Arsenic trioxide phosphorylates c-Fos to transactivate p21(WAF1/CIP1) expression.

abstract：:The direct-acting mutagenicity of 1-nitropyrene (1-NP), a tumorigenic environmental pollutant and model nitropolycyclic aromatic hydrocarbon, was studied in Chinese hamster ovary (CHO) cells. Previous reports indicated that 1-NP, a potent direct-acting mutagen in Salmonella typhimurium, was mutagenic in CHO cells only...

journal_title：Toxicology and applied pharmacology

authors： Thornton-Manning JR,Smith BA,Beland FA,Heflich RH

更新日期：1991-07-01 00:00:00

abstract：:Therapy of seizure activity following exposure to the nerve agent soman (GD) includes treatment with the anticonvulsant diazepam (DZP), an allosteric modulator of γ-aminobutyric acid A (GABA(A)) receptors. However, seizure activity itself causes the endocytosis of GABA(A) receptors and diminishes the inhibitory effect...

journal_title：Toxicology and applied pharmacology

authors： Schultz MK,Wright LK,Stone MF,Schwartz JE,Kelley NR,Moffett MC,Lee RB,Lumley LA

更新日期：2012-03-15 00:00:00

abstract：:Gene 33 (Mig6, ERRFI1) is an adaptor protein with multiple cellular functions. We recently reported that depletion of this protein promotes lung epithelial cell transformation induced by hexavalent chromium [Cr(VI)]. However, the early molecular events that mediate this process are not clear. In the present study, we ...

journal_title：Toxicology and applied pharmacology

authors： Park S,Zhang X,Li C,Yin C,Li J,Fallon JT,Huang W,Xu D

更新日期：2017-09-01 00:00:00

abstract：:There is concern that P-glycoprotein mediated efflux contributes to steroid resistance. Therefore, this study examined bidirectional corticosteroid transport and induction capabilities for P-glycoprotein (P-gp) to understand which of the systemic and inhaled corticosteroids interacted with P-gp to the greatest extent....

journal_title：Toxicology and applied pharmacology

authors： Crowe A,Tan AM

更新日期：2012-05-01 00:00:00

abstract：:Combretastatin A-4 (CA-4) has already entered clinical trials of solid tumors over ten years. However, the limited anticancer activity and dose-dependent toxicity restrict its clinical application. Here, we offered convincing evidence that CA-4 induced autophagy in various cancer cells, which was demonstrated by acrid...

journal_title：Toxicology and applied pharmacology

authors： Li Y,Luo P,Wang J,Dai J,Yang X,Wu H,Yang B,He Q

更新日期：2014-01-15 00:00:00

abstract：:Using a highly sensitive membrane permeability assay, a viral infection was discovered in the lungs of virus antibody free (VAF) Swiss-Webster mice purchased for respiratory toxicology studies. The assay is based on the uptake of a charged fluorescent compound by cells lacking an intact plasma membrane. Lungs from 74%...

journal_title：Toxicology and applied pharmacology

authors： Phimister AJ,Day KC,Gunderson AD,Wong VJ,Lawson GW,Fanucchi MV,Van Winkle LS,Kendall LV,Plopper CG

更新日期：2003-08-01 00:00:00

abstract：:All nutritional selenium sources are transformed into the assumed common intermediate selenide for the syntheses of selenoproteins for utilization and/or of selenosugar for excretion. Methylselenol [monomethylselenide, MMSe] is the assumed intermediate leading to other methylated metabolites, dimethylselenide (DMSe) a...

journal_title：Toxicology and applied pharmacology

authors： Ohta Y,Suzuki KT

更新日期：2008-01-15 00:00:00

abstract：:Melittin is a cationic, hemolytic peptide that is the main toxic component in the venom of the honey bee (Apis mellifera). Melittin has multiple effects, including anti-bacterial, anti-viral and anti-inflammatory, in various cell types. However, the anti-apoptotic mechanisms of melittin have not been fully elucidated ...

journal_title：Toxicology and applied pharmacology

authors： Lee WR,Park JH,Kim KH,Park YY,Han SM,Park KK

更新日期：2011-10-15 00:00:00

abstract：:Inoculation of metallic tin powder produced marked proliferation of plasma cells and Russell body cells in draining lymph nodes. Prior, but not concurrent, administration of a soluble tin salt in the drinking water prevented the plasma cell hyperplasia. Various Na, Zn, Ag, and Cu salts were not inhibitory. The inhibit...

journal_title：Toxicology and applied pharmacology

authors： Levine S,Sowinski R

更新日期：1983-03-30 00:00:00

abstract：:A case study was conducted, using dibutyl phthalate (DBP), to explore an approach to using toxicogenomic data in risk assessment. The toxicity and toxicogenomic data sets relative to DBP-related male reproductive developmental outcomes were considered conjointly to derive information about mode and mechanism of action...

