Estrogen signaling is not required for prostatic bud patterning or for its disruption by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

abstract：:Oxido-inflammatory aberrations play a substantial role in the pathophysiology of depression. Oxido-inflammatory stress increases catabolism of tryptophan into kynurenine which leads to imbalance in kynurenine and serotonin levels in the brain. Naringenin a flavonoid, has been reported to possess antidepressant propert...

journal_title：Toxicology and applied pharmacology

authors： Bansal Y,Singh R,Saroj P,Sodhi RK,Kuhad A

更新日期：2018-09-15 00:00:00

abstract：:Metformin is a first-line drug for the treatment of type 2 diabetes (T2D) and is often prescribed in combination with other drugs to control a patient's blood glucose level and achieve their HbA1c goal. New treatment options for T2D will likely include fixed dose combinations with metformin, which may require preclini...

journal_title：Toxicology and applied pharmacology

authors： Quaile MP,Melich DH,Jordan HL,Nold JB,Chism JP,Polli JW,Smith GA,Rhodes MC

更新日期：2010-03-15 00:00:00

abstract：:The nephrotoxicity limits the clinical application of cisplatin. Human organic cation transporter 2 (OCT2) and multidrug and toxin extrusion proteins (MATEs) work in concert in the elimination of cationic drugs such as cisplatin from the kidney. We hypothesized that co-administration of ondansetron would have an effec...

journal_title：Toxicology and applied pharmacology

authors： Li Q,Guo D,Dong Z,Zhang W,Zhang L,Huang SM,Polli JE,Shu Y

更新日期：2013-11-15 00:00:00

abstract：:Morphine has been shown to reduce renal and hepatic clearance of several xenobiotics in rodents. After iv administration of gentamicin, 10 to 30 mg/kg, its plasma levels were elevated in mice given morphine, 20 mg/kg sc. Plasma clearance of gentamicin was nearly halved by morphine, due primarily to lowering of the eli...

journal_title：Toxicology and applied pharmacology

authors： Hurwitz A,Garty M,Ben-Zvi Z

更新日期：1988-05-01 00:00:00

abstract：:Intravenous administration of drug-loaded polyalkylcyanoacrylate (PACA) nanoparticles is followed by a rapid uptake by the tissues of the reticuloendothelial system, mainly the liver. Nevertheless, it is so far unknown whether chronic administration of nanoparticles can lead to damage to the liver cells. We have studi...

journal_title：Toxicology and applied pharmacology

authors： Fernandez-Urrusuno R,Fattal E,Porquet D,Feger J,Couvreur P

更新日期：1995-02-01 00:00:00

abstract：:Previous studies have shown that fumonisin B1 (FB1) inhibits ceramide synthase, resulting in accumulation of free sphinganine and sphingosine. Tumor necrosis factor-alpha (TNFalpha) plays an important role in FB1 toxicity and the expression of TNFalpha mRNA in liver and kidney is increased following FB1 exposure in mi...

journal_title：Toxicology and applied pharmacology

authors： He Q,Riley RT,Sharma RP

更新日期：2001-07-01 00:00:00

abstract：:Earlier studies with etretinate and its metabolite acitretin suggested that area under the concentration-time curve (AUC) is the most suitable pharmacokinetic correlate to etretinate-induced teratogenesis. In an attempt to test this hypothesis with respect to the embryotoxic effects of all-trans-retinoic acid (all-tra...

journal_title：Toxicology and applied pharmacology

authors： Tzimas G,Thiel R,Chahoud I,Nau H

更新日期：1997-04-01 00:00:00

abstract：:In the metabolism of isosorbide dinitrate (ISDN), fast denitration with the formation of nitrite ions and a mononitrate plays an important role. In contrast, the denitration of isosorbide-5-mononitrate (IS-5-MN) to isosorbide is very slow. Accordingly po administration of high doses of ISDN (92.5 and 236 mg/kg) in con...

journal_title：Toxicology and applied pharmacology

authors： Strein K,Bartsch W,Sponer G,Müller-Beckmann B,Lexa P

更新日期：1984-01-01 00:00:00

abstract：:The length distributions of single fibrils of Coalinga, UICC-B and wet dispersed chrysotile were measured by transmission electron microscopy (TEM). It was found that the distributions significantly diverged above approximately 10 μm (μm) in length, corresponding to differences in published results of animal experimen...

journal_title：Toxicology and applied pharmacology

authors： Chatfield EJ

更新日期：2018-12-15 00:00:00

abstract：:We have used a pharmacological approach to study the mechanisms underlying the rat lung injury and the airway reactivity changes induced by inhalation of formaldehyde (FA) (1% formalin solution, 90 min once a day, 4 days). The reactivity of isolated tracheae and intrapulmonary bronchi were assessed in dose-response cu...

journal_title：Toxicology and applied pharmacology

authors： Lino dos Santos Franco A,Damazo AS,Beraldo de Souza HR,Domingos HV,Oliveira-Filho RM,Oliani SM,Costa SK,Tavares de Lima W

