Alteration of cytosolic calcium levels in PC12 cells by potassium cyanide.

abstract：:Cyclosporin A (CsA) has nephrotoxic effects known to involve reactive oxygen species (ROS), since antioxidants prevent the kidney damage induced by this drug. Given that mitochondria are among the main sources of intracellular ROS, the aims of our study were to examine the mitochondrial effects of CsA in the porcine r...

journal_title：Toxicology and applied pharmacology

authors： de Arriba G,de Hornedo JP,Rubio SR,Fernández MC,Martínez SB,Camarero MM,Cid TP

更新日期：2009-09-15 00:00:00

abstract：:The rate-limiting step in chemically induced, male rat-specific hyaline droplet nephropathy is the reversible binding of a xenobiotic to alpha 2u-globulin. In this study, equilibrium saturation binding experiments were conducted to evaluate the in vitro binding of d-limonene-1,2-oxide (dLO) and 2,4,4-trimethyl-2-penta...

journal_title：Toxicology and applied pharmacology

authors： Lehman-McKeeman LD,Caudill D

更新日期：1992-10-01 00:00:00

abstract：:The specificity of two major types of cytochrome P-450 of rat liver microsomes induced by phenobarbital (PB) and 3-methylcholanthrene (MC) toward activation of three 14C-labeled tetrachlorobiphenyl (TCB) isomers to protein-bound metabolites was examined by intact microsomal and reconstituted monooxygenase systems. The...

journal_title：Toxicology and applied pharmacology

authors： Shimada T,Sawabe Y

更新日期：1983-09-30 00:00:00

abstract：:Allergic airway diseases in children are a common and a growing health problem. Changes in the central nervous system (CNS) have been implicated in contributing to some of the symptoms. We hypothesized that airway allergic diseases are associated with altered histamine H3 receptor expression in the nucleus tractus sol...

journal_title：Toxicology and applied pharmacology

authors： Sekizawa S,Bechtold AG,Tham RC,Kott KS,Hyde DM,Joad JP,Bonham AC

更新日期：2010-09-15 00:00:00

abstract：:Exposure to the anticonvulsant drug valproic acid (VPA) in utero is associated with a 1-2% increase in neural tube defects (NTDs), however the molecular mechanisms by which VPA induces teratogenesis are unknown. Previous studies demonstrated that VPA, a direct inhibitor of histone deacetylase, can induce histone hyper...

journal_title：Toxicology and applied pharmacology

authors： Tung EW,Winn LM

更新日期：2010-11-01 00:00:00

abstract：:Though nanomaterials (NMs) are being utilized worldwide, increasing use of NMs have raised concerns over their safety to human health and environment. Iron oxide (Fe(2)O(3)) NMs have important applications. The aim of this study was to assess the genotoxicity of Fe(2)O(3)-30nm and Fe(2)O(3)-bulk in female Wistar rats....

journal_title：Toxicology and applied pharmacology

authors： Singh SP,Rahman MF,Murty US,Mahboob M,Grover P

更新日期：2013-01-01 00:00:00

abstract：:Carcinogenic chromium (VI) compounds are persistent environmental contaminants with potential for human exposure through drinking water. One lesion associated with chromium (VI) exposure is the formation of DNA-protein crosslinks (DPC). In an attempt to develop markers of chromium exposure, the formation of DPC in lym...

journal_title：Toxicology and applied pharmacology

authors： Coogan TP,Motz J,Snyder CA,Squibb KS,Costa M

更新日期：1991-06-01 00:00:00

abstract：:The comparative antiestrogenic effects of progesterone and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on cytosolic and nuclear estrogen (ERc and ERn, respectively) and progesterone (PRc and PRn, respectively) receptor levels were determined in female Long Evans rats. Estradiol treatment typically increases ER and PR l...

journal_title：Toxicology and applied pharmacology

authors： Romkes M,Safe S

更新日期：1988-03-15 00:00:00

abstract：:Field potential duration (FPD) in human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs), which can express QT interval in an electrocardiogram, is reported to be a useful tool to predict K(+) channel and Ca(2+) channel blocker effects on QT interval. However, there is no report showing that this techni...

journal_title：Toxicology and applied pharmacology

authors： Nozaki Y,Honda Y,Tsujimoto S,Watanabe H,Kunimatsu T,Funabashi H

更新日期：2014-07-01 00:00:00

abstract：:Although insulin and atorvastatin have been shown to exert glycemic control and could improve brain function, the effects of atorvastatin or insulin as well as the combination of atorvastatin plus insulin on brain pathology in diabetes mellitus type 1 (T1DM) are unclear. Therefore, this study investigated the effect o...

journal_title：Toxicology and applied pharmacology

authors： Pratchayasakul W,Thongnak LO,Chattipakorn K,Lungaphin A,Pongchaidecha A,Satjaritanun P,Jaiwongkam T,Kerdphoo S,Chattipakorn SC

