当前位置： SCI文献检索 > TOXICOLOGY AND APPLIED PHARMACOLOGY期刊下所有文献 > Lead-induced behavioral impairment on a spatial discrimination reversal task in monkeys exposed during different periods of development.

Lead-induced behavioral impairment on a spatial discrimination reversal task in monkeys exposed during different periods of development.

Abstract：

:A total of 52 monkeys (Macaca fascicularis) were dosed orally with vehicle or 1.5 mg/kg/day of lead on one of four dosing regimens (13 monkeys/group): Group 1, vehicle only; Group 2, dosed with lead from birth onward; Group 3, dosed with lead from birth to 400 days of age and vehicle thereafter; Group 4, dosed with vehicle from birth to 300 days of age and lead thereafter. Blood lead concentrations averaged 3-6 micrograms/dl when monkeys were not being dosed with lead, 32-36 micrograms/dl when being dosed with lead and having access to infant formula, and 19-26 micrograms/dl when being dosed with lead after weaning from infant formula. When monkeys were 7-8 years old, they were tested on three spatial discrimination reversal tasks: no irrelevant cues, irrelevant form cues, and irrelevant form and color cues. Fifteen reversals were run for each task. Only Group 2 was impaired in the absence of irrelevant cues, while all three treated groups were impaired in the presence of irrelevant cues. These results are in contrast to results from a series of nonspatial discrimination reversal tasks in these monkeys in which Groups 2 and 4 were impaired and Group 3 was unimpaired. The present results are in agreement with results from another spatial task, delayed alternation, in which all three treated groups were impaired.

journal_name

Toxicol Appl Pharmacol

journal_title

Toxicology and applied pharmacology

authors

Rice DC

doi

10.1016/0041-008x(90)90251-o

subject

Has Abstract

pub_date

1990-11-01 00:00:00

pages

327-33

issue

2

eissn

0041-008X

issn

1096-0333

journal_volume

106

pub_type

杂志文章

相关文献

TOXICOLOGY AND APPLIED PHARMACOLOGY文献大全
  • Testicular dysgenesis syndrome and the development and occurrence of male reproductive disorders.

    abstract：:Patients with 45,X0/46XY karyotype often present with intersex phenotype and testicular dysgenesis. These patients may also have undescended testes (cryptorchidism), hypospadias and their spermatogenesis is severely disrupted. They have a high risk for testicular cancer. These patients have the most severe form of tes...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.taap.2005.01.058

    authors： Virtanen HE,Rajpert-De Meyts E,Main KM,Skakkebaek NE,Toppari J

    更新日期：2005-09-01 00:00:00

  • Epigenetic mediated transcriptional activation of WNT5A participates in arsenical-associated malignant transformation.

    abstract：:Arsenic is a human carcinogen with exposure associated with cancer of the lung, skin, and bladder. Many potential mechanisms have been implicated as playing a role in the process of arsenical-induced malignancy including the perturbation of signaling pathways and aberrant epigenetic regulation. We initiated studies to...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2008.10.013

    authors： Jensen TJ,Wozniak RJ,Eblin KE,Wnek SM,Gandolfi AJ,Futscher BW

    更新日期：2009-02-15 00:00:00

  • Effects of garlic oil and two of its major organosulfur compounds, diallyl disulfide and diallyl trisulfide, on intestinal damage in rats injected with endotoxin.

    abstract：:Garlic and its active components are known to possess antioxidant and antiinflammatory effects. The present study investigated the effects of garlic oil and its organosulfur compounds on endotoxin-induced intestinal mucosal damage. Wistar rats received by gavage 50 or 200 mg/kg body weight garlic oil (GO), 0.5 mmol/kg...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2005.08.008

    authors： Chiang YH,Jen LN,Su HY,Lii CK,Sheen LY,Liu CT

    更新日期：2006-05-15 00:00:00

  • Effect of JP-8 jet fuel on molecular and histological parameters related to acute skin irritation.

