Effects of ricin administration to rabbits on the ability of their coronary arteries to contract and relax in vitro.

abstract：:Mitotic catastrophe, a form of cell death resulting from abnormal mitosis, is a cytotoxic death pathway as well as an appealing mechanistic strategy for the development of anti-cancer drugs. In this study, 6-bromine-5-hydroxy-4-methoxybenzaldehyde was demonstrated to induce DNA double-strand break, multipolar spindles...

journal_title：Toxicology and applied pharmacology

authors： Zhang B,Huang B,Guan H,Zhang SM,Xu QZ,He XP,Liu XD,Wang Y,Shang ZF,Zhou PK

更新日期：2011-05-01 00:00:00

abstract：UNLABELLED:In the heart, cardiac fibroblasts (CF) and cardiac myofibroblasts (CMF) are the main cells responsible for wound healing after cardiac insult. Exchange protein activated by cAMP (EPAC) is a downstream effector of cAMP, and it has been not completely studied on CF. Moreover, in CMF, which are the main cells r...

journal_title：Toxicology and applied pharmacology

authors： Olmedo I,Muñoz C,Guzmán N,Catalán M,Vivar R,Ayala P,Humeres C,Aránguiz P,García L,Velarde V,Díaz-Araya G

更新日期：2013-10-15 00:00:00

abstract：:Tongue cancer is one of the most common oral malignancies. Quisinostat is a histone deacetylase inhibitor with antitumor activity. The aim of this study was to evaluate the effects of quisinostat on the viability of tongue squamous cell carcinoma (TSCC) cells (CAL-27, TCA-8113) in vitro and in vivo. Cell viability, ce...

journal_title：Toxicology and applied pharmacology

authors： Wang X,Liu K,Gong H,Li D,Chu W,Zhao D,Wang X,Xu D

更新日期：2021-01-01 00:00:00

abstract：:Zinc pretreatment has been shown in vitro (rat myoblasts) to induce metallothionein (MT) and inhibit cadmium (Cd)-induced protooncogenes c-myc and c-jun mRNA levels. therefore, the purpose of this study was to determine whether the mRNA expression of the protooncogene c-jun as well as the tumor suppressor gene p53 is ...

journal_title：Toxicology and applied pharmacology

authors： Zheng H,Liu J,Choo KH,Michalska AE,Klaassen CD

更新日期：1996-02-01 00:00:00

abstract：:Arsenate (AsV) is a structural analogue of phosphate (P(i)), yet its toxic effect is likely due to its reduction to the more toxic arsenite (AsIII), the mechanism of which is still unclear. Since mitochondria take up AsV as they do P(i), they may reduce AsV to AsIII. To test this hypothesis isolated rat liver mitochon...

journal_title：Toxicology and applied pharmacology

authors： Németi B,Gregus Z

更新日期：2002-08-01 00:00:00

abstract：:Cannabinoid receptor (CB) expression was characterized in immunological cell and tissue preparations. Northern analysis revealed approximately 6-kb transcripts for CB1 (brain-type) in mouse spleen and brain and in rat cerebellum. CB1 was not detected in mouse thymus or rat spleen RNA by Northern analysis. CB2 (periphe...

journal_title：Toxicology and applied pharmacology

authors： Schatz AR,Lee M,Condie RB,Pulaski JT,Kaminski NE

更新日期：1997-02-01 00:00:00

abstract：:Phytochemicals show promise as potential chemopreventive or chemotherapeutic agents against various cancers. Here we report the chemotherapeutic effects of berberine, a phytochemical, on human prostate cancer cells. The treatment of human prostate cancer cells (PC-3) with berberine induced dose-dependent apoptosis but...

journal_title：Toxicology and applied pharmacology

authors： Meeran SM,Katiyar S,Katiyar SK

更新日期：2008-05-15 00:00:00

abstract：:Nanotechnology has the potential to make a beneficial impact on several agricultural, forestry, and environmental challenges, such as urbanization, energy constraints, and sustainable use of resources. However, new environmental and human health hazards may emerge from nano-enhanced applications. This raises concerns ...

journal_title：Toxicology and applied pharmacology

authors： Iavicoli I,Leso V,Beezhold DH,Shvedova AA

更新日期：2017-08-15 00:00:00

abstract：:Air pollution particles (PM) are known to elicit an acute inflammatory response in vivo that is mediated in part through PM-induced activation of the NF-kappaB signaling pathway. Many of the details of this process and particularly where in the cell it occurs are unclear. To determine whether contact of PM particles w...

journal_title：Toxicology and applied pharmacology

authors： Churg A,Xie C,Wang X,Vincent R,Wang RD

更新日期：2005-10-01 00:00:00

abstract：:Mitochondrial oxidative stress plays important roles in aging and age-related degenerative disorders. The newly identified mitochondrial thioredoxin (mtTrx; Trx2) is a key component of the mitochondrial antioxidant system which is responsible for the clearance of reactive intermediates and repairs proteins with oxidat...

