Comparison of the effects of methyl-N-butyl ketone and phenobarbital on rat liver cytochromes P-450 and the metabolism of chloroform to phosgene.

abstract：:Following a formulation change, a leather conditioner was involved in a 1992 nationwide outbreak of respiratory illness. We investigated the composition and toxicity of the conditioner produced before (previous product) and after (new product) the disease outbreak. The new product induced tachypnea, pulmonary edema, p...

journal_title：Toxicology and applied pharmacology

authors： Hubbs AF,Castranova V,Ma JY,Frazer DG,Siegel PD,Ducatman BS,Grote A,Schwegler-Berry D,Robinson VA,Van Dyke C,Barger M,Xiang J,Parker J

更新日期：1997-03-01 00:00:00

abstract：:An experimental system was chosen to investigate the bioactivity of a lipoprotein-sequestered toxicant at the cellular level based on recent studies demonstrating receptor-mediated uptake of lipoproteins by macrophages. Rat peritoneal exudate cell suspensions (PEC) were exposed to DDT and lipoprotein-sequestered DDT, ...

journal_title：Toxicology and applied pharmacology

authors： Kaminski NE,Wells DS,Dauterman WC,Roberts JF,Guthrie FE

更新日期：1986-03-15 00:00:00

abstract：:The present study investigates the effects of nicotine treatment on exocrine pancreatic function. Adult male, Sprague-Dawley rats received nicotine via a time-release pellet, at a rate of 1.65 micrograms/min for 3 weeks. At the end of the experimental period, it was observed that although nicotine did not affect final...

journal_title：Toxicology and applied pharmacology

authors： Dubick MA,Palmer R,Lau PP,Morrill PR,Geokas MC

更新日期：1988-10-01 00:00:00

abstract：:2,2,4-Trimethylpentane (TMP), a component of unleaded gasoline, causes nephrotoxicity in male, but not in female, rats. In the present study, male and female Fischer 344 rats were treated with a single oral dose of [14C]TMP (4.4 mmol/kg; 2 microCi/mmol). Radiolabeled material in kidney, liver, and plasma was determine...

journal_title：Toxicology and applied pharmacology

authors： Charbonneau M,Lock EA,Strasser J,Cox MG,Turner MJ,Bus JS

更新日期：1987-11-01 00:00:00

abstract：:Interleukin-6 (IL-6) is a central mediator of immunotoxicity that is associated with exposure to the trichothecene vomitoxin (VT). The purpose of this investigation was to test the hypothesis that the inducible cyclooxygenase-2 (COX-2) and its metabolites contribute to VT-induced IL-6 upregulation. VT at 100 to 250 ng...

journal_title：Toxicology and applied pharmacology

authors： Moon Y,Pestka JJ

更新日期：2003-03-01 00:00:00

abstract：:This study was undertaken to determine the ability of a series of 19 compounds representing different chemical classes of carcinogens to induce lung tumors in strain A/J mice after either ip or po administration. Aflatoxin B1, dibutylnitrosamine, 1,2-dimethylhydrazine, and methylnitrosourea induced a significant incre...

journal_title：Toxicology and applied pharmacology

authors： Stoner GD,Conran PB,Greisiger EA,Stober J,Morgan M,Pereira MA

更新日期：1986-01-01 00:00:00

abstract：:Age-dependent changes related to liver injury and regeneration were studied in rats aged 2, 12, and 30 months in a time period of 96 hr following a sublethal dose of thioacetamide (6.6 mmoles/kg body wt). Serum aspartate aminotransferase activity increased earlier in young rats, but the severity of injury was higher i...

journal_title：Toxicology and applied pharmacology

authors： Sanz N,Díez-Fernández C,Alvarez AM,Fernández-Simón L,Cascales M

更新日期：1999-01-01 00:00:00

abstract：:The effect of butylated hydroxytoluene (BHT), which is used widely as an antioxidant, on IgE-dependent allergic responses in vivo and in vitro was investigated. For in vivo study, passive cutaneous anaphylaxis (PCA) was elicited in rats by i.d. injection of anti-DNP IgE and 48 h later by i.v. injection of DNP-HSA. BHT...

