in APL patients treated with arsenic trioxide.

    abstract::Arsenic-induced side effects limit its application in the treatment of acute promyelocytic leukemia (APL). We recently demonstrated that AS3MT 14215 (rs3740390) genotypes were associated with urinary arsenic metabolites and hematological and biochemical values. To further decipher the role of AS3MT genotypes on arseni...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2019.114687

    authors: Lu J,Yu K,Fan S,Liu W,Dong Z,Li J,Wang X,Hai X,Zhou J

    更新日期:2019-09-15 00:00:00

  • Topovectorial mechanisms control the juxtamembrane proteolytic processing of Nrf1 to remove its N-terminal polypeptides during maturation of the CNC-bZIP factor.

    abstract::The topobiological behaviour of Nrf1 dictates its post-translational modification and its ability to transactivate target genes. Here, we have elucidated that topovectorial mechanisms control the juxtamembrane processing of Nrf1 on the cyto/nucleoplasmic side of endoplasmic reticulum (ER), whereupon it is cleaved and ...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2018.09.039

    authors: Xiang Y,Halin J,Fan Z,Hu S,Wang M,Qiu L,Zhang Z,Mattjus P,Zhang Y

    更新日期:2018-12-01 00:00:00

  • Reproductive toxicity of 2,4-dinitrotoluene in the rat.

    abstract::The present study was undertaken to evaluate the effects of the chemosterilant 2,4-dinitrotoluene (DNT) on the rat testis. Adult male rats were fed control, or 0.1%, or 0.2% DNT for 3 weeks. An ultrastructural study of the testes was performed, serum was assayed for testosterone and gonadotropins, and sperm reserve co...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/0041-008x(88)90287-6

    authors: Bloch E,Gondos B,Gatz M,Varma SK,Thysen B

    更新日期:1988-07-01 00:00:00

  • Activation of protein kinase C and disruption of endothelial monolayer integrity by sodium arsenite--Potential mechanism in the development of atherosclerosis.

    abstract::Arsenic exposure has been shown to exacerbate atherosclerosis, beginning with activation of the endothelium that lines the vessel wall. Endothelial barrier integrity is maintained by proteins of the adherens junction (AJ) such as vascular endothelial cadherin (VE-cadherin) and beta-catenin and their association with t...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2006.12.035

    authors: Pereira FE,Coffin JD,Beall HD

    更新日期:2007-04-15 00:00:00

  • Gene expression profiling in the liver of CD-1 mice to characterize the hepatotoxicity of triazole fungicides.

    abstract::Four triazole fungicides used in agricultural or pharmaceutical applications were examined for hepatotoxic effects in mouse liver. Besides organ weight, histopathology, and cytochrome P450 (CYP) enzyme induction, DNA microarrays were used to generate gene expression profiles and hypotheses on potential mechanisms of a...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2006.02.016

    authors: Goetz AK,Bao W,Ren H,Schmid JE,Tully DB,Wood C,Rockett JC,Narotsky MG,Sun G,Lambert GR,Thai SF,Wolf DC,Nesnow S,Dix DJ

    更新日期:2006-09-15 00:00:00

  • Female-specific activation of pregnane X receptor mediates sex difference in fetal hepatotoxicity by prenatal monocrotaline exposure.

    abstract::Pyrrolizidine alkaloids (PAs) are a group of hepatic toxicant widely present in plants. Cytochrome P450 (CYP) 3A plays a key role in metabolic activation of PAs to generate electrophilic metabolites, which is the main cause of hepatotoxicity. We have previously demonstrated the sex difference in developmental toxicity...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2020.115137

    authors: Xiang E,Guo Q,Dai YG,Sun XX,Liu J,Fan CP,Wang YQ,Qiu SK,Wang H,Guo Y

    更新日期:2020-11-01 00:00:00

  • A precisely substituted benzopyran targets androgen refractory prostate cancer cells through selective modulation of estrogen receptors.

    abstract::Dietary consumption of phytoestrogens like genistein has been linked with lower incidence of prostate cancer. The estradiol-like benzopyran core of genistein confers estrogen receptor-β (ER-β) selectivity that imparts weak anti-proliferative activity against prostate cancer cells. DL-2-[4-(2-piperidinoethoxy)phenyl]-3...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2015.01.017

    authors: Kumar R,Verma V,Sharma V,Jain A,Singh V,Sarswat A,Maikhuri JP,Sharma VL,Gupta G

    更新日期:2015-03-15 00:00:00

  • Inhibition of proliferative activity of pulmonary fibroblasts by tetrandrine.

