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Cocaine detoxification by human plasma butyrylcholinesterase.

Abstract：

:The ability of human plasma butyrylcholinesterase (BChE) to detoxify cocaine in vivo was evaluated. Intravenous administration of BChE, at doses sufficient to increase the plasma levels of the enzyme as much as 800-fold, produced no adverse effects on the cardiovascular, autonomic, or central nervous systems of rats. Most of the enzyme could be recovered in the plasma immediately after administration and remained active with a beta-t(1/2) of 21.6 +/- 2.4 hr. Pretreatment of chloralose-urethane anesthetized rats with BChE, 0.1-7.8 mg/kg, decreased the hypertensive and arrhythmogenic effects produced by cocaine and increased the lethal dose of cocaine by three- to fourfold. Treatment of conscious rats with 1 and 10 mg/kg BChE decreased the incidence of seizures and deaths produced by a prior dose of cocaine (80 mg/kg, i.p.). These results suggest that BChE would provide a safe and highly efficacious treatment for cocaine intoxication.

journal_name

Toxicol Appl Pharmacol

journal_title

Toxicology and applied pharmacology

authors

Lynch TJ,Mattes CE,Singh A,Bradley RM,Brady RO,Dretchen KL

doi

10.1006/taap.1997.8187

subject

Has Abstract

pub_date

1997-08-01 00:00:00

pages

363-71

issue

2

eissn

0041-008X

issn

1096-0333

pii

S0041-008X(97)98187-4

journal_volume

145

pub_type

杂志文章

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