Opiates depress ACh and ATP release from cholinergic synaptosomes by blocking calcium uptake.

abstract：:An experimental system was chosen to investigate the bioactivity of a lipoprotein-sequestered toxicant at the cellular level based on recent studies demonstrating receptor-mediated uptake of lipoproteins by macrophages. Rat peritoneal exudate cell suspensions (PEC) were exposed to DDT and lipoprotein-sequestered DDT, ...

journal_title：Toxicology and applied pharmacology

authors： Kaminski NE,Wells DS,Dauterman WC,Roberts JF,Guthrie FE

更新日期：1986-03-15 00:00:00

abstract：:Inoculation of metallic tin powder produced marked proliferation of plasma cells and Russell body cells in draining lymph nodes. Prior, but not concurrent, administration of a soluble tin salt in the drinking water prevented the plasma cell hyperplasia. Various Na, Zn, Ag, and Cu salts were not inhibitory. The inhibit...

journal_title：Toxicology and applied pharmacology

authors： Levine S,Sowinski R

更新日期：1983-03-30 00:00:00

abstract：:The DDT metabolite 3-methylsulfonyl-DDE (3-MeSO(2)-DDE) has been proposed as a lead compound for an improved adrenocortical carcinoma (ACC) treatment. ACC is a rare malignant disorder with poor prognosis, and the current pharmacological therapy o,p'-DDD (mitotane) has limited efficacy and causes severe adverse effects...

journal_title：Toxicology and applied pharmacology

authors： Asp V,Ullerås E,Lindström V,Bergström U,Oskarsson A,Brandt I

更新日期：2010-02-01 00:00:00

abstract：:Mercury (Hg) has long been recognized as a neurotoxicant; however, recent work in animal models has implicated Hg as an immunotoxicant. In particular, Hg has been shown to induce autoimmune disease in susceptible animals with effects including overproduction of specific autoantibodies and pathophysiologic signs of lup...

journal_title：Toxicology and applied pharmacology

authors： Silbergeld EK,Silva IA,Nyland JF

更新日期：2005-09-01 00:00:00

abstract：:Several studies have shown that ultrafine particles (UFPs) may pass from the lungs to the circulation because of their very small diameter, and induce lung oxidative stress with a resultant increase in lung epithelial permeability. The direct effects of UFPs on vascular endothelium remain unknown. We hypothesized that...

journal_title：Toxicology and applied pharmacology

authors： Mo Y,Wan R,Chien S,Tollerud DJ,Zhang Q

更新日期：2009-04-15 00:00:00

abstract：:It was investigated whether protective influence of zinc (Zn) against cadmium (Cd)-induced disorders in bone metabolism may be related to its antioxidative properties and impact on the receptor activator of nuclear factor (NF)-κΒ (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) system. Numerous indices of oxidative/an...

journal_title：Toxicology and applied pharmacology

authors： Brzóska MM,Rogalska J

更新日期：2013-10-01 00:00:00

abstract：:Pulmonary exposure to multi-walled carbon nanotubes (MWCNT) causes inflammation, fibroproliferation, immunotoxicity, and systemic responses in rodents. However, the search for representative biomarkers of exposure is an ongoing endeavor. Whole blood gene expression profiling is a promising new approach for the identif...

journal_title：Toxicology and applied pharmacology

authors： Khaliullin TO,Yanamala N,Newman MS,Kisin ER,Fatkhutdinova LM,Shvedova AA

更新日期：2020-03-01 00:00:00

abstract：:Previous work from this laboratory (J. S. Lazo, J. D. Catravas, and C. N. Gillis, Biochem. Pharmacol. 30, 2577-2584, 1981; J. D. Catraveras, J. S. Lazo, and C. N. Gillis, J. Pharmacol. Exp. Ther. 217, 524-529, 1981) demonstrated that subacute bleomycin (BLM) administration (5 mg/kg) to rabbits three times weekly for 4...

journal_title：Toxicology and applied pharmacology

authors： Lazo JS,Catravas JD,Dobuler KJ,Gillis CN

更新日期：1983-06-30 00:00:00

abstract：:Carnosic acid (CA), a major bioactive component in rosemary extract, has many biological and pharmaceutical activities. Smad3 acetylation can regulate the transcription of type I α2 collagen (COL1A2), which is the major component of the extracellular matrix (ECM). The aim of the current study was to evaluate whether C...

