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The kinetics of intravenously administered methyl mercury in man.

Abstract：

:We describe a compartmental pharmacokinetic model for methyl mercury and its metabolite mercuric mercury in humans. A tracer dose of 203Hg-labeled methyl mercury was administered iv to seven healthy young adult male volunteers. Blood samples were obtained periodically and urine and feces were collected throughout the 70 days of the study. The blood contained predominantly methyl mercury, while the excreta contained principally inorganic mercury. The behavior of both methyl mercury and inorganic mercury in the body was modeled with the simplest compartmental model which fit the data. This five-compartment model shows that inorganic mercury accumulates in the body and at longer times is the predominant form of mercury present. The biological half-life of methyl mercury in the body is 44 days and 1.6% of the body burden is lost each day by both metabolism and excretion. This rate of loss is 60% greater than that currently accepted (1.0% per day). Thus, the risk associated with dietary methyl mercury may have been overestimated.

journal_name

Toxicol Appl Pharmacol

journal_title

Toxicology and applied pharmacology

authors

Smith JC,Allen PV,Turner MD,Most B,Fisher HL,Hall LL

doi

10.1006/taap.1994.1204

subject

Has Abstract

pub_date

1994-10-01 00:00:00

pages

251-6

issue

2

eissn

0041-008X

issn

1096-0333

pii

S0041-008X(84)71204-X

journal_volume

128

pub_type

临床试验,杂志文章

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