Inhibition of Na+ channel currents in rat myoblasts by 4-aminopyridine.

abstract：:Menadione (2-methyl-1,4-naphthoquinone, a redox cycling and arylating quinone; 5-100 microM) inhibited the canalicular vacuolar accumulation (CVA) of a fluorescent bile acid, cholyl-lysyl-fluorescein (CLF), in rat hepatocyte couplets. This was associated with depletion of reduced glutathione and accumulation of oxidiz...

journal_title：Toxicology and applied pharmacology

authors： Stone V,Coleman R,Chipman JK

更新日期：1996-06-01 00:00:00

abstract：:L-Buthionine-S,R-sulfoximine (BSO), a potent inhibitor of gamma-glutamylcysteine synthetase, is commonly used as an experimental tool for the specific depletion of glutathione. Since cysteine is a key precursor for glutathione biosynthesis, we investigated the possibility that BSO might also affect the free cysteine p...

journal_title：Toxicology and applied pharmacology

authors： Standeven AM,Wetterhahn KE

更新日期：1991-02-01 00:00:00

abstract：:Previous studies from this laboratory have demonstrated that the addition of methyl groups at the 3 and 4 positions of the 2,5-hexanedione (2,5-HD) molecule results both in more rapid pyrrole formation and in enhanced neurotoxicity. In order to define more clearly the relationship between rates of pyrrole formation an...

journal_title：Toxicology and applied pharmacology

authors： Genter MB,Szakál-Quin G,Anderson CW,Anthony DC,Graham DG

更新日期：1987-02-01 00:00:00

abstract：:Heme oxygenase (HO)-1 is an oxidative stress-response enzyme which catalyzes the degradation of heme into bilirubin, ferric ion, and carbon monoxide (CO). Induction of HO-1 was reported to have antitumor activity; the inhibitory mechanism, however, is still unclear. In the present study, we found that treatment with [...

journal_title：Toxicology and applied pharmacology

authors： Lee WY,Chen YC,Shih CM,Lin CM,Cheng CH,Chen KC,Lin CW

更新日期：2014-01-01 00:00:00

abstract：:Mitoguazone is a known inhibitor of polyamine biosynthesis through competitive inhibition of S-adenosylmethionine decarboxylase. A recent renewed interest in mitoguazone as an antineoplastic agent prompted us to investigate the effect of the drug on polyamine catabolism in rat liver, since the organ plays an important...

journal_title：Toxicology and applied pharmacology

authors： Ferioli ME,Berselli D,Caimi S

更新日期：2004-12-01 00:00:00

abstract：:A single, intravenous administration of a low dose of monocrotaline pyrrole (MCTP), a derivative of the pyrrolizidine alkaloid monocrotaline (MCT), induces progressive pulmonary hypertension and right ventricular hypertrophy (RVH) in rats. The temporal relationship between morphologic alterations, biochemical markers ...

journal_title：Toxicology and applied pharmacology

authors： Reindel JF,Ganey PE,Wagner JG,Slocombe RF,Roth RA

更新日期：1990-11-01 00:00:00

abstract：:Occupational exposure to low molecular weight chemicals, like trimellitic anhydride (TMA), can result in occupational asthma. Alveolar macrophages (AMs) are among the first cells to encounter inhaled compounds. These cells can produce many different mediators that have a putative role in asthma. In this study, we exam...

journal_title：Toxicology and applied pharmacology

authors： Valstar DL,Schijf MA,Nijkamp FP,Storm G,Arts JH,Kuper CF,Bloksma N,Henricks PA

更新日期：2006-02-15 00:00:00

abstract：:Data taken from Aberg et al. ((1969) Arch. Environ. Health 19, 478-484) and Miettinen et al. ((1971) Ann. Clin. Res. 3, 116-122) were analyzed by means of models that describe methyl mercury pharmacokinetics in man in terms of parent compound only (Model I) or in terms of parent compound plus metabolite, inorganic mer...

journal_title：Toxicology and applied pharmacology

authors： Smith JC,Farris FF

更新日期：1996-04-01 00:00:00

abstract：:This study was undertaken to characterize the long-term toxic and carcinogenic potential of a polybrominated biphenyl (PBB) mixture in rats and mice of both sexes. Fischer 344 rats and B6C3F1 mice were given 125 po doses of PBB over a 6-month period at 0 (control), 0.1, 0.3, 1.0, 3.0, and 10.0 mg/kg body weight/day (5...

journal_title：Toxicology and applied pharmacology

authors： Gupta BN,McConnell EE,Moore JA,Haseman JK

更新日期：1983-03-30 00:00:00

abstract：:Many herbal medicines and dietary supplements sold as aids to improve memory or treat neurodegenerative diseases or have other favorable effects on the CNS contain a catechol or similar 1,2-dihydroxy aromatic moiety in their structure. As an approach to isolate and examine the neuroprotective properties of catechols, ...

