Acute doxorubicin cardiotoxicity alters cardiac cytochrome P450 expression and arachidonic acid metabolism in rats.

abstract：:Erionite, a naturally occurring fibrous zeolite, is associated with the development of nonmalignant and malignant lung diseases and is more carcinogenic than asbestos fibers in man and rodent inhalation models of disease. To investigate the possible molecular mechanisms of erionite-induced toxicity and carcinogenesis ...

journal_title：Toxicology and applied pharmacology

authors： Timblin CR,Guthrie GD,Janssen YW,Walsh ES,Vacek P,Mossman BT

更新日期：1998-07-01 00:00:00

abstract：:Engineered nanomaterials are being developed for a variety of technological applications. However, the increasing use of nanomaterials in society has led to concerns about their potential adverse effects on human health and the environment. During the first decade of nanotoxicological research, the realization has eme...

journal_title：Toxicology and applied pharmacology

authors： Costa PM,Fadeel B

更新日期：2016-05-15 00:00:00

abstract：:Morphine has been shown to reduce renal and hepatic clearance of several xenobiotics in rodents. After iv administration of gentamicin, 10 to 30 mg/kg, its plasma levels were elevated in mice given morphine, 20 mg/kg sc. Plasma clearance of gentamicin was nearly halved by morphine, due primarily to lowering of the eli...

journal_title：Toxicology and applied pharmacology

authors： Hurwitz A,Garty M,Ben-Zvi Z

更新日期：1988-05-01 00:00:00

abstract：:Morphine may induce cardioprotection by targeting mitochondria, but little is known about the exact mitochondrial events that mediate morphine's protection. We aimed to address the role of the mitochondrial Src tyrosine kinase in morphine's protection. Isolated rat hearts were subjected to 30 min ischemia and 2h of re...

journal_title：Toxicology and applied pharmacology

authors： He H,Huh J,Wang H,Kang Y,Lou J,Xu Z

更新日期：2016-01-01 00:00:00

abstract：:We have studied the effects of opiates on ATP and acetylcholine (ACh) release from cholinergic nerve terminals isolated from the electric organ of Torpedo marmorata. The release of ATP was inhibited by morphine and this action was reversed by naloxone. Morphine, [D-Met2-Pro5]enkephalinamide and [D-Ala2-Leu5]enkephalin...

journal_title：Toxicology and applied pharmacology

authors： Saltó C,Calvet R,Guitart X,Solsona C,Marsal J

更新日期：1990-10-01 00:00:00

abstract：:Vinylcyclohexene (VCH) is an industrial byproduct that is known to cause the destruction of ovarian follicles in mice. Its analog, 4-phenylcyclohexene (4PC), is a volatile product from latex-backed carpeting. These studies were undertaken to assess the structure-activity relationships of these compounds and the potent...

journal_title：Toxicology and applied pharmacology

authors： Hooser SB,Parola LR,Van Ert MD,Sipes IG

更新日期：1993-04-01 00:00:00

abstract：:Arsenic is an effective therapeutic agent for the treatment of patients with refractory or relapsed acute promyelocytic leukemia. The use of arsenic for treating solid tumors, particularly in combination with other chemotherapeutic agents, has been extensively studied. Here, we report that arsenite-resistant human lun...

journal_title：Toxicology and applied pharmacology

authors： Lin YL,Ho IC,Su PF,Lee TC

更新日期：2006-08-01 00:00:00

abstract：:Cyclosporin (Cs), a cyclic nonpolar undecapeptide of fungal origin, has potent immunosuppressive and antiparasitic activities, and renal and hepatic toxicities, the mechanisms of which are not worked out. Many nephrotoxins and hepatotoxins are predictably more or less harmful, depending upon the circadian stage at whi...

journal_title：Toxicology and applied pharmacology

authors： Magnus G,Cavallini M,Halberg F,Cornelissen G,Sutherland DE,Najarian JA,Hrushesky WJ

更新日期：1985-01-01 00:00:00

abstract：:Eicosanoids released after ozone exposure of a human bronchial epithelial cell line, BEAS-S6, were analyzed by high-pressure liquid chromatography (HPLC) of supernatants from exposed cells prelabeled with [3H]arachidonic acid. BEAS cells released thromboxane B2 (TxB2), prostaglandin E2 (PGE2), leukotriene C4 (LTC4), L...

journal_title：Toxicology and applied pharmacology

authors： McKinnon KP,Madden MC,Noah TL,Devlin RB

更新日期：1993-02-01 00:00:00

abstract：:The sensory irritation potential of a series of saturated and unsaturated aliphatic and cyclic aldehydes was investigated in B6C3F1 and Swiss-Webster mice. With the reflex decrease in respiratory rate as the endpoint response, alpha, beta-unsaturated aliphatic aldehydes yielded RD50 values (concentration which elicits...

