A low-molecular-weight cadmium-binding substance in human and rat livers and human blood.

abstract：:In order to elucidate the oxidative effects and genotoxicity of nickel on human lymphocytes in vitro, we report the level of intracellular reactive oxygen species (ROS), lipid peroxidation, hydroxyl radical ((*)OH), and DNA damage in human lymphocytes after acute exposure to inorganic nickel. NiCl(2) appeared to incre...

journal_title：Toxicology and applied pharmacology

authors： Chen CY,Wang YF,Huang WR,Huang YT

更新日期：2003-06-15 00:00:00

abstract：:Vinylcyclohexene (VCH) is an industrial byproduct that is known to cause the destruction of ovarian follicles in mice. Its analog, 4-phenylcyclohexene (4PC), is a volatile product from latex-backed carpeting. These studies were undertaken to assess the structure-activity relationships of these compounds and the potent...

journal_title：Toxicology and applied pharmacology

authors： Hooser SB,Parola LR,Van Ert MD,Sipes IG

更新日期：1993-04-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) activate neutrophils to induce degranulation and undergo superoxide production through a mechanism that involves stimulation of phospholipase A(2) (PLA(2)). Since the biochemical processes leading to the PCB-induced activation of this enzyme are unknown, the objective of this study was...

journal_title：Toxicology and applied pharmacology

authors： Olivero J,Ganey PE

更新日期：2000-02-15 00:00:00

abstract：:Hexachlorobenzene (HCB) induces hepatic porphyria and liver cancer in female rats, whereas toxicity is minimal in male rats. HCB is biotransformed to sulfur-containing metabolites originating from conjugation to glutathione (GSH). This study aimed to assess differences in GSH conjugation of HCB between male and female...

journal_title：Toxicology and applied pharmacology

authors： D'Amour M,Charbonneau M

更新日期：1992-02-01 00:00:00

abstract：:Several large epidemiological and animal studies demonstrate a direct correlation between dietary heme iron intake and/or systemic iron levels and cancer risk in several cancers including colorectal cancer (CRC). However, the precise mechanisms for how heme iron contributes to CRC and how cancer cells respond to heme ...

journal_title：Toxicology and applied pharmacology

authors： Kim H,Yin K,Falcon DM,Xue X

更新日期：2019-07-01 00:00:00

abstract：:Acetaminophen (APAP) nephrotoxicity has been observed both in humans and research animals. Recent studies suggest a contributory role for glutathione (GSH)-derived conjugates of APAP in the development of nephrotoxicity. Inhibitors of either gamma-glutamyl transpeptidase (gamma-GT) or the probenecid-sensitive organic ...

journal_title：Toxicology and applied pharmacology

authors： Stern ST,Bruno MK,Hennig GE,Horton RA,Roberts JC,Cohen SD

更新日期：2005-01-15 00:00:00

abstract：:Histone deacetylase inhibitors (HDI) have been shown to increase differentiation-related gene expression in several tumor-derived cell lines by hyperacetylating core histones. Effects of HDI on primary cultured cells, however, have hardly been investigated. In the present study, the ability of trichostatin A (TSA), a ...

journal_title：Toxicology and applied pharmacology

authors： Henkens T,Papeleu P,Elaut G,Vinken M,Rogiers V,Vanhaecke T

更新日期：2007-01-01 00:00:00

abstract：:Studies in recent years have revealed that excess mitochondrial superoxide production is an important etiological factor in neurodegenerative diseases, resulting from oxidative modifications of cellular lipids, proteins, and nucleic acids. Hence, it is important to understand the mechanism by which mitochondrial oxida...

journal_title：Toxicology and applied pharmacology

authors： Fukui M,Choi HJ,Zhu BT

更新日期：2012-07-15 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD),12 the most toxic congener of dioxins, exhibits wide sensitivity differences between a sensitive Long-Evans (L-E) rat and a resistant Han/Wistar (H/W) rat. The sensitivity is determined probably by two autosomal genes and it is highly end point dependent. The difference is mo...

journal_title：Toxicology and applied pharmacology

authors： Tuomisto JT,Viluksela M,Pohjanvirta R,Tuomisto J

更新日期：1999-02-15 00:00:00

abstract：:Thiazacridine derivatives (ATZD) are a novel class of cytotoxic agents that combine an acridine and thiazolidine nucleus. In this study, the cytotoxic action of four ATZD were tested in human colon carcinoma HCT-8 cells: (5Z)-5-acridin-9-ylmethylene-3-(4-methylbenzyl)-thiazolidine-2,4-dione - AC-4; (5ZE)-5-acridin-9-y...

journal_title：Toxicology and applied pharmacology

authors： Barros FW,Bezerra DP,Ferreira PM,Cavalcanti BC,Silva TG,Pitta MG,de Lima Mdo C,Galdino SL,Pitta Ida R,Costa-Lotufo LV,Moraes MO,Burbano RR,Guecheva TN,Henriques JA,Pessoa C