更新日期：2018-03-01 00:00:00

abstract：:Many environmental chemicals and drugs negatively affect human health through deleterious effects on mitochondrial function. Currently there is no chemical library of mitochondrial toxicants, and no reliable methods for predicting mitochondrial toxicity. We hypothesized that discrete toxicophores defined by distinct c...

journal_title：Toxicology and applied pharmacology

authors： Wills LP,Beeson GC,Trager RE,Lindsey CC,Beeson CC,Peterson YK,Schnellmann RG

更新日期：2013-10-15 00:00:00

abstract：:MicroRNAs (miRNAs) are post-transcriptional regulators that silence messenger RNAs. Because miRNAs are stable at room temperature and long-lived, they have been proposed as molecular biomarkers to monitor disease and exposure status. While urinary miRNAs have been used clinically as potential diagnostic markers for ki...

journal_title：Toxicology and applied pharmacology

authors： Weldon BA,Shubin SP,Smith MN,Workman T,Artemenko A,Griffith WC,Thompson B,Faustman EM

更新日期：2016-12-01 00:00:00

abstract：:Acetaminophen (N-Acetyl-p-Aminophenol or APAP)-induced hepatotoxicity is the most common cause of acute liver failure in the United States and Western Europe. Previous studies have shown that TGFβ1 is elevated during APAP-induced hepatotoxicity and promotes liver injury by reducing liver regeneration while inducing he...

journal_title：Toxicology and applied pharmacology

authors： Frampton G,Reddy P,Jefferson B,Ali M,Khan D,McMillin M

更新日期：2020-12-15 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) patients harboring EGFR mutation who initially respond to EGFR-TKI will gradually develop acquired resistance. There is still a challenge to treat EGFR-TKI resistant NSCLC patients. Polyphyllin I (PP I), a steroidal saponin isolated from Paris polyphylla., has been exhibited antitumo...

journal_title：Toxicology and applied pharmacology

authors： Yang Q,Chen W,Xu Y,Lv X,Zhang M,Jiang H

更新日期：2018-10-01 00:00:00

abstract：:The toxicokinetics of deltamethrin and its metabolite 4'-HO-deltamethrin after single doses of 26 mg of deltamethrin/kg (oral) or 1.2 mg of deltamethrin/kg (intravenous) were studied in male Wistar rats. Serial blood samples were obtained after oral and intravenous administration. Brain, vas deferens, and anococcygeus...

journal_title：Toxicology and applied pharmacology

authors： Anadón A,Martinez-Larrañaga MR,Fernandez-Cruz ML,Diaz MJ,Fernandez MC,Martinez MA

更新日期：1996-11-01 00:00:00

abstract：:A negative regulatory element (NRE1; position -794 to -774) was previously identified that mediates the downregulation of CYP1A1, including partial suppression of Ah receptor-dependent induction. The CCAAT-box binding protein, nuclear factor-Y (NF-Y), is a component of one of two protein complexes that specifically an...

journal_title：Toxicology and applied pharmacology

authors： Poch MT,Al-Kassim L,Smolinski SM,Hines RN

更新日期：2004-09-15 00:00:00

abstract：:Fibrinogen, a soluble 340kDa plasma glycoprotein, is critical in achieving and maintaining hemostasis. Reduced fibrinogen levels are associated with an increased risk of bleeding and recent research has investigated the efficacy of fibrinogen concentrate for controlling perioperative bleeding. European guidelines on t...

journal_title：Toxicology and applied pharmacology

authors： Beyerle A,Nolte MW,Solomon C,Herzog E,Dickneite G

更新日期：2014-10-01 00:00:00

abstract：:p,p'-DDT (1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane; 75 mg/kg) or corn oil was administered po to male Fischer 344N rats. Tremor was quantified 8 hr later by spectral analysis of whole body movements. The effect of sc injection of pharmacological challenges on the spectral profile of body movements was determined....

journal_title：Toxicology and applied pharmacology

authors： Herr DW,Tilson HA

更新日期：1987-11-01 00:00:00

abstract：:Various drugs have been shown to stimulate surfactant phospholipid metabolism. Particularly beta-adrenergic agonists play an important role under physiologic conditions. For the first time we have studied whether nitrogen dioxide (NO2) inhalation alters beta-adrenergic regulation of surfactant phospholipid metabolism ...

journal_title：Toxicology and applied pharmacology

authors： Mengel RG,Bernhard W,Barth P,von Wichert P,Müller B

更新日期：1993-06-01 00:00:00

abstract：:Besides pathology endpoints, additional immune function endpoints have been included in the Note for Guidance on Repeated Dose Toxicity by the European Union (July 2001), which concern the analysis of antibody responses to a T-cell-dependent antigen. Guidance papers of other regulatory authorities are published as wel...

