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Ozone uptake in awake Sprague-Dawley rats.

Abstract：

:Knowledge of ozone (O3) uptake in rats in integral to efforts to quantitatively extrapolate animal data to man. We have measured percentage O3 uptake in 30 adult Sprague-Dawley rats exposed, nose only, for 1 hr to 0.3, 0.6, or 1.0 ppm O3. Tidal volume and breathing rate measurements, obtained by plethysmography, were time-matched with changes in airstream concentrations of O3, oxygen, and carbon dioxide, due to animal breathing, for computation of O3 uptake and respiratory gas exchange values. Ozone uptake was calculated by a fractional deposition technique, i.e. O3 in vs O3 out. Total respiratory system O3 uptake was found to be approximately 40% of that inspired and did not vary with O3 concentration nor during the 1-hr exposure. The quantity of O3 inhaled and retained by the rat increased proportionally with O3 concentration.

journal_name

Toxicol Appl Pharmacol

journal_title

Toxicology and applied pharmacology

authors

Wiester MJ,Williams TB,King ME,Ménache MG,Miller FJ

doi

10.1016/0041-008x(87)90162-1

subject

Has Abstract

pub_date

1987-07-01 00:00:00

pages

429-37

issue

3

eissn

0041-008X

issn

1096-0333

journal_volume

89

pub_type

杂志文章

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