当前位置： SCI文献检索 > TOXICOLOGY AND APPLIED PHARMACOLOGY期刊下所有文献 > Pesticides and human chronic diseases: evidences, mechanisms, and perspectives.

Pesticides and human chronic diseases: evidences, mechanisms, and perspectives.

Abstract：

:Along with the wide use of pesticides in the world, the concerns over their health impacts are rapidly growing. There is a huge body of evidence on the relation between exposure to pesticides and elevated rate of chronic diseases such as different types of cancers, diabetes, neurodegenerative disorders like Parkinson, Alzheimer, and amyotrophic lateral sclerosis (ALS), birth defects, and reproductive disorders. There is also circumstantial evidence on the association of exposure to pesticides with some other chronic diseases like respiratory problems, particularly asthma and chronic obstructive pulmonary disease (COPD), cardiovascular disease such as atherosclerosis and coronary artery disease, chronic nephropathies, autoimmune diseases like systemic lupus erythematous and rheumatoid arthritis, chronic fatigue syndrome, and aging. The common feature of chronic disorders is a disturbance in cellular homeostasis, which can be induced via pesticides' primary action like perturbation of ion channels, enzymes, receptors, etc., or can as well be mediated via pathways other than the main mechanism. In this review, we present the highlighted evidence on the association of pesticide's exposure with the incidence of chronic diseases and introduce genetic damages, epigenetic modifications, endocrine disruption, mitochondrial dysfunction, oxidative stress, endoplasmic reticulum stress and unfolded protein response (UPR), impairment of ubiquitin proteasome system, and defective autophagy as the effective mechanisms of action.

journal_name

Toxicol Appl Pharmacol

journal_title

Toxicology and applied pharmacology

authors

Mostafalou S,Abdollahi M

doi

10.1016/j.taap.2013.01.025

subject

Has Abstract

pub_date

2013-04-15 00:00:00

pages

157-77

issue

2

eissn

0041-008X

issn

1096-0333

pii

S0041-008X(13)00054-9

journal_volume

268

pub_type

杂志文章,评审

相关文献

TOXICOLOGY AND APPLIED PHARMACOLOGY文献大全
  • Increases in the number of reactive glia in the visual cortex of Macaca fascicularis following subclinical long-term methyl mercury exposure.

    abstract：:The number of neurons, astrocytes, reactive glia, oligodendrocytes, endothelia, and pericytes in the cortex of the calcarine sulcus of adult female Macaca fascicularis following long-term subclinical exposure to methyl mercury (MeHg) and mercuric chloride (inorganic mercury; IHg) has been estimated by use of the optic...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1994.1244

    authors： Charleston JS,Bolender RP,Mottet NK,Body RL,Vahter ME,Burbacher TM

    更新日期：1994-12-01 00:00:00

  • Immunoreactivity and pharmacokinetics of horse anti-scorpion venom F(ab')2-scorpion venom interactions.

    abstract：:The immunoreactivity and pharmacokinetics of a new horse F(ab')2 scorpion antivenom and its effect on Buthus occitanus mardochei venom plasma disposition in the rabbit were studied. The scorpion venom-specific F(ab')2 affinity constant determined by immunoradiometric assay was 1.6 +/- 0.6 10(8) M-1. One group received...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1996.0284

    authors： Pépin-Covatta S,Lutsch C,Grandgeorge M,Lang J,Scherrmann JM

    更新日期：1996-11-01 00:00:00

  • 4-Chlorotetrazolo[1,5-a]quinoxaline inhibits activation of Syk kinase to suppress mast cells in vitro and mast cell-mediated passive cutaneous anaphylaxis in mice.

    abstract：:4-Chlorotetrazolo[1,5-a]quinoxaline is a quinoxaline derivative. We aimed to study the effects of 4-chlorotetrazolo[1,5-a]quinoxaline on activation of mast cells in vitro and in mice. 4-Chlorotetrazolo[1,5-a]quinoxaline reversibly inhibited degranulation of mast cells in a dose-dependent manner, and also suppressed th...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2011.09.009

    authors： Park KL,Ko NY,Lee JH,Kim DK,Kim HS,Kim AR,Her E,Kim B,Kim HS,Moon EY,Kim YM,Kim HR,Choi WS

