Nickel induces increased oxidants in intact cultured mammalian cells as detected by dichlorofluorescein fluorescence.

abstract：:A transformer cooled and insulated with a mixture of 65% Aroclor 1254 and 35% chlorinated benzenes located in the Binghamton State Office Building in Binghamton, New York, was involved in a fire, which produced soot containing polychlorinated biphenyls, biphenylenes, dioxins, and dibenzofurans. A single dose of either...

journal_title：Toxicology and applied pharmacology

authors： Turner JN,Collins DN

更新日期：1983-03-15 00:00:00

abstract：:In order to elucidate the oxidative effects and genotoxicity of nickel on human lymphocytes in vitro, we report the level of intracellular reactive oxygen species (ROS), lipid peroxidation, hydroxyl radical ((*)OH), and DNA damage in human lymphocytes after acute exposure to inorganic nickel. NiCl(2) appeared to incre...

journal_title：Toxicology and applied pharmacology

authors： Chen CY,Wang YF,Huang WR,Huang YT

更新日期：2003-06-15 00:00:00

abstract：:Side effects of methotrexate (MTX) especially hepatotoxicity limits clinical applications of this anticancer agent. Carboxypeptidase G2 (CPG2) is administrated for the treatment of elevated plasma concentrations of MTX. In this study, we have investigated the intracellular delivery of CPG2 fused to the transactivator ...

journal_title：Toxicology and applied pharmacology

authors： Sadeghian I,Khalvati B,Ghasemi Y,Hemmati S

更新日期：2018-05-01 00:00:00

abstract：:Previous studies have demonstrated that mice lacking a functional folate binding protein 2 gene (Folbp2-/-) were significantly more sensitive to in utero arsenic exposure than were the wild-type mice similarly exposed. When these mice were fed a folate-deficient diet, the embryotoxic effect of arsenate was further exa...

journal_title：Toxicology and applied pharmacology

authors： Spiegelstein O,Gould A,Wlodarczyk B,Tsie M,Lu X,Le C,Troen A,Selhub J,Piedrahita JA,Salbaum JM,Kappen C,Melnyk S,James J,Finnell RH

更新日期：2005-02-15 00:00:00

abstract：:Cadmium (Cd) is a common environmental toxicant and an established carcinogen. Epidemiological studies implicate Cd with human breast cancer. Low micromolar concentrations of Cd promote proliferation of human breast cancer cells in vitro. The growth promotion of breast cancer cells is associated with the activation of...

journal_title：Toxicology and applied pharmacology

authors： Song X,Wei Z,Shaikh ZA

更新日期：2015-08-15 00:00:00

abstract：:Health agencies are often required to predict the effects of long term low level exposure in humans based on annual data involving short-term high-level exposures. Uncertainties in extrapolation can be, in part, based on potentially different mechanism associated with different exposure scenarios. This study evaluated...

journal_title：Toxicology and applied pharmacology

authors： Crofton KM,Padilla S,Tilson HA,Anthony DC,Raymer JH,MacPhail RC

更新日期：1996-07-01 00:00:00

abstract：:1p4studied the effect of L-2-chloropropionic acid (L-CPA)-induced (250 mg/kg/po/day for 3 days) neurotoxicity, which results in an almost total destruction of cerebellar granule cells over 5 days, on forebrain and cerebellar neurochemistry. There was a reduction in cerebellar aspartate and glutamate concentrations of ...

journal_title：Toxicology and applied pharmacology

authors： Widdowson PS,Gyte A,Simpson MG,Wyatt I,Lock EA

更新日期：1996-01-01 00:00:00

abstract：:Chronic exposure to high concentrations of arsenic in drinking water is associated with an increased risk for developing type 2 diabetes. The present revision focuses on the effect of arsenic on tissues that participate directly in glucose homeostasis, integrating the most important published information about the imp...

journal_title：Toxicology and applied pharmacology

authors： Díaz-Villaseñor A,Burns AL,Hiriart M,Cebrián ME,Ostrosky-Wegman P

更新日期：2007-12-01 00:00:00

abstract：:Several neurotoxic compounds cause aggregation of neurofilaments in peripheral axons. This may represent a primary action of these chemicals or a secondary response to other cellular damage. To distinguish between these possibilities, the effects of acrylamide and 2,5-hexanedione (2,5-HD) on vimentin were examined in ...

journal_title：Toxicology and applied pharmacology

authors： Sager PR

更新日期：1989-01-01 00:00:00

abstract：:Mice lacking the modifier subunit of glutamate cysteine ligase (Gclm), the rate-limiting enzyme in glutathione (GSH) synthesis, have decreased tissue GSH. We previously showed that Gclm-/- embryos have increased sensitivity to the prenatal in vivo ovarian toxicity of the polycyclic aromatic hydrocarbon benzo[a]pyrene ...