更新日期：2013-04-01 00:00:00

abstract：:Human-based in silico models are emerging as important tools to study the effects of integrating inward and outward ion channel currents to predict clinical proarrhythmic risk. The aims of this study were 2-fold: 1) Evaluate the capacity of an in silico model to predict QTc interval prolongation in the in vivo anesthe...

journal_title：Toxicology and applied pharmacology

authors： Morissette P,Polak S,Chain A,Zhai J,Imredy JP,Wildey MJ,Travis J,Fitzgerald K,Fanelli P,Passini E,Rodriguez B,Sannajust F,Regan C

更新日期：2020-03-01 00:00:00

abstract：:Calcium channel blockers (CCBs) are important in the management of hypertension and limit restenosis. Although CCB efficacy could derive from decreased blood pressure, other mechanisms independent of CCB activity also can contribute to antiproliferative action. To understand mechanisms of CCB-mediated antiproliferatio...

journal_title：Toxicology and applied pharmacology

authors： Salabei JK,Balakumaran A,Frey JC,Boor PJ,Treinen-Moslen M,Conklin DJ

更新日期：2012-08-01 00:00:00

abstract：:Epidemiological studies have established a positive correlation between human mortality and increased concentration of airborne particulate matters (PM). However, the mechanisms underlying PM related human diseases, as well as the molecules and pathways mediating the cellular response to PM, are not fully understood. ...

journal_title：Toxicology and applied pharmacology

authors： Sun H,Shamy M,Kluz T,Muñoz AB,Zhong M,Laulicht F,Alghamdi MA,Khoder MI,Chen LC,Costa M

更新日期：2012-12-01 00:00:00

abstract：:Cyclosporin (Cs), a cyclic nonpolar undecapeptide of fungal origin, has potent immunosuppressive and antiparasitic activities, and renal and hepatic toxicities, the mechanisms of which are not worked out. Many nephrotoxins and hepatotoxins are predictably more or less harmful, depending upon the circadian stage at whi...

journal_title：Toxicology and applied pharmacology

authors： Magnus G,Cavallini M,Halberg F,Cornelissen G,Sutherland DE,Najarian JA,Hrushesky WJ

更新日期：1985-01-01 00:00:00

abstract：:The catalytic activities of glutathione S-transferases (GSTs), particularly the alpha-class isozymes, can provide protection against oxidative stress through GSH-mediated metabolism of reactive products of lipid peroxidation. Lipid peroxidation products from oxidative metabolism in alveolar macrophages play an importa...

journal_title：Toxicology and applied pharmacology

authors： Morrison RJ,Singhal SS,Bidani A,Heming TA,Awasthi S

更新日期：1998-02-01 00:00:00

abstract：:Previous studies performed in this laboratory have shown that certain benzo(a)pyrene (BaP) metabolites, such as benzo(a)pyrene-7,8-dihydrodiol (BaP-7,8-diol) and benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE), were more effective in elevating intracellular Ca2+ in normal human peripheral blood mononuclear cell (HP...

journal_title：Toxicology and applied pharmacology

authors： Mounho BJ,Burchiel SW

更新日期：1998-03-01 00:00:00

abstract：:Steatosis is the characteristic type of VPA-induced hepatotoxicity and may result in life-threatening hepatic lesion. Approximately 61% of patients treated with VPA have been diagnosed with hepatic steatosis through ultrasound examination. However, the mechanisms underlying VPA-induced intracellular fat accumulation a...

journal_title：Toxicology and applied pharmacology

authors： Bai X,Hong W,Cai P,Chen Y,Xu C,Cao D,Yu W,Zhao Z,Huang M,Jin J

更新日期：2017-06-01 00:00:00

abstract：:Mercury (Hg) has long been recognized as a neurotoxicant; however, recent work in animal models has implicated Hg as an immunotoxicant. In particular, Hg has been shown to induce autoimmune disease in susceptible animals with effects including overproduction of specific autoantibodies and pathophysiologic signs of lup...

journal_title：Toxicology and applied pharmacology

authors： Silbergeld EK,Silva IA,Nyland JF

更新日期：2005-09-01 00:00:00

abstract：:Recent studies have demonstrated that macrophages are the cell types capable of metabolizing benzo[a]pyrene (B(a)P) within the spleens of untreated mice. Since repeated exposure to B(a)P results in immunosuppression and B(a)P is known to induce cytochrome P450 levels, the first objective of this study was to investiga...

journal_title：Toxicology and applied pharmacology

authors： Ladics GS,Kawabata TT,Munson AE,White KL Jr

更新日期：1992-10-01 00:00:00

abstract：:Freely moving rats were exposed to sarin vapor (34.2+/-0.8 microg/l) for 10 min. Mortality at 24 h was 35% and toxic sings in the surviving rats ranged from sever (prolonged convulsions) through moderate to almost no overt signs. Some of the surviving rats developed delayed, intermittent convulsions. All rats were eva...