    abstract::Tetrandrine, an herbal drug, has been employed in China to treat pulmonary fibrosis. To date, the mechanisms governing the antifibrotic action of tetrandrine are unknown. The present study employs a fibroblast mitogenic assay to determine whether tetrandrine directly inhibits the ability of fibroblasts to respond to s...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1006/taap.1993.1173

    authors: Reist RH,Dey RD,Durham JP,Rojanasakul Y,Castranova V

    更新日期:1993-09-01 00:00:00

  • The surface charge of visible particulate matter predicts biological activation in human bronchial epithelial cells.

    abstract::The physicochemical complexity of airborne particulate matter (PM) has hampered identifying a specific mechanism(s) for its toxicity. In this study, selected physicochemical characteristics (i.e., size, particle number, acidity, and surface charge) were measured on various field PM, derived from urban ambient (St. Lou...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1006/taap.2001.9341

    authors: Veronesi B,de Haar C,Lee L,Oortgiesen M

    更新日期:2002-02-01 00:00:00

  • Circadian toxicology of cyclosporin.

    abstract::Cyclosporin (Cs), a cyclic nonpolar undecapeptide of fungal origin, has potent immunosuppressive and antiparasitic activities, and renal and hepatic toxicities, the mechanisms of which are not worked out. Many nephrotoxins and hepatotoxins are predictably more or less harmful, depending upon the circadian stage at whi...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/0041-008x(85)90279-0

    authors: Magnus G,Cavallini M,Halberg F,Cornelissen G,Sutherland DE,Najarian JA,Hrushesky WJ

    更新日期:1985-01-01 00:00:00

  • St. John's wort significantly increased the systemic exposure and toxicity of methotrexate in rats.

    abstract::St. John's wort (SJW, Hypericum perforatum) is one of the popular nutraceuticals for treating depression. Methotrexate (MTX) is an immunosuppressant with narrow therapeutic window. This study investigated the effect of SJW on MTX pharmacokinetics in rats. Rats were orally given MTX alone and coadministered with 300 an...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2012.05.020

    authors: Yang SY,Juang SH,Tsai SY,Chao PD,Hou YC

    更新日期:2012-08-15 00:00:00

  • Alteration of cytosolic calcium levels in PC12 cells by potassium cyanide.

    abstract::The effect of KCN on cytosolic Ca2+ levels was measured in PC12 cells using Quin II/AM, a fluorometric calcium indicator. The resting cytosolic Ca2+ concentration, 115.0 +/- 4.9 nm, increased gradually and steadily over a 30-min time period following addition of 10(-4), 10(-3), or 10(-2)M KCN to the cells. After 15 mi...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/0041-008x(87)90007-x

    authors: Johnson JD,Conroy WG,Isom GE

    更新日期:1987-04-01 00:00:00

  • Testicular toxicity and reduced Sertoli cell numbers in neonatal rats by di(2-ethylhexyl)phthalate and the recovery of fertility as adults.

    abstract::Neonatal and adult rats (1, 2, 3, 6, and 12 weeks of age) were given five daily oral doses of di(2-ethylhexyl) phthalate (DEHP) (0, 10, 100, 1000, 2000 mg/kg) and histological changes in the testes were examined 24 hr after the last dose. Relative testis weights were reduced at doses of 1000 mg/kg in 1, 2, 3, and 6-we...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0041-008x(88)80012-7

    authors: Dostal LA,Chapin RE,Stefanski SA,Harris MW,Schwetz BA

    更新日期:1988-08-01 00:00:00

  • Human T cells are highly sensitive to suppression of mitogenesis by polycyclic aromatic hydrocarbons and this effect is differentially reversed by alpha-naphthoflavone.

    abstract::The immunosuppressive effects of polycyclic aromatic hydrocarbons (PAHs) on immune responses in rodents, both in vivo and in vitro, have been widely documented. However, few studies have addressed the immunotoxicity of PAHs in the human system. In this report, we examined the toxic effects of nine different PAHs on hu...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1006/taap.1996.0173

    authors: Davila DR,Romero DL,Burchiel SW

    更新日期:1996-08-01 00:00:00

  • Renal necrosis and DNA damage caused by selectively deuterated and methylated analogs of 1,2-dibromo-3-chloropropane in the rat.

    abstract::Selectively deuterated and methylated analogs of the nematocide 1,2-dibromo-3-chloropropane (DBCP) were compared to DBCP in causing acute renal damage in rats. All of the six deuterated analogs tested at 340 mumol/kg, including the perdeutero compound, failed to significantly alter the kidney necrosis observed at 48 h...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/0041-008x(87)90058-5

    authors: Omichinski JG,Brunborg G,Søderlund EJ,Dahl JE,Bausano JA,Holme JA,Nelson SD,Dybing E

    更新日期:1987-12-01 00:00:00

  • Opiates depress ACh and ATP release from cholinergic synaptosomes by blocking calcium uptake.