    abstract：:Organic chemicals such as jet fuels and solvents can cause skin irritation after dermal exposure. The molecular responses to these chemicals resulting in acute irritation are not understood well enough to establish safe exposure limits. Male F-344 rats were dermally exposed to JP-8 jet fuel for 1 h using Hill Top Cham...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.2001.9248

    authors： Kabbur MB,Rogers JV,Gunasekar PG,Garrett CM,Geiss KT,Brinkley WW,McDougal JN

    更新日期：2001-08-15 00:00:00

  • Oxidative stress is involved in Dasatinib-induced apoptosis in rat primary hepatocytes.

    abstract：:Dasatinib, a multitargeted inhibitor of BCR-ABL and SRC kinases, exhibits antitumor activity and extends the survival of patients with chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL). However, some patients suffer from hepatotoxicity, which occurs through an unkno...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2012.04.010

    authors： Xue T,Luo P,Zhu H,Zhao Y,Wu H,Gai R,Wu Y,Yang B,Yang X,He Q

    更新日期：2012-06-15 00:00:00

  • The polymorphisms of P53 codon 72 and MDM2 SNP309 and renal cell carcinoma risk in a low arsenic exposure area.

    abstract：:Our recent study demonstrated the increased risk of renal cell carcinoma (RCC) associated with high urinary total arsenic levels among people living in a low arsenic exposure area. Genomic instability is important in arsenic carcinogenesis. This study evaluated the relationship between the polymorphisms of p53, p21, a...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2011.09.018

    authors： Huang CY,Su CT,Chu JS,Huang SP,Pu YS,Yang HY,Chung CJ,Wu CC,Hsueh YM

    更新日期：2011-12-15 00:00:00

  • Modulation of gamma-glutamylcysteine synthetase large subunit mRNA expression by butylated hydroxyanisole.

    abstract：:Dietary 2(3)-tert-butyl-4-hydroxyanisole (BHA) treatment has been shown to increase hepatic glutathione (GSH) content in rats and mice. Subsequent studies in our laboratory have demonstrated that hepatic gamma-glutamylcysteine synthetase (GCS) activity is increased in mice treated with dietary BHA. To test whether thi...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1994.1101

    authors： Borroz KI,Buetler TM,Eaton DL

    更新日期：1994-05-01 00:00:00

  • Late dimethyl sulfoxide administration provides a protective action against chemically induced injury in both the liver and the kidney.

    abstract：:Dimethyl sulfoxide (DMSO) can protect the liver from injury produced by a variety of hepatotoxicants when administered prior to or concomitant with the toxicants. This protective action has previously been attributed to DMSO-induced inhibition of bioactivation of the compounds to toxic intermediates. In these studies,...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1996.8009

    authors： Lind RC,Gandolfi AJ

    更新日期：1997-01-01 00:00:00

  • RPF101, a new capsaicin-like analogue, disrupts the microtubule network accompanied by arrest in the G2/M phase, inducing apoptosis and mitotic catastrophe in the MCF-7 breast cancer cells.

    abstract：:Breast cancer is the world's leading cause of death among women. This situation imposes an urgent development of more selective and less toxic agents. The use of natural molecular fingerprints as sources for new bioactive chemical entities has proven to be a quite promising and efficient method. Capsaicin, which is th...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2012.11.029

    authors： de-Sá-Júnior PL,Pasqualoto KF,Ferreira AK,Tavares MT,Damião MC,de Azevedo RA,Câmara DA,Pereira A,de Souza DM,Parise Filho R

    更新日期：2013-02-01 00:00:00

  • Simulation modeling of carcinogenesis.

    abstract：:A discrete-time simulation model of carcinogenesis is described mathematically using recursive relationships between time-varying model variables. The dynamics of cellular behavior is represented within a biological framework that encompasses two irreversible and heritable genetic changes. Empirical data and biologica...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(92)90013-i

    authors： Ellwein LB,Cohen SM

    更新日期：1992-03-01 00:00:00

  • Maturational changes in dermal absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in Fischer 344 rats.