更新日期：2006-07-01 00:00:00

abstract：:Metallothionein (MT) is a sulfhydryl-rich protein whose levels are increased by administration of a variety of agents including metals, cytokines, and oxidative stress agents. Recent studies have suggested that MT is involved in protecting against various forms of oxidative stress, but little is known about the induct...

journal_title：Toxicology and applied pharmacology

authors： Bauman JW,McKim JM Jr,Liu J,Klaassen CD

更新日期：1992-06-01 00:00:00

abstract：:Pulmonary fibrosis is a consequence of severe injury from some toxic agents including high doses of ozone. It is not known, however, whether chronic exposure to low doses of ozone, such as those encountered in polluted ambient atmospheres, could also result in abnormal accumulations of lung collagen. Rats were exposed...

journal_title：Toxicology and applied pharmacology

authors： Wright ES,Kehrer JP,White DM,Smiler KL

更新日期：1988-03-15 00:00:00

abstract：:Lactate Dehydrogenase Isoenzymes in Hamster Lung Lavage Fluid after Lung Injury. Beck, B. D., Gerson, B., Feldman, H. A., and Brain, J. D. (1983). Toxicol. Appl. Pharmacol. 71, 59-71. Lactate dehydrogenase (LD) levels and isoenzyme patterns were determined in the cell-free supernatant fractions of lung lavage fluid fr...

journal_title：Toxicology and applied pharmacology

authors： Beck BD,Gerson B,Feldman HA,Brain JD

更新日期：1983-10-01 00:00:00

abstract：:These studies were initiated to determine (1) if cisplatin (cis-DDP)-induced hyperglucagonemia is related to decreased hormone degradation, (2) the relationship between impaired kidney function associated with cis-DDP nephrotoxicity and hyperglucagonemia, and (3) the contribution of cis-DDP-induced hyperglucagonemia t...

journal_title：Toxicology and applied pharmacology

authors： Goldstein RS,Mayor GH,Gingerich RL,Hook JB,Robinson B,Bond JT

更新日期：1983-04-01 00:00:00

abstract：:During postnatal skeletal growth, adaptation to mechanical loading leads to cellular activities at the growth plate. It has recently become evident that bone forming and bone resorbing cells are affected by the receptor tyrosine kinase (RTK) inhibitor imatinib mesylate (STI571, Gleevec®). Imatinib targets PDGF, ABL-re...

journal_title：Toxicology and applied pharmacology

authors： Nurmio M,Joki H,Kallio J,Määttä JA,Väänänen HK,Toppari J,Jahnukainen K,Laitala-Leinonen T

更新日期：2011-08-01 00:00:00

abstract：:The DDT metabolite 3-methylsulfonyl-DDE (3-MeSO(2)-DDE) has been proposed as a lead compound for an improved adrenocortical carcinoma (ACC) treatment. ACC is a rare malignant disorder with poor prognosis, and the current pharmacological therapy o,p'-DDD (mitotane) has limited efficacy and causes severe adverse effects...

journal_title：Toxicology and applied pharmacology

authors： Asp V,Ullerås E,Lindström V,Bergström U,Oskarsson A,Brandt I

更新日期：2010-02-01 00:00:00

abstract：:Hexabromocyclododecane (HBCDD), a brominated flame retardant added to various consumer products, is a ubiquitous environmental contaminant. We have previously shown that 6-hour exposure to HBCDD disturbs basal and human chorionic gonadotropin (hCG)-induced steroidogenesis in rat Leydig cells. Reduction in mitochondria...

journal_title：Toxicology and applied pharmacology

authors： Fa S,Pogrmic-Majkic K,Samardzija D,Hrubik J,Glisic B,Kovacevic R,Andric N

更新日期：2015-01-01 00:00:00

abstract：:Our recent study demonstrated the increased risk of renal cell carcinoma (RCC) associated with high urinary total arsenic levels among people living in a low arsenic exposure area. Genomic instability is important in arsenic carcinogenesis. This study evaluated the relationship between the polymorphisms of p53, p21, a...

journal_title：Toxicology and applied pharmacology

authors： Huang CY,Su CT,Chu JS,Huang SP,Pu YS,Yang HY,Chung CJ,Wu CC,Hsueh YM

更新日期：2011-12-15 00:00:00

abstract：:Along with the wide use of pesticides in the world, the concerns over their health impacts are rapidly growing. There is a huge body of evidence on the relation between exposure to pesticides and elevated rate of chronic diseases such as different types of cancers, diabetes, neurodegenerative disorders like Parkinson,...

journal_title：Toxicology and applied pharmacology

authors： Mostafalou S,Abdollahi M

更新日期：2013-04-15 00:00:00

abstract：:It has been suggested that airway irritation, by acting as an adjuvant, as well as producing damage, may be an important factor related to asthma. The present study examined the window of time following acute upper and lower airway irritant exposure to determine the period of increased risk of immunological sensitizat...

journal_title：Toxicology and applied pharmacology

authors： Siegel PD,Al-Humadi NH,Nelson ER,Lewis DM,Hubbs AF

更新日期：1997-06-01 00:00:00

abstract：:A clinical study was performed to determine the effects of patch testing human skin with four industrially used surfactants on erythema formation, transepidermal water loss, and the contents in suction blister fluids of primary proinflammatory mediators including arachidonic acid, eicosanoids, and IL-1 alpha, which we...

