Strain differences in tissue concentrations of mercury in inbred mice treated with mercuric chloride.

Abstract:

:Tissue concentrations of mercury were determined by cold vapor atomic absorption spectrometry in different inbred mouse strains after continuous treatment with HgCl2 (3 weekly sc injections of 0.5 mg/kg bw) for up to 12 weeks. Except for the thymus, in which steadily increasing mercury concentrations were found, in steady state levels of mercury were reached in blood and liver after 4 weeks and in spleen and kidney after 8 weeks. In the closely related strains C57BL/6, B10.D2, and B10.S, which differ only or primarily at the major histocompatibility complex, mercury concentrations in blood and liver were about twofold lower and renal concentrations were about three- to fivefold lower than those detected in strains A.SW and DBA/2. Another strain difference was observed in the spleen: after 8 and 12 weeks of continuous HgCl2 treatment, mercury concentrations in the spleen of strains A.SW, C57BL/6, and B10.S were significantly higher than those in strains DBA/2 and B10.D2. The strain difference in the spleen, an organ of the immune system, correlates with the susceptibility to the HgCl2-induced systemic autoimmune syndrome in mice in that the strains showing a higher mercury accumulation in the spleen are susceptible to this form of chemically induced autoimmunity, whereas the strains with lower mercury concentrations in the spleen are resistant.

journal_name

Toxicol Appl Pharmacol

authors

Griem P,Scholz E,Turfeld M,Zander D,Wiesner U,Dunemann L,Gleichmann E

doi

10.1006/taap.1997.8124

subject

Has Abstract

pub_date

1997-05-01 00:00:00

pages

163-70

issue

1

eissn

0041-008X

issn

1096-0333

pii

S0041-008X(97)98124-2

journal_volume

144

pub_type

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