journal_title：Toxicology and applied pharmacology

authors： Lo YC,Liu Y,Lin YC,Shih YT,Liu CM,Burka LT

更新日期：2008-04-15 00:00:00

abstract：:Luteolin, a flavonoid that exhibits antioxidative properties, exerts myocardial protection effects. However, the underlying molecular mechanisms are not yet fully understood. To investigate the effects of luteolin on myocardial injury protection and its possible mechanisms, a myocardial injury model was established wi...

journal_title：Toxicology and applied pharmacology

authors： Sun GB,Sun X,Wang M,Ye JX,Si JY,Xu HB,Meng XB,Qin M,Sun J,Wang HW,Sun XB

更新日期：2012-12-01 00:00:00

abstract：:The mechanism by which acrylamide (ACR) produces distal axonopathy in humans and laboratory animals is unknown. The possibility that this neuropathy involves deregulation of elements and water in rat peripheral nerve has been investigated. Electron probe X-ray microanalysis was used to measure percentages of water and...

journal_title：Toxicology and applied pharmacology

authors： LoPachin RM,Castiglia CM,Saubermann AJ

更新日期：1992-07-01 00:00:00

abstract：:Acute exposure to Cd produces liver injury, whereas chronic exposure results in kidney injury. Tolerance to the hepatotoxicity is observed during chronic exposure to Cd due to the induction of metallothionein (MT). The nephrotoxicity produced by chronic Cd exposure purportedly results from renal uptake of Cd-metalloth...

journal_title：Toxicology and applied pharmacology

authors： Sendelbach LE,Klaassen CD

更新日期：1988-01-01 00:00:00

abstract：:Female Sprague-Dawley rats were treated with a single ip dose of aflatoxin B1 (AFB1) (3 or 6 mg/kg). Twenty-four hours later and weekly until killed, some of the rats treated with AFB1 were given ethynylestradiol (EE) by gavage at the dose of 13 mg/kg. One, three, six, and nine months following the beginning of the ex...

journal_title：Toxicology and applied pharmacology

authors： Kamdem L,Magdalou J,Siest G,Ban M,Zissu D

更新日期：1983-01-01 00:00:00

abstract：:In this study, the effects of pentavalent dimethylarsinic acid ((CH(3))(2)AsO(OH); DMA(V)) and trivalent dimethylarsinous acid ((CH(3))(2)As(OH); DMA(III)) on synaptic transmission generated by the excitatory Schaffer collateral-CA1 synapse were tested in hippocampal slices of young (14-21 day-old) and adult (2-4 mont...

journal_title：Toxicology and applied pharmacology

authors： Krüger K,Repges H,Hippler J,Hartmann LM,Hirner AV,Straub H,Binding N,Musshoff U

更新日期：2007-11-15 00:00:00

abstract：:Chelating agents commonly used in therapy of heavy metal intoxication alter the levels of essential metals in liver, kidneys, and serum. Induction of metallothionein synthesis in liver occurs following exposure to a variety of chemical and environmental insults and, in some cases, has been attributed to enhanced hepat...

journal_title：Toxicology and applied pharmacology

authors： Goering PL,Tandon SK,Klaassen CD

更新日期：1985-09-30 00:00:00

abstract：:Polycyclic Aromatic Hydrocarbons (PAHs) constitute a family of over one hundred compounds and can generally be found in complex mixtures. PAHs metabolites cause DNA damage which can lead to the development of carcinogenesis. Toxicity assessment of PAH complex mixtures is currently expressed in terms of toxic equivalen...

journal_title：Toxicology and applied pharmacology

authors： Audebert M,Zeman F,Beaudoin R,Péry A,Cravedi JP

更新日期：2012-04-01 00:00:00

abstract：:The aim of the present study was to evaluate the in vitro modulation of muscarinic autoreceptor function by the organophosphorus (OP) anticholinesterases chlorpyrifos oxon, paraoxon, and methyl paraoxon. Acetylcholine (ACh) release was studied by preloading slices from rat striatum with [3H]choline and depolarizing wi...

journal_title：Toxicology and applied pharmacology

authors： Liu J,Chakraborti T,Pope C

更新日期：2002-01-15 00:00:00

abstract：:Nuclear receptors (NRs) are key regulators of human health and constitute a relevant target for medicinal chemistry applications as well as for toxicological risk assessment. Several open databases dedicated to small molecules that modulate NRs exist; however, depending on their final aim (i.e., adverse effect assessm...

journal_title：Toxicology and applied pharmacology

authors： Valsecchi C,Grisoni F,Motta S,Bonati L,Ballabio D

更新日期：2020-11-15 00:00:00

abstract：:Low dietary concentrations of methionine and cysteine are known to decrease hepatic glutathione content. However, it is not known if restricting the dietary content of these sulfur containing amino acids also affects hepatic levels of adenosine 3'-phosphate 5'-phosphosulfate (PAPS), the cofactor for sulfation, or meta...

