Abstract：
:Ammonium perfluorooctanoate (CAS Registry No. 3825-26-2) is used commercially in the aqueous polymerization of fluorinated monomers. Because the chemical exists as a fine white powder which can come in contact with skin, its dermal toxicology was studied in rabbits and rats. Dermal applications of 0.5 g for 24 hr produced mild irritation to rabbit skin. The dermal LD50 was 4300 mg/kg for rabbits, 7000 mg/kg for male rats, and greater than 7500 mg/kg for female rats. Rat skin showed less irritation than rabbit skin and the general effects were more pronounced for the male (compared to the female) rat. Subchronic dermal treatment (10 applications, 5 doses, 2 rest days, 5 doses) with either 0, 20, 200, or 2000 mg/kg resulted in no, no, mild, or marked decreases in body weights, respectively. Increases in serum enzyme activities indicating hepatic effects occurred in treated rats. Liver weights were increased and necrosis and enlargement of hepatocytes were microscopically observed. Rats in the 2000 mg/kg-dose group also had epidermal necrosis at the application site. Blood organofluorine amounts were increased in a dose-related manner. All of the treatment-related toxicity findings resolved during a 42-day recovery period although prior exposure was evident by the presence of organofluorine in the blood.
journal_name
Toxicol Appl Pharmacoljournal_title
Toxicology and applied pharmacologyauthors
Kennedy GL Jrdoi
10.1016/0041-008x(85)90172-3subject
Has Abstractpub_date
1985-11-01 00:00:00pages
348-55issue
2eissn
0041-008Xissn
1096-0333journal_volume
81pub_type
杂志文章abstract：:Epidemiological studies indicated that people exposed to dioxins were prone to the development of lung diseases including lung cancer. Animal studies demonstrated that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increased liver tumors and promoted lung metaplasia in females. Metabolic changes in 17beta-estradiol (E(2))...
journal_title：Toxicology and applied pharmacology
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journal_title：Toxicology and applied pharmacology
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doi：10.1016/0041-008x(90)90025-p
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doi：10.1016/j.taap.2012.02.016
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journal_title：Toxicology and applied pharmacology
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journal_title：Toxicology and applied pharmacology
pub_type： 杂志文章
doi：10.1016/0041-008x(85)90096-1
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journal_title：Toxicology and applied pharmacology
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journal_title：Toxicology and applied pharmacology
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journal_title：Toxicology and applied pharmacology
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doi：10.1016/j.taap.2013.01.027
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journal_title：Toxicology and applied pharmacology
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doi：10.1006/taap.1996.8009
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journal_title：Toxicology and applied pharmacology
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pub_type： 杂志文章
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journal_title：Toxicology and applied pharmacology
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journal_title：Toxicology and applied pharmacology
pub_type： 杂志文章
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journal_title：Toxicology and applied pharmacology
pub_type： 杂志文章
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journal_title：Toxicology and applied pharmacology
pub_type： 杂志文章
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更新日期：2011-12-15 00:00:00
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journal_title：Toxicology and applied pharmacology
pub_type： 杂志文章
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journal_title：Toxicology and applied pharmacology
pub_type： 杂志文章
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journal_title：Toxicology and applied pharmacology
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journal_title：Toxicology and applied pharmacology
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journal_title：Toxicology and applied pharmacology
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journal_title：Toxicology and applied pharmacology
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abstract：:Cyanide intoxication in mice can be antagonized by the local anesthetic, procaine HCI, either alone or in combination with sodium nitrite and/or sodium thiosulfate. Antitoxic potency, derived from LD50 values, was compared in groups of mice pretreated with sodium nitrite (43.9 mg/kg i.p.), sodium thiosulfate (1 g/kg i...
journal_title：Toxicology and applied pharmacology
pub_type： 杂志文章
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abstract：:Adult cynomolgus monkeys were administered trimethyltin (TMT) iv in dosages ranging from 0.75 to 4.0 mg TMT/kg and observed for behavioral changes. Animals were subsequently killed for light and electron microscopic examination. TMT showed a dose-related toxicity, with high dose animals (4.0 and 3.0 mg/kg) dying withi...
journal_title：Toxicology and applied pharmacology
pub_type： 杂志文章
doi：10.1016/0041-008x(85)90141-3
更新日期：1985-07-01 00:00:00
abstract：:Skin is the largest and most accessible drug-metabolizing organ. In mammals, it is the competent barrier that protects against exposure to harmful stimuli in the environment and in the systemic circulation. Skin expresses many cytochromes P450 that have critical roles in exogenous and endogenous substrate metabolism. ...
journal_title：Toxicology and applied pharmacology
pub_type： 杂志文章,评审
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更新日期：2004-03-15 00:00:00
abstract：:Cigarette smoke has been shown to cause gastric cancer. Overexpression of cyclooxygenase-2 (COX-2) is a common characteristic in gastric malignancy. The present study aimed to explore the correlation between cigarette smoke and COX-2 in the promotion of tumorigenesis in human gastric cancer cells (AGS). We further stu...
journal_title：Toxicology and applied pharmacology
pub_type： 杂志文章
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更新日期：2004-02-15 00:00:00
