Ascorbic acid chronic alcohol consumption in the guinea pig.

abstract：:Chemicals from anthropogenic and natural origins enter animal feed, human food and water either as undesirable contaminants or as part of the components of a diet. Over the last five decades, considerable efforts and progress to develop methodologies to protect humans and animals against potential risks associated wit...

journal_title：Toxicology and applied pharmacology

authors： Dorne JL,Fink-Gremmels J

更新日期：2013-08-01 00:00:00

abstract：:Acrolein is a highly toxic, volatile, unsaturated aldehyde generated during incomplete combustion as in tobacco smoke and indoor fires. Because the transient receptor potential ankyrin 1 (TRPA1) channel mediates tobacco smoke-induced lung injury, we assessed its role in high-level acrolein-induced toxicity in mice. Ac...

journal_title：Toxicology and applied pharmacology

authors： Conklin DJ,Haberzettl P,Jagatheesan G,Kong M,Hoyle GW

更新日期：2017-06-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) are a group of persistent and widely distributed environmental pollutants that have various deleterious effects, e.g., neurotoxicity, endocrine disruption and reproductive abnormalities. In order to verify the hypothesis that the PI3K/Akt and MAPK pathways play important roles in hepat...

journal_title：Toxicology and applied pharmacology

authors： Liu C,Yang J,Fu W,Qi S,Wang C,Quan C,Yang K

更新日期：2014-06-15 00:00:00

abstract：:The nephrotoxicity limits the clinical application of cisplatin. Human organic cation transporter 2 (OCT2) and multidrug and toxin extrusion proteins (MATEs) work in concert in the elimination of cationic drugs such as cisplatin from the kidney. We hypothesized that co-administration of ondansetron would have an effec...

journal_title：Toxicology and applied pharmacology

authors： Li Q,Guo D,Dong Z,Zhang W,Zhang L,Huang SM,Polli JE,Shu Y

更新日期：2013-11-15 00:00:00

abstract：:Inhalation of asbestos may activate the pulmonary endothelium to promote an inflammatory cell phenotype that participates in the development of pulmonary fibrosis. However, little is known about the effects of asbestos on endothelial cell function. Therefore, endothelial cells were exposed to chrysotile and crocidolit...

journal_title：Toxicology and applied pharmacology

authors： Treadwell MD,Mossman BT,Barchowsky A

更新日期：1996-07-01 00:00:00

abstract：:Arsenic is a toxicant found in ground water around the world, and human exposure mainly comes from drinking water or from crops grown in areas containing arsenic in soils or water. Epidemiological studies have shown that arsenic exposure during development decreased intellectual function, reduced birth weight, and alt...

journal_title：Toxicology and applied pharmacology

authors： Liu JT,Bain LJ

更新日期：2014-12-15 00:00:00

abstract：:Hypochlorous acid (HOCl) is potentially an important source of cellular oxidative stress. Human HOCl exposure can occur from chlorine gas inhalation or from endogenous sources of HOCl, such as respiratory burst by phagocytes. Transcription factor Nrf2 is a key regulator of cellular redox status and serves as a primary...

journal_title：Toxicology and applied pharmacology

authors： Woods CG,Fu J,Xue P,Hou Y,Pluta LJ,Yang L,Zhang Q,Thomas RS,Andersen ME,Pi J

更新日期：2009-07-01 00:00:00

abstract：:To determine if inhaled nephrotoxic branched and nonnephrotoxic straight chain alkanes differ substantially in their biological fate, male F344 rats were exposed to 14C-labeled isooctane and octane vapors at approximately 1 and 350 ppm by the nose-only mode for 2 hr. Radioactivity in exhalant, urine, and feces was det...

journal_title：Toxicology and applied pharmacology

authors： Dahl AR

更新日期：1989-09-01 00:00:00

abstract：:The effects of the cytochrome P450 inducer beta-naphthoflavone (BNF) on NO2 toxicity were studied in two strains of mice. In one strain (C57B1/6J), cytochrome P450 could be induced by the aromatic hydrocarbon, while in the other strain (DBA/2J) cytochrome P450 was not inducible by this compound. Mice were treated with...

journal_title：Toxicology and applied pharmacology

authors： Azoulay-Dupuis E,Mansour H,Moreau J,Lachia L

更新日期：1988-04-01 00:00:00

abstract：:Elevated levels of polyamines have long been associated with skin tumorigenesis. Tightly regulated metabolism of polyamines is critical for cell survival and normal skin homeostasis, and these controls are dysregulated in skin tumorigenesis. A key enzyme in polyamine biosynthesis, ornithine decarboxylase (ODC) is upre...

journal_title：Toxicology and applied pharmacology

authors： Gilmour SK

更新日期：2007-11-01 00:00:00

abstract：:Phenobarbital (PB) is an effective growth stimulator of hepatic hyperplastic nodules developed with diethylnitrosamine and 2-acetylaminofluorene plus partial hepatectomy (the Solt-Farber model), but it does not apparently stimulate the growth of preneoplastic lesions produced with aflatoxin B1 (AFB). Some studies have...