journal_title：Toxicology and applied pharmacology

authors： Lim J,Luderer U

更新日期：2018-08-01 00:00:00

abstract：:Increased incidence of mortality and morbidity due to cardiopulmonary complications has been found to associate with elevated levels of particulate air pollution (particulate matter with an aerodynamic diameter < 10 microm, PM10 and <2.5 microm, PM2. 5). Lung injury and an imbalance of inflammatory mediators are propo...

journal_title：Toxicology and applied pharmacology

authors： Monn C,Becker S

更新日期：1999-03-15 00:00:00

abstract：:The multidrug resistance (MDR) transporter is a phosphorylated glycoprotein (P-gp) that has been implicated in the efflux of a large variety of xenobiotics, thereby protecting vital organs. This study examines the hypothesis that the multidrug resistance transporter is involved in restricting the entry of polychlorina...

journal_title：Toxicology and applied pharmacology

authors： Tampal NM,Robertson LW,Srinivasan C,Ludewig G

更新日期：2003-03-15 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is well known for its immunotoxic effects particularly on the thymus. The exact mechanism by which TCDD induces thymic atrophy is not clear. In the current study, we investigated whether TCDD triggers apoptosis in thymocytes, when administered in vivo, by using the TdT-mediat...

journal_title：Toxicology and applied pharmacology

authors： Kamath AB,Xu H,Nagarkatti PS,Nagarkatti M

更新日期：1997-02-01 00:00:00

abstract：:Metabonomics is the evaluation of the multiparametric metabolic response of biological systems to pathophysiological stimuli. High-resolution nuclear magnetic resonance (NMR) spectroscopy of biofluids coupled with pattern recognition-based chemometric analysis is an emerging approach to the study of metabonomics and m...

journal_title：Toxicology and applied pharmacology

authors： Slim RM,Robertson DG,Albassam M,Reily MD,Robosky L,Dethloff LA

更新日期：2002-09-01 00:00:00

abstract：:Thiazacridine derivatives (ATZD) are a novel class of cytotoxic agents that combine an acridine and thiazolidine nucleus. In this study, the cytotoxic action of four ATZD were tested in human colon carcinoma HCT-8 cells: (5Z)-5-acridin-9-ylmethylene-3-(4-methylbenzyl)-thiazolidine-2,4-dione - AC-4; (5ZE)-5-acridin-9-y...

journal_title：Toxicology and applied pharmacology

authors： Barros FW,Bezerra DP,Ferreira PM,Cavalcanti BC,Silva TG,Pitta MG,de Lima Mdo C,Galdino SL,Pitta Ida R,Costa-Lotufo LV,Moraes MO,Burbano RR,Guecheva TN,Henriques JA,Pessoa C

更新日期：2013-04-01 00:00:00

abstract：:Some chemicals are known to induce limb malformations in mice. The occurrence of limb abnormality induced by chemical reagents is due to changes in the programmed cell death (PCD). 5-Bromodeoxyuridine (BrdU) is known as a potent teratogen and has been reported to induce polydactyly and other limb malformations in rode...

journal_title：Toxicology and applied pharmacology

authors： Nakamura N,Fujioka M,Mori C

更新日期：2000-09-01 00:00:00

abstract：:A physiologically based pharmacokinetic (PBPK) model describing transfer of inhaled tetrachloroethylene (PCE) into breast milk with the consequent exposure of the nursing pups was developed and validated in lactating rats. The PBPK model was based on partition coefficients (PCs), which were determined by the equilibra...

journal_title：Toxicology and applied pharmacology

authors： Byczkowski JZ,Kinkead ER,Leahy HF,Randall GM,Fisher JW

更新日期：1994-04-01 00:00:00

abstract：:Arsenic contamination of drinking water and food threatens the health of hundreds of millions of people worldwide by increasing the risk of numerous diseases. Arsenic exposure has been associated with infectious lung disease in epidemiological studies, but it is not yet understood how ingestion of low levels of arseni...

journal_title：Toxicology and applied pharmacology

authors： Goodale BC,Rayack EJ,Stanton BA

更新日期：2017-09-15 00:00:00

abstract：:Various drugs have been shown to stimulate surfactant phospholipid metabolism. Particularly beta-adrenergic agonists play an important role under physiologic conditions. For the first time we have studied whether nitrogen dioxide (NO2) inhalation alters beta-adrenergic regulation of surfactant phospholipid metabolism ...

journal_title：Toxicology and applied pharmacology

authors： Mengel RG,Bernhard W,Barth P,von Wichert P,Müller B

更新日期：1993-06-01 00:00:00

abstract：:Valinomycin and cereulide are bacterial toxins with closely similar chemical structure and properties but different toxic effects. Emetic poisoning is induced by cereulide but not by valinomycin. Both are specific potassium ionophores. Such compounds may affect mitochondrial functions. Both compounds cause a potassium...