journal_title：Toxicology and applied pharmacology

authors： Grauer E,Chapman S,Rabinovitz I,Raveh L,Weissman BA,Kadar T,Allon N

更新日期：2008-03-01 00:00:00

abstract：:The present study was conducted to clarify the acute effect of tris(2-chloroethyl)phosphate (TRCP), an organophosphate flame-retardant, on spontaneous ambulatory activity (AA) in male ICR mice and to examine the neurochemical mechanism of this effect. Single dose administration of 200 mg/kg i.p. of TRCP increased AA i...

journal_title：Toxicology and applied pharmacology

authors： Umezu T,Yonemoto J,Soma Y,Suzuki T

更新日期：1998-01-01 00:00:00

abstract：:Phytochemicals show promise as potential chemopreventive or chemotherapeutic agents against various cancers. Here we report the chemotherapeutic effects of berberine, a phytochemical, on human prostate cancer cells. The treatment of human prostate cancer cells (PC-3) with berberine induced dose-dependent apoptosis but...

journal_title：Toxicology and applied pharmacology

authors： Meeran SM,Katiyar S,Katiyar SK

更新日期：2008-05-15 00:00:00

abstract：:While the physiologic and molecular effects of capsaicinoids have been extensively studied in various model systems by a variety of administration routes, little is known about the uptake and elimination kinetic profiles in human skin following topical exposure. The present study evaluated the uptake and elimination k...

journal_title：Toxicology and applied pharmacology

authors： Pershing LK,Reilly CA,Corlett JL,Crouch DJ

更新日期：2004-10-01 00:00:00

abstract：:The role of metallothionein or metallothionein-like proteins (MT) in genetic resistance to the testicular and hepatic toxicity of cadmium was examined in inbred strains of mice. Mice of two strains resistant (AJ and C3H/HEJ) or susceptible (129J and DBA/2J) to cadmium-induced testicular necrosis were administered sc 3...

journal_title：Toxicology and applied pharmacology

authors： Nolan CV,Shaikh ZA

更新日期：1986-09-15 00:00:00

abstract：:Contact sensitization is caused by low molecular weight compounds which penetrate the skin and bind to protein. In many cases, these compounds are activated to reactive species, either by autoxidation on exposure to air or by metabolic activation in the skin. Geraniol, a widely used fragrance chemical, is considered t...

journal_title：Toxicology and applied pharmacology

authors： Hagvall L,Baron JM,Börje A,Weidolf L,Merk H,Karlberg AT

更新日期：2008-12-01 00:00:00

abstract：:Previous studies in this laboratory have shown that polycyclic aromatic hydrocarbons (PAHs) alter Ca2+ homeostasis and inhibit activation of both B and T lymphocytes obtained from rodents and humans. In the present studies, we demonstrate that alpha-naphthoflavone (ANF), an inhibitor of cytochrome P4501A activity, red...

journal_title：Toxicology and applied pharmacology

authors： Romero DL,Mounho BJ,Lauer FT,Born JL,Burchiel SW

更新日期：1997-05-01 00:00:00

abstract：:Methyl bromide is used as a disinfectant to fumigate soil and a wide range of stored food commodities in warehouses and mills. Human exposure occurs during the manufacture and use of the chemical. The purpose of this investigation was to determine the disposition and metabolism of [14C]methyl bromide in rats after inh...

journal_title：Toxicology and applied pharmacology

authors： Bond JA,Dutcher JS,Medinsky MA,Henderson RF,Birnbaum LS

更新日期：1985-04-01 00:00:00

abstract：:The influence of carbon monoxide (CO) on the development of systemic hypertension was studied in Dahl rats selectively bred for susceptibility (DS) and resistance (DR) to NaCl-induced hypertension. This study was designed to examine the interactions among rat line (DS or DR), NaCl content of diet, and exposure to CO. ...

journal_title：Toxicology and applied pharmacology

authors： Shiotsuka RN,Drew RT,Wehner RW

更新日期：1984-11-01 00:00:00

abstract：:Kidney is the primary target organ in chronic cadmium (Cd) toxicity, and oxidative stress plays an important role in this process. The nuclear transcription factor Nrf2 binds to antioxidant response elements (AREs) and regulates genes involved in protecting cells from oxidative damage. Whether kidney cells respond to ...

journal_title：Toxicology and applied pharmacology

authors： Chen J,Shaikh ZA

更新日期：2009-11-15 00:00:00

abstract：:Statins are widely used to treat lipid disorders. These drugs are safe and well tolerated; however, in <1% of patients, myopathy and/or rhabdomyolysis can develop. To better understand the mechanism of statin-induced myopathy, we examined the ability of structurally distinct statins to induce apoptosis in an optimized...

journal_title：Toxicology and applied pharmacology

authors： Johnson TE,Zhang X,Bleicher KB,Dysart G,Loughlin AF,Schaefer WH,Umbenhauer DR

更新日期：2004-11-01 00:00:00