The polymorphisms of P53 codon 72 and MDM2 SNP309 and renal cell carcinoma risk in a low arsenic exposure area.

abstract：:Several novel mechanistic findings regarding to arsenic's pathogenesis has been reported and some of them suggest that the etiology of some arsenic induced diseases are due in part to heritable changes to the genome via epigenetic processes such as DNA methylation, histone maintenance, and mRNA expression. Recently, w...

journal_title：Toxicology and applied pharmacology

authors： Gonzalez-Cortes T,Recio-Vega R,Lantz RC,Chau BT

更新日期：2017-08-15 00:00:00

abstract：:Marijuana or synthetic cannabinoids and alcohol are often used together, with these combinations causing motor impairments that can subsequently lead to motor vehicle accidents. This study investigated the combined use of both synthetic cannabinoids and ethanol and their effect on motor coordination in mice in additio...

journal_title：Toxicology and applied pharmacology

authors： Funada M,Takebayashi-Ohsawa M,Tomiyama KI

更新日期：2020-12-01 00:00:00

abstract：:The role of gamma-glutamyl transpeptidase (gamma-GTP) in the nephrotoxicity of hexachloro-1,3-butadiene (HCBD) was studied using male Sprague-Dawley rats pretreated with AT-125 (Acivicin; L-(alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid). Inhibition of gamma-GTP by more than 95% did not affect u...

journal_title：Toxicology and applied pharmacology

authors： Davis ME

更新日期：1988-08-01 00:00:00

abstract：:Peroxynitrite formed by the reaction of superoxide and nitric oxide is a highly reactive species with a role in various pathological processes such as cancer, chronic inflammation, and cardiovascular and neurological diseases. In the present study, the effect of the carotenoids, lycopene and beta-carotene, on peroxyni...

journal_title：Toxicology and applied pharmacology

authors： Muzandu K,Ishizuka M,Sakamoto KQ,Shaban Z,El Bohi K,Kazusaka A,Fujita S

更新日期：2006-09-15 00:00:00

abstract：:In an earlier study, we exposed nine healthy volunteers to known concentrations of mercury (Hg) vapor in air (median 399; range 365-430 micrograms/m3) for 15 min during light physical exercise (50 W) (Sandborgh-Englund, G., et al., Toxicol. Appl. Pharmacol. 150, 146-153, 1998). Exhaled air, urine, and plasma samples w...

journal_title：Toxicology and applied pharmacology

authors： Jonsson F,Sandborgh-Englund G,Johanson G

更新日期：1999-03-01 00:00:00

abstract：:The Adverse Outcome Pathway (AOP) framework describes the progression of a toxicity pathway from molecular perturbation to population-level outcome in a series of measurable, mechanistic responses. The controlled, computer-readable vocabulary that defines an AOP has the ability to, automatically and on a large scale, ...

journal_title：Toxicology and applied pharmacology

authors： Pittman ME,Edwards SW,Ives C,Mortensen HM

更新日期：2018-03-15 00:00:00

abstract：:During pregnancy, fetal thyroid hormones (THs) are dependent on maternal placental transport and their physiological level is crucial for normal fetal neurodevelopment. Earlier research has shown that Di-(2-ethylhexyl) phthalate (DEHP) disrupts thyroid function and THs homeostasis in pregnant women and fetuses, and af...

journal_title：Toxicology and applied pharmacology

authors： Du ZP,Feng S,Li YL,Li R,Lv J,Ren WQ,Feng QW,Liu P,Wang QN

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Bleeding episodes commonly occur in patients on warfarin treatment even in those within therapeutic range of international normalized ratio (INR). The objective of this study was to investigate the effects of the 8 examined polymorphisms on the risk of bleeding complications in a sample of Iranian patients. ...

journal_title：Toxicology and applied pharmacology

authors： Pourgholi L,Goodarzynejad H,Mandegary A,Ziaee S,Talasaz AH,Jalali A,Boroumand M

更新日期：2016-10-15 00:00:00

abstract：:Modified epigenetic programming early in life is proposed to underlie the development of an adverse adult phenotype, known as the Developmental Origins of Health and Disease (DOHaD) concept. Several environmental contaminants have been implicated as modifying factors of the developing epigenome. This underlines the ne...

journal_title：Toxicology and applied pharmacology

authors： Bouwmeester MC,Ruiter S,Lommelaars T,Sippel J,Hodemaekers HM,van den Brandhof EJ,Pennings JL,Kamstra JH,Jelinek J,Issa JP,Legler J,van der Ven LT

更新日期：2016-01-15 00:00:00

abstract：:Montelukast (MK),a cysteinyl leukotriene (CysLT1) receptor antagonist, latterly exhibited a remarkable neuroprotective activity in various neurodegenerative disorders. This study aims to elucidate the neuroprotective effect of MK in rotenone-induced Parkinson's disease(PD) model in rats. Ninety six male rats were spli...