    更新日期：2011-12-01 00:00:00

  • Arsenic-induced alteration in the expression of genes related to type 2 diabetes mellitus.

    abstract：:Chronic exposure to high concentrations of arsenic in drinking water is associated with an increased risk for developing type 2 diabetes. The present revision focuses on the effect of arsenic on tissues that participate directly in glucose homeostasis, integrating the most important published information about the imp...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.taap.2007.08.019

    authors： Díaz-Villaseñor A,Burns AL,Hiriart M,Cebrián ME,Ostrosky-Wegman P

    更新日期：2007-12-01 00:00:00

  • Sodium selenosulfate at an innocuous dose markedly prevents cisplatin-induced gastrointestinal toxicity.

    abstract：:Our previous studies in mice revealed that two weeks short-term toxicity of sodium selenosulfate was significantly lower than that of sodium selenite, but selenium repletion efficacy of both compounds was equivalent. In addition, we showed that sodium selenosulfate reduced nephrotoxicity of cisplatin (CDDP) without co...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2011.11.020

    authors： Li J,Sun K,Ni L,Wang X,Wang D,Zhang J

    更新日期：2012-02-01 00:00:00

  • Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines.

    abstract：:The aryl hydrocarbon receptor (AhR) is an important mediator of toxic responses after exposure to xenobiotics including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and dioxin-like polychlorinated biphenyls (PCBs). Activation of AhR responsive genes requires AhR dimerization with the aryl hydrocarbon receptor nuclear tr...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2013.12.002

    authors： Vorrink SU,Severson PL,Kulak MV,Futscher BW,Domann FE

    更新日期：2014-02-01 00:00:00

  • Protection of hepatocytes against death due to mitochondrial failure: effect of di-Calciphor on antimycin A-induced toxicity.

    abstract：:Di-Calciphor is a synthetic derivative of prostaglandin B1 that protects against cerebral and cardiac ischemia apparently by preserving mitochondrial function. To determine whether di-Calciphor specifically protects against mitochondrial failure, we studied its effects on mitochondrial functions in hepatocytes treated...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1994.1087

    authors： Park Y,Devlin TM,Jones DP

    更新日期：1994-05-01 00:00:00

  • Moving into advanced nanomaterials. Toxicity of rutile TiO2 nanoparticles immobilized in nanokaolin nanocomposites on HepG2 cell line.

    abstract：:Immobilization of nanoparticles on inorganic supports has been recently developed, resulting in the creation of nanocomposites. Concerning titanium dioxide nanoparticles (TiO2 NPs1), these have already been developed in conjugation with clays, but so far there are no available toxicological studies on these nanocompos...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2016.12.018

    authors： Bessa MJ,Costa C,Reinosa J,Pereira C,Fraga S,Fernández J,Bañares MA,Teixeira JP

    更新日期：2017-02-01 00:00:00

  • Taurine protects methamphetamine-induced developmental angiogenesis defect through antioxidant mechanism.

    abstract：:Investigations have characterized addictive drug-induced developmental cardiovascular malformation in human, non-human primate and rodent. However, the underlying mechanism of malformation caused by drugs during pregnancy is still largely unknown, and preventive and therapeutic measures have been lacking. Using 1H NMR...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2012.03.003

    authors： Shao X,Hu Z,Hu C,Bu Q,Yan G,Deng P,Lv L,Wu D,Deng Y,Zhao J,Zhu R,Li Y,Li H,Xu Y,Yang H,Zhao Y,Cen X

    更新日期：2012-05-01 00:00:00

  • Contribution of acetaminophen-cysteine to acetaminophen nephrotoxicity in CD-1 mice: I. Enhancement of acetaminophen nephrotoxicity by acetaminophen-cysteine.