journal_title：Toxicology and applied pharmacology

authors： Chen Y,Yu M,Jones DP,Greenamyre JT,Cai J

更新日期：2006-10-15 00:00:00

abstract：:This study investigated the in vivo metabolism of di(2-ethylhexyl) phthalate (DEHP) and mono(2-ethylhexyl) phthalate (MEHP) in rats after multiple dosing, the metabolism of MEHP in primary rat hepatocyte cultures for periods of up to 3 days, and the biotransformation of some major metabolites of MEHP. Rats were orally...

journal_title：Toxicology and applied pharmacology

authors： Lhuguenot JC,Mitchell AM,Milner G,Lock EA,Elcombe CR

更新日期：1985-08-01 00:00:00

abstract：:The disposition of [3H]diisopropylfluorophosphate (DFP) and its metabolites was studied in mice after iv treatment. In addition, disposition of [3H]DFP in selected tissues was correlated with cholinesterase activity and spontaneous activity following DFP treatment. Within 1 min of administration [3H]DFP had penetrated...

journal_title：Toxicology and applied pharmacology

authors： Martin BR

更新日期：1985-02-01 00:00:00

abstract：:Single-pass perfusion of mouse livers in situ with the phosphorothioate pesticide parathion resulted in formation of the cholinesterase inhibitor paraoxon (PO), p-nitrophenol (PNP), p-nitrophenyl sulfate (PNPS), and p-nitrophenyl glucuronide (PNPG). Daily pretreatment of mice with phenobarbital (80 mg/kg, ip) for 4 da...

journal_title：Toxicology and applied pharmacology

authors： Sultatos LG

更新日期：1986-10-01 00:00:00

abstract：:I-compounds are recently discovered, age-dependent covalent DNA modifications, which are detectable by 32P-postlabeling assay for DNA adducts. The effects of the catatoxic antiglucocorticoid, pregnenolone-16 alpha-carbonitrile (PCN), on hepatic and renal I-compound levels have been studied in male and female Sprague-D...

journal_title：Toxicology and applied pharmacology

authors： Moorthy B,van Golen KL,Randerath K

更新日期：1992-04-01 00:00:00

abstract：:To study the interaction of retinoid-induced limb defects and cleft palate on day 11 of gestation, a RXR-selective agonist (AGN191701, an arylpropenyl-thiophene-carboxylic acid derivative, 20 mg/kg orally) was coadministered with a RARalpha-agonist (Am580, an arylcarboxamidobenzoic acid derivative, 5 mg/kg orally) to ...

journal_title：Toxicology and applied pharmacology

authors： Elmazar MM,Rühl R,Nau H

更新日期：2001-01-01 00:00:00

abstract：:Cadmium (Cd(2+)) is a widespread environmental pollutant, which is associated with a wide variety of cytotoxic and metabolic effects. Recent studies showed that intoxication with the heavy metal most importantly targets the integrity of the epithelial barrier. In our study, the lung epithelial cell line, NCI H441, was...

journal_title：Toxicology and applied pharmacology

authors： Papritz M,Pohl C,Wübbeke C,Moisch M,Hofmann H,Hermanns MI,Thiermann H,Kirkpatrick CJ,Kehe K

更新日期：2010-06-15 00:00:00

abstract：:The biochemical and biological behavior of methylmercury (MeHg) was investigated by measurement of MeHg release rate from erythrocytes (RBC) of selected animal strains and species, by measurement of the intracellular distribution of MeHg in RBC, and by measurement of the binding affinity of hemoglobin (Hb) for MeHg. M...

journal_title：Toxicology and applied pharmacology

authors： Doi R,Tagawa M

更新日期：1983-07-01 00:00:00

abstract：:Phenobarbital (PB) is an effective growth stimulator of hepatic hyperplastic nodules developed with diethylnitrosamine and 2-acetylaminofluorene plus partial hepatectomy (the Solt-Farber model), but it does not apparently stimulate the growth of preneoplastic lesions produced with aflatoxin B1 (AFB). Some studies have...

journal_title：Toxicology and applied pharmacology

authors： Chen ZY,Eaton DL

更新日期：1991-10-01 00:00:00

abstract：:Benzene is used at large volumes in many different human activities. Hematotoxicity and cancer-causation as a result of benzene exposure was recognized many years ago, but the mechanisms involved remain unclear. Aberrant regulation of gap junction intercellular communication (GJIC) has been linked to both cancer induc...

journal_title：Toxicology and applied pharmacology

authors： Rivedal E,Leithe E

更新日期：2008-11-01 00:00:00

abstract：:Acetaminophen (APAP) and 7-hydroxy-2-acetylaminofluorene (7-OH-AAF) each produced a similar incidence of, as well as a qualitatively similar, abnormal closure of the anterior neuropore at similar concentrations when added to the medium of cultured rat embryos. At concentrations producing a 50-65% incidence of abnormal...

journal_title：Toxicology and applied pharmacology

authors： Stark KL,Harris C,Juchau MR

更新日期：1989-03-01 00:00:00

abstract：:Diurnal patterns of feeding, drinking, locomotor activity, and rearing in male Fischer-344 rats were examined for 2 weeks after a single oral dose of trimethyltin chloride (TMT) at 0, 3, 5, or 7 mg/kg. Body weights and feeding and drinking efficiency ratios (ratios of amount of food or water consumed per unit effort) ...

