Abstract:
:Experiments were conducted to study the acute and subacute effects of intramuscularly injected T-2 toxin in rats and rabbits. The LD50 values of T-2 toxin were 0.85 +/- 0.03 and 1.10 +/- 0.08 mg/kg body wt in rats and rabbits, respectively. The intoxication was characterized by a consistent decrease in serum alkaline phosphatase (ALP) activity following either a single injection of 0.5, 0.6, or 0.9 mg/kg T-2 toxin in rats or daily injections of 0.2 mg/kg T-2 toxin for 10 days in rats and rabbits. Significant increases in bromosulfalein (BSP) retention and ALP activity were also observed in rabbits 24 hr following a single injection of 0.6 mg/kg T-2 toxin. The results indicated that the hepatobiliary system is a major target organ for T-2 toxin. Alterations in the activity of lactate dehydrogenase (LDH) and creatine kinase (CK) and in the hematocrit values were also observed.
journal_name
Toxicol Appl Pharmacoljournal_title
Toxicology and applied pharmacologyauthors
Chan PK,Gentry PAdoi
10.1016/0041-008x(84)90092-9subject
Has Abstractpub_date
1984-05-01 00:00:00pages
402-10issue
3eissn
0041-008Xissn
1096-0333journal_volume
73pub_type
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