Baicalein attenuates vinorelbine-induced vascular endothelial cell injury and chemotherapeutic phlebitis in rabbits.


:Chemotherapy is one of the major strategies for cancer treatment. Several antineoplastic drugs including vinorelbine (VRB) are commonly intravenously infused and liable to cause serious phlebitis. The therapeutic drugs for preventing this complication are limited. In this study, the mechanism of baicalein (BCN) was investigated on VRB-induced phlebitis in vivo and vascular endothelial cell injury in vitro. Treatment with BCN obviously attenuated vascular endothelial cell loss, edema, inflammatory cell infiltration and blood clots, and reduced the serum levels of TNF-α, IL-1β, IL-6 and ICAM-1 in the rabbit model of phlebitis induced by intravenous injection of VRB compared with vehicle. Further tests in vitro demonstrated that BCN lessened VRB-induced endothelial cell apoptosis, decreased intracellular ROS levels, suppressed phosphorylation of p38 and eventually inhibited activation of NF-κB signaling pathway. And these effects could be reversed by p38 agonist P79350. These results suggested that BCN exerted the protective effects against VRB-induced endothelial disruption in the rabbit model of phlebitis via inhibition of intracellular ROS generation and inactivation of p38/NF-κB pathway, leading to the decreased production of pro-inflammatory cytokines. Thus, BCN could be used as a potential agent for the treatment of phlebitis.


Toxicol Appl Pharmacol


Ge GF,Shi WW,Yu CH,Jin XY,Zhang HH,Zhang WY,Wang LC,Yu B




Has Abstract


2017-03-01 00:00:00












  • Dioxin-like effects observed in male rats following exposure to octachlorodibenzo-p-dioxin (OCDD) during a 13-week study.

    abstract::Octachlorodibenzo-p-dioxin (OCDD) is a ubiquitous environmental pollutant which has been reported to be nontoxic following acute exposure but has recently been shown to accumulate upon repeated exposure. To determine if this accumulation results in toxic effects, male Fischer 344 rats were treated with 50 micrograms/k...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Couture LA,Elwell MR,Birnbaum LS

    更新日期:1988-03-30 00:00:00

  • Ethanol-induced enhancement of trichloroethylene metabolism and hepatotoxicity: difference from the effect of phenobarbital.

    abstract::Male Wistar rats pretreated with ethanol (2.0 g in 80 ml liquid diet/day for 3 weeks) or phenobarbital (PB, 80 mg/kg/day ip for 4 days) were exposed by inhalation to 500, 1000, 2000, 4000, or 8000 ppm trichloroethylene (TRI) for 2 or 8 hr, and the blood concentration of TRI and the urinary concentration of TRI metabol...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Nakajima T,Okino T,Okuyama S,Kaneko T,Yonekura I,Sato A

    更新日期:1988-06-30 00:00:00

  • Maturation-dependent effects of chlorpyrifos and parathion and their oxygen analogs on acetylcholinesterase and neuronal and glial markers in aggregating brain cell cultures.

    abstract::An in vitro model, the aggregating brain cell culture of fetal rat telencephalon, has been used to study the maturation-dependent sensitivity of brain cells to two organophosphorus pesticides (OPs), chlorpyrifos and parathion, and to their oxon derivatives. Immature (DIV 5-15) or differentiated (DIV 25-35) brain cells...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Monnet-Tschudi F,Zurich MG,Schilter B,Costa LG,Honegger P

    更新日期:2000-06-15 00:00:00

  • Suppression of polyamine biosynthesis prevents monocrotaline-induced pulmonary edema and arterial medial thickening.

    abstract::Previous work in our laboratory has shown that the continuous administration of alpha-difluoromethylornithine (DFMO), a highly specific irreversible inhibitor of ornithine decarboxylase (ODC), which is the rate-limiting enzyme in polyamine biosynthesis, prevented the development of pulmonary hypertension and right ven...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Olson JW,Atkinson JE,Hacker AD,Altiere RJ,Gillespie MN

    更新日期:1985-10-01 00:00:00

  • Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way.

    abstract::The Constitutive Androstane Receptor (CAR, NR1I3) has been newly described as a regulator of energy metabolism. A relevant number of studies using animal models of obesity suggest that CAR activation could be beneficial on the metabolic balance. However, this remains controversial and the underlying mechanisms are sti...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Marmugi A,Lukowicz C,Lasserre F,Montagner A,Polizzi A,Ducheix S,Goron A,Gamet-Payrastre L,Gerbal-Chaloin S,Pascussi JM,Moldes M,Pineau T,Guillou H,Mselli-Lakhal L

    更新日期:2016-07-15 00:00:00

  • Increases in the number of reactive glia in the visual cortex of Macaca fascicularis following subclinical long-term methyl mercury exposure.

