Constitutive and xenobiotics-induced expression of a novel CYP3A gene from zebrafish larva.

abstract：:Homocysteine is increased during pathological conditions, endangering vascular and cognitive functions, and elevated homocysteine during pregnancy may be correlated with an increased incidence of schizophrenia in the offspring. This study showed that millimolar homocysteine concentrations in saline medium cause phosph...

journal_title：Toxicology and applied pharmacology

authors： Gu L,Hu X,Xue Z,Yang J,Wan L,Ren Y,Hertz L,Peng L

更新日期：2010-01-15 00:00:00

abstract：:The use of toxicokinetic (TK) data is becoming more prevalent in the evaluation of food ingredient safety as more TK information is being incorporated in safety data packages. Data demonstrating "1) the extent of absorption, 2) tissue distribution, 3) pathways and rates of metabolism, and 4) rate(s) of elimination" of...

journal_title：Toxicology and applied pharmacology

authors： Kabadi SV,Zang Y,Fisher JW,Smith N,Whiteside C,Aungst J

更新日期：2019-11-01 00:00:00

abstract：:Targeting excessive production of reactive oxygen species (ROS) could be an effective therapeutic strategy to prevent oxidative stress-associated gastrointestinal inflammation. NADPH oxidase (NOX) and mitochondrial complexes (I and II) are the major sources of ROS production contributing to TNF-α/cycloheximide (CHX)-i...

journal_title：Toxicology and applied pharmacology

authors： Babu D,Leclercq G,Goossens V,Remijsen Q,Vandenabeele P,Motterlini R,Lefebvre RA

更新日期：2015-10-15 00:00:00

abstract：:1-Nitropyrene (1-NP), a constituent of diesel exhaust, is carcinogenic to rats and is a bacterial and mammalian mutagen. Biliary and fecal excretion of 1-NP metabolites are the major routes of excretion in rats, suggesting that hepatic metabolism plays a dominant role in determining the biological fate of 1-NP. The pu...

journal_title：Toxicology and applied pharmacology

authors： Bond JA,Medinsky MA,Dutcher JS

更新日期：1984-09-30 00:00:00

abstract：:Previous work has shown that chlordecone (CD)-amplified CCl4 hepatotoxicity and lethality can be mitigated by pretreatment with cyanidanol. These studies also revealed that stimulated hepatocellular regeneration might play an important role in the cyanidanol protection of CD-amplified CCl4 toxicity. The present studie...

journal_title：Toxicology and applied pharmacology

authors： Soni MG,Mehendale HM

更新日期：1991-03-15 00:00:00

abstract：:Recent studies have demonstrated that macrophages are the cell types capable of metabolizing benzo[a]pyrene (B(a)P) within the spleens of untreated mice. Since repeated exposure to B(a)P results in immunosuppression and B(a)P is known to induce cytochrome P450 levels, the first objective of this study was to investiga...

journal_title：Toxicology and applied pharmacology

authors： Ladics GS,Kawabata TT,Munson AE,White KL Jr

更新日期：1992-10-01 00:00:00

abstract：:Recent breakthroughs in stem cell biology, especially the development of the induced pluripotent stem cell techniques, have generated tremendous enthusiasm and efforts to explore the therapeutic potential of stem cells in regenerative medicine. Stem cell therapies are being considered for the treatment of degenerative...

journal_title：Toxicology and applied pharmacology

authors： Sharpe ME,Morton D,Rossi A

更新日期：2012-08-01 00:00:00

abstract：:Combretastatin A-4 (CA-4) has already entered clinical trials of solid tumors over ten years. However, the limited anticancer activity and dose-dependent toxicity restrict its clinical application. Here, we offered convincing evidence that CA-4 induced autophagy in various cancer cells, which was demonstrated by acrid...

journal_title：Toxicology and applied pharmacology

authors： Li Y,Luo P,Wang J,Dai J,Yang X,Wu H,Yang B,He Q

更新日期：2014-01-15 00:00:00

abstract：:Occupational exposure to nickel (Ni), chromium (Cr), and arsenic (As) containing compounds has been associated with lung cancer and other adverse health effects. Their carcinogenic properties may be attributable in part, to activation and/or repression of gene expression induced by changes in the DNA methylation statu...

journal_title：Toxicology and applied pharmacology

authors： Zhou X,Li Q,Arita A,Sun H,Costa M

更新日期：2009-04-01 00:00:00

abstract：:The mechanism of action of Cd on Na,K-ATPase was investigated in two "classical" model systems, the shark rectal gland and rabbit kidney outer medulla. In lyophilized plasma membranes from dogfish rectal gland Cd inhibited Na,K-ATPase activity after 30 min of preincubation with an I50 of 1.3 x 10(-5) M. K-Dependent p-...

