The effects of gestational and chronic atrazine exposure on motor behaviors and striatal dopamine in male Sprague-Dawley rats.

abstract：:Cadmium chloride (CdCl2) at a dose of 1 mg/kg body wt was injected into male rats of the Wistar strain, weighing 250 g on the average, twice a day (12-hr intervals) for 7 consecutive days. DNA and RNA contents and [3H]-thymidine and [3H]-uridine incorporation into the acid-insoluble fraction significantly increased in...

journal_title：Toxicology and applied pharmacology

authors： Nishiyama S,Nakamura K

更新日期：1984-07-01 00:00:00

abstract：:Diclofenac, a widely used nonsteroidal anti-inflammatory drug, has been associated with rare but severe cases of clinical hepatotoxicity. Diclofenac causes concentration-dependent cell death in human hepatocytes (after 24-48 h) by mitochondrial permeabilization via poorly defined mechanisms. To explore whether the cyc...

journal_title：Toxicology and applied pharmacology

authors： Siu WP,Pun PB,Latchoumycandane C,Boelsterli UA

更新日期：2008-03-15 00:00:00

abstract：:Allergic airway diseases in children are a common and a growing health problem. Changes in the central nervous system (CNS) have been implicated in contributing to some of the symptoms. We hypothesized that airway allergic diseases are associated with altered histamine H3 receptor expression in the nucleus tractus sol...

journal_title：Toxicology and applied pharmacology

authors： Sekizawa S,Bechtold AG,Tham RC,Kott KS,Hyde DM,Joad JP,Bonham AC

更新日期：2010-09-15 00:00:00

abstract：:Fibrinogen, a soluble 340kDa plasma glycoprotein, is critical in achieving and maintaining hemostasis. Reduced fibrinogen levels are associated with an increased risk of bleeding and recent research has investigated the efficacy of fibrinogen concentrate for controlling perioperative bleeding. European guidelines on t...

journal_title：Toxicology and applied pharmacology

authors： Beyerle A,Nolte MW,Solomon C,Herzog E,Dickneite G

更新日期：2014-10-01 00:00:00

abstract：:Free gold nanoparticles easily aggregate when the environment conditions change. Here, gold nanoparticles (AuNPs) with average diameter of 3.7 nm were prepared and then modified with poly(ethylene glycol) (PEG) to improve stability. The gold nanoparticles were first surface-modified with 3-mercaptopropionic acid (MPA)...

journal_title：Toxicology and applied pharmacology

authors： Gu YJ,Cheng J,Lin CC,Lam YW,Cheng SH,Wong WT

更新日期：2009-06-01 00:00:00

abstract：:Arsenic in drinking water is a worldwide health problem that is associated with cardiovascular disease, but the cause is currently unknown. Arsenic effects on platelets, which are important in development of cardiovascular disease, were examined in vitro and in a drinking water study using a rat animal model. Trivalen...

journal_title：Toxicology and applied pharmacology

authors： Lee MY,Bae ON,Chung SM,Kang KT,Lee JY,Chung JH

更新日期：2002-03-01 00:00:00

abstract：:Alteration in the expression pattern of Nrf-2 and NFκB has been reported in ulcerative colitis (UC) in which functional crosstalk between these two critical pathways has been suggested. The ameliorative potential of the AT1R blocker olmesartan (OLM) on oxidative stress and inflammatory cytokines has received considera...

journal_title：Toxicology and applied pharmacology

authors： Saber S,Khalil RM,Abdo WS,Nassif D,El-Ahwany E

更新日期：2019-02-01 00:00:00

abstract：:Interferon α (IFNα) is used to treat malignancies and chronic viral infections. It has been found to decrease the rate of drug metabolism by acting on cytochrome P450 enzymes, but no studies have investigated the consequences of IFNα treatment on the CYP3A4 isoform, responsible for the metabolism of a majority of drug...

journal_title：Toxicology and applied pharmacology

authors： Flaman AS,Gravel C,Hashem AM,Tocchi M,Li X

更新日期：2011-06-01 00:00:00

abstract：:Tributyltin (TBT) and triphenyltin (TPT) are known to cause imposex, the superimposing of male genitals on female ones, in some species of gastropods. However, the molecular mechanism of the trialkyltin-induced endocrine dysfunction remains to be elucidated. To clarify the effects of organotin compounds on the activat...

journal_title：Toxicology and applied pharmacology

authors： Yamabe Y,Hoshino A,Imura N,Suzuki T,Himeno S

更新日期：2000-12-01 00:00:00

abstract：:4-Hydroxy-2-trans-nonenal (4HNE), one of the major end products of lipid peroxidation (LPO), has been shown to induce apoptosis in a variety of cell lines. It appears to modulate signaling processes in more than one way because it has been suggested to have a role in signaling for differentiation and proliferation. It...

