Polyamines and nonmelanoma skin cancer.

abstract：:I-compounds are recently discovered, age-dependent covalent DNA modifications, which are detectable by 32P-postlabeling assay for DNA adducts. The effects of the catatoxic antiglucocorticoid, pregnenolone-16 alpha-carbonitrile (PCN), on hepatic and renal I-compound levels have been studied in male and female Sprague-D...

journal_title：Toxicology and applied pharmacology

authors： Moorthy B,van Golen KL,Randerath K

更新日期：1992-04-01 00:00:00

abstract：:Single-pass perfusion of mouse livers in situ with the phosphorothioate pesticide parathion resulted in formation of the cholinesterase inhibitor paraoxon (PO), p-nitrophenol (PNP), p-nitrophenyl sulfate (PNPS), and p-nitrophenyl glucuronide (PNPG). Daily pretreatment of mice with phenobarbital (80 mg/kg, ip) for 4 da...

journal_title：Toxicology and applied pharmacology

authors： Sultatos LG

更新日期：1986-10-01 00:00:00

abstract：:Three major enzyme systems have been shown to metabolize epoxidized xenobiotics in vertebrate tissues, and this study demonstrates that these enzyme systems can be differentially induced. The cytosolic epoxide hydrolase activity was routinely monitored with trans-beta-ethylstyrene oxide, the microsomal epoxide hydrola...

journal_title：Toxicology and applied pharmacology

authors： Hammock BD,Ota K

更新日期：1983-11-01 00:00:00

abstract：:The aims of this study were to investigate whether several histamine receptor agonists and antagonists are subjected to receptor-independent ion trapping into acidic organelles, and whether this sequestration influences their pharmacological or toxicological properties. Vacuolar (V)-ATPase-dependent intracellular sequ...

journal_title：Toxicology and applied pharmacology

authors： Morissette G,Lodge R,Bouthillier J,Marceau F

更新日期：2008-06-15 00:00:00

abstract：:The mechanism underlying glaucoma remains controversial, but apoptosis caused by increased levels of reactive oxygen species (ROS) is thought to play a role in its pathogenesis. We investigated the effects of compounds isolated from Psoralea corylifolia on oxidative stress-induced cell death in vitro and in vivo. Tran...

journal_title：Toxicology and applied pharmacology

authors： Kim KA,Shim SH,Ahn HR,Jung SH

更新日期：2013-06-01 00:00:00

abstract：:4-Alkylbicyclophosphates, R1C(CH2O)3P(O), with suitable R1 substituents (e.g., t-butyl, isopropyl, or cyclohexyl) are highly toxic compounds [mouse intraperitoneal (ip) LD50 values 0.036-0.52 mg/kg] and are potent noncompetitive gamma-aminobutyric acid (GABA) antagonists. 4-Alkylmonocyclophosphates of the type R1(HOCH...

journal_title：Toxicology and applied pharmacology

authors： Toia RF,Casida JE

更新日期：1985-10-01 00:00:00

abstract：:We use a stochastic model describing initiation and clonal growth of altered cells to analyze data from an initiation-promotion hepatocarcinogenesis experiment in female Wistar rats. Starting at 7 weeks of age, the animals were treated for 10 days with the initiating agent diethylnitrosamine (DEN, 10 mg/kg body wt per...

journal_title：Toxicology and applied pharmacology

authors： Luebeck EG,Buchmann A,Stinchcombe S,Moolgavkar SH,Schwarz M

更新日期：2000-08-15 00:00:00

abstract：:The disposition of 2,3,4,7,8-pentachlorodibenzofuran (PeCDF), a highly toxic environmental contaminant which accumulates in human tissues, was examined in the male Fischer rat after iv and oral exposure. Greater than 70% of an oral dose of 0.1, 0.5, or 1.0 mumol PeCDF/kg body wt was absorbed by the gastrointestinal sy...

journal_title：Toxicology and applied pharmacology

authors： Brewster DW,Birnbaum LS

更新日期：1987-09-15 00:00:00

abstract：:The effects of high protein dietary regimens prior to the administration of inorganic mercury were investigated. Male Sprague-Dawley rats were pair-fed on purified test diets containing either normal (20%) or high (60%) concentrations of protein. Mercury was administered as a single intravenous injection of mercuric c...

journal_title：Toxicology and applied pharmacology

authors： Andrews PM,Chung EM

更新日期：1990-09-01 00:00:00

abstract：:Free gold nanoparticles easily aggregate when the environment conditions change. Here, gold nanoparticles (AuNPs) with average diameter of 3.7 nm were prepared and then modified with poly(ethylene glycol) (PEG) to improve stability. The gold nanoparticles were first surface-modified with 3-mercaptopropionic acid (MPA)...