    abstract：:An earlier study indicated that percutaneous absorption of a 40-nmol dose of TCDD decreased with aging in rats, suggesting that the potential for systemic exposure following dermal contact would be decreased in older age groups. In this study, maturational changes in potential for systemic exposure to TCDD following d...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1993.1062

    authors： Anderson YB,Jackson JA,Birnbaum LS

    更新日期：1993-04-01 00:00:00

  • Phyllanthus orbicularis aqueous extract: cytotoxic, genotoxic, and antimutagenic effects in the CHO cell line.

    abstract：:The present work evaluates the cytotoxic, genotoxic, and antimutagenic effects of Phyllanthus orbicularis (plant of genus Phyllantus) aqueous extract in Chinese hamster ovary (CHO) cells. P. orbicularis aqueous extracts are used in Cuban traditional medicine for their antiviral activity against Hepatitis B virus and A...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1999.8814

    authors： Sànchez-Lamar A,Fiore M,Cundari E,Ricordy R,Cozzi R,De Salvia R

    更新日期：1999-12-15 00:00:00

  • Two distinct classes of CCAAT box elements that bind nuclear factor-Y/alpha-actinin-4: potential role in human CYP1A1 regulation.

    abstract：:A negative regulatory element (NRE1; position -794 to -774) was previously identified that mediates the downregulation of CYP1A1, including partial suppression of Ah receptor-dependent induction. The CCAAT-box binding protein, nuclear factor-Y (NF-Y), is a component of one of two protein complexes that specifically an...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2003.12.023

    authors： Poch MT,Al-Kassim L,Smolinski SM,Hines RN

    更新日期：2004-09-15 00:00:00

  • Infantile 4-tert-octylphenol exposure transiently inhibits rat ovarian steroidogenesis and steroidogenic acute regulatory protein (StAR) expression.

    abstract：:Phenolic compounds, such as 4-tert-octylphenol (OP), have been shown to interfere with rat ovarian steroidogenesis. However, little is known about steroidogenic effects of infantile OP exposure on immature ovary. The aim of the present study was to investigate the effects of infantile OP exposure on plasma FSH, LH, es...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2004.12.001

    authors： Myllymäki SA,Karjalainen M,Haavisto TE,Toppari J,Paranko J

    更新日期：2005-08-22 00:00:00

  • Increasing ERK phosphorylation by inhibition of p38 activity protects against cadmium-induced apoptotic cell death through ERK/Drp1/p38 signaling axis in spermatocyte-derived GC-2spd cells.

    abstract：:Many studies report that cadmium chloride (CdCl2)-induces oxidative stress is associated with male reproductive damage in the testes. CdCl2 also induces mitochondrial fission by increasing dynamin-related protein 1 (Drp1) expression as well as the mitochondria-dependent apoptosis pathway by extracellular signal-regula...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2019.114797

    authors： Seong JB,Bae YC,Lee HS,Huh JW,Lee SR,Lee HJ,Lee DS

    更新日期：2019-12-01 00:00:00

  • Tungsten-induced carcinogenesis in human bronchial epithelial cells.

    abstract：:Metals such as arsenic, cadmium, beryllium, and nickel are known human carcinogens; however, other transition metals, such as tungsten (W), remain relatively uninvestigated with regard to their potential carcinogenic activity. Tungsten production for industrial and military applications has almost doubled over the pas...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2015.07.003

    authors： Laulicht F,Brocato J,Cartularo L,Vaughan J,Wu F,Kluz T,Sun H,Oksuz BA,Shen S,Peana M,Medici S,Zoroddu MA,Costa M

    更新日期：2015-10-01 00:00:00

  • Acrylonitrile-induced gastrointestinal hemorrhage and the effects of metabolism modulation in rats.