journal_title：Toxicology and applied pharmacology

authors： Yamaki K,Taneda S,Yanagisawa R,Inoue K,Takano H,Yoshino S

更新日期：2007-09-01 00:00:00

abstract：:Induction of hepatic metallothionein (MT) by urethane (ethyl carbamate) was characterized. Male CF-1 mice were treated with urethane (0, 0.5, 1.0, 1.5, and 2 g/kg; ip) and 18 hr later hepatic MT concentrations were determined with the Cd-hemoglobin radioassay. Urethane (1 g/kg and higher) significantly increased hepat...

journal_title：Toxicology and applied pharmacology

authors： Brzeznicka EA,Lehman LD,Klaassen CD

更新日期：1987-03-15 00:00:00

abstract：:Poly(amidoamine) (PAMAM) dendrimer nanoparticles have been demonstrated to elicit a well defined cytotoxicological response from mammalian cell lines, the response increasing systematically with dendrimer generation and number of surface amino groups. In this work, using generation G4, G5, and G6 dendrimers, this syst...

journal_title：Toxicology and applied pharmacology

authors： Mukherjee SP,Lyng FM,Garcia A,Davoren M,Byrne HJ

更新日期：2010-11-01 00:00:00

abstract：:Acrylonitrile (VCN) is a heavily used monomer in plastic and fiber industries. Quantitatively, VCN-induced gastrointestinal hemorrhage is time and dose dependent and is not the result of a direct irritating action of VCN on gastric tissues. The effect of cytochrome P-450 enzymes inducers was studied. Pretreatment with...

journal_title：Toxicology and applied pharmacology

authors： Ghanayem BI,Ahmed AE

更新日期：1983-04-01 00:00:00

abstract：:Chronic arsenic exposure through contaminated drinking water is a major environmental health issue. Chronic arsenic exposure is known to exert its toxic effects by a variety of mechanisms, of which generation of reactive oxygen species (ROS) is one of the most important. A high level of ROS, in turn, leads to DNA dama...

journal_title：Toxicology and applied pharmacology

authors： Banerjee M,Banerjee N,Ghosh P,Das JK,Basu S,Sarkar AK,States JC,Giri AK

更新日期：2010-11-15 00:00:00

abstract：:Rodent bioassays indicate that B6C3F1 mice are more sensitive to the carcinogenicity of benzene than are rats. The urinary profile of benzene metabolites is different in rats vs mice. Mice produce higher proportions of hydroquinone conjugates and muconic acid, indicators of metabolism via pathways leading to putative ...

journal_title：Toxicology and applied pharmacology

authors： Sabourin PJ,Muggenburg BA,Couch RC,Lefler D,Lucier G,Birnbaum LS,Henderson RF

更新日期：1992-06-01 00:00:00

abstract：:We developed an in vivo model for cadmium-induced bone loss in which mice excrete bone mineral in feces beginning 8 h after cadmium gavage. Female mice of three strains [CF1, MTN (metallothionein-wild-type), and MT1,2KO (MT1,2-deficient)] were placed on a low-calcium diet for 2 weeks. Each mouse was gavaged with 200 m...

journal_title：Toxicology and applied pharmacology

authors： Regunathan A,Glesne DA,Wilson AK,Song J,Nicolae D,Flores T,Bhattacharyya MH

更新日期：2003-09-15 00:00:00

abstract：:Metallothionein (MT) is a sulfhydryl-rich protein whose levels are increased by administration of a variety of agents including metals, cytokines, and oxidative stress agents. Recent studies have suggested that MT is involved in protecting against various forms of oxidative stress, but little is known about the induct...