journal_title：Toxicology and applied pharmacology

authors： Müller-Decker K,Heinzelmann T,Fürstenberger G,Kecskes A,Lehmann WD,Marks F

更新日期：1998-11-01 00:00:00

abstract：:Melatonin is a modified tryptophan with potent biological activity, exerted by stimulation of specific plasma membrane (MT1/MT2) receptors, by lower affinity intracellular enzymatic targets (quinone reductase, calmodulin), or through its strong anti-oxidant ability. Scattered studies also report a perplexing pro-oxida...

journal_title：Toxicology and applied pharmacology

authors： Radogna F,Paternoster L,De Nicola M,Cerella C,Ammendola S,Bedini A,Tarzia G,Aquilano K,Ciriolo M,Ghibelli L

更新日期：2009-08-15 00:00:00

abstract：:Acrylonitrile (VCN) is a heavily used monomer in plastic and fiber industries. Quantitatively, VCN-induced gastrointestinal hemorrhage is time and dose dependent and is not the result of a direct irritating action of VCN on gastric tissues. The effect of cytochrome P-450 enzymes inducers was studied. Pretreatment with...

journal_title：Toxicology and applied pharmacology

authors： Ghanayem BI,Ahmed AE

更新日期：1983-04-01 00:00:00

abstract：:In rat hepatocytes and isolated liver mitochondrial fractions, Cyclosporine A (CsA) is often used as a specific inhibitor of mitochondrial Ca(2+) release and as a specific blocker of mitochondrial membrane potential and permeability transition (MPT), which are all processes involved in the inhibition of apoptosis. How...

journal_title：Toxicology and applied pharmacology

authors： Grub S,Persohn E,Trommer WE,Wolf A

更新日期：2000-03-15 00:00:00

abstract：:Clofibric acid (CA), a potent peroxisome proliferator (PP), has been shown to cause tumor formation in rat liver. The precise mechanism of action of PPs remains largely unknown. However, it has been proposed that they act by increasing reactive oxygen species (ROS), leading to a cellular oxidative stress. In the prese...

journal_title：Toxicology and applied pharmacology

authors： Bécuwe P,Bianchi A,Dauça M

更新日期：2001-08-01 00:00:00

abstract：:The debate on tungsten (W) is fostered by its continuous usage in military munitions. Reports demonstrate W solubilizes in soil and can migrate into drinking water supplies and, therefore, is a potential health risk to humans. This study evaluated the reproductive, systemic and neurobehavioral effects of sodium tungst...

journal_title：Toxicology and applied pharmacology

authors： McInturf SM,Bekkedal MY,Wilfong E,Arfsten D,Chapman G,Gunasekar PG

更新日期：2011-07-15 00:00:00

abstract：:An infamous poison, arsenic also has been used as a drug for nearly 2400 years; in recently years, arsenic has been effective in the treatment of acute promyelocytic leukemia. Increasing evidence suggests that opposite effects of arsenic trioxide (ATO) on tumors depend on its concentrations. For this reason, the mecha...

journal_title：Toxicology and applied pharmacology

authors： Liu ZM,Huang HS

更新日期：2008-12-01 00:00:00

abstract：:The cDNA sequences for two dioxin-inducible cytochrome P450s in chicken, CYP1A4 and CYP1A5, have recently been reported which correspond to two dioxin-inducible forms of P450 previously designated as TCDDAHH and TCDDAA, respectively. The developmental expression of CYP1A4-associated aryl hydrocarbon (benzo[a]pyrene) h...

journal_title：Toxicology and applied pharmacology

authors： Bentivegna CS,Ihnat MA,Baptiste NS,Hamilton JW

更新日期：1998-07-01 00:00:00

abstract：:The purpose of this study was to determine whether exposure to levels of sarin causing no overt clinical signs would cause more subtle, adverse health effects that persisted after the exposure ended. Inhalation exposures of male Fischer 344 rats to 0, 0.2, or 0.4 mg/m(3) of sarin for 1 h/day for 1, 5, or 10 days under...

journal_title：Toxicology and applied pharmacology

authors： Henderson RF,Barr EB,Blackwell WB,Clark CR,Conn CA,Kalra R,March TH,Sopori ML,Tesfaigzi Y,Ménache MG,Mash DC

更新日期：2002-10-15 00:00:00

abstract：:Three novel P450 members of the cytochrome P450 4A family were cloned as partial cDNAs from hamster liver, characterised as novel members of the CYP4A subfamily, and designated CYP4A17, 18, and 19. Hamsters were treated with the peroxisome proliferator-activated receptor alpha (PPARalpha) agonists, methylclofenapate (...

journal_title：Toxicology and applied pharmacology

authors： Choudhury AI,Sims HM,Horley NJ,Roberts RA,Tomlinson SR,Salter AM,Bruce M,Shaw PN,Kendall D,Barrett DA,Bell DR

更新日期：2004-05-15 00:00:00