Generation of reactive dysmorphogenic intermediates by rat embryos in culture: effects of cytochrome P-450 inducers.

abstract：:F(ab')2 fragments are sometimes preferred to whole IgG for therapeutic or diagnostic uses. Preclinical pharmaceutical development studies are necessary before their use in humans. Here we propose an allometric approach among three mammalian species to predict F(ab')2 pharmacokinetic parameters in humans. Plasma dispos...

journal_title：Toxicology and applied pharmacology

authors： Bazin-Redureau M,Pepin S,Hong G,Debray M,Scherrmann JM

更新日期：1998-06-01 00:00:00

abstract：:The effects of erythropoiesis on cadmium-metallothionein (Cd-MT)2 levels in spleen, a major erythropoietic tissue, was examined following sc injection of 109CdCl2 into mice. As the concentration of Cd in plasma decreased following injection of 109CdCl2 into control mice, the levels in spleen and liver increased rapidl...

journal_title：Toxicology and applied pharmacology

authors： Min KS,Ohyanagi N,Ohta M,Onosaka S,Tanaka K

更新日期：1995-10-01 00:00:00

abstract：:Infants exposed to second hand smoke (SHS) experience more problems with wheezing. This study was designed to determine if perinatal SHS exposure increases intrinsic and/or in vivo airway responsiveness to methacholine and whether potential structural/cellular alterations in the airway might explain the change in resp...

journal_title：Toxicology and applied pharmacology

authors： Joad JP,Kott KS,Bric JM,Peake JL,Pinkerton KE

更新日期：2009-02-01 00:00:00

abstract：:A comparative study was undertaken in order to assess the hematotoxic effects of hydroquinone (HQ), 1,4-benzoquinone (BQ), and doxorubicin (DX) on mouse and human bone marrow (BM) cells. Initial experiments indicated that the inhibitory effects of near-ambient pO2 and HQ on granulocyte/macrophage colony-stimulating fa...

journal_title：Toxicology and applied pharmacology

authors： Colinas RJ,Burkart PT,Lawrence DA

更新日期：1994-11-01 00:00:00

abstract：:Metallothioneins (MTs) are metal-binding, low molecular weight proteins and are involved in pathophysiological processes like metabolism of essential metals, metal ion homeostasis and detoxification of heavy metals. Metallothionein expression is induced by various heavy metals especially cadmium, mercury and zinc; MTs...

journal_title：Toxicology and applied pharmacology

authors： Kayaalti Z,Mergen G,Söylemezoğlu T

更新日期：2010-06-01 00:00:00

abstract：:Apoptosis was measured in rat alveolar macrophage NR8383 cells challenged in vitro with respirable quartz or kaolin dust and with the dusts pretreated with dipalmitoyl phosphatidylcholine (DPPC) to model conditioning of respired dusts by interaction with a primary phospholipid component of pulmonary surfactant. Quartz...

journal_title：Toxicology and applied pharmacology

authors： Gao N,Keane MJ,Ong T,Ye J,Miller WE,Wallace WE

更新日期：2001-09-15 00:00:00

abstract：:Organic chemicals such as jet fuels and solvents can cause skin irritation after dermal exposure. The molecular responses to these chemicals resulting in acute irritation are not understood well enough to establish safe exposure limits. Male F-344 rats were dermally exposed to JP-8 jet fuel for 1 h using Hill Top Cham...

journal_title：Toxicology and applied pharmacology

authors： Kabbur MB,Rogers JV,Gunasekar PG,Garrett CM,Geiss KT,Brinkley WW,McDougal JN

更新日期：2001-08-15 00:00:00

abstract：:The effect of T2-toxin on DNA and protein synthesis was investigated, both in vivo and in vitro. For mice which had been submitted to different treatment schedules (single dose, 3-, or 7-day treatment), the rate of DNA and protein biosynthesis was measured in thymus, bone marrow, liver, and spleen cells. T2-toxin inhi...

journal_title：Toxicology and applied pharmacology

authors： Rosenstein Y,Lafarge-Frayssinet C

更新日期：1983-09-15 00:00:00

abstract：:The role of gamma-glutamyl transpeptidase (gamma-GTP) in the nephrotoxicity of hexachloro-1,3-butadiene (HCBD) was studied using male Sprague-Dawley rats pretreated with AT-125 (Acivicin; L-(alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid). Inhibition of gamma-GTP by more than 95% did not affect u...

journal_title：Toxicology and applied pharmacology

authors： Davis ME

更新日期：1988-08-01 00:00:00

abstract：:Arsenic is a ubiquitous metalloid element present in both inorganic and organic forms in the environment. The liver is considered to be a primary organ of arsenic biotransformation and methylation, as well as the main target of arsenic toxicity. Studies have confirmed that Chang human hepatocytes have an efficient ars...

