当前位置： SCI文献检索 > TOXICOLOGY AND APPLIED PHARMACOLOGY期刊下所有文献 > Gene polymorphisms and the risk of warfarin-induced bleeding complications at therapeutic international normalized ratio (INR).

Gene polymorphisms and the risk of warfarin-induced bleeding complications at therapeutic international normalized ratio (INR).

Abstract：

BACKGROUND:Bleeding episodes commonly occur in patients on warfarin treatment even in those within therapeutic range of international normalized ratio (INR). The objective of this study was to investigate the effects of the 8 examined polymorphisms on the risk of bleeding complications in a sample of Iranian patients. METHODS:A total of 552 warfarin treated patients who maintained on a target INR level of 2.0-3.5 for at least three consecutive intervals were enrolled from those attended our anticoagulation clinics. Ninety-two bleeding events were observed in 87 patients. The presences of the examined polymorphisms were analyzed using polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). RESULTS:Patients with the T allele in NQO1*2 (CT or TT genotypes) had a higher risk of bleeding than patients with the CC genotype (adjusted OR: 2.25, 95% CI: 1.37 to 3.70, P=0.001). Those who were carriers of CYP2C9 one-variant haplotypes (*1/*2 or *1/*3) were also found to be associated with the higher risk of bleeding events. Compared to reference group (*1/*1), the odds of bleeding increased for carriers of one variant allele (*1/*2 or *1/*3) (adjusted OR: 1.75, 95% CI: 1.03 to 2.97, P=0.039). Variant VKORC1, Factor VII, and EPHX1 genotypes were not significantly associated with the risk of bleeding events. CONCLUSION:The SNP C609T within NQO1 and haplotypes of CYP2C9 (1*2 or 1*3) are independently associated to bleeding complications of warfarin at normal INR. Further studies are required to confirm such associations in diverse racial and ethnic populations.

journal_name

Toxicol Appl Pharmacol

journal_title

Toxicology and applied pharmacology

authors

Pourgholi L,Goodarzynejad H,Mandegary A,Ziaee S,Talasaz AH,Jalali A,Boroumand M

doi

10.1016/j.taap.2016.08.026

subject

Has Abstract

pub_date

2016-10-15 00:00:00

pages

37-43

eissn

0041-008X

issn

1096-0333

pii

S0041-008X(16)30249-6

journal_volume

309

pub_type

杂志文章

相关文献

TOXICOLOGY AND APPLIED PHARMACOLOGY文献大全
  • Arsenic trioxide phosphorylates c-Fos to transactivate p21(WAF1/CIP1) expression.

    abstract：:An infamous poison, arsenic also has been used as a drug for nearly 2400 years; in recently years, arsenic has been effective in the treatment of acute promyelocytic leukemia. Increasing evidence suggests that opposite effects of arsenic trioxide (ATO) on tumors depend on its concentrations. For this reason, the mecha...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2008.08.015

    authors： Liu ZM,Huang HS

    更新日期：2008-12-01 00:00:00

  • Availability of human induced pluripotent stem cell-derived cardiomyocytes in assessment of drug potential for QT prolongation.

    abstract：:Field potential duration (FPD) in human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs), which can express QT interval in an electrocardiogram, is reported to be a useful tool to predict K(+) channel and Ca(2+) channel blocker effects on QT interval. However, there is no report showing that this techni...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2014.04.007

    authors： Nozaki Y,Honda Y,Tsujimoto S,Watanabe H,Kunimatsu T,Funabashi H

    更新日期：2014-07-01 00:00:00

  • Metabolic profiling using HPLC allows classification of drugs according to their mechanisms of action in HL-1 cardiomyocytes.

    abstract：:Along with hepatotoxicity, cardiotoxic side effects remain one of the major reasons for drug withdrawals and boxed warnings. Prediction methods for cardiotoxicity are insufficient. High content screening comprising of not only electrophysiological characterization but also cellular molecular alterations are expected t...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2011.02.008

    authors： Strigun A,Wahrheit J,Beckers S,Heinzle E,Noor F

    更新日期：2011-04-15 00:00:00

  • Interspecies scaling of clearance and volume of distribution for horse antivenom F(ab')2.

