Detection and characterization of [3H]2,3,7,8-tetrachlorodibenzo-p-dioxin binding to Ah receptor in a rainbow trout hepatoma cell line.

abstract：:The present studies were designed to evaluate the role that metabolic activation plays in allylamine (AAM)-induced vascular toxicity. The effects of AAM were evaluated in primary cultures of rat vascular endothelial (VEC) and smooth muscle cells (SMC). Semicarbazide (SC) and diethyldithiocarbamate (DDC) were used as i...

journal_title：Toxicology and applied pharmacology

authors： Ramos K,Grossman SL,Cox LR

更新日期：1988-08-01 00:00:00

abstract：:The effect of maternal selenium deficiency on methyl mercury fetotoxicity was examined in the ICR strain of mice. Pregnant mice were fed either selenium-deficient diets based on torula yeast or selenium-supplemented diets which were identical to the former except that 0.1, 0.2, or 0.4 mg of selenium per kilogram of di...

journal_title：Toxicology and applied pharmacology

authors： Nishikido N,Furuyashiki K,Naganuma A,Suzuki T,Imura N

更新日期：1987-05-01 00:00:00

abstract：:Ethanol induces cumulative liver damage including steatosis, steatohepatitis and cirrhosis. The aim of this study is to investigate the global intrahepatic gene expression profile in the mouse liver treated with ethanol. A single oral dose of 0.5 or 5 g/kg ethanol was administered to male ICR mice, and liver samples w...

journal_title：Toxicology and applied pharmacology

authors： Yin HQ,Kim M,Kim JH,Kong G,Kang KS,Kim HL,Yoon BI,Lee MO,Lee BH

更新日期：2007-09-15 00:00:00

abstract：:The mechanism of action of Cd on Na,K-ATPase was investigated in two "classical" model systems, the shark rectal gland and rabbit kidney outer medulla. In lyophilized plasma membranes from dogfish rectal gland Cd inhibited Na,K-ATPase activity after 30 min of preincubation with an I50 of 1.3 x 10(-5) M. K-Dependent p-...

journal_title：Toxicology and applied pharmacology

authors： Kinne-Saffran E,Hülseweh M,Pfaff C,Kinne RK

更新日期：1993-07-01 00:00:00

abstract：:Carbendazim inhibits microtubule assembly, thus blocking mitosis and inhibiting cancer cell proliferation. Accordingly, carbendazim is being explored as an anticancer drug. Data show that carbendazim increased mRNA and protein expressions and promoter activity of CYP1A1. In addition, carbendazim activated transcriptio...

journal_title：Toxicology and applied pharmacology

authors： Wei KL,Chen FY,Lin CY,Gao GL,Kao WY,Yeh CH,Chen CR,Huang HC,Tsai WR,Jong KJ,Li WJ,Su JG

更新日期：2016-09-01 00:00:00

abstract：:The role of gamma-glutamyl transpeptidase (gamma-GTP) in the nephrotoxicity of hexachloro-1,3-butadiene (HCBD) was studied using male Sprague-Dawley rats pretreated with AT-125 (Acivicin; L-(alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid). Inhibition of gamma-GTP by more than 95% did not affect u...

journal_title：Toxicology and applied pharmacology

authors： Davis ME

更新日期：1988-08-01 00:00:00

abstract：:Garlic and its active components are known to possess antioxidant and antiinflammatory effects. The present study investigated the effects of garlic oil and its organosulfur compounds on endotoxin-induced intestinal mucosal damage. Wistar rats received by gavage 50 or 200 mg/kg body weight garlic oil (GO), 0.5 mmol/kg...

journal_title：Toxicology and applied pharmacology

authors： Chiang YH,Jen LN,Su HY,Lii CK,Sheen LY,Liu CT

更新日期：2006-05-15 00:00:00

abstract：:While the physiologic and molecular effects of capsaicinoids have been extensively studied in various model systems by a variety of administration routes, little is known about the uptake and elimination kinetic profiles in human skin following topical exposure. The present study evaluated the uptake and elimination k...

journal_title：Toxicology and applied pharmacology

authors： Pershing LK,Reilly CA,Corlett JL,Crouch DJ

更新日期：2004-10-01 00:00:00

abstract：:Intracellular retention of toxic bile salts contributes to hepatocellular injury during cholestasis. We have recently demonstrated that toxic bile salts directly induce apoptosis in hepatocytes. As oxidative stress has been implicated in many models of apoptosis, our aim was to determine if oxidative injury is a criti...

journal_title：Toxicology and applied pharmacology

authors： Patel T,Gores GJ

更新日期：1997-01-01 00:00:00

abstract：:Methemoglobin formation, as well as hemoglobin or DNA adducts, are useful biomarkers of occupational exposure to certain arylamines. It has been suggested that, in liver from animals not treated with a cytochrome P450 (CYP) inducer, hepatic CYP1A2 is the major P450 involved in N-hydroxylation. This is the first step i...

