Acute lung injury induced by a commercial leather conditioner.

abstract：:The InnoMed PredTox consortium was formed to evaluate whether conventional preclinical safety assessment can be significantly enhanced by incorporation of molecular profiling ("omics") technologies. In short-term toxicological studies in rats, transcriptomics, proteomics and metabolomics data were collected and analyz...

journal_title：Toxicology and applied pharmacology

authors： Ellinger-Ziegelbauer H,Adler M,Amberg A,Brandenburg A,Callanan JJ,Connor S,Fountoulakis M,Gmuender H,Gruhler A,Hewitt P,Hodson M,Matheis KA,McCarthy D,Raschke M,Riefke B,Schmitt CS,Sieber M,Sposny A,Suter L,Sweatman

更新日期：2011-04-15 00:00:00

abstract：:The effect of maternal selenium deficiency on methyl mercury fetotoxicity was examined in the ICR strain of mice. Pregnant mice were fed either selenium-deficient diets based on torula yeast or selenium-supplemented diets which were identical to the former except that 0.1, 0.2, or 0.4 mg of selenium per kilogram of di...

journal_title：Toxicology and applied pharmacology

authors： Nishikido N,Furuyashiki K,Naganuma A,Suzuki T,Imura N

更新日期：1987-05-01 00:00:00

abstract：:Methyl palmitate (MP) has been shown earlier to inhibit Kupffer cells and rat peritoneal macrophages. To evaluate the potential of MP to inhibit the activation of other macrophages, RAW cells (macrophages of alveolar origin) were treated with varying concentrations of MP (0.25, 0.5, 1mM). Assessment of cytotoxicity us...

journal_title：Toxicology and applied pharmacology

authors： El-Demerdash E

更新日期：2011-08-01 00:00:00

abstract：:Biochemical, functional and morphologic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the hearts of female rats were examined. Six days after the treatment of rats with TCDD, the blood pressures and resting heart rates were significantly less than in control animals. Treated animals were also less responsiv...

journal_title：Toxicology and applied pharmacology

authors： Hermansky SJ,Holcslaw TL,Murray WJ,Markin RS,Stohs SJ

更新日期：1988-09-15 00:00:00

abstract：:Although piperonyl butoxide (PBO) is commonly used both in vivo and in vitro as an inhibitor of cytochrome P-450-dependent monooxygenase (MO) activity in a wide variety of species, the effect of PBO on the hepatic MO of fishes has never been characterized. The MO activity in hepatic microsomes from rainbow trout expos...

journal_title：Toxicology and applied pharmacology

authors： Erickson DA,Goodrich MS,Lech JJ

更新日期：1988-06-15 00:00:00

abstract：:Application of global gene expression analysis in the study of mechanisms of toxicity could provide a more comprehensive interpretation of the molecular basis of drug action. WAY-144122 has pharmacological activity against several targets improving insulin responsiveness and favorably altering lipid profiles. Normal r...

journal_title：Toxicology and applied pharmacology

authors： Peterson RL,Casciotti L,Block L,Goad ME,Tong Z,Meehan JT,Jordan RA,Vinlove MP,Markiewicz VR,Weed CA,Dorner AJ

更新日期：2004-04-01 00:00:00

abstract：:The influence of carbon monoxide (CO) on the development of systemic hypertension was studied in Dahl rats selectively bred for susceptibility (DS) and resistance (DR) to NaCl-induced hypertension. This study was designed to examine the interactions among rat line (DS or DR), NaCl content of diet, and exposure to CO. ...

journal_title：Toxicology and applied pharmacology

authors： Shiotsuka RN,Drew RT,Wehner RW

更新日期：1984-11-01 00:00:00

abstract：:In the present study we have examined the effects of hydrocarbons on the formation of reactive oxygen species (ROS) in human neutrophil granulocytes in vitro. We found that hydrocarbons induce ROS formation in a concentration-dependent manner and that the ROS-inducing potency increases with increasing number of carbon...

journal_title：Toxicology and applied pharmacology

authors： Dreiem A,Myhre O,Fonnum F

更新日期：2003-07-15 00:00:00

abstract：:Inflammatory responses are accompanied by increased expression of hepatocyte-derived proteins collectively known as acute phase reactants (APR). B6C3F1 female mice were exposed intraperitoneally every 24 hr to either vehicle (PBS) or DMN (5 mg/kg) for up to six exposures. Following a single treatment (acute), liver ti...

journal_title：Toxicology and applied pharmacology

authors： Lockwood JF,Rutherford MS,Myers MJ,Schook LB

更新日期：1994-04-01 00:00:00

abstract：:The Constitutive Androstane Receptor (CAR, NR1I3) has been newly described as a regulator of energy metabolism. A relevant number of studies using animal models of obesity suggest that CAR activation could be beneficial on the metabolic balance. However, this remains controversial and the underlying mechanisms are sti...