    abstract：:F(ab')2 fragments are sometimes preferred to whole IgG for therapeutic or diagnostic uses. Preclinical pharmaceutical development studies are necessary before their use in humans. Here we propose an allometric approach among three mammalian species to predict F(ab')2 pharmacokinetic parameters in humans. Plasma dispos...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1997.8363

    authors： Bazin-Redureau M,Pepin S,Hong G,Debray M,Scherrmann JM

    更新日期：1998-06-01 00:00:00

  • Nickel induces oxidative stress and genotoxicity in human lymphocytes.

    abstract：:In order to elucidate the oxidative effects and genotoxicity of nickel on human lymphocytes in vitro, we report the level of intracellular reactive oxygen species (ROS), lipid peroxidation, hydroxyl radical ((*)OH), and DNA damage in human lymphocytes after acute exposure to inorganic nickel. NiCl(2) appeared to incre...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0041-008x(03)00086-3

    authors： Chen CY,Wang YF,Huang WR,Huang YT

    更新日期：2003-06-15 00:00:00

  • Pesticides and human chronic diseases: evidences, mechanisms, and perspectives.

    abstract：:Along with the wide use of pesticides in the world, the concerns over their health impacts are rapidly growing. There is a huge body of evidence on the relation between exposure to pesticides and elevated rate of chronic diseases such as different types of cancers, diabetes, neurodegenerative disorders like Parkinson,...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.taap.2013.01.025

    authors： Mostafalou S,Abdollahi M

    更新日期：2013-04-15 00:00:00

  • Sarin-like and soman-like organophosphorous agents activate PLCgamma in rat brains.

    abstract：:We report that there is a time-related change in the phospholipase C (PLC) activities of rat brain cytosol and membrane fractions after iv injection of a soman-like or a sarin-like organophosphorous agent (bis(isopropyl methyl)phosphonate [BIMP] and bis(pinacolyl methyl)phosphonate [BPMP]). PLCgamma was activated in t...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1998.8628

    authors： Niijima H,Nagao M,Nakajima M,Takatori T,Matsuda Y,Iwase H,Kobayashi M

    更新日期：1999-04-01 00:00:00

  • EPR studies of in vivo radical production by 3,3',5,5'-tetrabromobisphenol A (TBBPA) in the Sprague-Dawley rat.

    abstract：:Brominated flame retardants (BFRs) are present in many consumer products ranging from fabrics to plastics and electronics. Wide use of flame retardants can pose an environmental hazard and it is of interest to determine the mechanism of their toxicity. Of all the BFRs, 3,3',5,5'-tetrabromobisphenol A (TBBPA) is produc...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2008.01.035

    authors： Chignell CF,Han SK,Mouithys-Mickalad A,Sik RH,Stadler K,Kadiiska MB

    更新日期：2008-07-01 00:00:00

  • Testicular dysgenesis syndrome and the development and occurrence of male reproductive disorders.

    abstract：:Patients with 45,X0/46XY karyotype often present with intersex phenotype and testicular dysgenesis. These patients may also have undescended testes (cryptorchidism), hypospadias and their spermatogenesis is severely disrupted. They have a high risk for testicular cancer. These patients have the most severe form of tes...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.taap.2005.01.058

    authors： Virtanen HE,Rajpert-De Meyts E,Main KM,Skakkebaek NE,Toppari J

    更新日期：2005-09-01 00:00:00

  • Dioscin alleviates BDL- and DMN-induced hepatic fibrosis via Sirt1/Nrf2-mediated inhibition of p38 MAPK pathway.

    abstract：:Oxidative stress is involved in hepatic stellate cells (HSCs) activation and extracellular matrix overproduction. We previously reported the promising effects of dioscin against CCl4-induced liver fibrosis, but its effects and mechanisms on BDL- and DMN-induced liver fibrosis remain unknown. The results in the present...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2015.12.024

    authors： Gu L,Tao X,Xu Y,Han X,Qi Y,Xu L,Yin L,Peng J

    更新日期：2016-02-01 00:00:00

  • Effect of dexamethasone on the metabonomics profile associated with phosphodiesterase inhibitor-induced vascular lesions in rats.