journal_title：Toxicology and applied pharmacology

authors： van der Laan JW,van Loveren H

更新日期：2005-09-01 00:00:00

abstract：:Methylglyoxal is found in high levels in the blood and other tissues of diabetic patients and exerts deleterious effects on cells and tissues. Previously, we reported that resveratrol, a polyphenol in grapes, induced the expression of Sestrin2 (SESN2), a novel antioxidant protein, and inhibited hepatic lipogenesis. Th...

journal_title：Toxicology and applied pharmacology

authors： Seo K,Seo S,Han JY,Ki SH,Shin SM

更新日期：2014-10-15 00:00:00

abstract：:Exposure to excessive manganese (Mn) levels leads to neurotoxicity, referred to as manganism, which resembles Parkinson's disease (PD). Manganism is caused by neuronal injury in both cortical and subcortical regions, particularly in the basal ganglia. The basis for the selective neurotoxicity of Mn is not yet fully un...

journal_title：Toxicology and applied pharmacology

authors： Milatovic D,Gupta RC,Yu Y,Zaja-Milatovic S,Aschner M

更新日期：2011-11-01 00:00:00

abstract：:Chronic exposure to high concentrations of arsenic in drinking water is associated with an increased risk for developing type 2 diabetes. The present revision focuses on the effect of arsenic on tissues that participate directly in glucose homeostasis, integrating the most important published information about the imp...

journal_title：Toxicology and applied pharmacology

authors： Díaz-Villaseñor A,Burns AL,Hiriart M,Cebrián ME,Ostrosky-Wegman P

更新日期：2007-12-01 00:00:00

abstract：:A physiologically based pharmacokinetic (PBPK) model describing transfer of inhaled tetrachloroethylene (PCE) into breast milk with the consequent exposure of the nursing pups was developed and validated in lactating rats. The PBPK model was based on partition coefficients (PCs), which were determined by the equilibra...

journal_title：Toxicology and applied pharmacology

authors： Byczkowski JZ,Kinkead ER,Leahy HF,Randall GM,Fisher JW

更新日期：1994-04-01 00:00:00

abstract：:Calcium uptake in cells occurs through specific membrane channels. Since cadmium and mercury inhibit calcium uptake, this study examined whether the calcium channels may also be involved in the uptake of these metals. Primary cultures of rat hepatocytes were incubated with 3 microM CdCl2 or HgCl2 in the absence or pre...

journal_title：Toxicology and applied pharmacology

authors： Blazka ME,Shaikh ZA

更新日期：1991-09-01 00:00:00

abstract：:Previous research has shown that intraperitoneal injection of the solvent pyridine results in a dose- and time-dependent induction of hepatic P450IIE1 in rats, with a twofold increase observed at 6 hr post-treatment. However, inhalation is the primary route of exposure expected for humans exposed to pyridine in labora...

journal_title：Toxicology and applied pharmacology

authors： Hotchkiss JA,Kim SG,Novak RF,Dahl AR

更新日期：1993-01-01 00:00:00

abstract：:Zidovudine (ZDV) is a thymidine analogue activated to its triphosphate (ZDVTP) by the host's intracellular enzymes. The initial phosphorylation step is conversion to ZDV monophosphate (ZDVMP). The poor affinity of ZDVMP for thymidylate kinase results in intracellular accumulation of ZDVMP. Clinical use of ZDV is assoc...

journal_title：Toxicology and applied pharmacology

authors： Sales SD,Hoggard PG,Sunderland D,Khoo S,Hart CA,Back DJ

更新日期：2001-11-15 00:00:00

abstract：:The use of toxicokinetic (TK) data is becoming more prevalent in the evaluation of food ingredient safety as more TK information is being incorporated in safety data packages. Data demonstrating "1) the extent of absorption, 2) tissue distribution, 3) pathways and rates of metabolism, and 4) rate(s) of elimination" of...

journal_title：Toxicology and applied pharmacology

authors： Kabadi SV,Zang Y,Fisher JW,Smith N,Whiteside C,Aungst J

更新日期：2019-11-01 00:00:00

abstract：:Di-Calciphor is a synthetic derivative of prostaglandin B1 that protects against cerebral and cardiac ischemia apparently by preserving mitochondrial function. To determine whether di-Calciphor specifically protects against mitochondrial failure, we studied its effects on mitochondrial functions in hepatocytes treated...

journal_title：Toxicology and applied pharmacology

authors： Park Y,Devlin TM,Jones DP

更新日期：1994-05-01 00:00:00

abstract：:A total of 52 monkeys (Macaca fascicularis) were dosed orally with vehicle or 1.5 mg/kg/day of lead on one of four dosing regimens (13 monkeys/group): Group 1, vehicle only; Group 2, dosed with lead from birth onward; Group 3, dosed with lead from birth to 400 days of age and vehicle thereafter; Group 4, dosed with ve...

journal_title：Toxicology and applied pharmacology

authors： Rice DC

更新日期：1990-11-01 00:00:00