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Longitudinal distribution of ozone absorption in the lung: comparison of cigarette smokers and nonsmokers.

Abstract：

:In nonsmokers, ozone (O(3)) is removed primarily by the epithelial lining fluid (ELF) of the conducting airways. We hypothesized that cigarette smokers, whose ELF antioxidant capacity may be limited by smoking, would remove less O(3) from their conducting airways than nonsmokers. We recruited 29 nonsmokers (17M, 12F) and 30 smokers (19M, 11F, 4+/-4 pack-years) with similar anthropometric characteristics and measured the longitudinal distribution of O(3) using the bolus inhalation method. We also assessed the physiological effect of this transient exposure regimen using forced spirometry and capnography. Contrary to our hypothesis, the penetration volume at which 50% of a bolus was absorbed was not different between smokers and nonsmokers (97.1+/-5.4 mL versus 97.9+/-5.8 mL, p=0.92). However, smokers did experience an increase in the slope of the alveolar plateau of the capnogram (S(N)) (8.1+/-3.2%, p=0.02) and a small decrease in FEV(1) (-1.3+/-0.6%, p=0.03), whereas nonsmokers did not (DeltaFEV(1) -0.1+/-0.5% and DeltaS(N) -0.2+/-2.5%, p>0.10). Thus, smokers are more sensitive to inhaled O(3) boluses than nonsmokers, despite a similar internal dose distribution.

journal_name

Toxicol Appl Pharmacol

journal_title

Toxicology and applied pharmacology

authors

Bates ML,Brenza TM,Ben-Jebria A,Bascom R,Ultman JS

doi

10.1016/j.taap.2009.02.006

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

270-5

issue

3

eissn

0041-008X

issn

1096-0333

pii

S0041-008X(09)00072-6

journal_volume

236

pub_type

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