Availability of human induced pluripotent stem cell-derived cardiomyocytes in assessment of drug potential for QT prolongation.

abstract：:Ethanolic extract of Casearia sylvestris is thought to be antimutagenic. In this study, we attempted to determine whether this extract and casearin X (a clerodane diterpene from C. sylvestris) are protective against the harmful effects of airborne pollutants from sugarcane burning. To that end, we used the Tradescanti...

journal_title：Toxicology and applied pharmacology

authors： Prieto AM,Santos AG,Csipak AR,Caliri CM,Silva IC,Arbex MA,Silva FS,Marchi MR,Cavalheiro AJ,Silva DH,Bolzani VS,Soares CP

更新日期：2012-12-15 00:00:00

abstract：:The rate-limiting step in chemically induced, male rat-specific hyaline droplet nephropathy is the reversible binding of a xenobiotic to alpha 2u-globulin. In this study, equilibrium saturation binding experiments were conducted to evaluate the in vitro binding of d-limonene-1,2-oxide (dLO) and 2,4,4-trimethyl-2-penta...

journal_title：Toxicology and applied pharmacology

authors： Lehman-McKeeman LD,Caudill D

更新日期：1992-10-01 00:00:00

abstract：:Bropirimine is an immunomodulator with experimental antiviral and antitumor activities. This pyrimidinone has been found to be embryolethal at doses (200 and 400 mg/kg) that produce only transient maternal toxicity, when administered to pregnant Upj:TUC(SD)spf rats on specific days of gestation. Serum analyses carried...

journal_title：Toxicology and applied pharmacology

authors： Black DL,Marks TA,Branstetter DG,Kirton KT

更新日期：1991-03-15 00:00:00

abstract：:To determine if inhaled nephrotoxic branched and nonnephrotoxic straight chain alkanes differ substantially in their biological fate, male F344 rats were exposed to 14C-labeled isooctane and octane vapors at approximately 1 and 350 ppm by the nose-only mode for 2 hr. Radioactivity in exhalant, urine, and feces was det...

journal_title：Toxicology and applied pharmacology

authors： Dahl AR

更新日期：1989-09-01 00:00:00

abstract：:Celecoxib, an inhibitor of cyclooxygenase-2, is being investigated for enhancement of chemotherapy efficacy in cancer clinical trials. This study investigates the ability of cyclooxygenase-2 inhibitors to sensitize cells from different origins to several chemotherapeutic agents. The effect of the drug's mechanism of a...

journal_title：Toxicology and applied pharmacology

authors： El-Awady RA,Saleh EM,Ezz M,Elsayed AM

更新日期：2011-09-15 00:00:00

abstract：:The primary mechanisms proposed for acetaminophen-induced hepatic necrosis should deplete protein thiols, either by covalent binding and thioether formation or by oxidative reactions such as S-thiolations. However, in previous studies we did not detect significant losses of protein thiol contents in response to admini...

journal_title：Toxicology and applied pharmacology

authors： Gupta S,Rogers LK,Taylor SK,Smith CV

更新日期：1997-10-01 00:00:00

abstract：:There is a subpopulation of the CF-1 mouse strain that is very sensitive to the neurotoxicity induced by the avermectins, a class of natural products widely used in veterinary and human medicine as anti-parasitic agents. This sensitivity results from a lack of P-glycoprotein in the intestine and brain of sensitive ani...

journal_title：Toxicology and applied pharmacology

authors： Umbenhauer DR,Lankas GR,Pippert TR,Wise LD,Cartwright ME,Hall SJ,Beare CM

更新日期：1997-09-01 00:00:00

abstract：:Inhibition of intercellular communication, as measured by metabolic cooperation between 6-thioguanine-sensitive and 6-thioguanine-resistant Chinese hamster V79 cells, has been previously shown to be correlated with a large variety of known tumor promoters, including some of the organochlorine pesticides. Since further...

journal_title：Toxicology and applied pharmacology

authors： Lin ZX,Kavanagh T,Trosko JE,Chang CC

更新日期：1986-03-30 00:00:00

abstract：:Intravenous administration of drug-loaded polyalkylcyanoacrylate (PACA) nanoparticles is followed by a rapid uptake by the tissues of the reticuloendothelial system, mainly the liver. Nevertheless, it is so far unknown whether chronic administration of nanoparticles can lead to damage to the liver cells. We have studi...

journal_title：Toxicology and applied pharmacology

authors： Fernandez-Urrusuno R,Fattal E,Porquet D,Feger J,Couvreur P

更新日期：1995-02-01 00:00:00

abstract：:The acaricide chlordimeform has been reported to have adverse effects in mammals that may be mediated by an interaction with alpha-adrenergic receptors. Since the hormonal signals involved in the regulation of reproductive function are themselves under hypothalamic adrenergic control, the present study was designed to...

