Molecular analysis of peroxisome proliferation in the hamster.

abstract：:Prenatal ethanol exposure (PEE) induces dyslipidemia and hyperglycemia in fetus and adult offspring. However, whether PEE increases the susceptibility to non-alcoholic fatty liver disease (NAFLD) in offspring and its underlying mechanism remain unknown. This study aimed to demonstrate an increased susceptibility to hi...

journal_title：Toxicology and applied pharmacology

authors： Shen L,Liu Z,Gong J,Zhang L,Wang L,Magdalou J,Chen L,Wang H

更新日期：2014-01-15 00:00:00

abstract：:Octachlorodibenzo-p-dioxin (OCDD) is a ubiquitous environmental pollutant which has been reported to be nontoxic following acute exposure but has recently been shown to accumulate upon repeated exposure. To determine if this accumulation results in toxic effects, male Fischer 344 rats were treated with 50 micrograms/k...

journal_title：Toxicology and applied pharmacology

authors： Couture LA,Elwell MR,Birnbaum LS

更新日期：1988-03-30 00:00:00

abstract：:Health agencies are often required to predict the effects of long term low level exposure in humans based on annual data involving short-term high-level exposures. Uncertainties in extrapolation can be, in part, based on potentially different mechanism associated with different exposure scenarios. This study evaluated...

journal_title：Toxicology and applied pharmacology

authors： Crofton KM,Padilla S,Tilson HA,Anthony DC,Raymer JH,MacPhail RC

更新日期：1996-07-01 00:00:00

abstract：:The esters of the general structure, [CH(SH)COOR]2, i.e., Di-BDMS, R = CH2CH(CH3)2; Ds-BDMS, R = CH(CH3)CH2CH3; Di-ADMS, R = CH2CH2CH(CH3)2; and D3-ADMS, R = CH(CH2CH3)2 from the reaction of meso-2,3-dimercaptosuccinic acid with isobutyl, sec-butyl, isoamyl, and 3-amyl alcohols, respectively, have been prepared, chara...

journal_title：Toxicology and applied pharmacology

authors： Singh PK,Jones MM,Gale GR,Atkins LM,Smith AB

更新日期：1989-03-01 00:00:00

abstract：:The female reproductive toxicity of di-(2-ethylhexyl) phthalate and its active metabolite mono-(2-ethylhexyl) phthalate (MEHP) is attributed to suppression of ovarian granulosa cell estradiol production. In these studies, several structurally related phthalates (0-200 microM) and Wy-14,643 (0-100 microM) were compared...

journal_title：Toxicology and applied pharmacology

authors： Lovekamp TN,Davis BJ

更新日期：2001-05-01 00:00:00

abstract：:Propiconazole is a mouse hepatotumorigenic fungicide designed to inhibit CYP51, a key enzyme in the biosynthesis of ergosterol in fungi and is widely used in agriculture to prevent fungal growth. Metabolomic studies in mice revealed that propiconazole increased levels of hepatic cholesterol metabolites and bile acids,...

journal_title：Toxicology and applied pharmacology

authors： Murphy LA,Moore T,Nesnow S

更新日期：2012-04-15 00:00:00

abstract：:The concentration of mercury in milk and the distribution pattern in the sucking pup was followed over time after administration of a single iv injection of 0.5 mg/kg body wt of 203Hg-labeled methylmercuric chloride or mercuric chloride to lactating mice on Day 10 of lactation. Mercury concentrations in milk of the da...

journal_title：Toxicology and applied pharmacology

authors： Sundberg J,Jönsson S,Karlsson MO,Oskarsson A

更新日期：1999-01-15 00:00:00

abstract：:The influence of GSH concentration on metabolism of monocrotaline was examined in the isolated, perfused rat liver. Chloroethanol (0.37 mmol/kg), diethyl maleate (5.6 mmol/kg), and buthionine sulfoximine (72.9 mmol/kg) given in vivo reduced hepatic GSH from 3.7 mumol/g wet weight to 1.5, 0.6 and 0.9 mumol/g, respectiv...

journal_title：Toxicology and applied pharmacology

authors： Yan CC,Huxtable RJ

更新日期：1995-01-01 00:00:00

abstract：:Dietary consumption of phytoestrogens like genistein has been linked with lower incidence of prostate cancer. The estradiol-like benzopyran core of genistein confers estrogen receptor-β (ER-β) selectivity that imparts weak anti-proliferative activity against prostate cancer cells. DL-2-[4-(2-piperidinoethoxy)phenyl]-3...

journal_title：Toxicology and applied pharmacology

authors： Kumar R,Verma V,Sharma V,Jain A,Singh V,Sarswat A,Maikhuri JP,Sharma VL,Gupta G

更新日期：2015-03-15 00:00:00

abstract：:Drinking water contaminated with arsenic, a human carcinogen, is a worldwide health issue. An understanding of cellular signaling events in response to arsenic exposure and rational designing of strategies to reduce arsenic damages by modulating signaling events are important to fight against arsenic-induced diseases....