journal_title：Toxicology and applied pharmacology

authors： Chen ZY,Eaton DL

更新日期：1991-10-01 00:00:00

abstract：:Alcoholic liver disease (ALD) is a major complication of heavy alcohol (EtOH) drinking and is characterized by three progressive stages of pathology: steatosis, steatohepatitis, and fibrosis/cirrhosis. Alcoholic steatosis (AS) is the initial stage of ALD and consists of fat accumulation in the liver accompanied by min...

journal_title：Toxicology and applied pharmacology

authors： Apte UM,Banerjee A,McRee R,Wellberg E,Ramaiah SK

更新日期：2005-08-22 00:00:00

abstract：BACKGROUND:The aim of our study was to identify the genetic background of thiopurine-induced toxicity in a patient with a wild-type thiopurine methyltransferase genotype and activity. A 38-year-old Caucasian woman presented with cutaneous necrotizing vasculitis pancytopenia one month after starting azathioprine therapy...

journal_title：Toxicology and applied pharmacology

authors： Stiburkova B,Pavelcova K,Petru L,Krijt J

更新日期：2018-08-15 00:00:00

abstract：:Cannabinoid receptor (CB) expression was characterized in immunological cell and tissue preparations. Northern analysis revealed approximately 6-kb transcripts for CB1 (brain-type) in mouse spleen and brain and in rat cerebellum. CB1 was not detected in mouse thymus or rat spleen RNA by Northern analysis. CB2 (periphe...

journal_title：Toxicology and applied pharmacology

authors： Schatz AR,Lee M,Condie RB,Pulaski JT,Kaminski NE

更新日期：1997-02-01 00:00:00

abstract：:The antioxidant N-acetyl-L-cysteine (NAC) has been increasingly used as an experimental tool to assess involvement of reactive oxygen species in cell signaling and is being evaluated as a preventive and therapeutic agent for cancer and pulmonary diseases related to inflammation and oxidative stress. However, a detaile...

journal_title：Toxicology and applied pharmacology

authors： Sekharam M,Trotti A,Cunnick JM,Wu J

更新日期：1998-04-01 00:00:00

abstract：:Prenatal ethanol exposure (PEE) induces dyslipidemia and hyperglycemia in fetus and adult offspring. However, whether PEE increases the susceptibility to non-alcoholic fatty liver disease (NAFLD) in offspring and its underlying mechanism remain unknown. This study aimed to demonstrate an increased susceptibility to hi...

journal_title：Toxicology and applied pharmacology

authors： Shen L,Liu Z,Gong J,Zhang L,Wang L,Magdalou J,Chen L,Wang H

更新日期：2014-01-15 00:00:00

abstract：:We have investigated the capacity of cultured whole rat embryos to convert 2-acetylaminofluorene (AAF) to reactive metabolites capable of eliciting dysmorphogenic effects in the same embryos. Cultured embryos (Sprague-Dawley) were exposed to AAF for periods of 2 or 24 hr, after which metabolites were isolated from the...

journal_title：Toxicology and applied pharmacology

authors： Juchau MR,Bark DH,Shewey LM,Greenaway JC

更新日期：1985-12-01 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD),12 the most toxic congener of dioxins, exhibits wide sensitivity differences between a sensitive Long-Evans (L-E) rat and a resistant Han/Wistar (H/W) rat. The sensitivity is determined probably by two autosomal genes and it is highly end point dependent. The difference is mo...

journal_title：Toxicology and applied pharmacology

authors： Tuomisto JT,Viluksela M,Pohjanvirta R,Tuomisto J

更新日期：1999-02-15 00:00:00

abstract：:We have studied the effects of opiates on ATP and acetylcholine (ACh) release from cholinergic nerve terminals isolated from the electric organ of Torpedo marmorata. The release of ATP was inhibited by morphine and this action was reversed by naloxone. Morphine, [D-Met2-Pro5]enkephalinamide and [D-Ala2-Leu5]enkephalin...

journal_title：Toxicology and applied pharmacology

authors： Saltó C,Calvet R,Guitart X,Solsona C,Marsal J

更新日期：1990-10-01 00:00:00

abstract：:The selenoprotein thioredoxin reductase (TXNRD) is a promising therapeutic target for cancer. To discover novel TXNRD inhibitors, a library of α, β-unsaturated carbonyl compounds were applied in structure-based virtual screening for the selection of hit compounds. Fifteen top-ranked compounds were further validated ex...

journal_title：Toxicology and applied pharmacology

authors： Liu R,Shi D,Zhang J,Li X,Han X,Yao X,Fang J

更新日期：2019-05-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) patients harboring EGFR mutation who initially respond to EGFR-TKI will gradually develop acquired resistance. There is still a challenge to treat EGFR-TKI resistant NSCLC patients. Polyphyllin I (PP I), a steroidal saponin isolated from Paris polyphylla., has been exhibited antitumo...