journal_title：Toxicology and applied pharmacology

authors： Singhal SS,Singh SP,Singhal P,Horne D,Singhal J,Awasthi S

更新日期：2015-12-15 00:00:00

abstract：:Along with the wide use of pesticides in the world, the concerns over their health impacts are rapidly growing. There is a huge body of evidence on the relation between exposure to pesticides and elevated rate of chronic diseases such as different types of cancers, diabetes, neurodegenerative disorders like Parkinson,...

journal_title：Toxicology and applied pharmacology

authors： Mostafalou S,Abdollahi M

更新日期：2013-04-15 00:00:00

abstract：:The immunotoxic effects of the environmental carcinogen benzo[a]pyrene (BaP) have been evaluated using mouse, but not human, lymphocytes. Since susceptibility to immunomodulation by BaP may be species-related, the effects of BaP on human peripheral blood mononuclear cells (HPBMC) from several individuals were investig...

journal_title：Toxicology and applied pharmacology

authors： Mudzinski SP

更新日期：1993-04-01 00:00:00

abstract：:High- and low- Se diets received by dams during gestation and lactation are related to insulin resistance in their pups. High-Se diet leads to an increase in serum insulin levels, which does not function properly, and an anabolic process. Low-Se diet is related to very low insulin values and an extreme catabolic energ...

journal_title：Toxicology and applied pharmacology

authors： Ojeda ML,Carreras O,Díaz-Castro J,Murillo ML,Nogales F

更新日期：2019-11-01 00:00:00

abstract：:To clarify the immunotoxicity of benzene, the effects of benzene inhalation on T and B lymphocytes and immune responses in mice were examined. BALB/c male mice were exposed to 50 or 200 ppm benzene vapor, 6 hr/day for 7 or 14 consecutive days. T and B lymphocytes, in blood and spleen, were detected by the cytotoxicity...

journal_title：Toxicology and applied pharmacology

authors： Aoyama K

更新日期：1986-08-01 00:00:00

abstract：:Arsenic is a well-documented human carcinogen and is known to cause oxidative stress in cultured cells and animals. A hospital-based case-control study was conducted to evaluate the relationship among the levels of urinary 8-hydroxydeoxyguanosine (8-OHdG), the arsenic profile, and urothelial carcinoma (UC). Urinary 8-...

journal_title：Toxicology and applied pharmacology

authors： Chung CJ,Huang CJ,Pu YS,Su CT,Huang YK,Chen YT,Hsueh YM

更新日期：2008-01-01 00:00:00

abstract：:The Fluorescent Cell Chip for in vitro immunotoxicity testing employs cell lines derived from lymphocytes, mast cells, and monocytes-macrophages transfected with various EGFP cytokine reporter gene constructs. While cytokine expression is a valid endpoint for in vitro immunotoxicity screening, additional marker for th...

journal_title：Toxicology and applied pharmacology

authors： Trzaska D,Zembek P,Olszewski M,Adamczewska V,Ullerås E,Dastych J

更新日期：2005-09-01 00:00:00

abstract：:Vertebrate embryos are particularly sensitive to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Identification of tissues that are susceptible to the adverse effects of TCDD is requisite for understanding the embryo toxic effects of TCDD. The objective of the present study was to quantitate the temporal appearance of and...

journal_title：Toxicology and applied pharmacology

authors： Cantrell SM,Joy-Schlezinger J,Stegeman JJ,Tillitt DE,Hannink M

更新日期：1998-01-01 00:00:00

abstract：:Kidney is the primary target organ in chronic cadmium (Cd) toxicity, and oxidative stress plays an important role in this process. The nuclear transcription factor Nrf2 binds to antioxidant response elements (AREs) and regulates genes involved in protecting cells from oxidative damage. Whether kidney cells respond to ...

journal_title：Toxicology and applied pharmacology

authors： Chen J,Shaikh ZA

更新日期：2009-11-15 00:00:00

abstract：:The debate on tungsten (W) is fostered by its continuous usage in military munitions. Reports demonstrate W solubilizes in soil and can migrate into drinking water supplies and, therefore, is a potential health risk to humans. This study evaluated the reproductive, systemic and neurobehavioral effects of sodium tungst...

journal_title：Toxicology and applied pharmacology

authors： McInturf SM,Bekkedal MY,Wilfong E,Arfsten D,Chapman G,Gunasekar PG

更新日期：2011-07-15 00:00:00

abstract：:Studies were conducted to assess the in vitro toxicity of three chloropropanones: monochloropropanone (MCP), 1,1-dichloropropanone (1,1-DCP), and 1,3-dichloropropanone (1,3-DCP). Chloropropanones reacted directly with reduced glutathione (GSH) in sodium phosphate buffer at pH 7.4. All chloropropanones were cytotoxic t...

journal_title：Toxicology and applied pharmacology

authors： Merrick BA,Smallwood CL,Meier JR,McKean DL,Kaylor WH,Condie LW

更新日期：1987-10-01 00:00:00

abstract：:F(ab')2 fragments are sometimes preferred to whole IgG for therapeutic or diagnostic uses. Preclinical pharmaceutical development studies are necessary before their use in humans. Here we propose an allometric approach among three mammalian species to predict F(ab')2 pharmacokinetic parameters in humans. Plasma dispos...

