In utero and lactational exposure of the male Holtzman rat to 2,3,7,8-tetrachlorodibenzo-p-dioxin: decreased epididymal and ejaculated sperm numbers without alterations in sperm transit rate.

abstract：:Despite the depth of knowledge concerning the pathogenesis of acute myeloblastic leukemia (AML), long-term survival remains unresolved. Therefore, new agents that act more selectively and more potently are required. In that line, we have recently characterized a novel diterpene ester, called 3-hydrogenkwadaphnin (3-HK...

journal_title：Toxicology and applied pharmacology

authors： Moosavi MA,Yazdanparast R

更新日期：2008-07-01 00:00:00

abstract：:The industrial solvent ethylene glycol monomethyl ether (EGME) is a known teratogen that has been reported to alter calcium metabolism in guinea pigs during chronic exposure. Because of the tremendous demand of reproduction on maternal calcium stores, the effects of EGME on calcium and vitamin D metabolism during gest...

journal_title：Toxicology and applied pharmacology

authors： Toraason M,Niemeier RW,Hardin BD

更新日期：1986-11-01 00:00:00

abstract：:Male Wistar rats pretreated with ethanol (2.0 g in 80 ml liquid diet/day for 3 weeks) or phenobarbital (PB, 80 mg/kg/day ip for 4 days) were exposed by inhalation to 500, 1000, 2000, 4000, or 8000 ppm trichloroethylene (TRI) for 2 or 8 hr, and the blood concentration of TRI and the urinary concentration of TRI metabol...

journal_title：Toxicology and applied pharmacology

authors： Nakajima T,Okino T,Okuyama S,Kaneko T,Yonekura I,Sato A

更新日期：1988-06-30 00:00:00

abstract：:Juvenile rat toxicity studies with the direct renin inhibitor aliskiren were initiated to support treatment in the pediatric population. In Study 1, aliskiren was administered orally to juvenile rats at doses of 0, 30, 100 or 300 mg/kg/day with repeated dosing from postpartum day (PPD) 8 to PPD 35/36. In-life, clinica...

journal_title：Toxicology and applied pharmacology

authors： Hoffmann P,Beckman D,McLean LA,Yan JH

更新日期：2014-02-15 00:00:00

abstract：:Recent data suggest that vanadium (V5+) compounds exert protective effects against chemical-induced carcinogenesis, mainly through modifying various xenobiotic metabolizing enzymes. In fact, we have shown that V5+ down-regulates the expression of Cyp1a1 at the transcriptional level through an ATP-dependent mechanism. ...

journal_title：Toxicology and applied pharmacology

authors： Anwar-Mohamed A,El-Kadi AO

更新日期：2009-05-01 00:00:00

abstract：:Methyl bromide is used as a disinfectant to fumigate soil and a wide range of stored food commodities in warehouses and mills. Human exposure occurs during the manufacture and use of the chemical. The purpose of this investigation was to determine the disposition and metabolism of [14C]methyl bromide in rats after inh...

journal_title：Toxicology and applied pharmacology

authors： Bond JA,Dutcher JS,Medinsky MA,Henderson RF,Birnbaum LS

更新日期：1985-04-01 00:00:00

abstract：:The sensory irritant properties of ozone have been considered to be responsible for symptoms that occur in humans after exposure. This assumption has not been studied explicitly. One way to assess the aversive properties of airborne irritants is to give the exposed individual an opportunity to control the duration of ...

journal_title：Toxicology and applied pharmacology

authors： Tepper JS,Wood RW

更新日期：1985-05-01 00:00:00

abstract：:The immunoreactivity and pharmacokinetics of a new horse F(ab')2 scorpion antivenom and its effect on Buthus occitanus mardochei venom plasma disposition in the rabbit were studied. The scorpion venom-specific F(ab')2 affinity constant determined by immunoradiometric assay was 1.6 +/- 0.6 10(8) M-1. One group received...

journal_title：Toxicology and applied pharmacology

authors： Pépin-Covatta S,Lutsch C,Grandgeorge M,Lang J,Scherrmann JM

更新日期：1996-11-01 00:00:00

abstract：:3-Methylindole (3MI), a fermentation product of tryptophan produced by intestinal and ruminal microflora, has been shown to cause pneumotoxicity in several species subsequent to cytochrome P450-mediated biotransformation. Among several species studied, rabbits are comparatively resistant to 3MI-induced pneumotoxicity,...

journal_title：Toxicology and applied pharmacology

authors： Thornton-Manning JR,Nichols WK,Manning BW,Skiles GL,Yost GS

更新日期：1993-10-01 00:00:00

abstract：:For highly water soluble and reactive gases, such as formaldehyde, the reported distribution of nasal lesions in rats and rhesus monkeys following inhalation exposure may be attributable, at least in part, to regional gas uptake patterns that are a consequence of nasal airflow characteristics. Inspiratory nasal airflo...