journal_title：Toxicology and applied pharmacology

authors： Makris SL,Euling SY,Gray LE Jr,Benson R,Foster P

更新日期：2013-09-15 00:00:00

abstract：:Nanotechnology has the potential to make a beneficial impact on several agricultural, forestry, and environmental challenges, such as urbanization, energy constraints, and sustainable use of resources. However, new environmental and human health hazards may emerge from nano-enhanced applications. This raises concerns ...

journal_title：Toxicology and applied pharmacology

authors： Iavicoli I,Leso V,Beezhold DH,Shvedova AA

更新日期：2017-08-15 00:00:00

abstract：:An experimental system was chosen to investigate the bioactivity of a lipoprotein-sequestered toxicant at the cellular level based on recent studies demonstrating receptor-mediated uptake of lipoproteins by macrophages. Rat peritoneal exudate cell suspensions (PEC) were exposed to DDT and lipoprotein-sequestered DDT, ...

journal_title：Toxicology and applied pharmacology

authors： Kaminski NE,Wells DS,Dauterman WC,Roberts JF,Guthrie FE

更新日期：1986-03-15 00:00:00

abstract：:Pretreatment of rats with the polychlorinated biphenyl (PCB) Aroclor 1254 or phenobarbital markedly increased the duodenal ulcerogenic action of acrylonitrile. The extent of forestomach and hepatic lesions in these rats, on the other hand, was not modified. The duodenal ulcers produced by Aroclor 1254 and acrylonitril...

journal_title：Toxicology and applied pharmacology

authors： Szabo S,Silver EH,Gallagher GT,Maull EA

更新日期：1983-12-01 00:00:00

abstract：:Inhalation of methyl chloride (CH3Cl) by male B6C3F1 mice resulted in a concentration-dependent depletion of glutathione (GSH) in liver, kidney, and brain. Exposure for 6 hr to 100 ppm CH3Cl decreased the concentration of GSH in mouse liver by 45%, while exposure to 2500 ppm for 6 hr lowered liver GSH to approximately...

journal_title：Toxicology and applied pharmacology

authors： Kornbrust DJ,Bus JS

更新日期：1984-03-15 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs) derived from fossil fuels are ubiquitous contaminants and occur in aquatic habitats as highly variable and complex mixtures of compounds containing 2 to 6 rings. For aquatic species, PAHs are generally accepted as acting through either of two modes of action: (1) "dioxin-like" t...

journal_title：Toxicology and applied pharmacology

authors： Incardona JP,Day HL,Collier TK,Scholz NL

更新日期：2006-12-15 00:00:00

abstract：:Dietary 2(3)-tert-butyl-4-hydroxyanisole (BHA) treatment has been shown to increase hepatic glutathione (GSH) content in rats and mice. Subsequent studies in our laboratory have demonstrated that hepatic gamma-glutamylcysteine synthetase (GCS) activity is increased in mice treated with dietary BHA. To test whether thi...

journal_title：Toxicology and applied pharmacology

authors： Borroz KI,Buetler TM,Eaton DL

更新日期：1994-05-01 00:00:00

abstract：:The use of isocyanates in industry has been increasing and, therefore, the potential for human exposure has also increased. Two such isocyanates are diphenylmethane-4,4'-diisocyanate (MDI) and dicyclohexylmethane-4,4'-diisocyanate (SMDI). Furthermore, there are only a few reports describing the toxicity of these diiso...

journal_title：Toxicology and applied pharmacology

authors： Weyel DA,Schaffer RB

更新日期：1985-03-15 00:00:00

abstract：:To evaluate the effect of exposure to an environmentally relevant polychlorinated biphenyl mixture, adult male rats were treated with Aroclor 1260 for 7 days and levels of several cytochrome P450 (CYP) enzymes were measured in liver microsomes prepared 3 days after the last dose. Treatment with Aroclor 1260 at dosages...

journal_title：Toxicology and applied pharmacology

authors： Ngui JS,Bandiera SM

更新日期：1999-12-01 00:00:00

abstract：:Staphylococcal enterotoxin C2 (SEC2), a member of bacterial superantigen, is one of the most potent known activators of T lymphocytes. With this property, SEC2 has already been used in clinic as a tumor immunotherapy agent in China. To increase the antitumor activity, a SEC2 mutant named ST-4 (GKVTG102-106WWH) with am...

journal_title：Toxicology and applied pharmacology

authors： Zhang G,Xu M,Zhang H,Song Y,Wang J,Zhang C

更新日期：2016-12-15 00:00:00

abstract：:The anti-HIV drug 3'-azido-3'-deoxythymidine (AZT) is the drug of choice for preventing maternal-fetal HIV transmission during pregnancy. Our aim was to assess the cytotoxic effects of AZT on human placenta in vitro. The mechanisms of AZT-induced effects were investigated using JEG-3 choriocarcinoma cells and primary ...