journal_title：Toxicology and applied pharmacology

authors： Gu YJ,Cheng J,Lin CC,Lam YW,Cheng SH,Wong WT

更新日期：2009-06-01 00:00:00

abstract：:Our previous study revealed that 4-aminopyridine (4-AP), a specific blocker of A-type current, could also inhibit inward Na+ currents (I(Na)) with a state-independent mechanism in rat cerebellar granule cells. In the present study, we report an inhibitory effect of 4-AP on voltage-gated and tetrodotoxin (TTX)-sensitiv...

journal_title：Toxicology and applied pharmacology

authors： Lu BX,Liu LY,Liao L,Zhang ZH,Mei YA

更新日期：2005-09-15 00:00:00

abstract：:The immunosuppressive synthetic methylated polycyclic aromatic hydrocarbon (PAH), 7,12-dimethylbenz[a]anthracene (DMBA), has been shown to cause both an immediate and a sustained elevation of free intracellular calcium (Ca2+) in human T cells. In the present studies, a series of anthracene- and pyrene-based PAHs were ...

journal_title：Toxicology and applied pharmacology

authors： Krieger JA,Born JL,Burchiel SW

更新日期：1994-08-01 00:00:00

abstract：:Vinylcyclohexene (VCH) is an industrial byproduct that is known to cause the destruction of ovarian follicles in mice. Its analog, 4-phenylcyclohexene (4PC), is a volatile product from latex-backed carpeting. These studies were undertaken to assess the structure-activity relationships of these compounds and the potent...

journal_title：Toxicology and applied pharmacology

authors： Hooser SB,Parola LR,Van Ert MD,Sipes IG

更新日期：1993-04-01 00:00:00

abstract：:Changes in body weight, feed intake, hepatic cellularity, and intermediary metabolism were assessed in the mature male (450 g) rat following 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) administration. All animals were schedule-fed (8-hr feeding period/24 hr) and treated with a single oral dose of either TCDD (75 microg...

journal_title：Toxicology and applied pharmacology

authors： Christian BJ,Menahan LA,Peterson RE

更新日期：1986-04-01 00:00:00

abstract：:The distribution of 14C-labeled clodronate (dichloromethylene bisphosphonate), a new bisphosphonate for the treatment of osteolytic bone metastases and hypercalcemia, was studied in mice by whole-body autoradiography and by measuring the 14C activities in various tissues [14C]Clodronate was administered into the tail ...

journal_title：Toxicology and applied pharmacology

authors： Mönkkönen J,Ylitalo P,Elo HA,Airaksinen MM

更新日期：1987-06-30 00:00:00

abstract：:The results of a series of screening tests to determine the potential teratogenicity and neurotoxicity of developmental exposure to TBTO in rats are presented in this paper. For prenatal exposure, pregnant Long Evans rats were intubated with 0-16 mg/kg/day bis(tri-n-butyltin)oxide TBTO from Days 6 to 20 of gestation (...

journal_title：Toxicology and applied pharmacology

authors： Crofton KM,Dean KF,Boncek VM,Rosen MB,Sheets LP,Chernoff N,Reiter LW

更新日期：1989-01-01 00:00:00

abstract：:Environmental exposure to polychlorinated biphenyls (PCBs) is associated with an increased risk of incidence of metabolic disease, however the molecular mechanisms underlying this phenomenon are not fully understood. Our study provides new insights into molecular interactions between PCBs and retinoids (vitamin A and ...

journal_title：Toxicology and applied pharmacology

authors： Shmarakov IO,Lee YJ,Jiang H,Blaner WS

更新日期：2019-10-15 00:00:00

abstract：:A transformer cooled and insulated with a mixture of 65% Aroclor 1254 and 35% chlorinated benzenes located in the Binghamton State Office Building in Binghamton, New York, was involved in a fire, which produced soot containing polychlorinated biphenyls, biphenylenes, dioxins, and dibenzofurans. A single dose of either...

journal_title：Toxicology and applied pharmacology

authors： Turner JN,Collins DN

更新日期：1983-03-15 00:00:00

abstract：:The protective effect of ursodeoxycholic acid (UDCA), a biliary component found in bears, on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced testicular damage in mice was investigated. Fifty C57BL/6J mice were equally divided into five groups. The mice in the control group received the vehicle and standard chow. Th...

journal_title：Toxicology and applied pharmacology

authors： Kwon YI,Yeon JD,Oh SM,Chung KH

更新日期：2004-02-01 00:00:00

abstract：:An accumulation of hydrophobic bile acids is implicated in the pathogenesis of cholestatic liver diseases. In the present study, we determined if hydrophobic bile acid-induced cellular injury compromised hepatocyte glutathione (GSH) status, and if modulating intracellular GSH levels prevented or facilitated bile acid-...