    abstract::The number of neurons, astrocytes, reactive glia, oligodendrocytes, endothelia, and pericytes in the cortex of the calcarine sulcus of adult female Macaca fascicularis following long-term subclinical exposure to methyl mercury (MeHg) and mercuric chloride (inorganic mercury; IHg) has been estimated by use of the optic...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Charleston JS,Bolender RP,Mottet NK,Body RL,Vahter ME,Burbacher TM

    更新日期:1994-12-01 00:00:00

  • Single-tracer technique to evaluate pulmonary edema and its application to detect the effect of hexamethylene diisocyanate trimer aerosol exposures.

    abstract::Two hours after a four-hour exposure to hexamethylene diisocyanate trimer (HDIt) aerosol between 2.5 and 39 mg/m3, mice were injected iv with 51Cr-EDTA (chromium ethylenediaminetetraacetate). Ten minutes later the lung was lavaged. A larger amount of 51Cr-EDTA was detected in the lung lavage of HDIt mice than of contr...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Valentini JE,Wong KL,Alarie Y

    更新日期:1983-07-01 00:00:00

  • Receptor-independent, vacuolar ATPase-mediated cellular uptake of histamine receptor-1 ligands: possible origin of pharmacological distortions and side effects.

    abstract::The aims of this study were to investigate whether several histamine receptor agonists and antagonists are subjected to receptor-independent ion trapping into acidic organelles, and whether this sequestration influences their pharmacological or toxicological properties. Vacuolar (V)-ATPase-dependent intracellular sequ...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Morissette G,Lodge R,Bouthillier J,Marceau F

    更新日期:2008-06-15 00:00:00

  • Distance learning and toxicology: new horizons for Paracelsus.

    abstract::Distance learning offers many advantages to students and teachers of almost any scientific discipline. Toxicology is no exception. For example, should Paracelsus be interested in learning more about toxicology at Drexel University, he would have the opportunity to take two courses in this subject utilizing the content...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章,评审


    authors: Huggins J,Morris J,Peterson CE

    更新日期:2005-09-01 00:00:00

  • Time- and concentration-dependent genomic responses of the rat airway to inhaled nickel subsulfide.

    abstract:OBJECTIVE:To provide insights into the mode of action for Ni3S2 lung carcinogenicity by examining gene expression changes in target cells after inhalation exposure. METHODS:Gene expression changes were determined in micro-dissected lung broncho-alveolar cells from Fischer 344 rats following inhalation of Ni3S2 at 0.0,...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Efremenko AY,Campbell JL Jr,Dodd DE,Oller AR,Clewell HJ 3rd

    更新日期:2014-09-15 00:00:00

  • Role of extracellular Ca2+ in toxic liver injury: comparative studies with the perfused rat liver and isolated hepatocytes.

    abstract::The role of extracellular Ca2+ in toxic liver injury was examined in two in vitro models of the rat liver, the isolated perfused liver and isolated hepatocytes. The toxins t-butylhydroperoxide and carbon tetrachloride, as well as the Ca2+ ionophore, heptafluorodimethyloctanedione (FOD), were employed to induce cellula...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Smith MT,Sandy MS

    更新日期:1985-11-01 00:00:00

  • Zidovudine phosphorylation and mitochondrial toxicity in vitro.

    abstract::Zidovudine (ZDV) is a thymidine analogue activated to its triphosphate (ZDVTP) by the host's intracellular enzymes. The initial phosphorylation step is conversion to ZDV monophosphate (ZDVMP). The poor affinity of ZDVMP for thymidylate kinase results in intracellular accumulation of ZDVMP. Clinical use of ZDV is assoc...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Sales SD,Hoggard PG,Sunderland D,Khoo S,Hart CA,Back DJ

    更新日期:2001-11-15 00:00:00

  • Extension of a PBPK model for ethylene glycol and glycolic acid to include the competitive formation and clearance of metabolites associated with kidney toxicity in rats and humans.

    abstract::A previously developed PBPK model for ethylene glycol and glycolic acid was extended to include glyoxylic acid, oxalic acid, and the precipitation of calcium oxalate that is associated with kidney toxicity in rats and humans. The development and evaluation of the PBPK model was based upon previously published pharmaco...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Corley RA,Saghir SA,Bartels MJ,Hansen SC,Creim J,McMartin KE,Snellings WM

    更新日期:2011-02-01 00:00:00

  • Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase.

    abstract::Tabun represents the phosphoramidate class of organophosphates that are covalent inhibitors of acetylcholinesterase (AChE), an essential enzyme in neurotransmission. Currently used therapy in counteracting excessive cholinergic stimulation consists of a muscarinic antagonist (atropine) and an oxime reactivator of inhi...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Kovarik Z,Maček Hrvat N,Kalisiak J,Katalinić M,Sit RK,Zorbaz T,Radić Z,Fokin VV,Sharpless KB,Taylor P