    abstract：:Metabonomics is the evaluation of the multiparametric metabolic response of biological systems to pathophysiological stimuli. High-resolution nuclear magnetic resonance (NMR) spectroscopy of biofluids coupled with pattern recognition-based chemometric analysis is an emerging approach to the study of metabonomics and m...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：

    authors： Slim RM,Robertson DG,Albassam M,Reily MD,Robosky L,Dethloff LA

    更新日期：2002-09-01 00:00:00

  • Toxicodynamic analysis of the combined cholinesterase inhibition by paraoxon and methamidophos in human whole blood.

    abstract：:Theoretical work has shown that the isobole method is not generally valid as a method for testing the absence or presence of interaction (in the biochemical sense) between chemicals. The present study illustrates how interaction can be tested by fitting a toxicodynamic model to the results of a mixture experiment. The...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2009.01.001

    authors： Bosgra S,van Eijkeren JC,van der Schans MJ,Langenberg JP,Slob W

    更新日期：2009-04-01 00:00:00

  • Up-regulation of granzyme B and perforin by staphylococcal enterotoxin C2 mutant induces enhanced cytotoxicity in Hepa1-6 cells.

    abstract：:Staphylococcal enterotoxin C2 (SEC2), a member of bacterial superantigen, is one of the most potent known activators of T lymphocytes. With this property, SEC2 has already been used in clinic as a tumor immunotherapy agent in China. To increase the antitumor activity, a SEC2 mutant named ST-4 (GKVTG102-106WWH) with am...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2016.10.009

    authors： Zhang G,Xu M,Zhang H,Song Y,Wang J,Zhang C

    更新日期：2016-12-15 00:00:00

  • Cytochrome P450-mediated activation of the fragrance compound geraniol forms potent contact allergens.

    abstract：:Contact sensitization is caused by low molecular weight compounds which penetrate the skin and bind to protein. In many cases, these compounds are activated to reactive species, either by autoxidation on exposure to air or by metabolic activation in the skin. Geraniol, a widely used fragrance chemical, is considered t...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2008.08.014

    authors： Hagvall L,Baron JM,Börje A,Weidolf L,Merk H,Karlberg AT

    更新日期：2008-12-01 00:00:00

  • Contrasting effects of 1,1,1-trichloroethane on [14C]vinyl chloride metabolism and activation in hepatic microsomes from phenobarbital- and isoniazid-treated rats.

    abstract：:The interaction of 1,1,1-trichloroethane (TCE), a widely used chlorocarbon solvent, on the metabolism and activation of [14C]-vinyl chloride in rat hepatic microsomes was investigated to determine the effects of combined exposures to these compounds. In microsomes from phenobarbital (PB)-treated rats, TCE increased vi...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1993.1039

    authors： Baker MT,Ronnenberg WC Jr

    更新日期：1993-03-01 00:00:00

  • Use of cholinesterases as pretreatment drugs for the protection of rhesus monkeys against soman toxicity.

    abstract：:Purified fetal bovine serum acetylcholinesterase (FBS AChE) and horse serum butyrylcholinesterase (BChE) were successfully used as single pretreatment drugs for the prevention of pinacolyl methylphosphonofluoridate (soman) toxicity in nonhuman primates. Eight rhesus monkeys, trained to perform Primate Equilibrium Plat...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(92)90236-l

    authors： Wolfe AD,Blick DW,Murphy MR,Miller SA,Gentry MK,Hartgraves SL,Doctor BP

    更新日期：1992-12-01 00:00:00

  • Acute doxorubicin cardiotoxicity alters cardiac cytochrome P450 expression and arachidonic acid metabolism in rats.

