Di-(2-ethylhexyl) phthalate inhibits expression and internalization of transthyretin in human placental trophoblastic cells.

abstract：:Two members of the cytochrome P450 2A subfamily, CYP2A10 and 2A11, are abundant nasal enzymes previously characterized in rabbit olfactory microsomes. Rabbit CYP2A is active toward a number of nasal toxicants, including the rat nasal procarcinogen hexamethylphosphoramide (HMPA). While P450s immunochemically related to...

journal_title：Toxicology and applied pharmacology

authors： Thornton-Manning JR,Nikula KJ,Hotchkiss JA,Avila KJ,Rohrbacher KD,Ding X,Dahl AR

更新日期：1997-01-01 00:00:00

abstract：:Isolated rat lymphocytes in salts-glucose medium (pH 7.2) were incubated with nickel chloride, nickel acetate, nickel sulfate, and a soluble form of nickel subsulfide (0-2 mM) at 37 degrees C for 2 h. The soluble form of nickel subsulfide induced a significant increase in DNA-protein crosslinks (DPXLs) (111%) beginnin...

journal_title：Toxicology and applied pharmacology

authors： Chakrabarti SK,Bai C,Subramanian KS

更新日期：2001-02-01 00:00:00

abstract：:Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the male reproductive system were investigated. Sexually mature (290 g) Sprague-Dawley rats were given single oral doses of TCDD sufficient to cause varying degrees of hypophagia and impaired body weight gain. The largest doses decreased plasma testosterone and ...

journal_title：Toxicology and applied pharmacology

authors： Moore RW,Potter CL,Theobald HM,Robinson JA,Peterson RE

更新日期：1985-06-15 00:00:00

abstract：:Earlier studies with etretinate and its metabolite acitretin suggested that area under the concentration-time curve (AUC) is the most suitable pharmacokinetic correlate to etretinate-induced teratogenesis. In an attempt to test this hypothesis with respect to the embryotoxic effects of all-trans-retinoic acid (all-tra...

journal_title：Toxicology and applied pharmacology

authors： Tzimas G,Thiel R,Chahoud I,Nau H

更新日期：1997-04-01 00:00:00

abstract：:Octachlorodibenzo-p-dioxin (OCDD) is a ubiquitous environmental pollutant which has been reported to be nontoxic following acute exposure but has recently been shown to accumulate upon repeated exposure. To determine if this accumulation results in toxic effects, male Fischer 344 rats were treated with 50 micrograms/k...

journal_title：Toxicology and applied pharmacology

authors： Couture LA,Elwell MR,Birnbaum LS

更新日期：1988-03-30 00:00:00

abstract：:Breast cancer is the world's leading cause of death among women. This situation imposes an urgent development of more selective and less toxic agents. The use of natural molecular fingerprints as sources for new bioactive chemical entities has proven to be a quite promising and efficient method. Capsaicin, which is th...

journal_title：Toxicology and applied pharmacology

authors： de-Sá-Júnior PL,Pasqualoto KF,Ferreira AK,Tavares MT,Damião MC,de Azevedo RA,Câmara DA,Pereira A,de Souza DM,Parise Filho R

更新日期：2013-02-01 00:00:00

abstract：:Three major enzyme systems have been shown to metabolize epoxidized xenobiotics in vertebrate tissues, and this study demonstrates that these enzyme systems can be differentially induced. The cytosolic epoxide hydrolase activity was routinely monitored with trans-beta-ethylstyrene oxide, the microsomal epoxide hydrola...

journal_title：Toxicology and applied pharmacology

authors： Hammock BD,Ota K

更新日期：1983-11-01 00:00:00

abstract：:Chemotherapy is one of the major strategies for cancer treatment. Several antineoplastic drugs including vinorelbine (VRB) are commonly intravenously infused and liable to cause serious phlebitis. The therapeutic drugs for preventing this complication are limited. In this study, the mechanism of baicalein (BCN) was in...

journal_title：Toxicology and applied pharmacology

authors： Ge GF,Shi WW,Yu CH,Jin XY,Zhang HH,Zhang WY,Wang LC,Yu B

更新日期：2017-03-01 00:00:00

abstract：:The substrate preference of an aldehyde dehydrogenase induced in rat liver cytosol by 3-methylcholanthrene was examined. This enzyme, T-ALDH, is identical to the aldehyde dehydrogenase inducible in rat liver by 2,3,7,8-tetrachloro-dibenzo-p-dioxin and the tumor-associated aldehyde dehydrogenase found in rat hepatocell...

journal_title：Toxicology and applied pharmacology

authors： Marselos M,Lindahl R

更新日期：1988-09-15 00:00:00

abstract：:It has been suggested that airway irritation, by acting as an adjuvant, as well as producing damage, may be an important factor related to asthma. The present study examined the window of time following acute upper and lower airway irritant exposure to determine the period of increased risk of immunological sensitizat...