journal_title：Toxicology and applied pharmacology

authors： Kinne-Saffran E,Hülseweh M,Pfaff C,Kinne RK

更新日期：1993-07-01 00:00:00

abstract：:Sibutramine is an inhibitor of norepinephrine and 5-HT reuptake largely used in the management of obesity. Although a fairly safe drug, postmarketing adverse effects of sibutramine were reported including abnormal ejaculation in men. This study investigates the effects of sibutramine on ejaculation and vas deferens an...

journal_title：Toxicology and applied pharmacology

authors： Nojimoto FD,Piffer RC,Kiguti LR,Lameu C,de Camargo AC,Pereira OC,Pupo AS

更新日期：2009-09-15 00:00:00

abstract：:We describe a compartmental pharmacokinetic model for methyl mercury and its metabolite mercuric mercury in humans. A tracer dose of 203Hg-labeled methyl mercury was administered iv to seven healthy young adult male volunteers. Blood samples were obtained periodically and urine and feces were collected throughout the ...

journal_title：Toxicology and applied pharmacology

authors： Smith JC,Allen PV,Turner MD,Most B,Fisher HL,Hall LL

更新日期：1994-10-01 00:00:00

abstract：:Skin is the largest and most accessible drug-metabolizing organ. In mammals, it is the competent barrier that protects against exposure to harmful stimuli in the environment and in the systemic circulation. Skin expresses many cytochromes P450 that have critical roles in exogenous and endogenous substrate metabolism. ...

journal_title：Toxicology and applied pharmacology

authors： Du L,Hoffman SM,Keeney DS

更新日期：2004-03-15 00:00:00

abstract：:The effect of HgCl2 on kainate (KA)-induced depression of voltage-gated potassium (K+) current in chick embryo telencephalic cells was studied using conventional and nystatin-perforated whole-cell patch-clamp recordings, fluorescence imaging, and flow cytometry techniques. Hg2+ (1 microM) alone did not effect the 4-am...

journal_title：Toxicology and applied pharmacology

authors： Dyatlov VA,Platoshin AV,Lawrence DA,Carpenter DO

更新日期：1996-06-01 00:00:00

abstract：:Diurnal patterns of eating, drinking, locomotor activity, and rearing in male Fischer-344 rats were examined for 11 days after a single oral dose of triethyltin bromide (TET) at 0, 1.5, 3, or 5 mg/kg. The 5 mg/kg group exhibited a time-related drop in food consumption and body weight until 3 of 10 rats were sacrificed...

journal_title：Toxicology and applied pharmacology

authors： Bushnell PJ,Evans HL

更新日期：1986-09-30 00:00:00

abstract：:Carbon tetrachloride (CCl4) has been studied extensively for its hepatotoxic effects. There is a paucity of information, however, about its tissue deposition following administration by different routes and patterns of exposure. The specific objective of this study was to delineate the uptake, distribution, and elimin...

journal_title：Toxicology and applied pharmacology

authors： Sanzgiri UY,Srivatsan V,Muralidhara S,Dallas CE,Bruckner JV

更新日期：1997-03-01 00:00:00

abstract：:Stress response proteins can play integral roles as modulators of cellular function and can be involved in mechanisms that are important to immune function. Metallothionein (MT), a cysteine-rich stress response protein, has been shown to play numerous roles in the cell: it serves as a reservoir of essential heavy meta...

journal_title：Toxicology and applied pharmacology

authors： Crowthers KC,Kline V,Giardina C,Lynes MA

更新日期：2000-08-01 00:00:00

abstract：:Morphine may induce cardioprotection by targeting mitochondria, but little is known about the exact mitochondrial events that mediate morphine's protection. We aimed to address the role of the mitochondrial Src tyrosine kinase in morphine's protection. Isolated rat hearts were subjected to 30 min ischemia and 2h of re...

journal_title：Toxicology and applied pharmacology

authors： He H,Huh J,Wang H,Kang Y,Lou J,Xu Z

更新日期：2016-01-01 00:00:00

abstract：:Chronic inhalation of high concentrations of respirable quartz particles has been implicated in various lung diseases including lung fibrosis and cancer. Generation of reactive oxygen species (ROS) and oxidative stress is considered a major mechanism of quartz toxicity. Curcumin, a yellow pigment from Curcuma longa, h...

journal_title：Toxicology and applied pharmacology

authors： Li H,van Berlo D,Shi T,Speit G,Knaapen AM,Borm PJ,Albrecht C,Schins RP

更新日期：2008-02-15 00:00:00

abstract：:The skin cancer enhancing effect of chromium (in male mice) and nickel in UVR-irradiated female Skh1 mice was investigated. The dietary vitamin E and selenomethionine were tested for prevention of chromium-enhanced skin carcinogenesis. The mice were exposed to UVR (1.0 kJ/m(2) 3 x weekly) for 26 weeks either alone, or...