journal_title：Toxicology and applied pharmacology

authors： Gumpricht E,Devereaux MW,Dahl RH,Sokol RJ

更新日期：2000-04-01 00:00:00

abstract：:Oxido-inflammatory aberrations play a substantial role in the pathophysiology of depression. Oxido-inflammatory stress increases catabolism of tryptophan into kynurenine which leads to imbalance in kynurenine and serotonin levels in the brain. Naringenin a flavonoid, has been reported to possess antidepressant propert...

journal_title：Toxicology and applied pharmacology

authors： Bansal Y,Singh R,Saroj P,Sodhi RK,Kuhad A

更新日期：2018-09-15 00:00:00

abstract：:Pulmonary responses after continuous exposure of rats to concentrations of ozone (O3) ranging from 0.12 to 0.64 ppm were quantified by measuring tissue collagen synthesis rate, tissue protein and DNA content, and various constituents of bronchoalveolar lavage fluid. After 7 days of exposure to 0.64 ppm of O3, lung col...

journal_title：Toxicology and applied pharmacology

authors： Warren DL,Guth DJ,Last JA

更新日期：1986-07-01 00:00:00

abstract：:Exposure to environmental contaminants such as activators of the aryl hydrocarbon receptor (AhR) leads to the induction of defense and detoxification mechanisms. While these mechanisms allow organisms to metabolize and excrete at least some of these environmental contaminants, it has been proposed that these mechanism...

journal_title：Toxicology and applied pharmacology

authors： Nault R,Abdul-Fattah H,Mironov GG,Berezovski MV,Moon TW

更新日期：2013-08-15 00:00:00

abstract：:The ACuteTox Project (part of the EU 6th Framework Programme) was started up in January 2005. The aim of this project is to develop a simple and robust in vitro strategy for prediction of human acute systemic toxicity, which could replace animal tests used for regulatory purposes. Our group is responsible for the char...

journal_title：Toxicology and applied pharmacology

authors： Cerrato L,Valeri A,Bueren JA,Albella B

更新日期：2009-07-15 00:00:00

abstract：:To elucidate the underlying mechanisms in oxidative stress-related airway remodeling observed in chronic inflammatory pulmonary diseases such as asthma, we studied the effects of a thiol antioxidant, N-acetylcysteine (NAC), a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, AG-1478, and tyr...

journal_title：Toxicology and applied pharmacology

authors： Tsukagoshi H,Kawata T,Shimizu Y,Ishizuka T,Dobashi K,Mori M

更新日期：2002-11-01 00:00:00

abstract：:In previous work, we developed novel antibacterial hybrid coatings based on dextran containing dispersed Ag NPs (~5 nm, DEX-Ag) aimed to offer dual protection against two of the most common complications associated with implant surgery, infections and rejection of the implant. However, their blood-material interaction...

journal_title：Toxicology and applied pharmacology

authors： Coll Ferrer MC,Eckmann UN,Composto RJ,Eckmann DM

更新日期：2013-11-01 00:00:00

abstract：:Mitotic catastrophe, a form of cell death resulting from abnormal mitosis, is a cytotoxic death pathway as well as an appealing mechanistic strategy for the development of anti-cancer drugs. In this study, 6-bromine-5-hydroxy-4-methoxybenzaldehyde was demonstrated to induce DNA double-strand break, multipolar spindles...

journal_title：Toxicology and applied pharmacology

authors： Zhang B,Huang B,Guan H,Zhang SM,Xu QZ,He XP,Liu XD,Wang Y,Shang ZF,Zhou PK

更新日期：2011-05-01 00:00:00

abstract：:The effects of low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the reproductive system of male offspring rats were examined. The dams were treated subcutaneously 2 weeks prior to mating and throughout mating, pregnancy, and lactation. They received an initial loading dose of 25, 60, or 300 ng TCDD/kg body w...

journal_title：Toxicology and applied pharmacology

authors： Faqi AS,Dalsenter PR,Merker HJ,Chahoud I

更新日期：1998-06-01 00:00:00

abstract：:Nitrogen mustard is a vesicant that causes damage to the respiratory tract. In these studies, we characterized the acute effects of nitrogen mustard on lung structure, inflammatory mediator expression, and pulmonary function, with the goal of identifying mediators potentially involved in toxicity. Treatment of rats (m...

journal_title：Toxicology and applied pharmacology

authors： Sunil VR,Patel KJ,Shen J,Reimer D,Gow AJ,Laskin JD,Laskin DL

更新日期：2011-01-01 00:00:00

abstract：:Studies were conducted which examined urinary excretion and papillary production of cyclic-AMP in the rat following vasopressin (ADH) stimulation in the presence or absence of inorganic fluoride ion (F). In one set of experiments, six anesthetized Fischer 344 rats were administered 5 munits arginine vasopressin during...

journal_title：Toxicology and applied pharmacology

authors： Maxwell JA,Caffrey JL,Yorio T,Sinclair RJ

更新日期：1983-06-15 00:00:00