journal_title：Toxicology and applied pharmacology

authors： Bazin-Redureau M,Pepin S,Hong G,Debray M,Scherrmann JM

更新日期：1998-06-01 00:00:00

abstract：:Some widely used psychoactive drugs, such as tricyclic antidepressants and antipsychotic phenothiazines exhibit iatrogenic effects on the thyroid. These side effects may arise from interactions at different steps of thyroid hormone biosynthesis. These drugs can induce a change in iodine capture by thyroid cells or can...

journal_title：Toxicology and applied pharmacology

authors： Sauvage MF,Marquet P,Rousseau A,Raby C,Buxeraud J,Lachâtre G

更新日期：1998-04-01 00:00:00

abstract：:Polycyclic Aromatic Hydrocarbons (PAHs) constitute a family of over one hundred compounds and can generally be found in complex mixtures. PAHs metabolites cause DNA damage which can lead to the development of carcinogenesis. Toxicity assessment of PAH complex mixtures is currently expressed in terms of toxic equivalen...

journal_title：Toxicology and applied pharmacology

authors： Audebert M,Zeman F,Beaudoin R,Péry A,Cravedi JP

更新日期：2012-04-01 00:00:00

abstract：:Exposure of mice to cationic rhodamines, Rh 123 and Rh 6G, has been found to be associated with developmental toxicity, while neutral rhodamines (e.g., Rh B) had no such effect. When mouse embryos from dams given ip injections of Rh 123, Rh 6G (15 mg/kg), or Rh B (30 mg/kg) on gestation Day (GD) 10 were examined, Rh 1...

journal_title：Toxicology and applied pharmacology

authors： Ranganathan S,Churchill PF,Hood RD

更新日期：1989-06-01 00:00:00

abstract：:Epidemiological studies have demonstrated a high association of inorganic arsenic exposure with vascular diseases. Recent research has also linked this vascular damage to impairment of endothelial nitric oxide synthase (eNOS) function by arsenic exposure. However, the role of eNOS in regulating the arsenite-induced va...

journal_title：Toxicology and applied pharmacology

authors： Tsou TC,Tsai FY,Hsieh YW,Li LA,Yeh SC,Chang LW

更新日期：2005-11-01 00:00:00

abstract：:In this study, the effects of pentavalent dimethylarsinic acid ((CH(3))(2)AsO(OH); DMA(V)) and trivalent dimethylarsinous acid ((CH(3))(2)As(OH); DMA(III)) on synaptic transmission generated by the excitatory Schaffer collateral-CA1 synapse were tested in hippocampal slices of young (14-21 day-old) and adult (2-4 mont...

journal_title：Toxicology and applied pharmacology

authors： Krüger K,Repges H,Hippler J,Hartmann LM,Hirner AV,Straub H,Binding N,Musshoff U

更新日期：2007-11-15 00:00:00

abstract：:Chronic arsenic exposure through contaminated drinking water is a major environmental health issue. Chronic arsenic exposure is known to exert its toxic effects by a variety of mechanisms, of which generation of reactive oxygen species (ROS) is one of the most important. A high level of ROS, in turn, leads to DNA dama...

journal_title：Toxicology and applied pharmacology

authors： Banerjee M,Banerjee N,Ghosh P,Das JK,Basu S,Sarkar AK,States JC,Giri AK

更新日期：2010-11-15 00:00:00

abstract：:Acute oral toxicity of Cd (as cadmium chloride) was enhanced in rats fasted 24 hr, as shown by a markedly decreased LD50. To examine the relationship among Cd toxicity, hepatic glutathione (GSH), and metallothionein (MT) during fasting, rats were administered 75 mg Cd/kg orally 24 hr after fasting and euthanized after...

journal_title：Toxicology and applied pharmacology

authors： Shimizu M,Morita S

更新日期：1990-03-15 00:00:00

abstract：:Air pollution, especially fine particulate matter (PM2.5, particles <2.5 μm in size), induces adverse health effects on the respiratory system. Uncontrolled proliferation of bronchial epithelial cells, resulting from deregulated cell cycle progression, contributes to pulmonary homeostatic imbalance. Although dysregula...

journal_title：Toxicology and applied pharmacology

authors： Xiao T,Ling M,Xu H,Luo F,Xue J,Chen C,Bai J,Zhang Q,Wang Y,Bian Q,Liu Q

更新日期：2019-08-15 00:00:00

abstract：:WHO has highlighted the need to evaluate dermal toxicity of mycotoxins including Patulin (PAT), detected in several fruits. In this study the skin carcinogenic potential of topically applied PAT was investigated. Single topical application of PAT (400 nmol) showed enhanced cell proliferation (~2 fold), along with incr...

journal_title：Toxicology and applied pharmacology

authors： Saxena N,Ansari KM,Kumar R,Chaudhari BP,Dwivedi PD,Das M

更新日期：2011-12-01 00:00:00