Pancreatic cancer: pathogenesis, prevention and treatment.

abstract：:Naphthalene produces species and cell selective injury to respiratory tract epithelial cells of rodents. In these studies we determined the apparent Km, Vmax, and catalytic efficiency (Vmax/Km) for naphthalene metabolism in microsomal preparations from subcompartments of the respiratory tract of rodents and non-human ...

journal_title：Toxicology and applied pharmacology

authors： Buckpitt A,Morin D,Murphy S,Edwards P,Van Winkle L

更新日期：2013-07-15 00:00:00

abstract：:The toxicokinetics of deltamethrin and its metabolite 4'-HO-deltamethrin after single doses of 26 mg of deltamethrin/kg (oral) or 1.2 mg of deltamethrin/kg (intravenous) were studied in male Wistar rats. Serial blood samples were obtained after oral and intravenous administration. Brain, vas deferens, and anococcygeus...

journal_title：Toxicology and applied pharmacology

authors： Anadón A,Martinez-Larrañaga MR,Fernandez-Cruz ML,Diaz MJ,Fernandez MC,Martinez MA

更新日期：1996-11-01 00:00:00

abstract：:Inorganic arsenicals are clearly toxicants and carcinogens in humans. In mammals, including humans, inorganic arsenic often undergoes methylation, forming compounds such as monomethylarsonic acid (MMAs(V)) and dimethylarsinic acid (DMAs(V)). However, much less information is available on the in vitro toxic potential o...

journal_title：Toxicology and applied pharmacology

authors： Sakurai T,Kojima C,Ochiai M,Ohta T,Sakurai MH,Waalkes MP,Fujiwara K

更新日期：2004-03-01 00:00:00

abstract：:Isoflurane is known to increase β-amyloid aggregation and neuronal damage. We hypothesized that isoflurane will have similar effects on the polyglutamine huntingtin protein and will cause alterations in intracellular calcium homeostasis. We tested this hypothesis in striatal cells from the expanded glutamine huntingti...

journal_title：Toxicology and applied pharmacology

authors： Wang Q,Liang G,Yang H,Wang S,Eckenhoff MF,Wei H

更新日期：2011-02-01 00:00:00

abstract：:There is a subpopulation of the CF-1 mouse strain that is very sensitive to the neurotoxicity induced by the avermectins, a class of natural products widely used in veterinary and human medicine as anti-parasitic agents. This sensitivity results from a lack of P-glycoprotein in the intestine and brain of sensitive ani...

journal_title：Toxicology and applied pharmacology

authors： Umbenhauer DR,Lankas GR,Pippert TR,Wise LD,Cartwright ME,Hall SJ,Beare CM

更新日期：1997-09-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) patients harboring EGFR mutation who initially respond to EGFR-TKI will gradually develop acquired resistance. There is still a challenge to treat EGFR-TKI resistant NSCLC patients. Polyphyllin I (PP I), a steroidal saponin isolated from Paris polyphylla., has been exhibited antitumo...

journal_title：Toxicology and applied pharmacology

authors： Yang Q,Chen W,Xu Y,Lv X,Zhang M,Jiang H

更新日期：2018-10-01 00:00:00

abstract：:Chemotherapy is one of the major strategies for cancer treatment. Several antineoplastic drugs including vinorelbine (VRB) are commonly intravenously infused and liable to cause serious phlebitis. The therapeutic drugs for preventing this complication are limited. In this study, the mechanism of baicalein (BCN) was in...

journal_title：Toxicology and applied pharmacology

authors： Ge GF,Shi WW,Yu CH,Jin XY,Zhang HH,Zhang WY,Wang LC,Yu B

更新日期：2017-03-01 00:00:00

abstract：:Exposure to the anticonvulsant drug valproic acid (VPA) in utero is associated with a 1-2% increase in neural tube defects (NTDs), however the molecular mechanisms by which VPA induces teratogenesis are unknown. Previous studies demonstrated that VPA, a direct inhibitor of histone deacetylase, can induce histone hyper...

journal_title：Toxicology and applied pharmacology

authors： Tung EW,Winn LM

更新日期：2010-11-01 00:00:00

abstract：:This study investigated the in vivo metabolism of di(2-ethylhexyl) phthalate (DEHP) and mono(2-ethylhexyl) phthalate (MEHP) in rats after multiple dosing, the metabolism of MEHP in primary rat hepatocyte cultures for periods of up to 3 days, and the biotransformation of some major metabolites of MEHP. Rats were orally...

journal_title：Toxicology and applied pharmacology

authors： Lhuguenot JC,Mitchell AM,Milner G,Lock EA,Elcombe CR

更新日期：1985-08-01 00:00:00

abstract：:Skin is the largest and most accessible drug-metabolizing organ. In mammals, it is the competent barrier that protects against exposure to harmful stimuli in the environment and in the systemic circulation. Skin expresses many cytochromes P450 that have critical roles in exogenous and endogenous substrate metabolism. ...