journal_title：Toxicology and applied pharmacology

authors： Yang Q,Chen W,Xu Y,Lv X,Zhang M,Jiang H

更新日期：2018-10-01 00:00:00

abstract：:The effects of the chemical species and concentration of selenium (Se) in diets on the concentrations of Se in hair, blood serum, red blood cells (RBCs), and urine were studied to gain an insight into the toxicological and nutritional significance of different chemical forms of Se. Male Wistar rats were fed an Se-defi...

journal_title：Toxicology and applied pharmacology

authors： Shiobara Y,Yoshida T,Suzuki KT

更新日期：1998-10-01 00:00:00

abstract：:Historical studies report that cellular injury and silicosis are related to cytosolic free calcium (Ca2+). Moreover, reactive oxygen species (ROS) have been linked to cellular injury. However, the detail mechanism of the increase in [Ca2+]i and the relationship between [Ca2+]i and ROS production remains unknown. Quart...

journal_title：Toxicology and applied pharmacology

authors： Tian F,Zhu T,Shang Y

更新日期：2010-01-15 00:00:00

abstract：:This study was undertaken to determine the ability of a series of 19 compounds representing different chemical classes of carcinogens to induce lung tumors in strain A/J mice after either ip or po administration. Aflatoxin B1, dibutylnitrosamine, 1,2-dimethylhydrazine, and methylnitrosourea induced a significant incre...

journal_title：Toxicology and applied pharmacology

authors： Stoner GD,Conran PB,Greisiger EA,Stober J,Morgan M,Pereira MA

更新日期：1986-01-01 00:00:00

abstract：:Distance learning offers many advantages to students and teachers of almost any scientific discipline. Toxicology is no exception. For example, should Paracelsus be interested in learning more about toxicology at Drexel University, he would have the opportunity to take two courses in this subject utilizing the content...

journal_title：Toxicology and applied pharmacology

authors： Huggins J,Morris J,Peterson CE

更新日期：2005-09-01 00:00:00

abstract：:The esters of the general structure, [CH(SH)COOR]2, i.e., Di-BDMS, R = CH2CH(CH3)2; Ds-BDMS, R = CH(CH3)CH2CH3; Di-ADMS, R = CH2CH2CH(CH3)2; and D3-ADMS, R = CH(CH2CH3)2 from the reaction of meso-2,3-dimercaptosuccinic acid with isobutyl, sec-butyl, isoamyl, and 3-amyl alcohols, respectively, have been prepared, chara...

journal_title：Toxicology and applied pharmacology

authors： Singh PK,Jones MM,Gale GR,Atkins LM,Smith AB

更新日期：1989-03-01 00:00:00

abstract：:The anti-HIV drug 3'-azido-3'-deoxythymidine (AZT) is the drug of choice for preventing maternal-fetal HIV transmission during pregnancy. Our aim was to assess the cytotoxic effects of AZT on human placenta in vitro. The mechanisms of AZT-induced effects were investigated using JEG-3 choriocarcinoma cells and primary ...

journal_title：Toxicology and applied pharmacology

authors： Collier AC,Helliwell RJ,Keelan JA,Paxton JW,Mitchell MD,Tingle MD

更新日期：2003-10-15 00:00:00

abstract：:The mechanism of action of Cd on Na,K-ATPase was investigated in two "classical" model systems, the shark rectal gland and rabbit kidney outer medulla. In lyophilized plasma membranes from dogfish rectal gland Cd inhibited Na,K-ATPase activity after 30 min of preincubation with an I50 of 1.3 x 10(-5) M. K-Dependent p-...

journal_title：Toxicology and applied pharmacology

authors： Kinne-Saffran E,Hülseweh M,Pfaff C,Kinne RK

更新日期：1993-07-01 00:00:00

abstract：:The use of isocyanates in industry has been increasing and, therefore, the potential for human exposure has also increased. Two such isocyanates are diphenylmethane-4,4'-diisocyanate (MDI) and dicyclohexylmethane-4,4'-diisocyanate (SMDI). Furthermore, there are only a few reports describing the toxicity of these diiso...

journal_title：Toxicology and applied pharmacology

authors： Weyel DA,Schaffer RB

更新日期：1985-03-15 00:00:00

abstract：:There are conflicting reports in the literature regarding the role of the Ah locus in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) immunotoxicity. The present studies have utilized two congenic strains of C57Bl/6 mice that differ only at this locus to assess its influence on TCDD-induced suppression of antibody response...

journal_title：Toxicology and applied pharmacology

authors： Kerkvliet NI,Steppan LB,Brauner JA,Deyo JA,Henderson MC,Tomar RS,Buhler DR

更新日期：1990-08-01 00:00:00