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Increased hexokinase II expression in the renal glomerulus of mice in response to arsenic.

Abstract：

:Epidemiological studies link arsenic exposure to increased risks of cancers of the skin, kidney, lung, bladder and liver. Additionally, a variety of non-cancerous conditions such as diabetes mellitus, hypertension, and cardiovascular disease have been associated with chronic ingestion of low levels of arsenic. However, the biological and molecular mechanisms by which arsenic exerts its effects remain elusive. Here we report increased renal hexokinase II (HKII) expression in response to arsenic exposure both in vivo and in vitro. In our model, HKII was up-regulated in the renal glomeruli of mice exposed to low levels of arsenic (10 ppb or 50 ppb) via their drinking water for up to 21 days. Additionally, a similar effect was observed in cultured renal mesangial cells exposed to arsenic. This correlation between our in vivo and in vitro data provides further evidence for a direct link between altered renal HKII expression and arsenic exposure. Thus, our data suggest that alterations in renal HKII expression may be involved in arsenic-induced pathological conditions involving the kidney. More importantly, these results were obtained using environmentally relevant arsenic concentrations.

journal_name

Toxicol Appl Pharmacol

journal_title

Toxicology and applied pharmacology

authors

Pysher MD,Sollome JJ,Regan S,Cardinal TR,Hoying JB,Brooks HL,Vaillancourt RR

doi

10.1016/j.taap.2007.06.019

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

39-48

issue

1

eissn

0041-008X

issn

1096-0333

pii

S0041-008X(07)00277-3

journal_volume

224

pub_type

杂志文章

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