journal_title：Toxicology and applied pharmacology

authors： Marmugi A,Lukowicz C,Lasserre F,Montagner A,Polizzi A,Ducheix S,Goron A,Gamet-Payrastre L,Gerbal-Chaloin S,Pascussi JM,Moldes M,Pineau T,Guillou H,Mselli-Lakhal L

更新日期：2016-07-15 00:00:00

abstract：:Brominated flame retardants (BFRs) are present in many consumer products ranging from fabrics to plastics and electronics. Wide use of flame retardants can pose an environmental hazard and it is of interest to determine the mechanism of their toxicity. Of all the BFRs, 3,3',5,5'-tetrabromobisphenol A (TBBPA) is produc...

journal_title：Toxicology and applied pharmacology

authors： Chignell CF,Han SK,Mouithys-Mickalad A,Sik RH,Stadler K,Kadiiska MB

更新日期：2008-07-01 00:00:00

abstract：:Excessive fetal glucocorticoid exposure has been linked to increased susceptibility to hypertension and cardiac diseases in the adult life, a process called fetal programming. The cardiac contribution to the hypertensive phenotype of glucocorticoid-programmed progeny is less known, therefore, we investigated in vitro ...

journal_title：Toxicology and applied pharmacology

authors： Kiguti LRA,Borges CS,Mueller A,Silva KP,Polo CM,Rosa JL,Silva PV,Missassi G,Valencise L,Kempinas WG,Pupo AS

更新日期：2017-11-01 00:00:00

abstract：:The epithelial-mesenchymal transition (EMT) is a critical stage during the development of silicosis fibrosis. In the current study, we hypothesized that the anti-fibrotic tetrapeptide, N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) may exert its anti-fibrotic effects via activation of the TGF-β1/ROCK1 pathway, leadin...

journal_title：Toxicology and applied pharmacology

authors： Deng H,Xu H,Zhang X,Sun Y,Wang R,Brann D,Yang F

更新日期：2016-03-01 00:00:00

abstract：:As a class, the biguanides induce lactic acidosis, a hallmark of mitochondrial impairment. To assess potential mitochondrial impairment, we evaluated the effects of metformin, buformin and phenformin on: 1) viability of HepG2 cells grown in galactose, 2) respiration by isolated mitochondria, 3) metabolic poise of HepG...

journal_title：Toxicology and applied pharmacology

authors： Dykens JA,Jamieson J,Marroquin L,Nadanaciva S,Billis PA,Will Y

更新日期：2008-12-01 00:00:00

abstract：:A clinical study was performed to determine the effects of patch testing human skin with four industrially used surfactants on erythema formation, transepidermal water loss, and the contents in suction blister fluids of primary proinflammatory mediators including arachidonic acid, eicosanoids, and IL-1 alpha, which we...

journal_title：Toxicology and applied pharmacology

authors： Müller-Decker K,Heinzelmann T,Fürstenberger G,Kecskes A,Lehmann WD,Marks F

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVE:To provide insights into the mode of action for Ni3S2 lung carcinogenicity by examining gene expression changes in target cells after inhalation exposure. METHODS:Gene expression changes were determined in micro-dissected lung broncho-alveolar cells from Fischer 344 rats following inhalation of Ni3S2 at 0.0,...

journal_title：Toxicology and applied pharmacology

authors： Efremenko AY,Campbell JL Jr,Dodd DE,Oller AR,Clewell HJ 3rd

更新日期：2014-09-15 00:00:00

abstract：:The role of metallothionein or metallothionein-like proteins (MT) in genetic resistance to the testicular and hepatic toxicity of cadmium was examined in inbred strains of mice. Mice of two strains resistant (AJ and C3H/HEJ) or susceptible (129J and DBA/2J) to cadmium-induced testicular necrosis were administered sc 3...

journal_title：Toxicology and applied pharmacology

authors： Nolan CV,Shaikh ZA

更新日期：1986-09-15 00:00:00

abstract：:Many studies of nanomaterials make non-systematic alterations of nanoparticle physicochemical properties. Given the immense size of the property space for nanomaterials, such approaches are not very useful in elucidating fundamental relationships between inherent physicochemical properties of these materials and their...

journal_title：Toxicology and applied pharmacology

authors： Bai X,Liu F,Liu Y,Li C,Wang S,Zhou H,Wang W,Zhu H,Winkler DA,Yan B

更新日期：2017-05-15 00:00:00

abstract：:Intracellular retention of toxic bile salts contributes to hepatocellular injury during cholestasis. We have recently demonstrated that toxic bile salts directly induce apoptosis in hepatocytes. As oxidative stress has been implicated in many models of apoptosis, our aim was to determine if oxidative injury is a criti...

journal_title：Toxicology and applied pharmacology

authors： Patel T,Gores GJ

更新日期：1997-01-01 00:00:00

abstract：:Arsenic is an environmental toxicant and carcinogen. Exposure to arsenic is associated with development of liver fibrosis and portal hypertension through ill defined mechanisms. We evaluated hepatic fibrogenesis after long term arsenic exposure in a murine model. BALB/c mice were exposed to arsenic by daily gavages of...