    abstract：:Acrylonitrile (VCN) is a heavily used monomer in plastic and fiber industries. Quantitatively, VCN-induced gastrointestinal hemorrhage is time and dose dependent and is not the result of a direct irritating action of VCN on gastric tissues. The effect of cytochrome P-450 enzymes inducers was studied. Pretreatment with...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(83)90013-3

    authors： Ghanayem BI,Ahmed AE

    更新日期：1983-04-01 00:00:00

  • Interspecies scaling of clearance and volume of distribution for horse antivenom F(ab')2.

    abstract：:F(ab')2 fragments are sometimes preferred to whole IgG for therapeutic or diagnostic uses. Preclinical pharmaceutical development studies are necessary before their use in humans. Here we propose an allometric approach among three mammalian species to predict F(ab')2 pharmacokinetic parameters in humans. Plasma dispos...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1997.8363

    authors： Bazin-Redureau M,Pepin S,Hong G,Debray M,Scherrmann JM

    更新日期：1998-06-01 00:00:00

  • Ozone-induced inhibition of theophylline elimination in rabbits: effect of age and sex.

    abstract：:The effect of age and sex on the elimination of theophylline in New Zealand White rabbits was investigated following exposure to 0.3 ppm of ozone (O3) for 3.75 hr/day over 5 consecutive days. Animals were given air alone 5 to 7 days before and after the 5 days of O3 exposure. The elimination half-life of theophylline ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(85)90118-8

    authors： Canada AT,Calabrese EJ

    更新日期：1985-10-01 00:00:00

  • Benzoquinone inhibits the voltage-dependent induction of the mitochondrial permeability transition caused by redox-cycling naphthoquinones.

    abstract：:The mitochondrial permeability pore is subject to regulation by a thiol-dependent voltage sensor (Petronilli, V., Costantini, P., Scorrano, L., Colonna, R., Passamonti, S., and Bernardi, P., J. Biol. Chem. 269, 16638-16642, 1994); thiol oxidation increases the gating potential, which increases the probability of pore ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1996.8099

    authors： Palmeira CM,Wallace KB

    更新日期：1997-04-01 00:00:00

  • Goniothalamin prevents the development of chemically induced and spontaneous colitis in rodents and induces apoptosis in the HT-29 human colon tumor cell line.

    abstract：:Colon cancer is the third most incident type of cancer worldwide. One of the most important risk factors for colon cancer development are inflammatory bowel diseases (IBD), thus therapies focusing on IBD treatment have great potential to be used in cancer prevention. Nature has been a source of new therapeutic and pre...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2016.03.009

    authors： Vendramini-Costa DB,Alcaide A,Pelizzaro-Rocha KJ,Talero E,Ávila-Román J,Garcia-Mauriño S,Pilli RA,de Carvalho JE,Motilva V

    更新日期：2016-06-01 00:00:00

  • The importance of anatomical realism for validation of physiological models of disposition of inhaled toxicants.

    abstract：:The goodness of fit of three PBPK models to data for inhalation uptake of 1,3-butadiene by mice from closed chambers were compared. These models included a classical flow-limited model with blood consolidated into arterial and venous compartments, a flow-limited model with implicit blood and alveolar compartments, and...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1997.8289

    authors： Kohn MC

    更新日期：1997-12-01 00:00:00

  • Induction of cytokine mRNAs in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): relationship to toxin distribution and protein synthesis inhibition.

    abstract：:The effects of oral exposure to 0, 5, and 25 mg/kg body wt vomitoxin (VT) on cytokine mRNA levels in spleen, Peyer's patches (PP), liver, kidney, and small intestine were evaluated in B6C3F1 mice at 2 and 4 hr postexposure using RT-PCR in conjunction with Southern hybridization analysis. The abundance of mRNAs for sev...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1995.1132

    authors： Azcona-Olivera JI,Ouyang Y,Murtha J,Chu FS,Pestka JJ

    更新日期：1995-07-01 00:00:00

  • Gene expression influences on metal immunomodulation.