    abstract::We have studied the effects of opiates on ATP and acetylcholine (ACh) release from cholinergic nerve terminals isolated from the electric organ of Torpedo marmorata. The release of ATP was inhibited by morphine and this action was reversed by naloxone. Morphine, [D-Met2-Pro5]enkephalinamide and [D-Ala2-Leu5]enkephalin...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/0041-008x(90)90101-y

    authors: Saltó C,Calvet R,Guitart X,Solsona C,Marsal J

    更新日期:1990-10-01 00:00:00

  • Iron tetrakis (N-methyl-4'-pyridyl) porphyrinato inhibits proliferative activity of thymocytes by blocking activation of p38 mitogen-activated protein kinase, nuclear factor-kappaB, and interleukin-2 secretion.

    abstract::Iron tetrakis (N-methyl-4'-pyridyl) porphyrinato (FeTMPyP) has been demonstrated to be a potent scavenger of reactive oxygens and to have antiinflammatory activities. However, the effects of FeTMPyP on the function of T cells have not been illustrated. The objective of this study was to determine whether treatment of ...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0041-008x(02)00044-3

    authors: Kang JL,Lee HS,Jung HJ,Kim HJ

    更新日期:2003-09-01 00:00:00

  • Effects of sodium salts of phenobarbital and barbital on development of bladder tumors in male F344/NCr rats pretreated with either N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide or N-nitrosobutyl-4-hydroxybutylamine.

    abstract::Promoting effects of sodium salts of phenobarbital (NaPB) and barbital (NaBB) on the development of bladder tumors were investigated in F344 male rats initiated with N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) or N-nitrosobutyl-4-hydroxybutylamine (BBN). To initiate with FANFT, rats were fed 0.2% FANFT mixed ...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/0041-008x(89)90232-9

    authors: Diwan BA,Hagiwara A,Ward JM,Rice JM

    更新日期:1989-04-01 00:00:00

  • Neurotoxic injury pathways in differentiated mouse motor neuron-neuroblastoma hybrid (NSC-34D) cells in vitro--limited effect of riluzole on thapsigargin, but not staurosporine, hydrogen peroxide and homocysteine neurotoxicity.

    abstract::The neuroblastoma-spinal motor neuron fusion cell line, NSC-34, in its differentiated form, NSC-34D, permits examining the effects of riluzole, a proven treatment for amyotrophic lateral sclerosis (ALS) on cell death induction by staurosporine (STS), thapsigargin (Thaps), hydrogen peroxide (H(2)O(2)) and homocysteine ...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2011.10.022

    authors: Hemendinger RA,Armstrong EJ 3rd,Radio N,Brooks BR

    更新日期:2012-01-15 00:00:00

  • Activation of aryl hydrocarbon receptor reduces carbendazim-induced cell death.

    abstract::Carbendazim inhibits microtubule assembly, thus blocking mitosis and inhibiting cancer cell proliferation. Accordingly, carbendazim is being explored as an anticancer drug. Data show that carbendazim increased mRNA and protein expressions and promoter activity of CYP1A1. In addition, carbendazim activated transcriptio...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2016.06.004

    authors: Wei KL,Chen FY,Lin CY,Gao GL,Kao WY,Yeh CH,Chen CR,Huang HC,Tsai WR,Jong KJ,Li WJ,Su JG

    更新日期:2016-09-01 00:00:00

  • Disruption of inositol phosphate accumulation in cerebellar granule cells by polychlorinated biphenyls: a consequence of altered Ca2+ homeostasis.

    abstract::The present study examined the activation of protein kinase C (PKC) and disruption of Ca2+ homeostasis as potential mechanisms underlying effects of the polychlorinated biphenyl (PCB) congener 2,2'-dichlorobiphenyl (DCB) on inositol phosphate (IP) signaling in cerebellar granule cells. DCB (100 microM) increased basal...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1006/taap.1996.0311

    authors: Shafer TJ,Mundy WR,Tilson HA,Kodavanti PR

    更新日期:1996-12-01 00:00:00

  • The induction of heme oxygenase-1 suppresses heat shock protein 90 and the proliferation of human breast cancer cells through its byproduct carbon monoxide.

    abstract::Heme oxygenase (HO)-1 is an oxidative stress-response enzyme which catalyzes the degradation of heme into bilirubin, ferric ion, and carbon monoxide (CO). Induction of HO-1 was reported to have antitumor activity; the inhibitory mechanism, however, is still unclear. In the present study, we found that treatment with [...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2013.10.027

    authors: Lee WY,Chen YC,Shih CM,Lin CM,Cheng CH,Chen KC,Lin CW

    更新日期:2014-01-01 00:00:00