journal_title：Toxicology and applied pharmacology

authors： Bauman JW,McKim JM Jr,Liu J,Klaassen CD

更新日期：1992-06-01 00:00:00

abstract：:Targeting excessive production of reactive oxygen species (ROS) could be an effective therapeutic strategy to prevent oxidative stress-associated gastrointestinal inflammation. NADPH oxidase (NOX) and mitochondrial complexes (I and II) are the major sources of ROS production contributing to TNF-α/cycloheximide (CHX)-i...

journal_title：Toxicology and applied pharmacology

authors： Babu D,Leclercq G,Goossens V,Remijsen Q,Vandenabeele P,Motterlini R,Lefebvre RA

更新日期：2015-10-15 00:00:00

abstract：:Coenzyme Q10 (CoQ10), which is a key cofactor of the electron transport chain in the mitochondria has shown many beneficial effects on liver diseases. However, the mechanisms of CoQ10 protective role on the acetaminophen (APAP)-induced liver injury are elusive and unclear. In this study, we further investigated the Co...

journal_title：Toxicology and applied pharmacology

authors： Zhang P,Chen S,Tang H,Fang W,Chen K,Chen X

更新日期：2021-01-01 00:00:00

abstract：:We have investigated the capacity of cultured whole rat embryos to convert 2-acetylaminofluorene (AAF) to reactive metabolites capable of eliciting dysmorphogenic effects in the same embryos. Cultured embryos (Sprague-Dawley) were exposed to AAF for periods of 2 or 24 hr, after which metabolites were isolated from the...

journal_title：Toxicology and applied pharmacology

authors： Juchau MR,Bark DH,Shewey LM,Greenaway JC

更新日期：1985-12-01 00:00:00

abstract：:Apocynin (acetovanillone) is often used as a specific inhibitor of NADPH oxidase. In N11 glial cells, apocynin induced, in a dose-dependent way, a significant increase of both malonyldialdehyde level (index of lipid peroxidation) and lactate dehydrogenase release (index of a cytotoxic effect). Apocynin evoked also, in...

journal_title：Toxicology and applied pharmacology

authors： Riganti C,Costamagna C,Bosia A,Ghigo D

更新日期：2006-05-01 00:00:00

abstract：:Recent breakthroughs in stem cell biology, especially the development of the induced pluripotent stem cell techniques, have generated tremendous enthusiasm and efforts to explore the therapeutic potential of stem cells in regenerative medicine. Stem cell therapies are being considered for the treatment of degenerative...

journal_title：Toxicology and applied pharmacology

authors： Sharpe ME,Morton D,Rossi A

更新日期：2012-08-01 00:00:00

abstract：:As the main toxic component of aristolochic acid, aristolochic acid I (AAI) is primarily found in Aristolochiaceae plants such as Aristolochia, Aristolochia fangchi and Caulis aristolochiae manshuriensis. AAI has been proven to be carcinogenic, mutagenic and nephrotoxic. Although the role of AAI in testicular toxicity...

journal_title：Toxicology and applied pharmacology

authors： Cui Y,Han J,Ren J,Chen H,Xu B,Song N,Li H,Liang A,Shen G

更新日期：2019-06-15 00:00:00

abstract：:The industrial solvent ethylene glycol monomethyl ether (EGME) is a known teratogen that has been reported to alter calcium metabolism in guinea pigs during chronic exposure. Because of the tremendous demand of reproduction on maternal calcium stores, the effects of EGME on calcium and vitamin D metabolism during gest...

journal_title：Toxicology and applied pharmacology

authors： Toraason M,Niemeier RW,Hardin BD

更新日期：1986-11-01 00:00:00

abstract：:A cadmium-binding substance with a molecular weight even lower than that of metallothionein was demonstrated on Sephadex G-75 gel filtration chromatography of the soluble fractions from newborn human and adult rat liver homogenates and adult human hemolysate which were mixed with CdCl2 in vitro. This substance was pur...

