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Potentiation of duodenal ulcerogenic action of acrylonitrile by PCB or phenobarbital in the rat.

Abstract：

:Pretreatment of rats with the polychlorinated biphenyl (PCB) Aroclor 1254 or phenobarbital markedly increased the duodenal ulcerogenic action of acrylonitrile. The extent of forestomach and hepatic lesions in these rats, on the other hand, was not modified. The duodenal ulcers produced by Aroclor 1254 and acrylonitrile morphologically resembled the ulcers induced in other animal models of the human duodenal ulcer disease. The possible mechanisms of this potentiation of acrylonitrile action are discussed.

journal_name

Toxicol Appl Pharmacol

journal_title

Toxicology and applied pharmacology

authors

Szabo S,Silver EH,Gallagher GT,Maull EA

doi

10.1016/0041-008x(83)90034-0

subject

Has Abstract

pub_date

1983-12-01 00:00:00

pages

451-4

issue

3

eissn

0041-008X

issn

1096-0333

journal_volume

71

pub_type

杂志文章

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