journal_title：Toxicology and applied pharmacology

authors： Liu D,Xu G,Bai C,Gu Y,Wang D,Li B

更新日期：2021-01-09 00:00:00

abstract：:The effects of air pollution on human health are a great concern, particularly in big cities with severe traffic problems such as Bangkok, Thailand. In this study, exposure to genotoxic compounds in ambient air was studied by analysis of particle-associated polycyclic aromatic hydrocarbons (PAHs) and benzene through d...

journal_title：Toxicology and applied pharmacology

authors： Ruchirawat M,Navasumrit P,Settachan D,Tuntaviroon J,Buthbumrung N,Sharma S

更新日期：2005-08-07 00:00:00

abstract：:Bropirimine is an immunomodulator with experimental antiviral and antitumor activities. This pyrimidinone has been found to be embryolethal at doses (200 and 400 mg/kg) that produce only transient maternal toxicity, when administered to pregnant Upj:TUC(SD)spf rats on specific days of gestation. Serum analyses carried...

journal_title：Toxicology and applied pharmacology

authors： Black DL,Marks TA,Branstetter DG,Kirton KT

更新日期：1991-03-15 00:00:00

abstract：:The direct-acting mutagenicity of 1-nitropyrene (1-NP), a tumorigenic environmental pollutant and model nitropolycyclic aromatic hydrocarbon, was studied in Chinese hamster ovary (CHO) cells. Previous reports indicated that 1-NP, a potent direct-acting mutagen in Salmonella typhimurium, was mutagenic in CHO cells only...

journal_title：Toxicology and applied pharmacology

authors： Thornton-Manning JR,Smith BA,Beland FA,Heflich RH

更新日期：1991-07-01 00:00:00

abstract：:Dietary 2(3)-tert-butyl-4-hydroxyanisole (BHA) treatment has been shown to increase hepatic glutathione (GSH) content in rats and mice. Subsequent studies in our laboratory have demonstrated that hepatic gamma-glutamylcysteine synthetase (GCS) activity is increased in mice treated with dietary BHA. To test whether thi...

journal_title：Toxicology and applied pharmacology

authors： Borroz KI,Buetler TM,Eaton DL

更新日期：1994-05-01 00:00:00

abstract：:Along with the wide use of pesticides in the world, the concerns over their health impacts are rapidly growing. There is a huge body of evidence on the relation between exposure to pesticides and elevated rate of chronic diseases such as different types of cancers, diabetes, neurodegenerative disorders like Parkinson,...

journal_title：Toxicology and applied pharmacology

authors： Mostafalou S,Abdollahi M

更新日期：2013-04-15 00:00:00

abstract：:Studies were conducted to assess the in vitro toxicity of three chloropropanones: monochloropropanone (MCP), 1,1-dichloropropanone (1,1-DCP), and 1,3-dichloropropanone (1,3-DCP). Chloropropanones reacted directly with reduced glutathione (GSH) in sodium phosphate buffer at pH 7.4. All chloropropanones were cytotoxic t...

journal_title：Toxicology and applied pharmacology

authors： Merrick BA,Smallwood CL,Meier JR,McKean DL,Kaylor WH,Condie LW

更新日期：1987-10-01 00:00:00

abstract：:Metabonomics is the evaluation of the multiparametric metabolic response of biological systems to pathophysiological stimuli. High-resolution nuclear magnetic resonance (NMR) spectroscopy of biofluids coupled with pattern recognition-based chemometric analysis is an emerging approach to the study of metabonomics and m...

journal_title：Toxicology and applied pharmacology

authors： Slim RM,Robertson DG,Albassam M,Reily MD,Robosky L,Dethloff LA

更新日期：2002-09-01 00:00:00

abstract：:Chronic arsenic exposure through contaminated drinking water is a major environmental health issue. Chronic arsenic exposure is known to exert its toxic effects by a variety of mechanisms, of which generation of reactive oxygen species (ROS) is one of the most important. A high level of ROS, in turn, leads to DNA dama...

journal_title：Toxicology and applied pharmacology

authors： Banerjee M,Banerjee N,Ghosh P,Das JK,Basu S,Sarkar AK,States JC,Giri AK

更新日期：2010-11-15 00:00:00

abstract：:In vitro studies using rat and human hepatic microsomes have shown that the halogenated hydrocarbon 1,2,3-trichloropropane (TCP) is bioactivated to the direct acting mutagen 1,3-dichloroacetone (DCA). The presence of DCA in microsomal incubations was confirmed by gas chromatography-mass spectrometry. DCA formation was...

journal_title：Toxicology and applied pharmacology

authors： Weber GL,Sipes IG

更新日期：1992-03-01 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a highly toxic environmental pollutant and is well known for inducing thymic atrophy in mice, although the exact mechanism of its action remains unclear. Recent studies from our laboratory demonstrated that TCDD induces apoptosis in thymocytes and that Fas- mice (lpr/lpr) ...