journal_title：Toxicology and applied pharmacology

authors： Uddin AN,Burns FJ,Rossman TG,Chen H,Kluz T,Costa M

更新日期：2007-06-15 00:00:00

abstract：:Cigarette smoking, arsenic and occupational exposures are well-known risk factors for the development of urothelial carcinoma (UC). Therefore, the aim of this study is to investigate whether the effect of cigarette smoking, alcohol consumption, arsenic and occupational exposures on risk of UC could be modified by gene...

journal_title：Toxicology and applied pharmacology

authors： Wang YH,Yeh SD,Shen KH,Shen CH,Juang GD,Hsu LI,Chiou HY,Chen CJ

更新日期：2009-11-15 00:00:00

abstract：:Decreased daily sperm production (DSP) and cauda epididymal sperm number (CESN) are some of the most sensitive effects of in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure. The reduction in CESN cannot be fully accounted for by decreased spermatogenesis. To explain the decrease in CESN it wa...

journal_title：Toxicology and applied pharmacology

authors： Sommer RJ,Ippolito DL,Peterson RE

更新日期：1996-09-01 00:00:00

abstract：:Chemicals from anthropogenic and natural origins enter animal feed, human food and water either as undesirable contaminants or as part of the components of a diet. Over the last five decades, considerable efforts and progress to develop methodologies to protect humans and animals against potential risks associated wit...

journal_title：Toxicology and applied pharmacology

authors： Dorne JL,Fink-Gremmels J

更新日期：2013-08-01 00:00:00

abstract：:The embryonic stem cell test (EST) predicts developmental toxicity based on the inhibition of cardiomyocyte differentiation of embryonic stem cells (ESC). The subjective endpoint, the long culture duration together with the undefined applicability domain and related predictivity need further improvement to facilitate ...

journal_title：Toxicology and applied pharmacology

authors： van Dartel DA,Pennings JL,van Schooten FJ,Piersma AH

更新日期：2010-03-15 00:00:00

abstract：:Exposure to environmental contaminants such as activators of the aryl hydrocarbon receptor (AhR) leads to the induction of defense and detoxification mechanisms. While these mechanisms allow organisms to metabolize and excrete at least some of these environmental contaminants, it has been proposed that these mechanism...

journal_title：Toxicology and applied pharmacology

authors： Nault R,Abdul-Fattah H,Mironov GG,Berezovski MV,Moon TW

更新日期：2013-08-15 00:00:00

abstract：:Cyclosporin (Cs), a cyclic nonpolar undecapeptide of fungal origin, has potent immunosuppressive and antiparasitic activities, and renal and hepatic toxicities, the mechanisms of which are not worked out. Many nephrotoxins and hepatotoxins are predictably more or less harmful, depending upon the circadian stage at whi...

journal_title：Toxicology and applied pharmacology

authors： Magnus G,Cavallini M,Halberg F,Cornelissen G,Sutherland DE,Najarian JA,Hrushesky WJ

更新日期：1985-01-01 00:00:00

abstract：:Staphylococcal enterotoxin C2 (SEC2), a member of bacterial superantigen, is one of the most potent known activators of T lymphocytes. With this property, SEC2 has already been used in clinic as a tumor immunotherapy agent in China. To increase the antitumor activity, a SEC2 mutant named ST-4 (GKVTG102-106WWH) with am...

journal_title：Toxicology and applied pharmacology

authors： Zhang G,Xu M,Zhang H,Song Y,Wang J,Zhang C

更新日期：2016-12-15 00:00:00

abstract：:Apoptosis was measured in rat alveolar macrophage NR8383 cells challenged in vitro with respirable quartz or kaolin dust and with the dusts pretreated with dipalmitoyl phosphatidylcholine (DPPC) to model conditioning of respired dusts by interaction with a primary phospholipid component of pulmonary surfactant. Quartz...

journal_title：Toxicology and applied pharmacology

authors： Gao N,Keane MJ,Ong T,Ye J,Miller WE,Wallace WE

更新日期：2001-09-15 00:00:00

abstract：:Cadmium chloride (CdCl2) at a dose of 1 mg/kg body wt was injected into male rats of the Wistar strain, weighing 250 g on the average, twice a day (12-hr intervals) for 7 consecutive days. DNA and RNA contents and [3H]-thymidine and [3H]-uridine incorporation into the acid-insoluble fraction significantly increased in...

journal_title：Toxicology and applied pharmacology

authors： Nishiyama S,Nakamura K

更新日期：1984-07-01 00:00:00

abstract：:Drug-induced steatohepatitis is a rare form of liver injury known to be caused by only a handful of compounds. These compounds stimulate the development of steatohepatitis through their toxicity to hepatocyte mitochondria; inhibition of beta-oxidation, mitochondrial respiration, and/or oxidative phosphorylation. Other...

journal_title：Toxicology and applied pharmacology

authors： Schumacher JD,Guo GL

更新日期：2015-11-15 00:00:00