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Nickel induces oxidative stress and genotoxicity in human lymphocytes.

Abstract：

:In order to elucidate the oxidative effects and genotoxicity of nickel on human lymphocytes in vitro, we report the level of intracellular reactive oxygen species (ROS), lipid peroxidation, hydroxyl radical ((*)OH), and DNA damage in human lymphocytes after acute exposure to inorganic nickel. NiCl(2) appeared to increase the formation of the fluorescent oxidized compound dichlorofluorescein (DCF). Lipid peroxidation in lymphocytes significantly increased compared to control. 2,3- and 2,5-DHB increased markedly in a concentration-dependent manner. Single-strand DNA breakage induced by Ni in lymphocytes was evaluated by Comet assay. Significant increase in DNA damage score (arbitrary units) showed a dose-related elevation after treatment with NiCl(2). NiCl(2) induced lipid peroxidation at 0.5 mM but had no effect on DNA strand breakage. These results support the emerging concept that NiCl(2)-induced oxidative stress and genotoxicity may be caused by oxygen radical intermediates. NiCl(2)-induced DNA strand breakage is related to the generation of the (*)OH radical.

journal_name

Toxicol Appl Pharmacol

journal_title

Toxicology and applied pharmacology

authors

Chen CY,Wang YF,Huang WR,Huang YT

doi

10.1016/s0041-008x(03)00086-3

subject

Has Abstract

pub_date

2003-06-15 00:00:00

pages

153-9

issue

3

eissn

0041-008X

issn

1096-0333

pii

S0041008X03000863

journal_volume

189

pub_type

杂志文章

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