journal_title：Toxicology and applied pharmacology

authors： Goldman JM,Cooper RL,Laws SC,Rehnberg GL,Edwards TL,McElroy WK,Hein JF

更新日期：1990-06-01 00:00:00

abstract：:In previous work, we developed novel antibacterial hybrid coatings based on dextran containing dispersed Ag NPs (~5 nm, DEX-Ag) aimed to offer dual protection against two of the most common complications associated with implant surgery, infections and rejection of the implant. However, their blood-material interaction...

journal_title：Toxicology and applied pharmacology

authors： Coll Ferrer MC,Eckmann UN,Composto RJ,Eckmann DM

更新日期：2013-11-01 00:00:00

abstract：:Following po administration of a nephrotoxic dose (200 mg/kg) of hexachloro-1:3-butadiene (HCBD) to male rats, the principal route of excretion was biliary, 17-20% of the dose being eliminated on each of the first 2 days. Fecal excretion over this period was less than 5% of the dose per day, suggesting enterohepatic r...

journal_title：Toxicology and applied pharmacology

authors： Nash JA,King LJ,Lock EA,Green T

更新日期：1984-03-30 00:00:00

abstract：:Low dietary concentrations of methionine and cysteine are known to decrease hepatic glutathione content. However, it is not known if restricting the dietary content of these sulfur containing amino acids also affects hepatic levels of adenosine 3'-phosphate 5'-phosphosulfate (PAPS), the cofactor for sulfation, or meta...

journal_title：Toxicology and applied pharmacology

authors： Sendelbach LE,White CA,Howell S,Gregus Z,Klaassen CD

更新日期：1990-02-01 00:00:00

abstract：:Inflammatory responses are accompanied by increased expression of hepatocyte-derived proteins collectively known as acute phase reactants (APR). B6C3F1 female mice were exposed intraperitoneally every 24 hr to either vehicle (PBS) or DMN (5 mg/kg) for up to six exposures. Following a single treatment (acute), liver ti...

journal_title：Toxicology and applied pharmacology

authors： Lockwood JF,Rutherford MS,Myers MJ,Schook LB

更新日期：1994-04-01 00:00:00

abstract：:Sexually immature rainbow trout were dosed via gavage with 7,12-[14C]dimethylbenz[a]anthracene (DMBA) in order to study hepatic metabolite formation over time and at single and multiple doses. beta-Glucuronidase and aryl sulfatase hydrolyses of bile extracts and subsequent high-pressure liquid chromatography analysis ...

journal_title：Toxicology and applied pharmacology

authors： Schnitz AR,Squibb KS,O'Connor JM

更新日期：1993-07-01 00:00:00

abstract：:Although the tricyclic antidepressant drugs imipramine and doxepin exert similar direct electrophysiological effects on cardiac cells, toxic cardiac arrhythmias and conduction disturbances are much more commonly associated with imipramine than doxepin in clinical use. To ascertain if this discrepancy could be due to d...

journal_title：Toxicology and applied pharmacology

authors： Brennan FJ

更新日期：1984-06-30 00:00:00

abstract：:Oral administration of dimethylarsinic acid (DMAA), a major metabolite of inorganic arsenics, induces DNA damage in the mouse and rat lung due to both active oxygens and dimethylarsenic peroxyl radical produced in the metabolism of DMAA. Our paper describes the cellular response to DMAA in the mouse lung. In male ICR ...

journal_title：Toxicology and applied pharmacology

authors： Yamanaka K,Hasegawa A,Sawamura R,Okada S

更新日期：1991-04-01 00:00:00

abstract：:The biochemical mechanism involved in cadmium-induced cellular injury remains to be elucidated. Various theories have been proposed to account for this action, one of which is an interaction with reduced sulfhydryl (SH) groups of membranes. The ability of a known SH group reducing agent, dithiothreitol (DTT), to inter...

journal_title：Toxicology and applied pharmacology

authors： Stacey NH

更新日期：1986-02-01 00:00:00

abstract：:The effect of HgCl2 on kainate (KA)-induced depression of voltage-gated potassium (K+) current in chick embryo telencephalic cells was studied using conventional and nystatin-perforated whole-cell patch-clamp recordings, fluorescence imaging, and flow cytometry techniques. Hg2+ (1 microM) alone did not effect the 4-am...

journal_title：Toxicology and applied pharmacology

authors： Dyatlov VA,Platoshin AV,Lawrence DA,Carpenter DO

更新日期：1996-06-01 00:00:00

abstract：:In nonsmokers, ozone (O(3)) is removed primarily by the epithelial lining fluid (ELF) of the conducting airways. We hypothesized that cigarette smokers, whose ELF antioxidant capacity may be limited by smoking, would remove less O(3) from their conducting airways than nonsmokers. We recruited 29 nonsmokers (17M, 12F) ...