journal_title：Toxicology and applied pharmacology

authors： Wang XJ,Sun Z,Chen W,Li Y,Villeneuve NF,Zhang DD

更新日期：2008-08-01 00:00:00

abstract：:The immunotoxic effects of the environmental carcinogen benzo[a]pyrene (BaP) have been evaluated using mouse, but not human, lymphocytes. Since susceptibility to immunomodulation by BaP may be species-related, the effects of BaP on human peripheral blood mononuclear cells (HPBMC) from several individuals were investig...

journal_title：Toxicology and applied pharmacology

authors： Mudzinski SP

更新日期：1993-04-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor which plays a role in the development of multiple tissues and is activated by a large number of ligands, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In order to examine the roles of the AHR in both normal biological development an...

journal_title：Toxicology and applied pharmacology

authors： Harrill JA,Hukkanen RR,Lawson M,Martin G,Gilger B,Soldatow V,Lecluyse EL,Budinsky RA,Rowlands JC,Thomas RS

更新日期：2013-10-15 00:00:00

abstract：:Bisphenol A (BPA) is an important industrial chemical used in the manufacture of polycarbonate plastic products and epoxy resin-based food can liners. The presence of BPA metabolites in urine of >90% of Americans aged 6-60 suggests ubiquitous and frequent exposure in the range of 0.02-0.2μg/kgbw/d (25th-95th percentil...

journal_title：Toxicology and applied pharmacology

authors： Doerge DR,Twaddle NC,Vanlandingham M,Brown RP,Fisher JW

更新日期：2011-09-15 00:00:00

abstract：:Clofibric acid (CA), a potent peroxisome proliferator (PP), has been shown to cause tumor formation in rat liver. The precise mechanism of action of PPs remains largely unknown. However, it has been proposed that they act by increasing reactive oxygen species (ROS), leading to a cellular oxidative stress. In the prese...

journal_title：Toxicology and applied pharmacology

authors： Bécuwe P,Bianchi A,Dauça M

更新日期：2001-08-01 00:00:00

abstract：:Investigations have characterized addictive drug-induced developmental cardiovascular malformation in human, non-human primate and rodent. However, the underlying mechanism of malformation caused by drugs during pregnancy is still largely unknown, and preventive and therapeutic measures have been lacking. Using 1H NMR...

journal_title：Toxicology and applied pharmacology

authors： Shao X,Hu Z,Hu C,Bu Q,Yan G,Deng P,Lv L,Wu D,Deng Y,Zhao J,Zhu R,Li Y,Li H,Xu Y,Yang H,Zhao Y,Cen X

更新日期：2012-05-01 00:00:00

abstract：:There are conflicting reports in the literature regarding the role of the Ah locus in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) immunotoxicity. The present studies have utilized two congenic strains of C57Bl/6 mice that differ only at this locus to assess its influence on TCDD-induced suppression of antibody response...

journal_title：Toxicology and applied pharmacology

authors： Kerkvliet NI,Steppan LB,Brauner JA,Deyo JA,Henderson MC,Tomar RS,Buhler DR

更新日期：1990-08-01 00:00:00

abstract：:The ACuteTox Project (part of the EU 6th Framework Programme) was started up in January 2005. The aim of this project is to develop a simple and robust in vitro strategy for prediction of human acute systemic toxicity, which could replace animal tests used for regulatory purposes. Our group is responsible for the char...

journal_title：Toxicology and applied pharmacology

authors： Cerrato L,Valeri A,Bueren JA,Albella B

更新日期：2009-07-15 00:00:00

abstract：:Metoclopramide (MCA) and procainamide (PCA), two widely used benzamide drugs developed before the present regulatory climate but recently found to induce DNA breaks in human lymphocytes, were evaluated for their genotoxic effects in cultured rodent and human cells. In subtoxic concentrations neither MCA (from 0.10 to ...

journal_title：Toxicology and applied pharmacology

authors： Martelli A,Campart GB,Canonero R,Mattioli F,Brambilla G

更新日期：1995-04-01 00:00:00

abstract：:The iron chelate, ferric nitrilotriacetate (FeNTA), induces acute proximal tubular necrosis as a consequence of lipid peroxidation and oxidative tissue damage. Chronic exposure of FeNTA leads to a high incidence of renal adenocarcinomas in rodents. NF-E2-related factor 2 (Nrf2) is a transcription factor that is activa...

journal_title：Toxicology and applied pharmacology

authors： Tanaka Y,Aleksunes LM,Goedken MJ,Chen C,Reisman SA,Manautou JE,Klaassen CD

更新日期：2008-09-15 00:00:00

abstract：:Cadmium/Hg interactions have been studied in the TC7 clone of the enterocytic-like Caco-2 cells to test the hypothesis that these metals may compete for intestinal transport. Comparison of the kinetic parameter values for 203Hg(II) and 109Cd(II) uptake in a serum-free medium revealed that Hg is accumulated much more r...