journal_title：Toxicology and applied pharmacology

authors： Steinhagen WH,Barrow CS

更新日期：1984-03-15 00:00:00

abstract：:Drug-induced steatohepatitis is a rare form of liver injury known to be caused by only a handful of compounds. These compounds stimulate the development of steatohepatitis through their toxicity to hepatocyte mitochondria; inhibition of beta-oxidation, mitochondrial respiration, and/or oxidative phosphorylation. Other...

journal_title：Toxicology and applied pharmacology

authors： Schumacher JD,Guo GL

更新日期：2015-11-15 00:00:00

abstract：:It has been known for many years that administration of androgens or estrogens at critical periods of development in mammals causes severe long-term effects on the endocrine/genital systems. The environmental pollutant p-tert-octylphenol (OP) possesses a weak but clear estrogen agonist activity in in vitro and in vivo...

journal_title：Toxicology and applied pharmacology

authors： Katsuda S,Yoshida M,Watanabe G,Taya K,Maekawa A

更新日期：2000-06-15 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates toxicity of xenobiotics, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin. Genetic deletion of the AhR leads to cardiac hypertrophy, suggesting a role for the AhR in cardiovascular physiology and disease; however, the pathways invo...

journal_title：Toxicology and applied pharmacology

authors： Lund AK,Goens MB,Kanagy NL,Walker MK

更新日期：2003-12-01 00:00:00

abstract：:Arsenic is a toxicant found in ground water around the world, and human exposure mainly comes from drinking water or from crops grown in areas containing arsenic in soils or water. Epidemiological studies have shown that arsenic exposure during development decreased intellectual function, reduced birth weight, and alt...

journal_title：Toxicology and applied pharmacology

authors： Liu JT,Bain LJ

更新日期：2014-12-15 00:00:00

abstract：:Pulmonary responses after continuous exposure of rats to concentrations of ozone (O3) ranging from 0.12 to 0.64 ppm were quantified by measuring tissue collagen synthesis rate, tissue protein and DNA content, and various constituents of bronchoalveolar lavage fluid. After 7 days of exposure to 0.64 ppm of O3, lung col...

journal_title：Toxicology and applied pharmacology

authors： Warren DL,Guth DJ,Last JA

更新日期：1986-07-01 00:00:00

abstract：:Luteolin, a flavonoid that exhibits antioxidative properties, exerts myocardial protection effects. However, the underlying molecular mechanisms are not yet fully understood. To investigate the effects of luteolin on myocardial injury protection and its possible mechanisms, a myocardial injury model was established wi...

journal_title：Toxicology and applied pharmacology

authors： Sun GB,Sun X,Wang M,Ye JX,Si JY,Xu HB,Meng XB,Qin M,Sun J,Wang HW,Sun XB

更新日期：2012-12-01 00:00:00

abstract：:Immobilization of nanoparticles on inorganic supports has been recently developed, resulting in the creation of nanocomposites. Concerning titanium dioxide nanoparticles (TiO2 NPs1), these have already been developed in conjugation with clays, but so far there are no available toxicological studies on these nanocompos...

journal_title：Toxicology and applied pharmacology

authors： Bessa MJ,Costa C,Reinosa J,Pereira C,Fraga S,Fernández J,Bañares MA,Teixeira JP

更新日期：2017-02-01 00:00:00

abstract：:We report that intracellular calcium levels rise in mammalian neurosecretory terminals and in cultured pheochromocytoma cells during acute exposure to physiological medium incubated in IV drip chambers. The agent responsible for this effect is shown to be di(2-ethylhexyl)phthalate (DEHP). DEHP (800 nM) added to saline...

journal_title：Toxicology and applied pharmacology

authors： Tully K,Kupfer D,Dopico AM,Treistman SN

更新日期：2000-11-01 00:00:00

abstract：:Amphetamine has been shown previously to increase levels of the inducible 70-kDa heat shock protein (hsp70i) in mouse liver. In the present study, the hepatic concentrations of a variety of hsps in livers of mice pretreated with amphetamine (15 mg/kg, i.p.) were evaluated, and the time course of hsp induction was exam...

journal_title：Toxicology and applied pharmacology

authors： Salminen WF Jr,Voellmy R,Roberts SM

更新日期：1997-12-01 00:00:00

abstract：:The elevation of intracellular Ca2+ in various tissue through oxidative stress induced by menadione has been well documented. Increase of Ca2+ level in platelets results in aggregation of platelets. To test the hypothesis that menadione-induced Ca2+ elevations can play a role in platelet aggregation, we have studied t...