journal_title：Toxicology and applied pharmacology

authors： Shertzer HG,Dalton TP,Talaska G,Nebert DW

更新日期：2002-05-15 00:00:00

abstract：:The commonly used antidepressants imipramine, amitriptyline, and nortriptyline were found to significantly inhibit human natural killer (NK) cell-mediated cytolysis in vitro and suppress the stimulation of NK cells by IFN-gamma. This is a previously unrecognized biologic property of these drugs with psychotropic activ...

journal_title：Toxicology and applied pharmacology

authors： Xiao L,Eneroth P

更新日期：1996-04-01 00:00:00

abstract：:Marijuana or synthetic cannabinoids and alcohol are often used together, with these combinations causing motor impairments that can subsequently lead to motor vehicle accidents. This study investigated the combined use of both synthetic cannabinoids and ethanol and their effect on motor coordination in mice in additio...

journal_title：Toxicology and applied pharmacology

authors： Funada M,Takebayashi-Ohsawa M,Tomiyama KI

更新日期：2020-12-01 00:00:00

abstract：:Studies were conducted which examined urinary excretion and papillary production of cyclic-AMP in the rat following vasopressin (ADH) stimulation in the presence or absence of inorganic fluoride ion (F). In one set of experiments, six anesthetized Fischer 344 rats were administered 5 munits arginine vasopressin during...

journal_title：Toxicology and applied pharmacology

authors： Maxwell JA,Caffrey JL,Yorio T,Sinclair RJ

更新日期：1983-06-15 00:00:00

abstract：:Antrodia camphorata (A. camphorata) is a fungus commonly used for treatment of viral hepatitis and cancer in Chinese folk medicine. Extract of A. camphorate is reported to possess anti-inflammatory, antihepatitis B virus and anticancer activities. In this study, we tested the in vivo effects of polysaccharides derived...

journal_title：Toxicology and applied pharmacology

authors： Cheng PC,Hsu CY,Chen CC,Lee KM

更新日期：2008-03-01 00:00:00

abstract：:Clofibric acid (CA), a potent peroxisome proliferator (PP), has been shown to cause tumor formation in rat liver. The precise mechanism of action of PPs remains largely unknown. However, it has been proposed that they act by increasing reactive oxygen species (ROS), leading to a cellular oxidative stress. In the prese...

journal_title：Toxicology and applied pharmacology

authors： Bécuwe P,Bianchi A,Dauça M

更新日期：2001-08-01 00:00:00

abstract：:Azaspiranes are cationic amphiphilic compounds that are active in a number of models of autoimmune disease and transplantation. Repeated administration of cationic amphiphiles induces phospholipid accumulation in a variety of species. The present study was conducted to explore the mechanism of phospholipid accumulatio...

journal_title：Toxicology and applied pharmacology

authors： Handler JA,Badger A,Genell CA,Klinkner AM,Kassis S,Waites CR,Bugelski PJ

更新日期：1999-08-15 00:00:00

abstract：:The role of metallothionein or metallothionein-like proteins (MT) in genetic resistance to the testicular and hepatic toxicity of cadmium was examined in inbred strains of mice. Mice of two strains resistant (AJ and C3H/HEJ) or susceptible (129J and DBA/2J) to cadmium-induced testicular necrosis were administered sc 3...

journal_title：Toxicology and applied pharmacology

authors： Nolan CV,Shaikh ZA

更新日期：1986-09-15 00:00:00

abstract：:Growing use of carbon nanotubes (CNTs) have garnered concerns regarding their association with adverse health effects. Few studies have probed how CNTs affect a host's susceptibility to pathogens, particularly respiratory viruses. We reported that exposure of lung cells and mice to pristine single-walled CNTs (SWCNTs)...

journal_title：Toxicology and applied pharmacology

authors： Chen H,Humes ST,Rose M,Robinson SE,Loeb JC,Sabaraya IV,Smith LC,Saleh NB,Castleman WL,Lednicky JA,Sabo-Attwood T

更新日期：2020-10-01 00:00:00

abstract：:Endothelial apoptosis is a driving force in atherosclerosis development. Oxidized low-density lipoprotein (oxLDL) promotes inflammatory and thrombotic processes and is highly atherogenic, as it stimulates macrophage cholesterol accumulation and foam cell formation. Previous studies have shown that the phosphatidylinos...

journal_title：Toxicology and applied pharmacology

authors： Ou HC,Lee WJ,Lee SD,Huang CY,Chiu TH,Tsai KL,Hsu WC,Sheu WH

更新日期：2010-10-15 00:00:00

abstract：:The relationship of exposure and tissue concentration of parent chemical and metabolites over prolonged exposure is a critical issue for chronic toxicities mediated by metabolite(s) rather than parent chemical alone. This is an issue for AsV because its trivalent metabolites have unique toxicities and relatively great...

journal_title：Toxicology and applied pharmacology

authors： Kenyon EM,Hughes MF,Adair BM,Highfill JH,Crecelius EA,Clewell HJ,Yager JW

