Heme oxygenase-1 attenuates low-dose of deoxynivalenol-induced liver inflammation potentially associating with microbiota.

abstract：:Epidemiological studies have shown an association between elevated levels of particulate matter air pollution and increased morbidity and hospital visits in asthmatics. Residual oil fly ash (ROFA) is a primary combustion particle containing sulfate and metals such as vanadium, nickel, and iron. In this study the effec...

journal_title：Toxicology and applied pharmacology

authors： Lambert AL,Dong W,Winsett DW,Selgrade MK,Gilmour MI

更新日期：1999-08-01 00:00:00

abstract：:Diabetes is known to potentiate thioacetamide (TA)-induced liver injury via enhanced bioactivation. Little attention has been given to the role of compensatory tissue repair on ultimate outcome of hepatic injury in diabetes. The objective of this study was to investigate the effect of diabetes on TA-induced liver inju...

journal_title：Toxicology and applied pharmacology

authors： Wang T,Fontenot RD,Soni MG,Bucci TJ,Mehendale HM

更新日期：2000-07-15 00:00:00

abstract：:Inhaling concomitants from Asian sand dust (ASD) may result in exacerbation of pneumonia by the pathogen. The exacerbating effect of ASD on pneumonia induced by Klebsiella pneumoniae (KP) was investigated in ICR mice. The organic substances adsorbed onto ASD collected from the atmosphere of Iki-island in Japan were ex...

journal_title：Toxicology and applied pharmacology

authors： He M,Ichinose T,Yoshida S,Yamamoto S,Inoue K,Takano H,Yanagisawa R,Nishikawa M,Mori I,Sun G,Shibamoto T

更新日期：2012-01-15 00:00:00

abstract：:A number of methods have been developed to assess the impact of a xenobiotic on the various components of the immune system. For risk analysis, it is necessary to determine what degree of chemically induced immune perturbation translates into altered host resistance. Natural killer (NK) cells play a pivotal role in th...

journal_title：Toxicology and applied pharmacology

authors： Wilson SD,McCay JA,Butterworth LF,Munson AE,White KL Jr

更新日期：2001-12-15 00:00:00

abstract：:The metabolism of CCl(4) initiates the peroxidation of polyunsaturated fatty acids producing alpha,beta-unsaturated aldehydes, such as 4-hydroxynonenal (4-HNE) and malondialdehyde (MDA). The facile reactivity of these electrophilic aldehydic products suggests they play a role in the toxicity of compounds like CCl(4). ...

journal_title：Toxicology and applied pharmacology

authors： Hartley DP,Kolaja KL,Reichard J,Petersen DR

更新日期：1999-11-15 00:00:00

abstract：:In mammals, CYP3A isozymes collectively comprise the largest portion of the liver and small intestinal CYP protein. They are involved in the metabolism of an extensive range of endogenous substrates and xenobiotics and make a significant contribution to the termination of the action of steroid hormones. A full-length ...

journal_title：Toxicology and applied pharmacology

authors： Tseng HP,Hseu TH,Buhler DR,Wang WD,Hu CH

更新日期：2005-06-15 00:00:00

abstract：:While the effect that TCDD has on humoral immunity has been well documented for the mouse, it has not been for the rat. In this study, the effect that TCDD has on the antibody plaque-forming cell (PFC) response to sheep red blood cells (SRBC) in adult female B6C3F1 mice and F344 rats was compared. The effect that TCDD...

journal_title：Toxicology and applied pharmacology

authors： Smialowicz RJ,Riddle MM,Williams WC,Diliberto JJ

更新日期：1994-02-01 00:00:00

abstract：:This study assessed the role of aryl hydrocarbon receptor (AHR) affinity, and cytochrome P4501A (CYP1A) protein and activity in polyaromatic hydrocarbon (PAH)-induced oxidative stress. In the 1-100nM concentration range benzo[a]pyrene (BaP) but not benzo[e]pyrene (BeP) competitively displaced 2nM [(3)H]2, 3, 7, 8-tetr...