journal_title：Toxicology and applied pharmacology

authors： Kamath AB,Nagarkatti PS,Nagarkatti M

更新日期：1998-05-01 00:00:00

abstract：:Polychlorinated biphenyl (PCB)126 and perfluorooctane sulfonic acid (PFOS) are halogenated organic pollutants of high concern. Exposure to these chemicals is ubiquitous, and can lead to potential synergistic adverse effects in individuals exposed to both classes of chemicals. The present study was designed to identify...

journal_title：Toxicology and applied pharmacology

authors： Deng P,Wang C,Wahlang B,Sexton T,Morris AJ,Hennig B

更新日期：2020-12-15 00:00:00

abstract：:Mesaconitine (MA) and hypaconitine (HA) are the main bioactive/toxic alkaloids of Aconitum carmichaelii Debx, and MDR1, BCRP and MRP2 are involved in their efflux in vitro. This study aimed to explore the effects of Mdr1a, Bcrp and Mrp2 on the efficacy/toxicity of MA and HA by using efflux transporter gene knockout mo...

journal_title：Toxicology and applied pharmacology

authors： Li X,Ou X,Luo G,Ou X,Xie Y,Ying M,Qu W,Zuo H,Qi X,Wang Y,Liu Z,Zhu L

更新日期：2020-12-15 00:00:00

abstract：:Cerebellar granule cells are preferentially targeted during methylmercury (MeHg) poisoning. Following acute MeHg exposure, granule cells in culture undergo an increase in intracellular Ca2+ concentration ([Ca2+]i) that apparently contributes to cell death. This effect consists of several temporally and kinetically dis...

journal_title：Toxicology and applied pharmacology

authors： Limke TL,Atchison WD

更新日期：2002-01-01 00:00:00

abstract：:Metallothioneins (MTs) are ubiquitous low-molecular-weight proteins that are induced by a variety of inducers, including metals, lipopolysaccharides (LPS), cytokines, oxidative stress, etc., and are thought to play a protective role against various toxic insults. The constitutive level of metallothionein is an importa...

journal_title：Toxicology and applied pharmacology

authors： Choudhuri S,Kramer KK,Berman NE,Dalton TP,Andrews GK,Klaassen CD

更新日期：1995-03-01 00:00:00

abstract：:Pyrrolizidine alkaloids such as monocrotaline (MCT) are toxic plant constituents which poison livestock and humans. Low doses of MCT given to rats result in cardiopulmonary pathophysiologic sequelae similar to forms of chronic pulmonary hypertension in man. This provides a useful model of human disease. The toxicology...

journal_title：Toxicology and applied pharmacology

authors： Roth RA,Ganey PE

更新日期：1988-05-01 00:00:00

abstract：:Recent breakthroughs in stem cell biology, especially the development of the induced pluripotent stem cell techniques, have generated tremendous enthusiasm and efforts to explore the therapeutic potential of stem cells in regenerative medicine. Stem cell therapies are being considered for the treatment of degenerative...

journal_title：Toxicology and applied pharmacology

authors： Sharpe ME,Morton D,Rossi A

更新日期：2012-08-01 00:00:00

abstract：:Isoprene (2-methyl-1,3-butadiene), a volatile monomer occurring in the natural environment and used in the manufacture of elastomers, is a close chemical relative of the animal carcinogen 1,3-butadiene. To obtain toxicokinetic data for inhaled isoprene, male F344 rats were exposed in groups of 30 to 14C-labeled isopre...

journal_title：Toxicology and applied pharmacology

authors： Dahl AR,Birnbaum LS,Bond JA,Gervasi PG,Henderson RF

更新日期：1987-06-30 00:00:00

abstract：:The disposition of polycyclic aromatic hydrocarbons (PAHs) in the respiratory tract of the Beagle dog was measured and presented in two previous papers. In this paper, the data were used to demonstrate that highly lipophilic toxicants, such as PAHs, were diffusion-limited during clearance from the respiratory tract. O...

journal_title：Toxicology and applied pharmacology

authors： Gerde P,Muggenburg BA,Henderson RF

更新日期：1993-08-01 00:00:00

abstract：:Juvenile rat toxicity studies with the direct renin inhibitor aliskiren were initiated to support treatment in the pediatric population. In Study 1, aliskiren was administered orally to juvenile rats at doses of 0, 30, 100 or 300 mg/kg/day with repeated dosing from postpartum day (PPD) 8 to PPD 35/36. In-life, clinica...

journal_title：Toxicology and applied pharmacology

authors： Hoffmann P,Beckman D,McLean LA,Yan JH

更新日期：2014-02-15 00:00:00

abstract：:Gastric cancer ranks as the third leading cause of cancer-related death worldwide. The uncontrolled tumor growth and robust metastasis are key factors to cause the cancer patient death. Mechanistically, aberrant activation of Notch and NF-κB signaling pathways plays pivotal roles in the initiation and metastasis of ga...

journal_title：Toxicology and applied pharmacology

authors： Xiang S,Zhao Z,Zhang T,Zhang B,Meng M,Cao Z,Zhou Q

更新日期：2020-02-01 00:00:00