journal_title：Toxicology and applied pharmacology

authors： Kim KA,Lee JY,Park KS,Kim MJ,Chung JH

更新日期：1996-05-01 00:00:00

abstract：:Numbers of engineered nanomaterials (ENMs) are steadily increasing. Therefore, alternative testing approaches with reduced costs and high predictivity suitable for high throughput screening and prioritization are urgently needed to ensure a fast and effective development of safe products. In parallel, extensive resear...

journal_title：Toxicology and applied pharmacology

authors： Riebeling C,Wiemann M,Schnekenburger J,Kuhlbusch TA,Wohlleben W,Luch A,Haase A

更新日期：2016-05-15 00:00:00

abstract：:Celecoxib, an inhibitor of cyclooxygenase-2, is being investigated for enhancement of chemotherapy efficacy in cancer clinical trials. This study investigates the ability of cyclooxygenase-2 inhibitors to sensitize cells from different origins to several chemotherapeutic agents. The effect of the drug's mechanism of a...

journal_title：Toxicology and applied pharmacology

authors： El-Awady RA,Saleh EM,Ezz M,Elsayed AM

更新日期：2011-09-15 00:00:00

abstract：:Cerebellar granule cells are preferentially targeted during methylmercury (MeHg) poisoning. Following acute MeHg exposure, granule cells in culture undergo an increase in intracellular Ca2+ concentration ([Ca2+]i) that apparently contributes to cell death. This effect consists of several temporally and kinetically dis...

journal_title：Toxicology and applied pharmacology

authors： Limke TL,Atchison WD

更新日期：2002-01-01 00:00:00

abstract：:Stress response proteins can play integral roles as modulators of cellular function and can be involved in mechanisms that are important to immune function. Metallothionein (MT), a cysteine-rich stress response protein, has been shown to play numerous roles in the cell: it serves as a reservoir of essential heavy meta...

journal_title：Toxicology and applied pharmacology

authors： Crowthers KC,Kline V,Giardina C,Lynes MA

更新日期：2000-08-01 00:00:00

abstract：:Following exposure to 2 ppm ozone for 4 hr, two distinct effects on rat lung inflammatory cell oxidant generation were observed. TPA- and opsonized zymosan-stimulated superoxide production by the inflammatory cell population was found to be maximally inhibited 24 hr following ozone exposure. In contrast, luminol-ampli...

journal_title：Toxicology and applied pharmacology

authors： Esterline RL,Bassett DJ,Trush MA

更新日期：1989-06-15 00:00:00

abstract：:Previous studies have shown that fumonisin B1 (FB1) inhibits ceramide synthase, resulting in accumulation of free sphinganine and sphingosine. Tumor necrosis factor-alpha (TNFalpha) plays an important role in FB1 toxicity and the expression of TNFalpha mRNA in liver and kidney is increased following FB1 exposure in mi...

journal_title：Toxicology and applied pharmacology

authors： He Q,Riley RT,Sharma RP

更新日期：2001-07-01 00:00:00

abstract：:Corticosteroids will induce cleft palate in mice. One suggested mechanism for this effect is through inhibition of phospholipase activity. This hypothesis was tested by measuring the effects of dexamethasone, a synthetic corticosteroid, on phospholipase activity in cultures of palate mesenchymal cells. Palate mesenchy...

journal_title：Toxicology and applied pharmacology

authors： Bulleit RF,Zimmerman EF

更新日期：1984-09-15 00:00:00

abstract：:Previous work from this laboratory (J. S. Lazo, J. D. Catravas, and C. N. Gillis, Biochem. Pharmacol. 30, 2577-2584, 1981; J. D. Catraveras, J. S. Lazo, and C. N. Gillis, J. Pharmacol. Exp. Ther. 217, 524-529, 1981) demonstrated that subacute bleomycin (BLM) administration (5 mg/kg) to rabbits three times weekly for 4...

journal_title：Toxicology and applied pharmacology

authors： Lazo JS,Catravas JD,Dobuler KJ,Gillis CN

更新日期：1983-06-30 00:00:00

abstract：:The present study investigates the effects of nicotine treatment on exocrine pancreatic function. Adult male, Sprague-Dawley rats received nicotine via a time-release pellet, at a rate of 1.65 micrograms/min for 3 weeks. At the end of the experimental period, it was observed that although nicotine did not affect final...

journal_title：Toxicology and applied pharmacology

authors： Dubick MA,Palmer R,Lau PP,Morrill PR,Geokas MC

更新日期：1988-10-01 00:00:00

abstract：:To study the effect of cadmium exposure on maternal and fetal zinc metabolism, rats were exposed to 0, 5, 50, or 100 ppm Cd in the drinking water on Days 6 through 20 of pregnancy. In comparison to controls, fetal and maternal weights were slightly reduced in the 50- and 100-ppm groups, but not the 5-ppm group. Multip...

journal_title：Toxicology and applied pharmacology

authors： Sorell TL,Graziano JH

更新日期：1990-03-01 00:00:00