当前位置： SCI文献检索 > TOXICOLOGY AND APPLIED PHARMACOLOGY期刊下所有文献 > Liver morphology in guinea pigs administered either pyrolysis products of a polychlorinated biphenyl transformer fluid or 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Liver morphology in guinea pigs administered either pyrolysis products of a polychlorinated biphenyl transformer fluid or 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Abstract：

:A transformer cooled and insulated with a mixture of 65% Aroclor 1254 and 35% chlorinated benzenes located in the Binghamton State Office Building in Binghamton, New York, was involved in a fire, which produced soot containing polychlorinated biphenyls, biphenylenes, dioxins, and dibenzofurans. A single dose of either soot or 2,3,7,8-tetrachlorodibenzo-p-dioxin in aqueous methyl cellulose was administered by gavage to Hartley guinea pigs of both sexes. The liver tissue was examined 42 days after administration. By light microscopy hypertrophy of hepatocytes, steatosis, focal necrosis, and cytoplasmic hyalin-like bodies were observed as a result of both treatments. Bile duct proliferation (adenofibrosis) was observed only in the guinea pig groups administered soot. These animals also showed proliferation of the smooth endoplasmic reticulum, concentric membrane arrays (CMA), mitochondrial alterations, decreased rough endoplasmic reticulum, and autophagolysosomes by electron microscopy. The CMAs, which corresponded to the hyalin-like bodies, surrounded lipid droplets and cytoplasmic matrix containing mitochondria and degenerating organelles.

journal_name

Toxicol Appl Pharmacol

journal_title

Toxicology and applied pharmacology

authors

Turner JN,Collins DN

doi

10.1016/0041-008x(83)90326-5

subject

Has Abstract

pub_date

1983-03-15 00:00:00

pages

417-29

issue

3

eissn

0041-008X

issn

1096-0333

journal_volume

67

pub_type

杂志文章

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