更新日期：2008-11-01 00:00:00

abstract：:Male Wistar rats pretreated with ethanol (2.0 g in 80 ml liquid diet/day for 3 weeks) or phenobarbital (PB, 80 mg/kg/day ip for 4 days) were exposed by inhalation to 500, 1000, 2000, 4000, or 8000 ppm trichloroethylene (TRI) for 2 or 8 hr, and the blood concentration of TRI and the urinary concentration of TRI metabol...

journal_title：Toxicology and applied pharmacology

authors： Nakajima T,Okino T,Okuyama S,Kaneko T,Yonekura I,Sato A

更新日期：1988-06-30 00:00:00

abstract：:The Zrt/Irt-related protein 8 (ZIP8) encoded by slc39a8 is now emerging as an important zinc transporter involved in cellular cadmium incorporation. We have previously shown that mRNA and protein levels of ZIP8 were decreased in cadmium-resistant metallothionein-null (A7) cells, leading to a decrease in cadmium accumu...

journal_title：Toxicology and applied pharmacology

authors： Fujishiro H,Okugaki S,Yasumitsu S,Enomoto S,Himeno S

更新日期：2009-12-01 00:00:00

abstract：:Mitoguazone is a known inhibitor of polyamine biosynthesis through competitive inhibition of S-adenosylmethionine decarboxylase. A recent renewed interest in mitoguazone as an antineoplastic agent prompted us to investigate the effect of the drug on polyamine catabolism in rat liver, since the organ plays an important...

journal_title：Toxicology and applied pharmacology

authors： Ferioli ME,Berselli D,Caimi S

更新日期：2004-12-01 00:00:00

abstract：:Methylmercury (MeHg) is an ubiquitous environmental pollutant which is transported into the mammalian cells when present as the methylmercury-cysteine conjugate (MeHg-Cys). With special emphasis on hepatic cells, due to their particular propensity to accumulate an appreciable amount of Hg after exposure to MeHg, this ...

journal_title：Toxicology and applied pharmacology

authors： Roos DH,Puntel RL,Farina M,Aschner M,Bohrer D,Rocha JB,de Vargas Barbosa NB

更新日期：2011-04-01 00:00:00

abstract：:While the effect that TCDD has on humoral immunity has been well documented for the mouse, it has not been for the rat. In this study, the effect that TCDD has on the antibody plaque-forming cell (PFC) response to sheep red blood cells (SRBC) in adult female B6C3F1 mice and F344 rats was compared. The effect that TCDD...

journal_title：Toxicology and applied pharmacology

authors： Smialowicz RJ,Riddle MM,Williams WC,Diliberto JJ

更新日期：1994-02-01 00:00:00

abstract：:Benzene is a potent bone marrow toxicant. While all blood cell types are targets for benzene poisoning, lymphocytes are particularly sensitive. The immunotoxic consequences of benzene or its metabolites have been demonstrated in a number of in vitro studies; however, little data exist regarding the effects of benzene ...

journal_title：Toxicology and applied pharmacology

authors： Rosenthal GJ,Snyder CA

更新日期：1985-09-30 00:00:00

abstract：:CIL-102 (1-[4-(furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone) is the major active agent of the alkaloid derivative of Camptotheca acuminata, with multiple pharmacological activities, including anticancer effects and promotion of apoptosis. The mechanism by which CIL-102 inhibits growth remains poorly understood in hum...

journal_title：Toxicology and applied pharmacology

authors： Teng CC,Kuo HC,Cheng HC,Wang TC,Sze CI

更新日期：2012-08-15 00:00:00

abstract：:The physicochemical complexity of airborne particulate matter (PM) has hampered identifying a specific mechanism(s) for its toxicity. In this study, selected physicochemical characteristics (i.e., size, particle number, acidity, and surface charge) were measured on various field PM, derived from urban ambient (St. Lou...

journal_title：Toxicology and applied pharmacology

authors： Veronesi B,de Haar C,Lee L,Oortgiesen M

更新日期：2002-02-01 00:00:00

abstract：:BALB/c mice were sensitized to ovalbumin by systemic injection and then exposed for up to 8 weeks to ovalbumin aerosols in whole body chambers. A pattern of airway inflammation, mucous cell hypertrophy and hyperplasia, and airway remodeling with submucosal fibrosis was observed as lesions evolved over time. Larger con...

journal_title：Toxicology and applied pharmacology

authors： Kenyon NJ,Ward RW,Last JA

更新日期：2003-01-15 00:00:00

abstract：:Freely moving rats were exposed to sarin vapor (34.2+/-0.8 microg/l) for 10 min. Mortality at 24 h was 35% and toxic sings in the surviving rats ranged from sever (prolonged convulsions) through moderate to almost no overt signs. Some of the surviving rats developed delayed, intermittent convulsions. All rats were eva...

journal_title：Toxicology and applied pharmacology

authors： Grauer E,Chapman S,Rabinovitz I,Raveh L,Weissman BA,Kadar T,Allon N

更新日期：2008-03-01 00:00:00