journal_title：Toxicology and applied pharmacology

authors： Morgan KT,Kimbell JS,Monticello TM,Patra AL,Fleishman A

更新日期：1991-09-01 00:00:00

abstract：:We report that there is a time-related change in the phospholipase C (PLC) activities of rat brain cytosol and membrane fractions after iv injection of a soman-like or a sarin-like organophosphorous agent (bis(isopropyl methyl)phosphonate [BIMP] and bis(pinacolyl methyl)phosphonate [BPMP]). PLCgamma was activated in t...

journal_title：Toxicology and applied pharmacology

authors： Niijima H,Nagao M,Nakajima M,Takatori T,Matsuda Y,Iwase H,Kobayashi M

更新日期：1999-04-01 00:00:00

abstract：:Ethanol induces cumulative liver damage including steatosis, steatohepatitis and cirrhosis. The aim of this study is to investigate the global intrahepatic gene expression profile in the mouse liver treated with ethanol. A single oral dose of 0.5 or 5 g/kg ethanol was administered to male ICR mice, and liver samples w...

journal_title：Toxicology and applied pharmacology

authors： Yin HQ,Kim M,Kim JH,Kong G,Kang KS,Kim HL,Yoon BI,Lee MO,Lee BH

更新日期：2007-09-15 00:00:00

abstract：:The role of lipid peroxidation in the cell death produced by the haloalkene cysteine conjugates S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine (PCBC), S-(1,2-dichlorovinyl)-L-cysteine (DCVC), S-(1,1,2,2-tetrafluoroethyl)-L-cysteine (TFEC), and S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine (CTFC) was investigated using ...

journal_title：Toxicology and applied pharmacology

authors： Groves CE,Lock EA,Schnellmann RG

更新日期：1991-01-01 00:00:00

abstract：:Purified fetal bovine serum acetylcholinesterase (FBS AChE) and horse serum butyrylcholinesterase (BChE) were successfully used as single pretreatment drugs for the prevention of pinacolyl methylphosphonofluoridate (soman) toxicity in nonhuman primates. Eight rhesus monkeys, trained to perform Primate Equilibrium Plat...

journal_title：Toxicology and applied pharmacology

authors： Wolfe AD,Blick DW,Murphy MR,Miller SA,Gentry MK,Hartgraves SL,Doctor BP

更新日期：1992-12-01 00:00:00

abstract：:Two lines of evidence support the concept that cardiotoxin from Naja naja siamensis interacts directly with the plasma membrane to produce selective cytolysis of lymphocytes. Toxin adsorbed to the wells of microtiter plates retained the ability to lyse murine T-lymphocytes, but lost the ability to destroy natural kill...

journal_title：Toxicology and applied pharmacology

authors： Hinman CL,Jiang XL,Tang HP

更新日期：1990-06-15 00:00:00

abstract：:To assess the relevance of previously identified axonal atrophy to hexanedione neuropathy, the present study quantitated fiber size in peripheral nerve of rats intoxicated with 2,5-hexanedione (HD) by either oral ingestion (0.4% in drinking water) or ip injection (0.4 g/kg/day). Prior to the appearance of neurobehavio...

journal_title：Toxicology and applied pharmacology

authors： Lehning EJ,Dyer KS,Jortner BS,LoPachin RM

更新日期：1995-11-01 00:00:00

abstract：:To investigate the mechanisms of erythromycin cholestasis, the effects of erythromycin estolate (EE) on the excretory function of the isolated perfused rat liver and on liver plasma membrane (LM) preparations were studied and compared to those of erythromycin base (EB) and lauryl sulfate (LS), added alone or in combin...

journal_title：Toxicology and applied pharmacology

authors： Gaeta GB,Utili R,Adinolfi LE,Abernathy CO,Giusti G

更新日期：1985-09-15 00:00:00

abstract：:Embryo implantation is a crucial step in human reproduction and depends on the timely development of a receptive endometrium. The human endometrium is unique among adult tissues due to its dynamic alterations during each menstrual cycle. It hosts the implantation process which is governed by progesterone, whereas 17β-...

journal_title：Toxicology and applied pharmacology

authors： Fischer L,Deppert WR,Pfeifer D,Stanzel S,Weimer M,Hanjalic-Beck A,Stein A,Straßer M,Zahradnik HP,Schaefer WR

更新日期：2012-05-01 00:00:00

abstract：INTRODUCTION:Noncirrhotic portal fibrosis has been reported to occur in humans due to prolonged intake of arsenic contaminated water. Further, oxystress and hepatic fibrosis have been demonstrated by us in chronic arsenic induced hepatic damage in murine model. Cytokines like tumor necrosis factor alpha (TNF-alpha) and...

journal_title：Toxicology and applied pharmacology

authors： Das S,Santra A,Lahiri S,Guha Mazumder DN

更新日期：2005-04-01 00:00:00

abstract：:Age-dependent changes related to liver injury and regeneration were studied in rats aged 2, 12, and 30 months in a time period of 96 hr following a sublethal dose of thioacetamide (6.6 mmoles/kg body wt). Serum aspartate aminotransferase activity increased earlier in young rats, but the severity of injury was higher i...