journal_title：Toxicology and applied pharmacology

authors： Siegel PD,Al-Humadi NH,Nelson ER,Lewis DM,Hubbs AF

更新日期：1997-06-01 00:00:00

abstract：:The putative neurotoxicity of the organophosphorus compound triphenyl phosphite (TPP) was examined in Long Evans, adult male rats. Animals were exposed to two 1.0 ml/kg (1184 mg/kg) injections (sc) of TPP spaced 1 week apart and sampled for biochemical and neuropathological examination. At the time of sampling, rats d...

journal_title：Toxicology and applied pharmacology

authors： Veronesi B,Padilla S,Newland D

更新日期：1986-04-01 00:00:00

abstract：:Technologies that generate information about the genome are being used to explore changes in gene expression and related proteins following exposure to chemicals. Conceptually, this information allows a greater understanding of genomic level mRNA expression (transcriptomics), cell and tissue protein expression (proteo...

journal_title：Toxicology and applied pharmacology

authors： Oberemm A,Onyon L,Gundert-Remy U

更新日期：2005-09-01 00:00:00

abstract：:Iron tetrakis (N-methyl-4'-pyridyl) porphyrinato (FeTMPyP) has been demonstrated to be a potent scavenger of reactive oxygens and to have antiinflammatory activities. However, the effects of FeTMPyP on the function of T cells have not been illustrated. The objective of this study was to determine whether treatment of ...

journal_title：Toxicology and applied pharmacology

authors： Kang JL,Lee HS,Jung HJ,Kim HJ

更新日期：2003-09-01 00:00:00

abstract：:Epidemiological studies have demonstrated a high association of inorganic arsenic exposure with vascular diseases. Recent research has also linked this vascular damage to impairment of endothelial nitric oxide synthase (eNOS) function by arsenic exposure. However, the role of eNOS in regulating the arsenite-induced va...

journal_title：Toxicology and applied pharmacology

authors： Tsou TC,Tsai FY,Hsieh YW,Li LA,Yeh SC,Chang LW

更新日期：2005-11-01 00:00:00

abstract：:It is postulated that nicotine, as the main neurotoxic constituent of cigarette smoke, influences SIDS risk through effects on nicotinic acetylcholine receptors (nAChRs) in brainstem nuclei that control respiration and arousal. This study compared α7 and β2 nAChR subunit expression in eight nuclei of the caudal and ro...

journal_title：Toxicology and applied pharmacology

authors： Machaalani R,Say M,Waters KA

更新日期：2011-12-15 00:00:00

abstract：:Tributyltin (TBT) and triphenyltin (TPT) are known to cause imposex, the superimposing of male genitals on female ones, in some species of gastropods. However, the molecular mechanism of the trialkyltin-induced endocrine dysfunction remains to be elucidated. To clarify the effects of organotin compounds on the activat...

journal_title：Toxicology and applied pharmacology

authors： Yamabe Y,Hoshino A,Imura N,Suzuki T,Himeno S

更新日期：2000-12-01 00:00:00

abstract：:An infamous poison, arsenic also has been used as a drug for nearly 2400 years; in recently years, arsenic has been effective in the treatment of acute promyelocytic leukemia. Increasing evidence suggests that opposite effects of arsenic trioxide (ATO) on tumors depend on its concentrations. For this reason, the mecha...

journal_title：Toxicology and applied pharmacology

authors： Liu ZM,Huang HS

更新日期：2008-12-01 00:00:00

abstract：:Treatment of cancer patients with the antitumor antibiotic bleomycin (BLM) is associated with lung damage which can progress to pulmonary fibrosis. Shortly after intratracheal (it) administration of BLM to experimental animals there is an influx of inflammatory cells into the lung. These inflammatory cells, consisting...

journal_title：Toxicology and applied pharmacology

authors： Janick-Buckner D,Ranges GE,Hacker MP

更新日期：1989-09-15 00:00:00

abstract：:The use of isocyanates in industry has been increasing and, therefore, the potential for human exposure has also increased. Two such isocyanates are diphenylmethane-4,4'-diisocyanate (MDI) and dicyclohexylmethane-4,4'-diisocyanate (SMDI). Furthermore, there are only a few reports describing the toxicity of these diiso...

journal_title：Toxicology and applied pharmacology

authors： Weyel DA,Schaffer RB

更新日期：1985-03-15 00:00:00

abstract：:Organophosphorus esters (OP) are highly toxic chemicals used as pesticides and nerve agents. Their acute toxicity is attributed to inhibition of acetylcholinesterase (AChE, EC 3.1.1.7) in nerve synapses. Our goal was to find a new therapeutic for protection against OP toxicity. We used a gene therapy vector, adeno-ass...