    更新日期:2019-06-01 00:00:00

  • Measurement of genotoxic air pollutant exposures in street vendors and school children in and near Bangkok.

    abstract::The effects of air pollution on human health are a great concern, particularly in big cities with severe traffic problems such as Bangkok, Thailand. In this study, exposure to genotoxic compounds in ambient air was studied by analysis of particle-associated polycyclic aromatic hydrocarbons (PAHs) and benzene through d...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Ruchirawat M,Navasumrit P,Settachan D,Tuntaviroon J,Buthbumrung N,Sharma S

    更新日期:2005-08-07 00:00:00

  • Taurine protects methamphetamine-induced developmental angiogenesis defect through antioxidant mechanism.

    abstract::Investigations have characterized addictive drug-induced developmental cardiovascular malformation in human, non-human primate and rodent. However, the underlying mechanism of malformation caused by drugs during pregnancy is still largely unknown, and preventive and therapeutic measures have been lacking. Using 1H NMR...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Shao X,Hu Z,Hu C,Bu Q,Yan G,Deng P,Lv L,Wu D,Deng Y,Zhao J,Zhu R,Li Y,Li H,Xu Y,Yang H,Zhao Y,Cen X

    更新日期:2012-05-01 00:00:00

  • Role of oxidative stress in thuringiensin-induced pulmonary toxicity.

    abstract::To understand the effect of thuringiensin on the lungs tissues, male Sprague-Dawley rats were administrated with thuringiensin by intratracheal instillation at doses 0.8, 1.6 and 3.2 mg/kg of body weight, respectively. The rats were sacrificed 4 h after treatment, and lungs were isolated and examined. Subsequently, an...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Tsai SF,Yang C,Liu BL,Hwang JS,Ho SP

    更新日期:2006-10-15 00:00:00

  • Molecular mechanism of teratogenic effects induced by the fungicide triadimefon: study of the expression of TGF-beta mRNA and TGF-beta and CRABPI proteins during rat in vitro development.

    abstract::Azole derivatives are teratogenic in rats and mice in vitro and in vivo. The postulated mechanism for the dysmorphogenetic effects is the inhibition of retinoic acid (RA)-degrading enzyme CYP26. Azole-related abnormalities are confined to structures controlled by RA, especially the neural crest cells, hindbrain, crani...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Di Renzo F,Corsini E,Broccia ML,Marinovich M,Galli CL,Giavini E,Menegola E

    更新日期:2009-01-01 00:00:00

  • Zinc oxide nanoparticles and monocytes: impact of size, charge and solubility on activation status.

    abstract::Zinc oxide (ZnO) particle induced cytotoxicity was dependent on size, charge and solubility, factors which at sublethal concentrations may influence the activation of the human monocytic cell line THP1. ZnO nanoparticles (NP; average diameter 70nm) were more toxic than the bulk form (<44μm mesh) and a positive charge ...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Prach M,Stone V,Proudfoot L

    更新日期:2013-01-01 00:00:00

  • Prevention of short-term ultraviolet B radiation-mediated damages by resveratrol in SKH-1 hairless mice.

    abstract::Nonmelanoma skin cancer is the most common cancer among humans and solar UV radiation, particularly its UVB component (290-320 nm), is its major cause. One way to reduce the occurrence of the cancer is via the use of substances (often antioxidants) termed "photochemopreventive agents". Resveratrol (trans-3,4',5-trihyd...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Afaq F,Adhami VM,Ahmad N

    更新日期:2003-01-01 00:00:00

  • Activation of ERK and JNK signaling pathways by mycotoxin citrinin in human cells.

    abstract::Mycotoxin citrinin (CTN) is commonly found in foods and feeds that are contaminated/inoculated with Penicillium, Aspergillus and Monascus species. The exposure of human embryonic kidney (HEK293) and HeLa cells to CTN resulted in a dose-dependent increase in the phosphorylation of two major mitogen-activated protein ki...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Chang CH,Yu FY,Wang LT,Lin YS,Liu BH

    更新日期:2009-06-15 00:00:00

  • Evidence that 2,3,7,8-tetrachlorodibenzo-p-dioxin and thyroid hormones act through different mechanisms in human keratinocytes.

    abstract::It has been proposed [J. D. McKinney, J. Fawkes, S. Jordan, K. Chae, S. Oatley, R. E. Coleman, and W. Briner (1985). Environ. Health Perspect. 61, 41-53] that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) produces toxic responses through persistent occupancy of nuclear thyroxine (T4) receptors, and that maintenance of re...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Osborne R,Dold KM,Greenlee WF