journal_title：Toxicology and applied pharmacology

authors： Teplova VV,Mikkola R,Tonshin AA,Saris NE,Salkinoja-Salonen MS

更新日期：2006-01-01 00:00:00

abstract：:Many environmental chemicals and drugs negatively affect human health through deleterious effects on mitochondrial function. Currently there is no chemical library of mitochondrial toxicants, and no reliable methods for predicting mitochondrial toxicity. We hypothesized that discrete toxicophores defined by distinct c...

journal_title：Toxicology and applied pharmacology

authors： Wills LP,Beeson GC,Trager RE,Lindsey CC,Beeson CC,Peterson YK,Schnellmann RG

更新日期：2013-10-15 00:00:00

abstract：:Arsenate (AsV) is a structural analogue of phosphate (P(i)), yet its toxic effect is likely due to its reduction to the more toxic arsenite (AsIII), the mechanism of which is still unclear. Since mitochondria take up AsV as they do P(i), they may reduce AsV to AsIII. To test this hypothesis isolated rat liver mitochon...

journal_title：Toxicology and applied pharmacology

authors： Németi B,Gregus Z

更新日期：2002-08-01 00:00:00

abstract：:Nonmelanoma skin cancer is the most common cancer among humans and solar UV radiation, particularly its UVB component (290-320 nm), is its major cause. One way to reduce the occurrence of the cancer is via the use of substances (often antioxidants) termed "photochemopreventive agents". Resveratrol (trans-3,4',5-trihyd...

journal_title：Toxicology and applied pharmacology

authors： Afaq F,Adhami VM,Ahmad N

更新日期：2003-01-01 00:00:00

abstract：:MCC-555 is a novel PPARα/γ dual ligand of the thiazolidinedione class and was recently developed as an anti-diabetic drug with unique properties. MCC-555 also has anti-proliferative activity through growth inhibition and apoptosis induction in several cancer cell types. Our group has shown that MCC-555 targets several...

journal_title：Toxicology and applied pharmacology

authors： Min KW,Zhang X,Imchen T,Baek SJ

更新日期：2012-09-01 00:00:00

abstract：:Chlorhexidine (CHX), widely used as antiseptic and therapeutic agent in medicine and dentistry, has a toxic effect both in vivo and in vitro. The intrinsic mechanism underlying CHX-induced cytotoxicity in eukaryotic cells is, however, still unknown. A recent study from our laboratory has suggested that CHX may induce ...

journal_title：Toxicology and applied pharmacology

authors： Faria G,Cardoso CR,Larson RE,Silva JS,Rossi MA

更新日期：2009-01-15 00:00:00

abstract：:The transplacental crossover of 14C-2,4,5,2',4',5'-hexachlorobiphenyl (6-CB) from the maternal circulation to the fetal side of the placenta was examined in intact fetuses and following the in situ perfusion of the guinea pig placenta. Fetal, late pregnant, and nonpregnant female guinea pig lipoprotein profiles and th...

journal_title：Toxicology and applied pharmacology

authors： Ring BJ,Seitz KR,Vodicnik MJ

更新日期：1988-10-01 00:00:00

abstract：:An experimental design to simulate PUVA therapy (oral 8-methoxypsoralen followed by uv radiation) has been tested in a 13-week subchronic study to determine the relative toxicities of 8-methoxypsoralen (8-MOP), 5-methoxypsoralen (5-MOP), 5-methylisopsoralen (5-MIP), and 3-carbethoxypsoralen (3-CEP) in inbred hairless ...

journal_title：Toxicology and applied pharmacology

authors： Dunnick JK,Forbes PD,Davies RE,Iverson WO

更新日期：1987-06-15 00:00:00

abstract：:In three separate sets of studies, the effects of ureteral ligation and coadministration of cadmium with cysteine or glutathione (GSH) (in either a 4:1 or 2:1 ratio of thiol to cadmium) on the renal disposition of cadmium were assessed in rats 1 h after the administration of cadmium. In all experiments, co-administrat...

journal_title：Toxicology and applied pharmacology

authors： Zalups RK

更新日期：2000-04-01 00:00:00

abstract：:Sulindac is a nonsteroidal anti-inflammatory drug with demonstrated potency as a chemopreventive agent in animal models of carcinogenesis and in patients with familial adenomatous polyposis. Because tumor promotion is generally associated with exposure to pro-inflammatory stimuli, it is likely that anti-inflammatory a...

journal_title：Toxicology and applied pharmacology

authors： Athar M,An KP,Tang X,Morel KD,Kim AL,Kopelovich L,Bickers DR

更新日期：2004-03-15 00:00:00

abstract：:Benzene is a known human leukemogen, but its role as an in utero leukemogen remains controversial. Epidemiological studies have correlated parental exposure to benzene with an increased incidence of childhood leukemias. We hypothesize that in utero exposure to benzene may cause leukemogenesis by affecting the embryoni...

journal_title：Toxicology and applied pharmacology

authors： Wan J,Winn LM

更新日期：2008-05-01 00:00:00