journal_title：Toxicology and applied pharmacology

authors： Collier AC,Helliwell RJ,Keelan JA,Paxton JW,Mitchell MD,Tingle MD

更新日期：2003-10-15 00:00:00

abstract：:(-)-Epigallocatechin-3-gallate (EGCG) is the main bioactive component in tea (Camellia sinensis) catechins, and exhibits potential antitumor activity against colorectal cancer (CRC). However, the underlying mechanisms are largely unclear. We investigated the effects of EGCG on activities of CRC cells and the exact mol...

journal_title：Toxicology and applied pharmacology

authors： Zhang Z,Zhang S,Yang J,Yi P,Xu P,Yi M,Peng W

更新日期：2020-08-15 00:00:00

abstract：:Female Golden Syrian hamsters, F-344 rats, Swiss CD-1 mice, and B6C3F1 hybrid mice were exposed 6 hr/day, 5 days/week to carcinogenic levels of vinyl chloride (VC) for 6, 12, 18, or 24 months (rats and hamsters only). Other groups of rodents were held for 6 or 12 months and then exposed for 6 or 12 months. At the end ...

journal_title：Toxicology and applied pharmacology

authors： Drew RT,Boorman GA,Haseman JK,McConnell EE,Busey WM,Moore JA

更新日期：1983-03-30 00:00:00

abstract：:Field potential duration (FPD) in human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs), which can express QT interval in an electrocardiogram, is reported to be a useful tool to predict K(+) channel and Ca(2+) channel blocker effects on QT interval. However, there is no report showing that this techni...

journal_title：Toxicology and applied pharmacology

authors： Nozaki Y,Honda Y,Tsujimoto S,Watanabe H,Kunimatsu T,Funabashi H

更新日期：2014-07-01 00:00:00

abstract：:The effect of maternal selenium deficiency on methyl mercury fetotoxicity was examined in the ICR strain of mice. Pregnant mice were fed either selenium-deficient diets based on torula yeast or selenium-supplemented diets which were identical to the former except that 0.1, 0.2, or 0.4 mg of selenium per kilogram of di...

journal_title：Toxicology and applied pharmacology

authors： Nishikido N,Furuyashiki K,Naganuma A,Suzuki T,Imura N

更新日期：1987-05-01 00:00:00

abstract：:A microtiter hemolytic assay was utilized to determine sodium azide (NaN3) modulation of B6C3F1 and C3H mouse serum complement levels in vivo and in vitro. Functional complement was expressed in CH50 units per milliliter. Experiments were performed to determine the in vitro effect of NaN3 on complement mediated lysis ...

journal_title：Toxicology and applied pharmacology

authors： Johnson KW,Anderson AC,Munson AE,White KL Jr

更新日期：1984-05-01 00:00:00

abstract：:The effect of non-steroidal anti-inflammatory drugs (NSAIDs) on ion channels has been widely studied in several cell models, but less is known about their modulatory mechanisms. In this report, the effect of mefenamic acid on voltage-activated transient outward K(+) current (I(A)) in cultured rat cerebellar granule ce...

journal_title：Toxicology and applied pharmacology

authors： Zhang M,Shi WJ,Fei XW,Liu YR,Zeng XM,Mei YA

更新日期：2008-02-01 00:00:00

abstract：:The primary mechanisms proposed for acetaminophen-induced hepatic necrosis should deplete protein thiols, either by covalent binding and thioether formation or by oxidative reactions such as S-thiolations. However, in previous studies we did not detect significant losses of protein thiol contents in response to admini...

journal_title：Toxicology and applied pharmacology

authors： Gupta S,Rogers LK,Taylor SK,Smith CV

更新日期：1997-10-01 00:00:00

abstract：:Elevated levels of polyamines have long been associated with skin tumorigenesis. Tightly regulated metabolism of polyamines is critical for cell survival and normal skin homeostasis, and these controls are dysregulated in skin tumorigenesis. A key enzyme in polyamine biosynthesis, ornithine decarboxylase (ODC) is upre...

journal_title：Toxicology and applied pharmacology

authors： Gilmour SK

更新日期：2007-11-01 00:00:00

abstract：:The chemical risk assessment process plays an essential role in the potential human health risk evaluation. Setting priorities for this purpose is critical for better use of the available human and material resources. It has been generally accepted that all new chemicals require safety evaluation before manufacture an...

journal_title：Toxicology and applied pharmacology

authors： Alonzo C,Laborde A

更新日期：2005-09-01 00:00:00

abstract：:Free gold nanoparticles easily aggregate when the environment conditions change. Here, gold nanoparticles (AuNPs) with average diameter of 3.7 nm were prepared and then modified with poly(ethylene glycol) (PEG) to improve stability. The gold nanoparticles were first surface-modified with 3-mercaptopropionic acid (MPA)...

journal_title：Toxicology and applied pharmacology

authors： Gu YJ,Cheng J,Lin CC,Lam YW,Cheng SH,Wong WT

更新日期：2009-06-01 00:00:00