journal_title：Toxicology and applied pharmacology

authors： Ghatak S,Biswas A,Dhali GK,Chowdhury A,Boyer JL,Santra A

更新日期：2011-02-15 00:00:00

abstract：:Acetaminophen (APAP) administration (600 mg/kg, ip) to 18-hr fasted, 3-month-old male CD-1 mice results in necrosis of the convoluted renal proximal tubules with a corresponding elevation of plasma urea nitrogen (BUN). Administration of the gamma-glutamyl transpeptidase inhibitor, L-(alpha S,5S)-alpha-amino-3-chloro-4...

journal_title：Toxicology and applied pharmacology

authors： Emeigh Hart SG,Wyand DS,Khairallah EA,Cohen SD

更新日期：1996-01-01 00:00:00

abstract：:Statins are widely used to treat lipid disorders. These drugs are safe and well tolerated; however, in <1% of patients, myopathy and/or rhabdomyolysis can develop. To better understand the mechanism of statin-induced myopathy, we examined the ability of structurally distinct statins to induce apoptosis in an optimized...

journal_title：Toxicology and applied pharmacology

authors： Johnson TE,Zhang X,Bleicher KB,Dysart G,Loughlin AF,Schaefer WH,Umbenhauer DR

更新日期：2004-11-01 00:00:00

abstract：:To evaluate the effect of exposure to an environmentally relevant polychlorinated biphenyl mixture, adult male rats were treated with Aroclor 1260 for 7 days and levels of several cytochrome P450 (CYP) enzymes were measured in liver microsomes prepared 3 days after the last dose. Treatment with Aroclor 1260 at dosages...

journal_title：Toxicology and applied pharmacology

authors： Ngui JS,Bandiera SM

更新日期：1999-12-01 00:00:00

abstract：:Direct additions to culture media of either acetaminophen (APAP) or 7-hydroxy-2-acetylaminofluorene (7-OH-AAF) resulted in abnormal closure of the anterior neuropores of cultured rat embryos in the absence of an exogenous bioactivation system. Concentrations required to produce a 50% incidence of the defect were appro...

journal_title：Toxicology and applied pharmacology

authors： Harris C,Stark KL,Luchtel DL,Juchau MR

更新日期：1989-12-01 00:00:00

abstract：:The autoradiographic distribution of the toxic heavy metal nickel (Ni) was studied at 4 and 7 days post-coxsackievirus B3 (CB3) infection in Balb/c mice. The distribution of the iv injected 63Ni was studied 10 min, 4 hr, and 24 hr after administration. Results clearly show that the site of 63Ni accumulation is greatly...

journal_title：Toxicology and applied pharmacology

authors： Ilbäck NG,Fohlman J,Friman G

更新日期：1992-05-01 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a highly toxic environmental pollutant and is well known for inducing thymic atrophy in mice, although the exact mechanism of its action remains unclear. Recent studies from our laboratory demonstrated that TCDD induces apoptosis in thymocytes and that Fas- mice (lpr/lpr) ...

journal_title：Toxicology and applied pharmacology

authors： Kamath AB,Nagarkatti PS,Nagarkatti M

更新日期：1998-05-01 00:00:00

abstract：:Juvenile rat toxicity studies with the direct renin inhibitor aliskiren were initiated to support treatment in the pediatric population. In Study 1, aliskiren was administered orally to juvenile rats at doses of 0, 30, 100 or 300 mg/kg/day with repeated dosing from postpartum day (PPD) 8 to PPD 35/36. In-life, clinica...

journal_title：Toxicology and applied pharmacology

authors： Hoffmann P,Beckman D,McLean LA,Yan JH

更新日期：2014-02-15 00:00:00

abstract：:Occupational exposure to nickel (Ni), chromium (Cr), and arsenic (As) containing compounds has been associated with lung cancer and other adverse health effects. Their carcinogenic properties may be attributable in part, to activation and/or repression of gene expression induced by changes in the DNA methylation statu...

journal_title：Toxicology and applied pharmacology

authors： Zhou X,Li Q,Arita A,Sun H,Costa M

更新日期：2009-04-01 00:00:00

abstract：:Pathologic changes associated with 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) exposure have been reported in the livers of a wide range of species. While these changes have been extensively described, the mechanisms of toxic interaction(s) that produce these lesions remain unclear. Using an aryl hydrocarbon receptor ...

journal_title：Toxicology and applied pharmacology

authors： Thurmond TS,Silverstone AE,Baggs RB,Quimby FW,Staples JE,Gasiewicz TA

更新日期：1999-07-01 00:00:00

abstract：:Anoikis is defined as apoptosis, which is induced by inappropriate cell-matrix interactions. Cancer cells with anoikis resistance tend to undergo metastasis, and this phenomenon has been reported to be associated with integrin and FAK activity. HPW-RX40 is a derivative of 3,4-methylenedioxy-β-nitrostyrene, which is kn...

journal_title：Toxicology and applied pharmacology

authors： Chen IH,Shih HC,Hsieh PW,Chang FR,Wu YC,Wu CC

更新日期：2015-12-01 00:00:00