journal_title：Toxicology and applied pharmacology

authors： Sendelbach LE,White CA,Howell S,Gregus Z,Klaassen CD

更新日期：1990-02-01 00:00:00

abstract：:Arsenic is a toxicant found in ground water around the world, and human exposure mainly comes from drinking water or from crops grown in areas containing arsenic in soils or water. Epidemiological studies have shown that arsenic exposure during development decreased intellectual function, reduced birth weight, and alt...

journal_title：Toxicology and applied pharmacology

authors： Liu JT,Bain LJ

更新日期：2014-12-15 00:00:00

abstract：:A major obstacle in defining the mechanism of chemical-induced toxicity has been the inability to distinguish between events that cause cell death and those that result from cell death. This problem results from measuring biochemical parameters in tissues or cell pellets containing both viable and nonviable cells. In ...

journal_title：Toxicology and applied pharmacology

authors： Fariss MW,Brown MK,Schmitz JA,Reed DJ

更新日期：1985-06-30 00:00:00

abstract：:Ah receptor was identified and characterized in cytosol and nuclear extracts from the rainbow trout hepatoma cell line RTH-149. The cytosolic receptor was detectable with both halogenated ([3H]2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)) and non-halogenated ([3H]3-methylcholanthrene and [3H]benzo[a]pyrene) aromatic hyd...

journal_title：Toxicology and applied pharmacology

authors： Lorenzen A,Okey AB

更新日期：1990-10-01 00:00:00

abstract：:The autoradiographic distribution of the toxic heavy metal nickel (Ni) was studied at 4 and 7 days post-coxsackievirus B3 (CB3) infection in Balb/c mice. The distribution of the iv injected 63Ni was studied 10 min, 4 hr, and 24 hr after administration. Results clearly show that the site of 63Ni accumulation is greatly...

journal_title：Toxicology and applied pharmacology

authors： Ilbäck NG,Fohlman J,Friman G

更新日期：1992-05-01 00:00:00

abstract：:Staphylococcal enterotoxin C2 (SEC2), a member of bacterial superantigen, is one of the most potent known activators of T lymphocytes. With this property, SEC2 has already been used in clinic as a tumor immunotherapy agent in China. To increase the antitumor activity, a SEC2 mutant named ST-4 (GKVTG102-106WWH) with am...

journal_title：Toxicology and applied pharmacology

authors： Zhang G,Xu M,Zhang H,Song Y,Wang J,Zhang C

更新日期：2016-12-15 00:00:00

abstract：:We investigated the potential effects of monosodium glutamate (MSG)-induced obesity with regards to nitric oxide and prostanoid production, as well as potassium channel function, in rat thoracic arteries. Newborn male Wistar rats were injected intraperitoneally with typically reported MSG (4.0 mg/g) once daily for 4 c...

journal_title：Toxicology and applied pharmacology

authors： Majewski M,Jurgoński A,Fotschki B,Juśkiewicz J

更新日期：2018-11-15 00:00:00

abstract：:Patients with 45,X0/46XY karyotype often present with intersex phenotype and testicular dysgenesis. These patients may also have undescended testes (cryptorchidism), hypospadias and their spermatogenesis is severely disrupted. They have a high risk for testicular cancer. These patients have the most severe form of tes...

journal_title：Toxicology and applied pharmacology

authors： Virtanen HE,Rajpert-De Meyts E,Main KM,Skakkebaek NE,Toppari J

更新日期：2005-09-01 00:00:00

abstract：:Chronic exposure to high concentrations of arsenic in drinking water is associated with an increased risk for developing type 2 diabetes. The present revision focuses on the effect of arsenic on tissues that participate directly in glucose homeostasis, integrating the most important published information about the imp...

journal_title：Toxicology and applied pharmacology

authors： Díaz-Villaseñor A,Burns AL,Hiriart M,Cebrián ME,Ostrosky-Wegman P

更新日期：2007-12-01 00:00:00

abstract：:The ability of human plasma butyrylcholinesterase (BChE) to detoxify cocaine in vivo was evaluated. Intravenous administration of BChE, at doses sufficient to increase the plasma levels of the enzyme as much as 800-fold, produced no adverse effects on the cardiovascular, autonomic, or central nervous systems of rats. ...

journal_title：Toxicology and applied pharmacology

authors： Lynch TJ,Mattes CE,Singh A,Bradley RM,Brady RO,Dretchen KL

更新日期：1997-08-01 00:00:00

abstract：:The Constitutive Androstane Receptor (CAR, NR1I3) has been newly described as a regulator of energy metabolism. A relevant number of studies using animal models of obesity suggest that CAR activation could be beneficial on the metabolic balance. However, this remains controversial and the underlying mechanisms are sti...

journal_title：Toxicology and applied pharmacology

authors： Marmugi A,Lukowicz C,Lasserre F,Montagner A,Polizzi A,Ducheix S,Goron A,Gamet-Payrastre L,Gerbal-Chaloin S,Pascussi JM,Moldes M,Pineau T,Guillou H,Mselli-Lakhal L

更新日期：2016-07-15 00:00:00