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Influence of iron and zinc status on cadmium accumulation in Bangladeshi women.

Abstract：

:Cadmium is a widespread environmental contaminant present in food. The absorption in the intestine increases in individuals with low iron stores, but the effect of zinc deficiency is not clear. The aim of the present study was to assess the influence of iron and zinc status on cadmium accumulation in pregnant Bangladeshi women. We measured cadmium in urine from 890 women using inductively coupled plasma mass spectrometry (ICPMS). Further, we also measured ferritin and zinc in plasma. The median cadmium concentration in urine was 0.59 microg/L (adjusted to mean specific gravity of 1.012 g/mL). Analysis of covariance (ANCOVA) showed that urinary cadmium was associated with plasma ferritin and plasma zinc via a significant interaction between dichotomized plasma ferritin and plasma zinc. The analysis was adjusted for age and socioeconomic status. Women with low iron stores and adequate zinc status had significantly higher urinary cadmium compared to women with both adequate iron stores and zinc status. There was no difference in urinary cadmium between women with both low iron stores and zinc status compared to those with both adequate iron stores and zinc status. In conclusion, low iron stores were associated with increased cadmium accumulation, but only at adequate zinc status.

journal_name

Toxicol Appl Pharmacol

journal_title

Toxicology and applied pharmacology

authors

Kippler M,Ekström EC,Lönnerdal B,Goessler W,Akesson A,El Arifeen S,Persson LA,Vahter M

doi

10.1016/j.taap.2007.04.009

subject

Has Abstract

pub_date

2007-07-15 00:00:00

pages

221-6

issue

2

eissn

0041-008X

issn

1096-0333

pii

S0041-008X(07)00190-1

journal_volume

222

pub_type

杂志文章

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