journal_title：Toxicology and applied pharmacology

authors： Mansour RM,Ahmed MAE,El-Sahar AE,El Sayed NS

更新日期：2018-11-01 00:00:00

abstract：:2,2,4-Trimethylpentane (TMP), a component of unleaded gasoline, causes nephrotoxicity in male, but not in female, rats. In the present study, male and female Fischer 344 rats were treated with a single oral dose of [14C]TMP (4.4 mmol/kg; 2 microCi/mmol). Radiolabeled material in kidney, liver, and plasma was determine...

journal_title：Toxicology and applied pharmacology

authors： Charbonneau M,Lock EA,Strasser J,Cox MG,Turner MJ,Bus JS

更新日期：1987-11-01 00:00:00

abstract：:Naphthalene produces species and cell selective injury to respiratory tract epithelial cells of rodents. In these studies we determined the apparent Km, Vmax, and catalytic efficiency (Vmax/Km) for naphthalene metabolism in microsomal preparations from subcompartments of the respiratory tract of rodents and non-human ...

journal_title：Toxicology and applied pharmacology

authors： Buckpitt A,Morin D,Murphy S,Edwards P,Van Winkle L

更新日期：2013-07-15 00:00:00

abstract：:The ability of human plasma butyrylcholinesterase (BChE) to detoxify cocaine in vivo was evaluated. Intravenous administration of BChE, at doses sufficient to increase the plasma levels of the enzyme as much as 800-fold, produced no adverse effects on the cardiovascular, autonomic, or central nervous systems of rats. ...

journal_title：Toxicology and applied pharmacology

authors： Lynch TJ,Mattes CE,Singh A,Bradley RM,Brady RO,Dretchen KL

更新日期：1997-08-01 00:00:00

abstract：:L-Buthionine-S,R-sulfoximine (BSO), a potent inhibitor of gamma-glutamylcysteine synthetase, is commonly used as an experimental tool for the specific depletion of glutathione. Since cysteine is a key precursor for glutathione biosynthesis, we investigated the possibility that BSO might also affect the free cysteine p...

journal_title：Toxicology and applied pharmacology

authors： Standeven AM,Wetterhahn KE

更新日期：1991-02-01 00:00:00

abstract：:To determine if inhaled nephrotoxic branched and nonnephrotoxic straight chain alkanes differ substantially in their biological fate, male F344 rats were exposed to 14C-labeled isooctane and octane vapors at approximately 1 and 350 ppm by the nose-only mode for 2 hr. Radioactivity in exhalant, urine, and feces was det...

journal_title：Toxicology and applied pharmacology

authors： Dahl AR

更新日期：1989-09-01 00:00:00

abstract：:Renal glutathione (GSH) concentrations were reduced approximately 80% at 4 hr after a single injection of buthionine sulfoxime (BSO) (4 mmol/kg body wt) and remained reduced for at least 16 hr in male rats. Following BSO injection, rats were injected with a nephrotoxic dose of cadmium-metallothionein (Cd-MT) (0.3 mg C...

journal_title：Toxicology and applied pharmacology

authors： Suzuki CA,Cherian MG

更新日期：1989-05-01 00:00:00

abstract：:Valproic acid (VPA) undergoes cytochrome P450-mediated desaturation to form 4-ene-VPA, which subsequently yields (E)-2,4-diene-VPA by β-oxidation. Another biotransformation pathway involves β-oxidation of VPA to form (E)-2-ene-VPA, which also generates (E)-2,4-diene-VPA by cytochrome P450-mediated desaturation. Althou...

journal_title：Toxicology and applied pharmacology

authors： Surendradoss J,Chang TK,Abbott FS

更新日期：2012-11-01 00:00:00

abstract：:Previous studies have shown that fumonisin B1 (FB1) inhibits ceramide synthase, resulting in accumulation of free sphinganine and sphingosine. Tumor necrosis factor-alpha (TNFalpha) plays an important role in FB1 toxicity and the expression of TNFalpha mRNA in liver and kidney is increased following FB1 exposure in mi...

journal_title：Toxicology and applied pharmacology

authors： He Q,Riley RT,Sharma RP

更新日期：2001-07-01 00:00:00

abstract：:Biodistribution of cocaine in female rats before and after delivery of litters was studied in order to provide an explanation for the observed differences in cocaine-induced toxicity in pregnant and postpartum rats. Cocaine (20 mg/kg, ip) given to female rats at 16 days of gestation or 20 days of gestation did not hav...

journal_title：Toxicology and applied pharmacology

authors： Dwivedi C,Engineer FN,Vaughan SL

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:The current COVID-19 pandemic is caused by SARS-CoV-2 which belongs to coronaviridae family. Despite the global prevalence, there are currently no vaccines or drugs. Dietary plant derived exosome-like vesicles are known as edible nanoparticles (ENPs). ENPs are filled with microRNAs (miRNAs), in bioavailable ...

journal_title：Toxicology and applied pharmacology

authors： Kalarikkal SP,Sundaram GM

更新日期：2021-01-28 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants and many of their toxic effects, including their immunotoxicities, are mediated by the activation of aryl hydrocarbon receptor (AhR). We previously reported that Aroclor 1254, one of the most widely used PCB mixtures, increased DNA fragmentatio...