journal_title：Toxicology and applied pharmacology

authors： Li B,Duysen EG,Poluektova LY,Murrin LC,Lockridge O

更新日期：2006-07-15 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is well known for its immunotoxic effects particularly on the thymus. The exact mechanism by which TCDD induces thymic atrophy is not clear. In the current study, we investigated whether TCDD triggers apoptosis in thymocytes, when administered in vivo, by using the TdT-mediat...

journal_title：Toxicology and applied pharmacology

authors： Kamath AB,Xu H,Nagarkatti PS,Nagarkatti M

更新日期：1997-02-01 00:00:00

abstract：:Epidemiological studies indicated that people exposed to dioxins were prone to the development of lung diseases including lung cancer. Animal studies demonstrated that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increased liver tumors and promoted lung metaplasia in females. Metabolic changes in 17beta-estradiol (E(2))...

journal_title：Toxicology and applied pharmacology

authors： Cheng Y,Chang LW,Cheng LC,Tsai MH,Lin P

更新日期：2007-05-01 00:00:00

abstract：:Clinical and experimental studies suggest an association between low-level lead exposure and hypertension. This association was investigated in six 3-month-old dogs who were randomly paired with their littermates. The daily oral dose of lead acetate was 1.0 mg Pb/kg body wt for 5 months; the controls received equimola...

journal_title：Toxicology and applied pharmacology

authors： Fine BP,Vetrano T,Skurnick J,Ty A

更新日期：1988-05-01 00:00:00

abstract：:Age-dependent changes related to liver injury and regeneration were studied in rats aged 2, 12, and 30 months in a time period of 96 hr following a sublethal dose of thioacetamide (6.6 mmoles/kg body wt). Serum aspartate aminotransferase activity increased earlier in young rats, but the severity of injury was higher i...

journal_title：Toxicology and applied pharmacology

authors： Sanz N,Díez-Fernández C,Alvarez AM,Fernández-Simón L,Cascales M

更新日期：1999-01-01 00:00:00

abstract：:Human-based in silico models are emerging as important tools to study the effects of integrating inward and outward ion channel currents to predict clinical proarrhythmic risk. The aims of this study were 2-fold: 1) Evaluate the capacity of an in silico model to predict QTc interval prolongation in the in vivo anesthe...

journal_title：Toxicology and applied pharmacology

authors： Morissette P,Polak S,Chain A,Zhai J,Imredy JP,Wildey MJ,Travis J,Fitzgerald K,Fanelli P,Passini E,Rodriguez B,Sannajust F,Regan C

更新日期：2020-03-01 00:00:00

abstract：:Rats received one or two consecutive daily ip injections, each 0.5 mg Pb2+/100 g body weight, and the kidneys were studied 48 or 24 hr, respectively, after the injection. Renal brush border preparations from Pb2+-treated rats exhibited significant decreases in the activity of alanine aminopeptidase and gamma-glutamyl ...

journal_title：Toxicology and applied pharmacology

authors： Nicholls DM,Teichert-Kuliszewska K,Kuliszewski MJ

更新日期：1983-02-01 00:00:00

abstract：:H-ras oncogenes have been identified in greater than 50% of the most common forms of human neoplasia. Ras-related proteins have been postulated to mediated signal transduction pathways involving mitogen-activated protein (MAP) kinases and nuclear responses that may be involved in the induction of apoptosis. We examine...

journal_title：Toxicology and applied pharmacology

authors： Davis MA,Chang SH,Trump BF

更新日期：1996-11-01 00:00:00

abstract：UNLABELLED:Traffic related particulate matter air pollution is a risk factor for cardiovascular events; however, the biological mechanisms are unclear. We hypothesize that diesel exhaust (DE) inhalation induces up-regulation of inducible nitric oxide synthase (iNOS), which is known to contribute to vascular dysfunction...

journal_title：Toxicology and applied pharmacology

authors： Bai N,Kido T,Kavanagh TJ,Kaufman JD,Rosenfeld ME,van Breemen C,van Eeden SF

更新日期：2011-09-01 00:00:00

abstract：:Diurnal patterns of feeding, drinking, locomotor activity, and rearing in male Fischer-344 rats were examined for 2 weeks after a single oral dose of trimethyltin chloride (TMT) at 0, 3, 5, or 7 mg/kg. Body weights and feeding and drinking efficiency ratios (ratios of amount of food or water consumed per unit effort) ...

journal_title：Toxicology and applied pharmacology

authors： Bushnell PJ,Evans HL

更新日期：1985-06-15 00:00:00

abstract：:Nodularin is a natural toxin with multiple features, including inhibitor of protein phosphatases 1 and 2A as well as tumor initiator and promoter. One unique feature of nodularin is that this chemical is a hepatotoxin. It can accumulate into the liver after contact and lead to severe damage to hepatocyte, such as apop...

journal_title：Toxicology and applied pharmacology

authors： Feng G,Li Y,Bai Y

更新日期：2011-03-15 00:00:00