journal_title：Toxicology and applied pharmacology

authors： Du L,Hoffman SM,Keeney DS

更新日期：2004-03-15 00:00:00

abstract：:A group of alkyl epoxides was compared for their guinea pig sensitization capacity and reactivities towards a protein-surrogate substrate, n-butylamine. Instead of the previously reported use of a titration method for determination of alkylation rate, proton nuclear magnetic resonance spectrometry (1H NMR) was used. T...

journal_title：Toxicology and applied pharmacology

authors： Betso JE,Carreon RE,Miner VM

更新日期：1991-05-01 00:00:00

abstract：:Oral administration of dimethylarsinic acid (DMAA), a major metabolite of inorganic arsenics, induces DNA damage in the mouse and rat lung due to both active oxygens and dimethylarsenic peroxyl radical produced in the metabolism of DMAA. Our paper describes the cellular response to DMAA in the mouse lung. In male ICR ...

journal_title：Toxicology and applied pharmacology

authors： Yamanaka K,Hasegawa A,Sawamura R,Okada S

更新日期：1991-04-01 00:00:00

abstract：:The hypothalamic paraventricular nucleus (PVN) plays crucial roles in central cardiovascular regulation. Increasing evidence in humans and rodents shows that vitamin D intake is important for achieving optimal cardiovascular function. The purpose of this study was to investigate whether calcitriol, an active form of v...

journal_title：Toxicology and applied pharmacology

authors： Xu ML,Yu XJ,Zhao JQ,Du Y,Xia WJ,Su Q,Du MM,Yang Q,Qi J,Li Y,Zhou SW,Zhu GQ,Li HB,Kang YM

更新日期：2020-05-01 00:00:00

abstract：:In the metabolism of isosorbide dinitrate (ISDN), fast denitration with the formation of nitrite ions and a mononitrate plays an important role. In contrast, the denitration of isosorbide-5-mononitrate (IS-5-MN) to isosorbide is very slow. Accordingly po administration of high doses of ISDN (92.5 and 236 mg/kg) in con...

journal_title：Toxicology and applied pharmacology

authors： Strein K,Bartsch W,Sponer G,Müller-Beckmann B,Lexa P

更新日期：1984-01-01 00:00:00

abstract：:Ethylnitrosourea (ENU) is a proven animal teratogen, although the mechanism of its developmental toxicity is unknown. The micromass rat embryo midbrain (CNS) and limb bud (LB) cultures were used in an effort to determine potential mechanisms by which ENU may exert its teratogenic effect. When cultured at high cell den...

journal_title：Toxicology and applied pharmacology

authors： Ribeiro PL,Faustman EM

更新日期：1990-06-15 00:00:00

abstract：:Montelukast (MK),a cysteinyl leukotriene (CysLT1) receptor antagonist, latterly exhibited a remarkable neuroprotective activity in various neurodegenerative disorders. This study aims to elucidate the neuroprotective effect of MK in rotenone-induced Parkinson's disease(PD) model in rats. Ninety six male rats were spli...

journal_title：Toxicology and applied pharmacology

authors： Mansour RM,Ahmed MAE,El-Sahar AE,El Sayed NS

更新日期：2018-11-01 00:00:00

abstract：:Daily subcutaneous administration of 20 or 100 mg/kg gentamicin for 4 days significantly decreased pyridoxal-5'-phosphate and lysosomal specific phosphatidylinositol-phospholipase C (PI-PLC) in newborn rat kidney. The fall in PI-PLC was associated with an elevation in renal phosphatidylinositol, phosphatidylserine, an...

journal_title：Toxicology and applied pharmacology

authors： Kacew S,Hewitt WR,Hook JB

更新日期：1989-06-01 00:00:00

abstract：:Arsenic trioxide (ATO) has a long history and it is recognized as both poison and drug for more than two thousand years. Since the establishment of ATO as a frontline therapeutic agent for acute promyelocytic leukemia (APL), the survival of APL patients have been greatly improved and APL is turned from highly fatal to...

journal_title：Toxicology and applied pharmacology

authors： Wang QQ,Hua HY,Naranmandura H,Zhu HH

更新日期：2020-12-15 00:00:00

abstract：:Exposure of mice to cationic rhodamines, Rh 123 and Rh 6G, has been found to be associated with developmental toxicity, while neutral rhodamines (e.g., Rh B) had no such effect. When mouse embryos from dams given ip injections of Rh 123, Rh 6G (15 mg/kg), or Rh B (30 mg/kg) on gestation Day (GD) 10 were examined, Rh 1...

journal_title：Toxicology and applied pharmacology

authors： Ranganathan S,Churchill PF,Hood RD

更新日期：1989-06-01 00:00:00

abstract：:The main curative treatment of colorectal cancer remains the surgery. However, when metastases are suspected, surgery is followed by a preventive chemotherapy using oxaliplatin which, unfortunately, may cause liver sinusoidal obstruction syndrome (SOS). Such hepatic damage is barely detected during or after chemothera...