journal_title：Toxicology and applied pharmacology

authors： Curtis LR,Garzon CB,Arkoosh M,Collier T,Myers MS,Buzitis J,Hahn ME

更新日期：2011-07-01 00:00:00

abstract：:Our previous study revealed that 4-aminopyridine (4-AP), a specific blocker of A-type current, could also inhibit inward Na+ currents (I(Na)) with a state-independent mechanism in rat cerebellar granule cells. In the present study, we report an inhibitory effect of 4-AP on voltage-gated and tetrodotoxin (TTX)-sensitiv...

journal_title：Toxicology and applied pharmacology

authors： Lu BX,Liu LY,Liao L,Zhang ZH,Mei YA

更新日期：2005-09-15 00:00:00

abstract：:Cadmium chloride (CdCl2) at a dose of 1 mg/kg body wt was injected into male rats of the Wistar strain, weighing 250 g on the average, twice a day (12-hr intervals) for 7 consecutive days. DNA and RNA contents and [3H]-thymidine and [3H]-uridine incorporation into the acid-insoluble fraction significantly increased in...

journal_title：Toxicology and applied pharmacology

authors： Nishiyama S,Nakamura K

更新日期：1984-07-01 00:00:00

abstract：:PCBs are neurotoxic compounds that have a known effect on the dopaminergic system in the brain. In a previous work it was established that PCBs are potent inhibitors of the uptake of dopamine into rat brain synaptic vesicles. In this work we further investigated the vesicular dopamine uptake in response to different P...

journal_title：Toxicology and applied pharmacology

authors： Mariussen E,Andersson PL,Tysklind M,Fonnum F

更新日期：2001-09-01 00:00:00

abstract：:The ASCT2 transport system catalyses a sodium-dependent antiport of glutamine and other neutral amino acids which is involved in amino acid metabolism. A library of 1,2,3-dithiazoles was designed, synthesized and evaluated as inhibitors of the glutamine/amino acid ASCT2 transporter in the model system of proteoliposom...

journal_title：Toxicology and applied pharmacology

authors： Oppedisano F,Catto M,Koutentis PA,Nicolotti O,Pochini L,Koyioni M,Introcaso A,Michaelidou SS,Carotti A,Indiveri C

更新日期：2012-11-15 00:00:00

abstract：:Exposure to cadmium (Cd) impairs renal transport systems for glucose, amino acids, phosphate, and dicarboxylates. To investigate if these changes are directly related to a Cd binding to the renal brush-border membrane, Cd binding and the Na+-dependent uptakes of d-glucose, l-alanine, phosphate, and succinate were dete...

journal_title：Toxicology and applied pharmacology

authors： Ahn DW,Kim YM,Kim KR,Park YS

更新日期：1999-02-01 00:00:00

abstract：:Baicalin is a major flavonoid compound purified from Scutellariae radix, which has been described as an herb in the Chinese Pharmacopoeia. Previous studies have suggested baicalin possessed extensive anti-inflammatory, anti-cancer, anti-viral properties. However, up to known, there have been no reports of safety and t...

journal_title：Toxicology and applied pharmacology

authors： Cai Y,Ma W,Xiao Y,Wu B,Li X,Liu F,Qiu J,Zhang G

更新日期：2017-10-15 00:00:00

abstract：:This study investigated the in vivo metabolism of di(2-ethylhexyl) phthalate (DEHP) and mono(2-ethylhexyl) phthalate (MEHP) in rats after multiple dosing, the metabolism of MEHP in primary rat hepatocyte cultures for periods of up to 3 days, and the biotransformation of some major metabolites of MEHP. Rats were orally...