journal_title：Toxicology and applied pharmacology

authors： Aduayom I,Campbell PG,Denizeau F,Jumarie C

更新日期：2003-05-15 00:00:00

abstract：:We developed an in vivo model for cadmium-induced bone loss in which mice excrete bone mineral in feces beginning 8 h after cadmium gavage. Female mice of three strains [CF1, MTN (metallothionein-wild-type), and MT1,2KO (MT1,2-deficient)] were placed on a low-calcium diet for 2 weeks. Each mouse was gavaged with 200 m...

journal_title：Toxicology and applied pharmacology

authors： Regunathan A,Glesne DA,Wilson AK,Song J,Nicolae D,Flores T,Bhattacharyya MH

更新日期：2003-09-15 00:00:00

abstract：:Previous reports from our laboratory indicated that prophylactic protection against cyanide intoxication in mice can be enhanced by administration of chlorpromazine when it is given with sodium thiosulfate. The mechanism of potentiation of sodium thiosulfate by chlorpromazine was studied alone and in combination with ...

journal_title：Toxicology and applied pharmacology

authors： Kong A,Shen A,Burrows G,Sylvester D,Isom GE,Way JL

更新日期：1983-12-01 00:00:00

abstract：:To evaluate the effect of exposure to an environmentally relevant polychlorinated biphenyl mixture, adult male rats were treated with Aroclor 1260 for 7 days and levels of several cytochrome P450 (CYP) enzymes were measured in liver microsomes prepared 3 days after the last dose. Treatment with Aroclor 1260 at dosages...

journal_title：Toxicology and applied pharmacology

authors： Ngui JS,Bandiera SM

更新日期：1999-12-01 00:00:00

abstract：:B200 cells are Ni(II)-transformed mouse BALB/c-3T3 fibroblasts displaying a malignant phenotype and increased resistance to Ni(II) toxicity. In an attempt to find genes whose expression has been altered by the transformation, the Atlas Mouse Stress/Toxicology cDNA Expression Array (Clontech Laboratories, Inc., Palo Al...

journal_title：Toxicology and applied pharmacology

authors： Kowara R,Karaczyn A,Cheng RY,Salnikow K,Kasprzak KS

更新日期：2005-05-15 00:00:00

abstract：:Air pollution particles (PM) are known to elicit an acute inflammatory response in vivo that is mediated in part through PM-induced activation of the NF-kappaB signaling pathway. Many of the details of this process and particularly where in the cell it occurs are unclear. To determine whether contact of PM particles w...

journal_title：Toxicology and applied pharmacology

authors： Churg A,Xie C,Wang X,Vincent R,Wang RD

更新日期：2005-10-01 00:00:00

abstract：:Gossypol, a polyphenolic compound isolated from cottonseeds, has been reported to possess many pharmacological activities, but whether it can influence inflammasome activation remains unclear. In this study, we found that in mouse macrophages, gossypol induced cell death characterized by rapid membrane rupture and rob...

journal_title：Toxicology and applied pharmacology

authors： Lin QR,Li CG,Zha QB,Xu LH,Pan H,Zhao GX,Ouyang DY,He XH

更新日期：2016-02-01 00:00:00

abstract：:Biphasic dose-response relationship induced by environmental agents is often characterized with the effect of low-dose stimulation and high-dose inhibition. Some studies showed that arsenite may induce cell proliferation and apoptosis via biphasic dose-response relationship in human cells; however, mechanisms underlyi...

journal_title：Toxicology and applied pharmacology

authors： He XQ,Chen R,Yang P,Li AP,Zhou JW,Liu QZ

更新日期：2007-04-01 00:00:00

abstract：:The effect of N-benzyl-D-glucamine dithiocarbamate (BGD) on the renal toxicity produced by subacute exposure to cadmium in rats was studied. Rats were injected sc with CdCl2 (1.5 mg Cd/kg) daily for 26 days and thereafter they received 13 injections of BGD (400 mumol/kg) every other day. Urinary protein concentration ...

journal_title：Toxicology and applied pharmacology

authors： Kojima S,Ono H,Kiyozumi M,Honda T,Takadate A

更新日期：1989-03-15 00:00:00

abstract：:Benzene is a ubiquitous occupational and environmental toxicant. Exposures to benzene both prenatally and during adulthood are associated with the development of disorders such as aplastic anemia and leukemia. Mechanisms of benzene toxicity are unknown; however, generation of reactive oxygen species (ROS) by benzene m...

journal_title：Toxicology and applied pharmacology

authors： Badham HJ,Winn LM

更新日期：2010-05-01 00:00:00

abstract：:In nonsmokers, ozone (O(3)) is removed primarily by the epithelial lining fluid (ELF) of the conducting airways. We hypothesized that cigarette smokers, whose ELF antioxidant capacity may be limited by smoking, would remove less O(3) from their conducting airways than nonsmokers. We recruited 29 nonsmokers (17M, 12F) ...

journal_title：Toxicology and applied pharmacology

authors： Bates ML,Brenza TM,Ben-Jebria A,Bascom R,Ultman JS

更新日期：2009-05-01 00:00:00