    abstract：:Heavy metals in the environment originate from both human activities and natural processes. Exposure to these metals can result in important changes to immune activity. Depending on the metal and dose, these changes can result in enhanced immune function, diminished immune responses, or altered responses that produce ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.taap.2005.04.021

    authors： Lynes MA,Fontenot AP,Lawrence DA,Rosenspire AJ,Pollard KM

    更新日期：2006-01-01 00:00:00

  • Photoprotective effects of sulindac against ultraviolet B-induced phototoxicity in the skin of SKH-1 hairless mice.

    abstract：:Sulindac is a nonsteroidal anti-inflammatory drug with demonstrated potency as a chemopreventive agent in animal models of carcinogenesis and in patients with familial adenomatous polyposis. Because tumor promotion is generally associated with exposure to pro-inflammatory stimuli, it is likely that anti-inflammatory a...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2003.09.030

    authors： Athar M,An KP,Tang X,Morel KD,Kim AL,Kopelovich L,Bickers DR

    更新日期：2004-03-15 00:00:00

  • Polycyclic aromatic hydrocarbons as skin carcinogens: comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse.

    abstract：:The polycyclic aromatic hydrocarbon (PAH), benzo[a]pyrene (BaP), was compared to dibenzo[def,p]chrysene (DBC) and combinations of three environmental PAH mixtures (coal tar, diesel particulate and cigarette smoke condensate) using a two stage, FVB/N mouse skin tumor model. DBC (4nmol) was most potent, reaching 100% tu...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2012.08.014

    authors： Siddens LK,Larkin A,Krueger SK,Bradfield CA,Waters KM,Tilton SC,Pereira CB,Löhr CV,Arlt VM,Phillips DH,Williams DE,Baird WM

    更新日期：2012-11-01 00:00:00

  • Zinc oxide nanoparticles and monocytes: impact of size, charge and solubility on activation status.

    abstract：:Zinc oxide (ZnO) particle induced cytotoxicity was dependent on size, charge and solubility, factors which at sublethal concentrations may influence the activation of the human monocytic cell line THP1. ZnO nanoparticles (NP; average diameter 70nm) were more toxic than the bulk form (<44μm mesh) and a positive charge ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2012.10.020

    authors： Prach M,Stone V,Proudfoot L

    更新日期：2013-01-01 00:00:00

  • Multiple effects of sibutramine on ejaculation and on vas deferens and seminal vesicle contractility.

    abstract：:Sibutramine is an inhibitor of norepinephrine and 5-HT reuptake largely used in the management of obesity. Although a fairly safe drug, postmarketing adverse effects of sibutramine were reported including abnormal ejaculation in men. This study investigates the effects of sibutramine on ejaculation and vas deferens an...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2009.05.021

    authors： Nojimoto FD,Piffer RC,Kiguti LR,Lameu C,de Camargo AC,Pereira OC,Pupo AS

    更新日期：2009-09-15 00:00:00

  • Arsenic inhibits hedgehog signaling during P19 cell differentiation.

    abstract：:Arsenic is a toxicant found in ground water around the world, and human exposure mainly comes from drinking water or from crops grown in areas containing arsenic in soils or water. Epidemiological studies have shown that arsenic exposure during development decreased intellectual function, reduced birth weight, and alt...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2014.10.007

    authors： Liu JT,Bain LJ

    更新日期：2014-12-15 00:00:00

  • Diethyl hexyl phthalate-induced changes in insulin signaling molecules and the protective role of antioxidant vitamins in gastrocnemius muscle of adult male rat.

    abstract：:Diethyl hexyl phthalate (DEHP) is an endocrine disruptor, it influences various organ systems in human beings and experimental animals. DEHP reduced the serum testosterone and increased the blood glucose, estradiol, T(3) and T(4) in rats. However, the effect of DEHP on insulin signaling and glucose oxidation in skelet...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2011.08.022

    authors： Srinivasan C,Khan AI,Balaji V,Selvaraj J,Balasubramanian K

    更新日期：2011-12-01 00:00:00