journal_title：Toxicology and applied pharmacology

authors： Katoh M,Mizutani N,Keino H,Kashiwamata S

更新日期：1984-03-30 00:00:00

abstract：:The differential effects of oral and dermal administration of single doses of 100 to 1000 mg/kg S,S,S-tri-n-butyl phosphorotrithioate (DEF) on nonspecific esterases and liver metabolism enzymes were investigated one day following administration. O,O-Diethyl O-(4-nitrophenyl) phosphorothioate (parathion) and tri-o-cres...

journal_title：Toxicology and applied pharmacology

authors： Lapadula DM,Carrington CD,Abou-Donia MB

更新日期：1984-04-01 00:00:00

abstract：:The mechanisms of action of o,p'-DDD on adrenal steroidogenesis were investigated in vitro in rainbow trout (Oncorhynchus mykiss). Acute exposures to o,p'-DDD inhibited ACTH-stimulated cortisol secretion while cell viability decreased significantly only at the highest concentration tested (200 microM o,p'-DDD). Stimul...

journal_title：Toxicology and applied pharmacology

authors： Lacroix M,Hontela A

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Bleeding episodes commonly occur in patients on warfarin treatment even in those within therapeutic range of international normalized ratio (INR). The objective of this study was to investigate the effects of the 8 examined polymorphisms on the risk of bleeding complications in a sample of Iranian patients. ...

journal_title：Toxicology and applied pharmacology

authors： Pourgholi L,Goodarzynejad H,Mandegary A,Ziaee S,Talasaz AH,Jalali A,Boroumand M

更新日期：2016-10-15 00:00:00

abstract：:Mycotoxin citrinin (CTN) is commonly found in foods and feeds that are contaminated/inoculated with Penicillium, Aspergillus and Monascus species. The exposure of human embryonic kidney (HEK293) and HeLa cells to CTN resulted in a dose-dependent increase in the phosphorylation of two major mitogen-activated protein ki...

journal_title：Toxicology and applied pharmacology

authors： Chang CH,Yu FY,Wang LT,Lin YS,Liu BH

更新日期：2009-06-15 00:00:00

abstract：:Menadione (2-methyl-1,4-naphthoquinone, a redox cycling and arylating quinone; 5-100 microM) inhibited the canalicular vacuolar accumulation (CVA) of a fluorescent bile acid, cholyl-lysyl-fluorescein (CLF), in rat hepatocyte couplets. This was associated with depletion of reduced glutathione and accumulation of oxidiz...

journal_title：Toxicology and applied pharmacology

authors： Stone V,Coleman R,Chipman JK

更新日期：1996-06-01 00:00:00

abstract：UNLABELLED:Traffic related particulate matter air pollution is a risk factor for cardiovascular events; however, the biological mechanisms are unclear. We hypothesize that diesel exhaust (DE) inhalation induces up-regulation of inducible nitric oxide synthase (iNOS), which is known to contribute to vascular dysfunction...

journal_title：Toxicology and applied pharmacology

authors： Bai N,Kido T,Kavanagh TJ,Kaufman JD,Rosenfeld ME,van Breemen C,van Eeden SF

更新日期：2011-09-01 00:00:00

abstract：:According to the advocated paradigm shift in toxicology, acquisition of knowledge on the mechanisms underlying the toxicity of chemicals, such as perturbations of biological pathways, is of primary interest. Pluripotent stem cells (PSCs), such as human embryonic stem cells (hESCs) and human induced pluripotent stem ce...

journal_title：Toxicology and applied pharmacology

authors： Pistollato F,Louisse J,Scelfo B,Mennecozzi M,Accordi B,Basso G,Gaspar JA,Zagoura D,Barilari M,Palosaari T,Sachinidis A,Bremer-Hoffmann S

更新日期：2014-10-15 00:00:00