journal_title：Toxicology and applied pharmacology

authors： Lhuguenot JC,Mitchell AM,Milner G,Lock EA,Elcombe CR

更新日期：1985-08-01 00:00:00

abstract：:Mitochondrial oxidative stress plays important roles in aging and age-related degenerative disorders. The newly identified mitochondrial thioredoxin (mtTrx; Trx2) is a key component of the mitochondrial antioxidant system which is responsible for the clearance of reactive intermediates and repairs proteins with oxidat...

journal_title：Toxicology and applied pharmacology

authors： Chen Y,Yu M,Jones DP,Greenamyre JT,Cai J

更新日期：2006-10-15 00:00:00

abstract：:Emerging evidence suggests that feeding a high-fat diet (HFD) to rodents affects the expression of genes involved in drug transport. However, gender-specific effects of HFD on drug transport are not known. The multidrug resistance-associated protein 2 (Mrp2, Abcc2) is a transporter highly expressed in the hepatocyte c...

journal_title：Toxicology and applied pharmacology

authors： Kong B,Csanaky IL,Aleksunes LM,Patni M,Chen Q,Ma X,Jaeschke H,Weir S,Broward M,Klaassen CD,Guo GL

更新日期：2012-06-01 00:00:00

abstract：:Exposure of intact cultured Chinese hamster ovary (CHO) cells to water-soluble nickel (Ni) salts and to relatively water-insoluble crystalline nickel subsulfide (Ni3S2) resulted in an increased formation of the fluorescent oxidized compound, dichlorofluorescein (DCF) from the parent nonfluorescent compound, 2,7-dichlo...

journal_title：Toxicology and applied pharmacology

authors： Huang X,Frenkel K,Klein CB,Costa M

更新日期：1993-05-01 00:00:00

abstract：:The disposition of polycyclic aromatic hydrocarbons (PAHs) in the respiratory tract of the Beagle dog was measured and presented in two previous papers. In this paper, the data were used to demonstrate that highly lipophilic toxicants, such as PAHs, were diffusion-limited during clearance from the respiratory tract. O...

journal_title：Toxicology and applied pharmacology

authors： Gerde P,Muggenburg BA,Henderson RF

更新日期：1993-08-01 00:00:00

abstract：:Thymic lymphoma/leukemia is the major cause of death in B6C3F1 mice chronically exposed to 1,3-butadiene (BD). Similar to radiation-induced murine thymic lymphoma, the bone marrow is also a major target organ. Because of the association of murine thymic lymphoma with endogenous type-C murine leukemia retroviruses (MuL...

journal_title：Toxicology and applied pharmacology

authors： Irons RD,Smith CN,Stillman WS,Shah RS,Steinhagen WH,Leiderman LJ

更新日期：1986-09-30 00:00:00

abstract：:Nonmelanoma skin cancer is the most common cancer among humans and solar UV radiation, particularly its UVB component (290-320 nm), is its major cause. One way to reduce the occurrence of the cancer is via the use of substances (often antioxidants) termed "photochemopreventive agents". Resveratrol (trans-3,4',5-trihyd...

journal_title：Toxicology and applied pharmacology

authors： Afaq F,Adhami VM,Ahmad N

更新日期：2003-01-01 00:00:00

abstract：:The nicotinic acetylcholine receptor (nAChR) of the electric organ of the electric ray. Torpedo sp., the richest source of nAChR, with similar structure and pharmacology to the mammalian skeletal muscle nAChR, carries several binding sites for different ligands. Incubation of Torpedo membrane-bound nAChRs with the ago...

journal_title：Toxicology and applied pharmacology

authors： Katz EJ,Cortes VI,Eldefrawi ME,Eldefrawi AT

更新日期：1997-10-01 00:00:00

abstract：:Carcinogenic chromium (VI) compounds are persistent environmental contaminants with potential for human exposure through drinking water. One lesion associated with chromium (VI) exposure is the formation of DNA-protein crosslinks (DPC). In an attempt to develop markers of chromium exposure, the formation of DPC in lym...