journal_title：Toxicology and applied pharmacology

authors： Bates ML,Brenza TM,Ben-Jebria A,Bascom R,Ultman JS

更新日期：2009-05-01 00:00:00

abstract：:Methylmercury (MeHg) causes a multiphasic disruption of intraneuronal cation regulation. Release of Ca2+ from internal stores and entry of extracellular Ca2+ (Ca2+e) contribute to the temporally distinct early (first Ca2+ phase) and late (second Ca2+ phase) components of increased intracellular Ca2+ concentration ([Ca...

journal_title：Toxicology and applied pharmacology

authors： Hare MF,Atchison WD

更新日期：1995-12-01 00:00:00

abstract：:Primary mixed cultures of Sertoli and germ cells were prepared from testes of immature rats and their response to the known testicular toxicants ethylene glycol monomethyl ether (EGM) and ethylene glycol monoethyl ether (EGE) was studied. Neither EGM nor EGE produced any morphological evidence of toxicity when added t...

journal_title：Toxicology and applied pharmacology

authors： Gray TJ,Moss EJ,Creasy DM,Gangolli SD

更新日期：1985-07-01 00:00:00

abstract：:Nitrogen dioxide (NO2), an environmental oxidant, alters the plasma membrane structure and function of pulmonary artery endothelial cells through peroxidative injury. Because perioxidative injury can activate membrane phospholipases and alter phospholipid composition of membranes, we evaluated the effects of NO2 expos...

journal_title：Toxicology and applied pharmacology

authors： Sekharam KM,Patel JM,Block ER

更新日期：1991-03-01 00:00:00

abstract：:Drug-induced steatohepatitis is a rare form of liver injury known to be caused by only a handful of compounds. These compounds stimulate the development of steatohepatitis through their toxicity to hepatocyte mitochondria; inhibition of beta-oxidation, mitochondrial respiration, and/or oxidative phosphorylation. Other...

journal_title：Toxicology and applied pharmacology

authors： Schumacher JD,Guo GL

更新日期：2015-11-15 00:00:00

abstract：:Acetaminophen (APAP) and 7-hydroxy-2-acetylaminofluorene (7-OH-AAF) each produced a similar incidence of, as well as a qualitatively similar, abnormal closure of the anterior neuropore at similar concentrations when added to the medium of cultured rat embryos. At concentrations producing a 50-65% incidence of abnormal...

journal_title：Toxicology and applied pharmacology

authors： Stark KL,Harris C,Juchau MR

更新日期：1989-03-01 00:00:00

abstract：:Oxidative stress can lead to expression of inflammatory transcription factors, which are important regulatory elements in the induction of inflammatory responses. One of the transcription factors, nuclear transcription factor kappa-B (NF-κB) plays a significant role in the inflammation regulatory process. Inflammatory...

journal_title：Toxicology and applied pharmacology

authors： Lee JE,Park JH,Jang SJ,Koh HC

更新日期：2014-07-15 00:00:00

abstract：:The influence of carbon monoxide (CO) on the development of systemic hypertension was studied in Dahl rats selectively bred for susceptibility (DS) and resistance (DR) to NaCl-induced hypertension. This study was designed to examine the interactions among rat line (DS or DR), NaCl content of diet, and exposure to CO. ...

journal_title：Toxicology and applied pharmacology

authors： Shiotsuka RN,Drew RT,Wehner RW

更新日期：1984-11-01 00:00:00

abstract：:An animal model was designed to study the chronopharmacokinetics of intravenous drugs and applied to anticancer agents vinorelbine (VNB) and methotrexate (MTX). Each experiment was performed on four pigs housed in a standardized light-dark cycle (12:12). Four pigs received a 0.16-mg bolus of VNB, followed by a 60-h co...

journal_title：Toxicology and applied pharmacology

authors： Prémaud A,Rousseau A,Gicquel M,Ragot S,Manceau J,Laurentie M,Marquet P

更新日期：2002-09-15 00:00:00

abstract：:Epidemiological studies indicated that people exposed to dioxins were prone to the development of lung diseases including lung cancer. Animal studies demonstrated that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increased liver tumors and promoted lung metaplasia in females. Metabolic changes in 17beta-estradiol (E(2))...

journal_title：Toxicology and applied pharmacology

authors： Cheng Y,Chang LW,Cheng LC,Tsai MH,Lin P

更新日期：2007-05-01 00:00:00

abstract：:This study was undertaken to characterize the long-term toxic and carcinogenic potential of a polybrominated biphenyl (PBB) mixture in rats and mice of both sexes. Fischer 344 rats and B6C3F1 mice were given 125 po doses of PBB over a 6-month period at 0 (control), 0.1, 0.3, 1.0, 3.0, and 10.0 mg/kg body weight/day (5...

journal_title：Toxicology and applied pharmacology

authors： Gupta BN,McConnell EE,Moore JA,Haseman JK

更新日期：1983-03-30 00:00:00