journal_title：Toxicology and applied pharmacology

authors： Jeon YJ,Youk ES,Lee SH,Suh J,Na YJ,Kim HM

更新日期：2002-06-01 00:00:00

abstract：:The H295R cell bioassay was used to evaluate the potential endocrine disrupting effects of 18 of the most commonly used pharmaceuticals in the United States. Exposures for 48 h with single pharmaceuticals and binary mixtures were conducted; the expression of five steroidogenic genes, 3betaHSD2, CYP11beta1, CYP11beta2,...

journal_title：Toxicology and applied pharmacology

authors： Gracia T,Hilscherova K,Jones PD,Newsted JL,Higley EB,Zhang X,Hecker M,Murphy MB,Yu RM,Lam PK,Wu RS,Giesy JP

更新日期：2007-12-01 00:00:00

abstract：:Ethanolic extract of Casearia sylvestris is thought to be antimutagenic. In this study, we attempted to determine whether this extract and casearin X (a clerodane diterpene from C. sylvestris) are protective against the harmful effects of airborne pollutants from sugarcane burning. To that end, we used the Tradescanti...

journal_title：Toxicology and applied pharmacology

authors： Prieto AM,Santos AG,Csipak AR,Caliri CM,Silva IC,Arbex MA,Silva FS,Marchi MR,Cavalheiro AJ,Silva DH,Bolzani VS,Soares CP

更新日期：2012-12-15 00:00:00

abstract：:The results of a series of screening tests to determine the potential teratogenicity and neurotoxicity of developmental exposure to TBTO in rats are presented in this paper. For prenatal exposure, pregnant Long Evans rats were intubated with 0-16 mg/kg/day bis(tri-n-butyltin)oxide TBTO from Days 6 to 20 of gestation (...

journal_title：Toxicology and applied pharmacology

authors： Crofton KM,Dean KF,Boncek VM,Rosen MB,Sheets LP,Chernoff N,Reiter LW

更新日期：1989-01-01 00:00:00

abstract：:Arsenic is an environmental pollutant that has been associated with an increased risk for the development of cancer and several other diseases through alterations of cellular homeostasis and hepatic function. Cytochrome P450 (P450) modification may be one of the factors contributing to these disorders. Several reports...

journal_title：Toxicology and applied pharmacology

authors： Medina-Díaz IM,Estrada-Muñiz E,Reyes-Hernández OD,Ramírez P,Vega L,Elizondo G

更新日期：2009-09-01 00:00:00

abstract：:Inhalation of ozone (O3) has been associated with development of inflammation in the respiratory airways and a variety of alterations in pulmonary function. Epithelial cells lining the airways are the first cells with which inhaled O3 comes into contact and thus represent a potential major target of acute O3 toxicity....

journal_title：Toxicology and applied pharmacology

authors： Wright DT,Adler KB,Akley NJ,Dailey LA,Friedman M

更新日期：1994-07-01 00:00:00

abstract：:Exposure to the anticonvulsant drug valproic acid (VPA) in utero is associated with a 1-2% increase in neural tube defects (NTDs), however the molecular mechanisms by which VPA induces teratogenesis are unknown. Previous studies demonstrated that VPA, a direct inhibitor of histone deacetylase, can induce histone hyper...

journal_title：Toxicology and applied pharmacology

authors： Tung EW,Winn LM

更新日期：2010-11-01 00:00:00

abstract：:Although piperonyl butoxide (PBO) is commonly used both in vivo and in vitro as an inhibitor of cytochrome P-450-dependent monooxygenase (MO) activity in a wide variety of species, the effect of PBO on the hepatic MO of fishes has never been characterized. The MO activity in hepatic microsomes from rainbow trout expos...

journal_title：Toxicology and applied pharmacology

authors： Erickson DA,Goodrich MS,Lech JJ

更新日期：1988-06-15 00:00:00

abstract：:F(ab')2 fragments are sometimes preferred to whole IgG for therapeutic or diagnostic uses. Preclinical pharmaceutical development studies are necessary before their use in humans. Here we propose an allometric approach among three mammalian species to predict F(ab')2 pharmacokinetic parameters in humans. Plasma dispos...

journal_title：Toxicology and applied pharmacology

authors： Bazin-Redureau M,Pepin S,Hong G,Debray M,Scherrmann JM

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:Atmospheric ultrafine particles (UFPs) and pesticide rotenone were considered as potential environmental risk factors for Parkinson's disease (PD). However, whether and how UFPs alone and in combination with rotenone affect the pathogenesis of PD remains largely unknown. METHODS:Ultrafine carbon black (ufCB...

journal_title：Toxicology and applied pharmacology

authors： Wang Y,Liu D,Zhang H,Wang Y,Wei L,Liu Y,Liao J,Gao HM,Zhou H

更新日期：2017-05-01 00:00:00