    abstract：:Doxorubicin (DOX) is a potent anti-neoplastic antibiotic used to treat a variety of malignancies; however, its use is limited by dose-dependent cardiotoxicity. Moreover, there is a strong correlation between cytochrome P450 (CYP)-mediated arachidonic acid metabolites and the pathogenesis of many cardiovascular disease...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2009.09.012

    authors： Zordoky BN,Anwar-Mohamed A,Aboutabl ME,El-Kadi AO

    更新日期：2010-01-01 00:00:00

  • Resveratrol attenuates methylglyoxal-induced mitochondrial dysfunction and apoptosis by Sestrin2 induction.

    abstract：:Methylglyoxal is found in high levels in the blood and other tissues of diabetic patients and exerts deleterious effects on cells and tissues. Previously, we reported that resveratrol, a polyphenol in grapes, induced the expression of Sestrin2 (SESN2), a novel antioxidant protein, and inhibited hepatic lipogenesis. Th...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2014.08.011

    authors： Seo K,Seo S,Han JY,Ki SH,Shin SM

    更新日期：2014-10-15 00:00:00

  • Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase.

    abstract：:Tabun represents the phosphoramidate class of organophosphates that are covalent inhibitors of acetylcholinesterase (AChE), an essential enzyme in neurotransmission. Currently used therapy in counteracting excessive cholinergic stimulation consists of a muscarinic antagonist (atropine) and an oxime reactivator of inhi...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2019.04.007

    authors： Kovarik Z,Maček Hrvat N,Kalisiak J,Katalinić M,Sit RK,Zorbaz T,Radić Z,Fokin VV,Sharpless KB,Taylor P

    更新日期：2019-06-01 00:00:00

  • Role of CYP2E1 in thioacetamide-induced mouse hepatotoxicity.

    abstract：:Previous experiments showed that treatment of mice and rats with thioacetamide (TAA) induced liver cell damage, fibrosis and/or cirrhosis, associated with increased oxidative stress and activation of hepatic stellate cells. Some experiments suggest that CYP2E1 may be involved in the metabolic activation of TAA. Howeve...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2007.11.010

    authors： Kang JS,Wanibuchi H,Morimura K,Wongpoomchai R,Chusiri Y,Gonzalez FJ,Fukushima S

    更新日期：2008-05-01 00:00:00

  • Nitrophenols isolated from diesel exhaust particles promote the growth of MCF-7 breast adenocarcinoma cells.

    abstract：:Diesel exhaust particles (DEPs) cause many adverse health problems, and reports indicate increased risk of breast cancer in men and women through exposure to gasoline and vehicle exhaust. However, DEPs include vast numbers of compounds, and the specific compound(s) responsible for these actions are not clear. We recen...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2008.02.027

    authors： Furuta C,Suzuki AK,Watanabe G,Li C,Taneda S,Taya K

    更新日期：2008-08-01 00:00:00

  • Physiologically based pharmacokinetics and the risk assessment process for methylene chloride.

    abstract：:Methylene chloride (dichloromethane, DCM) is metabolized by two pathways: one dependent on oxidation by mixed function oxidases (MFO) and the other dependent on glutathione S-transferases (GST). A physiologically based pharmacokinetic (PB-PK) model based on knowledge of these pathways was used to describe the metaboli...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(87)90281-x

    authors： Andersen ME,Clewell HJ 3rd,Gargas ML,Smith FA,Reitz RH

    更新日期：1987-02-01 00:00:00

  • The metabolism of di(2-ethylhexyl) phthalate (DEHP) and mono-(2-ethylhexyl) phthalate (MEHP) in rats: in vivo and in vitro dose and time dependency of metabolism.

    abstract：:This study investigated the in vivo metabolism of di(2-ethylhexyl) phthalate (DEHP) and mono(2-ethylhexyl) phthalate (MEHP) in rats after multiple dosing, the metabolism of MEHP in primary rat hepatocyte cultures for periods of up to 3 days, and the biotransformation of some major metabolites of MEHP. Rats were orally...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(85)90096-1

    authors： Lhuguenot JC,Mitchell AM,Milner G,Lock EA,Elcombe CR

    更新日期：1985-08-01 00:00:00

  • Genetic polymorphisms in hMTH1, hOGG1 and hMYH and risk of chronic benzene poisoning in a Chinese occupational population.