    更新日期:1987-09-30 00:00:00

  • P-glycoprotein activation by 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5) in rat distal ileum: ex vivo and in vivo studies.

    abstract::In vitro studies showed that 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5) increases P-glycoprotein (P-gp) expression and activity in Caco-2 cells, preventing xenobiotic toxicity. The present study aimed at investigating TX5 effects on P-gp expression/activity using Wistar Han rats: a) in vivo, evaluating ...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Rocha-Pereira C,Ghanem CI,Silva R,Casanova AG,Duarte-Araújo M,Gonçalves-Monteiro S,Sousa E,Bastos ML,Remião F

    更新日期:2020-01-01 00:00:00

  • Proliferative and genotoxic cellular effects in 2-acetylaminofluorene bladder and liver carcinogenesis: biological modeling of the ED01 study.

    abstract::The development of tumors in relationship to 2-acetylaminofluorene (AAF) dose and time on study has been evaluated in an experiment conducted by the National Center for Toxicological Research (NCTR) using more than 24,000 female BALB/c mice. By using a biologically based model of two-event carcinogenesis accounting ex...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Cohen SM,Ellwein LB

    更新日期:1990-06-01 00:00:00

  • Detection and characterization of [3H]2,3,7,8-tetrachlorodibenzo-p-dioxin binding to Ah receptor in a rainbow trout hepatoma cell line.

    abstract::Ah receptor was identified and characterized in cytosol and nuclear extracts from the rainbow trout hepatoma cell line RTH-149. The cytosolic receptor was detectable with both halogenated ([3H]2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)) and non-halogenated ([3H]3-methylcholanthrene and [3H]benzo[a]pyrene) aromatic hyd...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Lorenzen A,Okey AB

    更新日期:1990-10-01 00:00:00

  • Rotenone exerts developmental neurotoxicity in a human brain spheroid model.

    abstract::Growing concern suggests that some chemicals exert (developmental) neurotoxicity (DNT and NT) and are linked to the increase in incidence of autism, attention deficit and hyperactivity disorders. The high cost of routine tests for DNT and NT assessment make it difficult to test the high numbers of existing chemicals. ...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Pamies D,Block K,Lau P,Gribaldo L,Pardo CA,Barreras P,Smirnova L,Wiersma D,Zhao L,Harris G,Hartung T,Hogberg HT

    更新日期:2018-09-01 00:00:00

  • Thymoquinone suppresses metastasis of melanoma cells by inhibition of NLRP3 inflammasome.

    abstract::The inflammasome is a multi-protein complex which when activated regulates caspase-1 activation and IL-1β and IL-18 secretion. The NLRP3 (NACHT, LRR, and pyrin domain-containing protein 3) inflammasome is constitutively assembled and activated in human melanoma cells. We have examined the inhibitory effect of thymoqui...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Ahmad I,Muneer KM,Tamimi IA,Chang ME,Ata MO,Yusuf N

    更新日期:2013-07-01 00:00:00

  • EPAC expression and function in cardiac fibroblasts and myofibroblasts.

    abstract:UNLABELLED:In the heart, cardiac fibroblasts (CF) and cardiac myofibroblasts (CMF) are the main cells responsible for wound healing after cardiac insult. Exchange protein activated by cAMP (EPAC) is a downstream effector of cAMP, and it has been not completely studied on CF. Moreover, in CMF, which are the main cells r...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Olmedo I,Muñoz C,Guzmán N,Catalán M,Vivar R,Ayala P,Humeres C,Aránguiz P,García L,Velarde V,Díaz-Araya G

    更新日期:2013-10-15 00:00:00

  • Mechanism of inhibition of lysyl hydroxylase activity by the organophosphates malathion and malaoxon.

    abstract::Direct inhibition of lysyl hydroxylase by malathion and malaoxon was observed in an in vitro enzyme assay with recombinant lysyl hydroxylase expressed via a baculoviral system. The IC50 values for malathion and malaoxon were estimated to be approximately 60 and 45 mM, respectively. Additional kinetic studies showed th...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Samimi A,Last JA

    更新日期:2001-11-01 00:00:00

  • HPW-RX40 restores anoikis sensitivity of human breast cancer cells by inhibiting integrin/FAK signaling.

    abstract::Anoikis is defined as apoptosis, which is induced by inappropriate cell-matrix interactions. Cancer cells with anoikis resistance tend to undergo metastasis, and this phenomenon has been reported to be associated with integrin and FAK activity. HPW-RX40 is a derivative of 3,4-methylenedioxy-β-nitrostyrene, which is kn...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Chen IH,Shih HC,Hsieh PW,Chang FR,Wu YC,Wu CC

    更新日期:2015-12-01 00:00:00