    abstract：:Acetaminophen (APAP) nephrotoxicity has been observed both in humans and research animals. Recent studies suggest a contributory role for glutathione (GSH)-derived conjugates of APAP in the development of nephrotoxicity. Inhibitors of either gamma-glutamyl transpeptidase (gamma-GT) or the probenecid-sensitive organic ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2004.06.030

    authors： Stern ST,Bruno MK,Hennig GE,Horton RA,Roberts JC,Cohen SD

    更新日期：2005-01-15 00:00:00

  • Functional and morphologic changes in the lungs of guinea pigs exposed to freshly generated ultrafine zinc oxide.

    abstract：:Guinea pigs were exposed by nose only for 3 hr/day for 6 days to freshly formed zinc oxide (ZnO) particles (projected area diameter = 0.05 micron, sigma g = 2.0) at 5 mg/m3, the currently recommended threshold limit value (TLV). Ventilation, lung mechanics, lung volumes, and diffusing capacity for carbon monoxide (DLC...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(85)90301-1

    authors： Lam HF,Conner MW,Rogers AE,Fitzgerald S,Amdur MO

    更新日期：1985-03-30 00:00:00

  • Hydroxychavicol, a betel leaf component, inhibits prostate cancer through ROS-driven DNA damage and apoptosis.

    abstract：:Dietary phytochemicals are excellent ROS-modulating agents and have been shown to effectively enhance ROS levels beyond toxic threshold in cancer cells to ensure their selective killing while leaving normal cells unscathed. Here we demonstrate that hydroxychavicol (HC), extracted and purified from Piper betel leaves, ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2014.07.012

    authors： Gundala SR,Yang C,Mukkavilli R,Paranjpe R,Brahmbhatt M,Pannu V,Cheng A,Reid MD,Aneja R

    更新日期：2014-10-01 00:00:00

  • Ginsenoside-Rg1 induces angiogenesis by the inverse regulation of MET tyrosine kinase receptor expression through miR-23a.

    abstract：:Therapeutic angiogenesis has been implicated in ischemic diseases and wound healing. Ginsenoside-Rg1 (Rg1), one of the most abundant active components of ginseng, has been demonstrated as an angiogenesis-stimulating compound in different models. There is increasing evidence implicating microRNAs (miRNAs), a group of n...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2015.06.014

    authors： Kwok HH,Chan LS,Poon PY,Yue PY,Wong RN

    更新日期：2015-09-15 00:00:00

  • Di-(2-ethylhexyl) phthalate inhibits expression and internalization of transthyretin in human placental trophoblastic cells.

    abstract：:During pregnancy, fetal thyroid hormones (THs) are dependent on maternal placental transport and their physiological level is crucial for normal fetal neurodevelopment. Earlier research has shown that Di-(2-ethylhexyl) phthalate (DEHP) disrupts thyroid function and THs homeostasis in pregnant women and fetuses, and af...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2020.114960

    authors： Du ZP,Feng S,Li YL,Li R,Lv J,Ren WQ,Feng QW,Liu P,Wang QN

    更新日期：2020-05-01 00:00:00

  • Protective effects of dithiothreitol on cadmium-induced injury in isolated rat hepatocytes.

    abstract：:The biochemical mechanism involved in cadmium-induced cellular injury remains to be elucidated. Various theories have been proposed to account for this action, one of which is an interaction with reduced sulfhydryl (SH) groups of membranes. The ability of a known SH group reducing agent, dithiothreitol (DTT), to inter...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(86)90197-3

    authors： Stacey NH

    更新日期：1986-02-01 00:00:00

  • Advances in exposure and toxicity assessment of particulate matter: an overview of presentations at the 2009 Toxicology and Risk Assessment Conference.

    abstract：:The 2009 Toxicology and Risk Assessment Conference (TRAC) session on "Advances in Exposure and Toxicity Assessment of Particulate Matter" was held in April 2009 in West Chester, OH. The goal of this session was to bring together toxicology, geology and risk assessment experts from the Department of Defense and academi...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.taap.2010.10.020

    authors： Gunasekar PG,Stanek LW

    更新日期：2011-07-15 00:00:00

  • Toxicokinetics of deltamethrin and its 4'-HO-metabolite in the rat.