journal_title：Toxicology and applied pharmacology

authors： Coogan TP,Motz J,Snyder CA,Squibb KS,Costa M

更新日期：1991-06-01 00:00:00

abstract：:Male, English smooth haired guinea pigs were exposed to thermal decomposition products, i.e., smoke, generated by heating Douglas fir in an open system. Various amounts of Douglas fir were placed in a furnace, at room temperature, and heated at a rate of 11 degrees C/min until completely decomposed. Major decompositio...

journal_title：Toxicology and applied pharmacology

authors： Wong KL,Stock MF,Malek DE,Alarie Y

更新日期：1984-08-01 00:00:00

abstract：:Adult BALB/c mice, which are sensitive to hyperoxia (LT50 = 4.5 days 100% O2), were made tolerant to 100% O2 after treatment with butylated hydroxytoluene (BHT). Following a single ip dose of 400 mg/kg, mice survived longer periods in O2 when exposed to O2 at 7, 14, and 21, but not 2 days, following BHT injection. The...

journal_title：Toxicology and applied pharmacology

authors： Margaretten N,Tryka AF,Witschi H

更新日期：1988-10-01 00:00:00

abstract：:The neuroblastoma-spinal motor neuron fusion cell line, NSC-34, in its differentiated form, NSC-34D, permits examining the effects of riluzole, a proven treatment for amyotrophic lateral sclerosis (ALS) on cell death induction by staurosporine (STS), thapsigargin (Thaps), hydrogen peroxide (H(2)O(2)) and homocysteine ...

journal_title：Toxicology and applied pharmacology

authors： Hemendinger RA,Armstrong EJ 3rd,Radio N,Brooks BR

更新日期：2012-01-15 00:00:00

abstract：:Triaryl phosphates including tricresyl phosphate (TCP) and butylated triphenyl phosphate (BTP) are organophosphates used in the commercial manufacture of plastics, lubricants, and hydraulic fluids. Rat steroidogenic tissues such as adrenocortical (AC), ovarian interstitial (OI), and Leydig cells use an intracellular p...

journal_title：Toxicology and applied pharmacology

authors： Latendresse JR,Azhar S,Brooks CL,Capen CC

更新日期：1993-10-01 00:00:00

abstract：:1,3-butadiene (BD) has been classified as a human carcinogen, however, the relationship between chromosomal damage and its metabolic polymorphisms is not clear. The present study used the CBMN assay to detect chromosomal damage in the peripheral lymphocytes of 166 exposed workers and 41 non-exposed healthy individuals...

journal_title：Toxicology and applied pharmacology

authors： Tan H,Wang Q,Wang A,Ye Y,Feng N,Feng X,Lu L,Au W,Zheng Y,Xia Z

更新日期：2010-09-15 00:00:00

abstract：:Tissue concentrations of mercury were determined by cold vapor atomic absorption spectrometry in different inbred mouse strains after continuous treatment with HgCl2 (3 weekly sc injections of 0.5 mg/kg bw) for up to 12 weeks. Except for the thymus, in which steadily increasing mercury concentrations were found, in st...

journal_title：Toxicology and applied pharmacology

authors： Griem P,Scholz E,Turfeld M,Zander D,Wiesner U,Dunemann L,Gleichmann E

更新日期：1997-05-01 00:00:00

abstract：:Exposure to diesel exhaust particles (DEP) induces inflammatory signaling characterized by MAP kinase-mediated activation of NFkB and AP-1 in vitro and in bronchial biopsies obtained from human subjects exposed to DEP. NFkB and AP-1 activation results in the upregulation of genes involved in promoting inflammation in ...

journal_title：Toxicology and applied pharmacology

authors： Tal TL,Simmons SO,Silbajoris R,Dailey L,Cho SH,Ramabhadran R,Linak W,Reed W,Bromberg PA,Samet JM

更新日期：2010-02-15 00:00:00