journal_title：Toxicology and applied pharmacology

authors： Conotte R,Colet JM

更新日期：2014-04-15 00:00:00

abstract：:Accumulation, tissue distribution, and depuration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-derived 3H were examined in fingerling yellow perch fed a diet containing 494 ppt of [3H]TCDD for 13 weeks followed by the same diet without TCDD for 13 weeks. None of the TCDD-exposed perch showed any signs of overt toxici...

journal_title：Toxicology and applied pharmacology

authors： Kleeman JM,Olson JR,Chen SM,Peterson RE

更新日期：1986-05-01 00:00:00

abstract：:The current investigation was designed to determine if the pesticide methoxychlor (M) mimicked the effects of estrogen in the brain and on behavior. Running wheel activity (RWA) and sex behaviors were evaluated in this study because the role of estrogen in the regulation of these behaviors has been thoroughly establis...

journal_title：Toxicology and applied pharmacology

authors： Gray LE Jr,Ostby JS,Ferrell JM,Sigmon ER,Goldman JM

更新日期：1988-12-01 00:00:00

abstract：:The effect of KCN on cytosolic Ca2+ levels was measured in PC12 cells using Quin II/AM, a fluorometric calcium indicator. The resting cytosolic Ca2+ concentration, 115.0 +/- 4.9 nm, increased gradually and steadily over a 30-min time period following addition of 10(-4), 10(-3), or 10(-2)M KCN to the cells. After 15 mi...

journal_title：Toxicology and applied pharmacology

authors： Johnson JD,Conroy WG,Isom GE

更新日期：1987-04-01 00:00:00

abstract：:A series of psychopharmacological agents were administered to adult male Fischer-344 rats pretreated with a tremorigenic dose of chlordecone in an attempt to elucidate the involvement of spinal and supraspinal processes in the mediation and/or expression of chlordecone-induced tremor. Agents effective in attenuating t...

journal_title：Toxicology and applied pharmacology

authors： Gerhart JM,Hong JS,Tilson HA

更新日期：1983-09-30 00:00:00

abstract：:Carcinogenic chromium (VI) compounds are persistent environmental contaminants with potential for human exposure through drinking water. One lesion associated with chromium (VI) exposure is the formation of DNA-protein crosslinks (DPC). In an attempt to develop markers of chromium exposure, the formation of DPC in lym...

journal_title：Toxicology and applied pharmacology

authors： Coogan TP,Motz J,Snyder CA,Squibb KS,Costa M

更新日期：1991-06-01 00:00:00

abstract：:Liver and kidney injury following acute or chronic exposure to cadmium is well characterized. While hepatocytes and endothelial cells of the sinusoids are thought to be the primary cellular targets in the liver, ultrastructural changes may vary depending upon the exposure regimen and the time following administration....

journal_title：Toxicology and applied pharmacology

authors： Kayama F,Yoshida T,Elwell MR,Luster MI

更新日期：1995-04-01 00:00:00

abstract：:Increased oxygen species production has often been cited as a mechanism determining synergism on cell death and growth inhibition effects of arsenic-combined drugs. However the net effect of drug combination may not be easily anticipated solely from available knowledge of drug-induced death mechanisms. We evaluated th...

journal_title：Toxicology and applied pharmacology

authors： Lombardo T,Cavaliere V,Costantino SN,Kornblihtt L,Alvarez EM,Blanco GA

更新日期：2012-02-01 00:00:00

abstract：:The effect of HgCl2 on kainate (KA)-induced depression of voltage-gated potassium (K+) current in chick embryo telencephalic cells was studied using conventional and nystatin-perforated whole-cell patch-clamp recordings, fluorescence imaging, and flow cytometry techniques. Hg2+ (1 microM) alone did not effect the 4-am...

journal_title：Toxicology and applied pharmacology

authors： Dyatlov VA,Platoshin AV,Lawrence DA,Carpenter DO

更新日期：1996-06-01 00:00:00

abstract：:Some chemicals are known to induce limb malformations in mice. The occurrence of limb abnormality induced by chemical reagents is due to changes in the programmed cell death (PCD). 5-Bromodeoxyuridine (BrdU) is known as a potent teratogen and has been reported to induce polydactyly and other limb malformations in rode...

journal_title：Toxicology and applied pharmacology

authors： Nakamura N,Fujioka M,Mori C

更新日期：2000-09-01 00:00:00

abstract：:The goodness of fit of three PBPK models to data for inhalation uptake of 1,3-butadiene by mice from closed chambers were compared. These models included a classical flow-limited model with blood consolidated into arterial and venous compartments, a flow-limited model with implicit blood and alveolar compartments, and...

journal_title：Toxicology and applied pharmacology

authors： Kohn MC

更新日期：1997-12-01 00:00:00