    abstract：:The toxicokinetics of deltamethrin and its metabolite 4'-HO-deltamethrin after single doses of 26 mg of deltamethrin/kg (oral) or 1.2 mg of deltamethrin/kg (intravenous) were studied in male Wistar rats. Serial blood samples were obtained after oral and intravenous administration. Brain, vas deferens, and anococcygeus...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1996.0254

    authors： Anadón A,Martinez-Larrañaga MR,Fernandez-Cruz ML,Diaz MJ,Fernandez MC,Martinez MA

    更新日期：1996-11-01 00:00:00

  • Comparative studies on nafenopin-induced hepatic peroxisome proliferation in the rat, Syrian hamster, guinea pig, and marmoset.

    abstract：:Nafenopin was administered orally for 21 days to male Sprague-Dawley rats (0.5-50 mg/kg/day), Syrian hamsters (5-250 mg/kg/day), Dunkin-Hartley guinea pigs (50 and 250 mg/kg/day), and marmosets (Callithrix jacchus, 50 and 250 mg/kg/day). With the rat, and to a lesser extent in the hamster, nafenopin treatment produced...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(89)90120-8

    authors： Lake BG,Evans JG,Gray TJ,Körösi SA,North CJ

    更新日期：1989-06-01 00:00:00

  • Arsenite and its metabolites, MMA(III) and DMA(III), modify CYP3A4, PXR and RXR alpha expression in the small intestine of CYP3A4 transgenic mice.

    abstract：:Arsenic is an environmental pollutant that has been associated with an increased risk for the development of cancer and several other diseases through alterations of cellular homeostasis and hepatic function. Cytochrome P450 (P450) modification may be one of the factors contributing to these disorders. Several reports...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2008.11.009

    authors： Medina-Díaz IM,Estrada-Muñiz E,Reyes-Hernández OD,Ramírez P,Vega L,Elizondo G

    更新日期：2009-09-01 00:00:00

  • P-glycoprotein activation by 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5) in rat distal ileum: ex vivo and in vivo studies.

    abstract：:In vitro studies showed that 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5) increases P-glycoprotein (P-gp) expression and activity in Caco-2 cells, preventing xenobiotic toxicity. The present study aimed at investigating TX5 effects on P-gp expression/activity using Wistar Han rats: a) in vivo, evaluating ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2019.114832

    authors： Rocha-Pereira C,Ghanem CI,Silva R,Casanova AG,Duarte-Araújo M,Gonçalves-Monteiro S,Sousa E,Bastos ML,Remião F

    更新日期：2020-01-01 00:00:00

  • Methylation and demethylation of intermediates selenide and methylselenol in the metabolism of selenium.

    abstract：:All nutritional selenium sources are transformed into the assumed common intermediate selenide for the syntheses of selenoproteins for utilization and/or of selenosugar for excretion. Methylselenol [monomethylselenide, MMSe] is the assumed intermediate leading to other methylated metabolites, dimethylselenide (DMSe) a...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2007.09.011

    authors： Ohta Y,Suzuki KT

    更新日期：2008-01-15 00:00:00

  • Alveolar macrophages have a dual role in a rat model for trimellitic anhydride-induced occupational asthma.

    abstract：:Occupational exposure to low molecular weight chemicals, like trimellitic anhydride (TMA), can result in occupational asthma. Alveolar macrophages (AMs) are among the first cells to encounter inhaled compounds. These cells can produce many different mediators that have a putative role in asthma. In this study, we exam...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2005.05.012

    authors： Valstar DL,Schijf MA,Nijkamp FP,Storm G,Arts JH,Kuper CF,Bloksma N,Henricks PA

    更新日期：2006-02-15 00:00:00

  • Potentiation of the toxicity of model hepatotoxicants by acetaminophen.

    abstract：:A 24-hr oral pretreatment of rats with 1.6 g/kg acetaminophen potentiated hepatotoxicity of allyl alcohol, bromobenzene, carbon tetrachloride, 1,1-dichloroethylene, and thioacetamide, as assessed by elevation of serum alanine aminotransferase activity and histopathological examination. Doses, of these hepatotoxicants,...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(91)90179-i

    authors： Wright PB,Moore L

    更新日期：1991-06-15 00:00:00

  • Melanin, a promising radioprotector: mechanisms of actions in a mice model.

