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SATB2 expression increased anchorage-independent growth and cell migration in human bronchial epithelial cells.

Abstract：

:The special AT-rich sequence-binding protein 2 (SATB2) is a protein that binds to the nuclear matrix attachment region of the cell and regulates gene expression by altering chromatin structure. In our previous study, we reported that SATB2 gene expression was induced in human bronchial epithelial BEAS-2B cells transformed by arsenic, chromium, nickel and vanadium. In this study, we show that ectopic expression of SATB2 in the normal human bronchial epithelial cell-line BEAS-2B increased anchorage-independent growth and cell migration, meanwhile, shRNA-mediated knockdown of SATB2 significantly decreased anchorage-independent growth in Ni transformed BEAS-2B cells. RNA sequencing analyses of SATB2 regulated genes revealed the enrichment of those involved in cytoskeleton, cell adhesion and cell-movement pathways. Our evidence supports the hypothesis that SATB2 plays an important role in BEAS-2B cell transformation.

journal_name

Toxicol Appl Pharmacol

journal_title

Toxicology and applied pharmacology

authors

Wu F,Jordan A,Kluz T,Shen S,Sun H,Cartularo LA,Costa M

doi

10.1016/j.taap.2016.01.008

subject

Has Abstract

pub_date

2016-02-15 00:00:00

pages

30-6

eissn

0041-008X

issn

1096-0333

pii

S0041-008X(16)30007-2

journal_volume

293

pub_type

杂志文章

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