    abstract：:Oxidative damage to DNA induced by benzene is an important mechanism of its genotoxicity, which leads to chronic benzene poisoning (CBP). Therefore, genetic variation in DNA repair genes may contribute to susceptibility to CBP in the exposed population. We hypothesized that single nucleotide polymorphisms (SNPs) in hM...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2008.09.008

    authors： Wu F,Zhang Z,Wan J,Gu S,Liu W,Jin X,Xia Z

    更新日期：2008-12-15 00:00:00

  • The effects of diquat and ciprofibrate on mRNA expression and catalytic activities of hepatic xenobiotic metabolizing and antioxidant enzymes in rat liver.

    abstract：:Although the mechanisms responsible for chemically induced oxidative stress are under intense investigation, little is known about the effects of prooxidant chemicals on the expression of drug-metabolizing enzymes. We examined the effects of diquat (0.1 mmol/kg, ip) and ciprofibrate (0.025% w/w, diet), chemicals which...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1995.1171

    authors： Gallagher EP,Buetler TM,Stapleton PL,Wang C,Stahl DL,Eaton DL

    更新日期：1995-09-01 00:00:00

  • Inhibition of bile-salt-induced hepatocyte apoptosis by the antioxidant lazaroid U83836E.

    abstract：:Intracellular retention of toxic bile salts contributes to hepatocellular injury during cholestasis. We have recently demonstrated that toxic bile salts directly induce apoptosis in hepatocytes. As oxidative stress has been implicated in many models of apoptosis, our aim was to determine if oxidative injury is a criti...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1996.8031

    authors： Patel T,Gores GJ

    更新日期：1997-01-01 00:00:00

  • Gene expression profiling and pathway analysis of human bronchial epithelial cells exposed to airborne particulate matter collected from Saudi Arabia.

    abstract：:Epidemiological studies have established a positive correlation between human mortality and increased concentration of airborne particulate matters (PM). However, the mechanisms underlying PM related human diseases, as well as the molecules and pathways mediating the cellular response to PM, are not fully understood. ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2012.10.008

    authors： Sun H,Shamy M,Kluz T,Muñoz AB,Zhong M,Laulicht F,Alghamdi MA,Khoder MI,Chen LC,Costa M

    更新日期：2012-12-01 00:00:00

  • Differential transcriptional regulation of IL-8 expression by human airway epithelial cells exposed to diesel exhaust particles.

    abstract：:Exposure to diesel exhaust particles (DEP) induces inflammatory signaling characterized by MAP kinase-mediated activation of NFkB and AP-1 in vitro and in bronchial biopsies obtained from human subjects exposed to DEP. NFkB and AP-1 activation results in the upregulation of genes involved in promoting inflammation in ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2009.11.011

    authors： Tal TL,Simmons SO,Silbajoris R,Dailey L,Cho SH,Ramabhadran R,Linak W,Reed W,Bromberg PA,Samet JM

    更新日期：2010-02-15 00:00:00

  • A common viral infection can change nickel target organ distribution.

    abstract：:The autoradiographic distribution of the toxic heavy metal nickel (Ni) was studied at 4 and 7 days post-coxsackievirus B3 (CB3) infection in Balb/c mice. The distribution of the iv injected 63Ni was studied 10 min, 4 hr, and 24 hr after administration. Results clearly show that the site of 63Ni accumulation is greatly...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(92)90110-e

    authors： Ilbäck NG,Fohlman J,Friman G

    更新日期：1992-05-01 00:00:00

  • Nuclear penetration of surface functionalized gold nanoparticles.

    abstract：:Free gold nanoparticles easily aggregate when the environment conditions change. Here, gold nanoparticles (AuNPs) with average diameter of 3.7 nm were prepared and then modified with poly(ethylene glycol) (PEG) to improve stability. The gold nanoparticles were first surface-modified with 3-mercaptopropionic acid (MPA)...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2009.03.009

    authors： Gu YJ,Cheng J,Lin CC,Lam YW,Cheng SH,Wong WT

    更新日期：2009-06-01 00:00:00