    abstract：:The radioprotective effect of extracellular melanin, a naturally occurring pigment, isolated from the fungus Gliocephalotrichum simplex was examined in BALB/C mice, and the probable mechanism of action was established. At an effective dose of 50mg/kg body weight, melanin exhibited both prophylactic and mitigative acti...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2012.08.002

    authors： Kunwar A,Adhikary B,Jayakumar S,Barik A,Chattopadhyay S,Raghukumar S,Priyadarsini KI

    更新日期：2012-10-15 00:00:00

  • A chimeric aryl hydrocarbon receptor knockout mouse model indicates that aryl hydrocarbon receptor activation in hematopoietic cells contributes to the hepatic lesions induced by 2,3,7, 8-tetrachlorodibenzo-p-dioxin.

    abstract：:Pathologic changes associated with 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) exposure have been reported in the livers of a wide range of species. While these changes have been extensively described, the mechanisms of toxic interaction(s) that produce these lesions remain unclear. Using an aryl hydrocarbon receptor ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1999.8681

    authors： Thurmond TS,Silverstone AE,Baggs RB,Quimby FW,Staples JE,Gasiewicz TA

    更新日期：1999-07-01 00:00:00

  • Incomplete correlation of 2,3,7,8-tetrachlorodibenzo-p-dioxin hepatotoxicity with Ah phenotype in mice.

    abstract：:Pretreatment of male mice of the inbred strains A2G, BALB/c, C57BL/10, and AKR with iron dextran synergized the action of a single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, 75 micrograms/kg) in causing hepatic porphyria and necrosis 35 days later. There was no effect in DBA/2 mice. Increased porphyrin levels ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(84)90265-5

    authors： Greig JB,Francis JE,Kay SJ,Lovell DP,Smith AG

    更新日期：1984-06-15 00:00:00

  • Increased hexokinase II expression in the renal glomerulus of mice in response to arsenic.

    abstract：:Epidemiological studies link arsenic exposure to increased risks of cancers of the skin, kidney, lung, bladder and liver. Additionally, a variety of non-cancerous conditions such as diabetes mellitus, hypertension, and cardiovascular disease have been associated with chronic ingestion of low levels of arsenic. However...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2007.06.019

    authors： Pysher MD,Sollome JJ,Regan S,Cardinal TR,Hoying JB,Brooks HL,Vaillancourt RR

    更新日期：2007-10-01 00:00:00

  • Androgenic deficiency in male rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin.

    abstract：:Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the male reproductive system were investigated. Sexually mature (290 g) Sprague-Dawley rats were given single oral doses of TCDD sufficient to cause varying degrees of hypophagia and impaired body weight gain. The largest doses decreased plasma testosterone and ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(85)90372-2

    authors： Moore RW,Potter CL,Theobald HM,Robinson JA,Peterson RE

    更新日期：1985-06-15 00:00:00

  • Preconditioning induced by gentamicin protects against acute kidney injury: the role of prostaglandins but not nitric oxide.

    abstract：:Nephrotoxicity is the main side effect of gentamicin (GENTA). Preconditioning (PC) refers to a situation in which an organ subjected to an injury responds less intensely when exposed to another injury. The aim of this study was to evaluate the effect of PC with GENTA on nephrotoxic acute kidney injury (AKI). GENTA gro...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2011.02.022

    authors： Pessoa EA,Convento MB,Ribas OS,Tristão VR,Reis LA,Borges FT,Schor N

    更新日期：2011-05-15 00:00:00

  • Abnormal neurulation induced by 7-hydroxy-2-acetylaminofluorene and acetaminophen: evidence for catechol metabolites as proximate dysmorphogens.

    abstract：:Direct additions to culture media of either acetaminophen (APAP) or 7-hydroxy-2-acetylaminofluorene (7-OH-AAF) resulted in abnormal closure of the anterior neuropores of cultured rat embryos in the absence of an exogenous bioactivation system. Concentrations required to produce a 50% incidence of the defect were appro...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(89)90192-0

    authors： Harris C,Stark KL,Luchtel DL,Juchau MR

    更新日期：1989-12-01 00:00:00