journal_title：Toxicology and applied pharmacology

authors： Sanz N,Díez-Fernández C,Alvarez AM,Fernández-Simón L,Cascales M

更新日期：1999-01-01 00:00:00

abstract：:After a fire involving a transformer, the State Office Building in Binghamton, New York, was contaminated with soot containing polychlorinated biphenyls, biphenylenes, naphthalenes, dioxins, and dibenzofurans. The toxicity of the soot and its effect on liver morphology after prolonged (subchronic) exposure were determ...

journal_title：Toxicology and applied pharmacology

authors： Turner JN,Collins DN

更新日期：1984-05-01 00:00:00

abstract：:The threshold hemodynamic changes associated with the cardiovascular (CV) toxicity of minoxidil (MNX) in the dog, characterized by subendocardial necrosis, right atrial hemorrhagic lesions, and coronary vascular medial hemorrhage and necrosis, have not been defined. To determine the relationship between serum concentr...

journal_title：Toxicology and applied pharmacology

authors： Mesfin GM,Higgins MJ,Robinson FG,Zhong WZ

更新日期：1996-10-01 00:00:00

abstract：:1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin is a chemical inducer of Parkinson's disease (PD) whereas N-methylated beta-carbolines and isoquinolines are naturally occurring analogues of MPTP involved in PD. This research has studied the oxidation of MPTP by human CYP2D6 (CYP2D6*1 and CYP2D6*10 allel...

journal_title：Toxicology and applied pharmacology

authors： Herraiz T,Guillén H,Arán VJ,Idle JR,Gonzalez FJ

更新日期：2006-11-01 00:00:00

abstract：:Dietary consumption of phytoestrogens like genistein has been linked with lower incidence of prostate cancer. The estradiol-like benzopyran core of genistein confers estrogen receptor-β (ER-β) selectivity that imparts weak anti-proliferative activity against prostate cancer cells. DL-2-[4-(2-piperidinoethoxy)phenyl]-3...

journal_title：Toxicology and applied pharmacology

authors： Kumar R,Verma V,Sharma V,Jain A,Singh V,Sarswat A,Maikhuri JP,Sharma VL,Gupta G

更新日期：2015-03-15 00:00:00

abstract：:CD-1 mice were treated ip on Day 10 of gestation with 4, 6, or 7 g/kg ethanol. Maternal and embryonic tissues were analyzed for ethanol and acetaldehyde levels by head-space gas chromatography 5 min to 24 hr after treatment. Dose-dependent ethanol concentrations were observed in maternal blood and liver. Ethanol rapid...

journal_title：Toxicology and applied pharmacology

authors： Blakley PM,Scott WJ Jr

更新日期：1984-02-01 00:00:00

abstract：:Aromatase inhibitors like anastrozole play an undisputed key role in the treatment of breast cancer, but on the other hand, various side effects like osteoporosis and increased risk of bone fracture accompany the chronic administration of these drugs. Here we show for the first time that selenium nanoparticles, when g...

journal_title：Toxicology and applied pharmacology

authors： Vekariya KK,Kaur J,Tikoo K

更新日期：2013-04-15 00:00:00

abstract：:The Constitutive Androstane Receptor (CAR, NR1I3) has been newly described as a regulator of energy metabolism. A relevant number of studies using animal models of obesity suggest that CAR activation could be beneficial on the metabolic balance. However, this remains controversial and the underlying mechanisms are sti...

journal_title：Toxicology and applied pharmacology

authors： Marmugi A,Lukowicz C,Lasserre F,Montagner A,Polizzi A,Ducheix S,Goron A,Gamet-Payrastre L,Gerbal-Chaloin S,Pascussi JM,Moldes M,Pineau T,Guillou H,Mselli-Lakhal L

更新日期：2016-07-15 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) are persistent organic pollutants associated with non-alcoholic fatty liver disease (NAFLD) in epidemiologic studies. The purpose of this study was to evaluate the hepatic effects of a PCB mixture, Aroclor 1260, whose composition mimics human bioaccumulation patterns, in a mouse model ...

journal_title：Toxicology and applied pharmacology

authors： Wahlang B,Song M,Beier JI,Cameron Falkner K,Al-Eryani L,Clair HB,Prough RA,Osborne TS,Malarkey DE,States JC,Cave MC

更新日期：2014-09-15 00:00:00

abstract：:A physiologically based pharmacokinetic (PBPK) model describing transfer of inhaled tetrachloroethylene (PCE) into breast milk with the consequent exposure of the nursing pups was developed and validated in lactating rats. The PBPK model was based on partition coefficients (PCs), which were determined by the equilibra...

journal_title：Toxicology and applied pharmacology

authors： Byczkowski JZ,Kinkead ER,Leahy HF,Randall GM,Fisher JW

更新日期：1994-04-01 00:00:00

abstract：:Partition coefficients (PCs) are chemical-specific parameters used in physiologically based pharmacokinetic models to describe chemical solubility in tissues. Tissue:air PCs for volatile chemicals can be estimated using vial equilibration techniques in which the chemical concentration in the vial headspace is measured...

journal_title：Toxicology and applied pharmacology

authors： Teo SK,Kedderis GL,Gargas ML

更新日期：1994-09-01 00:00:00