journal_title：Toxicology and applied pharmacology

authors： Bushnell PJ,Evans HL

更新日期：1985-06-15 00:00:00

abstract：:The effect of lead exposure on beta2-adrenoceptor density and catecholamine response was studied in 26 male workers and 1 female worker, exposed to lead on average for 6 years. The systolic blood pressure in lead workers (101-160 mmHg, 124.4 +/- 14.7 mmHg) was found to be significantly higher than in controls (97-134 ...

journal_title：Toxicology and applied pharmacology

authors： Chang HR,Chen SS,Chen TJ,Ho CH,Chiang HC,Yu HS

更新日期：1996-07-01 00:00:00

abstract：:A comparative test in mice for pulmonary toxicity between butylated hydroxytoluene (2,6-di-tert.-butyl-4-methylphenol, BHT) and 2,6-di-tert.-butyl-4-[alpha, alpha, alpha-2H3]methylphenol (BHT-d3) showed a significantly lower toxic potency of the latter. The rate of in vitro BHT metabolism to 2,6-di-tert.-butyl-4-methy...

journal_title：Toxicology and applied pharmacology

authors： Mizutani T,Yamamoto K,Tajima K

更新日期：1983-06-30 00:00:00

abstract：:Ethambutol, an efficacious antituberculosis agent, can cause irreversible visual loss in a small but significant fraction of patients. However, the mechanism of ocular toxicity remains to be established. We previously reported that ethambutol caused severe vacuole formation in cultured retinal cells, and that the addi...

journal_title：Toxicology and applied pharmacology

authors： Chung H,Yoon YH,Hwang JJ,Cho KS,Koh JY,Kim JG

更新日期：2009-03-01 00:00:00

abstract：:This paper reviews the occurrence and properties of cyanobacterial toxins, with reference to the recognition and management of the human health risks which they may present. Mass populations of toxin-producing cyanobacteria in natural and controlled waterbodies include blooms and scums of planktonic species, and mats ...

journal_title：Toxicology and applied pharmacology

authors： Codd GA,Morrison LF,Metcalf JS

更新日期：2005-03-15 00:00:00

abstract：:3-Methylindole (3MI), a fermentation product of tryptophan produced by intestinal and ruminal microflora, has been shown to cause pneumotoxicity in several species subsequent to cytochrome P450-mediated biotransformation. Among several species studied, rabbits are comparatively resistant to 3MI-induced pneumotoxicity,...

journal_title：Toxicology and applied pharmacology

authors： Thornton-Manning JR,Nichols WK,Manning BW,Skiles GL,Yost GS

更新日期：1993-10-01 00:00:00

abstract：:The H295R cell bioassay was used to evaluate the potential endocrine disrupting effects of 18 of the most commonly used pharmaceuticals in the United States. Exposures for 48 h with single pharmaceuticals and binary mixtures were conducted; the expression of five steroidogenic genes, 3betaHSD2, CYP11beta1, CYP11beta2,...

journal_title：Toxicology and applied pharmacology

authors： Gracia T,Hilscherova K,Jones PD,Newsted JL,Higley EB,Zhang X,Hecker M,Murphy MB,Yu RM,Lam PK,Wu RS,Giesy JP

更新日期：2007-12-01 00:00:00

abstract：:Investigations have characterized addictive drug-induced developmental cardiovascular malformation in human, non-human primate and rodent. However, the underlying mechanism of malformation caused by drugs during pregnancy is still largely unknown, and preventive and therapeutic measures have been lacking. Using 1H NMR...

journal_title：Toxicology and applied pharmacology

authors： Shao X,Hu Z,Hu C,Bu Q,Yan G,Deng P,Lv L,Wu D,Deng Y,Zhao J,Zhu R,Li Y,Li H,Xu Y,Yang H,Zhao Y,Cen X

更新日期：2012-05-01 00:00:00

abstract：:The effect of age and sex on the elimination of theophylline in New Zealand White rabbits was investigated following exposure to 0.3 ppm of ozone (O3) for 3.75 hr/day over 5 consecutive days. Animals were given air alone 5 to 7 days before and after the 5 days of O3 exposure. The elimination half-life of theophylline ...

journal_title：Toxicology and applied pharmacology

authors： Canada AT,Calabrese EJ

更新日期：1985-10-01 00:00:00

abstract：:Deoxynivalenol (DON) is one of the most common mycotoxins which contaminate cereals and their by-products worldwide. Previous studies have stated toxic effects of DON on liver. Heme oxygenase-1 (HO-1) plays a potential role in protecting liver and maintaining gut microbiota homeostasis. Therefore, a study on the poten...

journal_title：Toxicology and applied pharmacology

authors： Peng Z,Liao Y,Chen L,Liu S,Shan Z,Nüssler AK,Yao P,Yan H,Liu L,Yang W

更新日期：2019-07-01 00:00:00