journal_title：Toxicology and applied pharmacology

authors： Zhao Y,Shi X,Ding C,Feng D,Li Y,Hu Y,Wang L,Gao D,Tian X,Yao J

更新日期：2018-01-15 00:00:00

abstract：:Blooms of Pfiesteria piscicida, a dinoflagellate in eastern U.S. coastal rivers, are believed to secrete toxins that kill fish and produce short-term memory loss in humans. Only one or two of Pfiesteria's multiple stages secrete the toxin, and only under certain environmental conditions. Thus, neither the presence of ...

journal_title：Toxicology and applied pharmacology

authors： El-Nabawi A,Quesenberry M,Saito K,Silbergeld E,Vasta G,Eldefrawi A

更新日期：2000-11-15 00:00:00

abstract：:Benzene exposure can result in bone marrow myelotoxicity. We examined the effects of benzene metabolites on bone marrow stromal cells of the hemopoietic microenvironment. Male B6C3F1 mouse bone marrow adherent stromal cells were plated at 4 X 10(6) cells per 2 ml of DMEM medium in 35-mm tissue culture dishes. The grow...

journal_title：Toxicology and applied pharmacology

authors： Gaido K,Wierda D

更新日期：1984-10-01 00:00:00

abstract：:The acute manifestations of experimental bleomycin- and hyperoxia-induced lung damage were examined. Hamsters were treated with 5 U/kg bleomycin intratracheally followed by exposure to 80% oxygen (O2). As little as 12 hr of O2 exposure potentiated the bleomycin injury; however, the onset of mortality was 72 hr after t...

journal_title：Toxicology and applied pharmacology

authors： Goad ME,Tryka AF,Witschi HP

更新日期：1987-08-01 00:00:00

abstract：:Methylmercury (MeHg) is an ubiquitous environmental pollutant which is transported into the mammalian cells when present as the methylmercury-cysteine conjugate (MeHg-Cys). With special emphasis on hepatic cells, due to their particular propensity to accumulate an appreciable amount of Hg after exposure to MeHg, this ...

journal_title：Toxicology and applied pharmacology

authors： Roos DH,Puntel RL,Farina M,Aschner M,Bohrer D,Rocha JB,de Vargas Barbosa NB

更新日期：2011-04-01 00:00:00

abstract：:Antineoplastic drugs cause severe cytotoxicity for normal cells, especially hematopoietic stem cells (HSCs). However, bleomycin (BLM) is glycopeptide antibiotic that is effective on various cancers and has either low or no myelosuppression effects. The aim of the present study was to investigate the effect of BLM on 5...

journal_title：Toxicology and applied pharmacology

authors： Fakhrabadi HG,Rabbani-Chadegani A,Ghadam P,Amiri S

更新日期：2020-06-01 00:00:00

abstract：:A quantitative method based upon a stochastic model was used to estimate rates of initiation (alteration to express the ATPase-deficient phenotype) and of clonal growth of altered cells in an initiation promotion experiment in the livers of female Wistar rats. Diethylnitrosamine (DEN) was used as the initiating agent ...

journal_title：Toxicology and applied pharmacology

authors： Moolgavkar SH,Luebeck EG,Buchmann A,Bock KW

更新日期：1996-05-01 00:00:00

abstract：:Valinomycin and cereulide are bacterial toxins with closely similar chemical structure and properties but different toxic effects. Emetic poisoning is induced by cereulide but not by valinomycin. Both are specific potassium ionophores. Such compounds may affect mitochondrial functions. Both compounds cause a potassium...

journal_title：Toxicology and applied pharmacology

authors： Teplova VV,Mikkola R,Tonshin AA,Saris NE,Salkinoja-Salonen MS

更新日期：2006-01-01 00:00:00

abstract：:To further elucidate the mechanism of cadmium inhibition of renal amino acid transport, brush border membrane vesicles were isolated from rabbit renal cortex and the effect of cadmium on the uptake of L-glutamate into the vesicles was investigated. Preincubation of the membranes with CdCl2 decreased sodium-dependent L...

journal_title：Toxicology and applied pharmacology

authors： Kinne RK,Schütz H,Kinne-Saffran E

更新日期：1995-12-01 00:00:00

abstract：:Energy metabolism and reproduction are closely linked and reciprocally regulated. The detrimental effect of underweight on reproduction complicates the safety evaluation of anti-obesity drugs, making it challenging to distinguish pathological changes mediated through the intended drug-induced weight loss from direct d...

journal_title：Toxicology and applied pharmacology

authors： Bolze F,Williams H,Bhuwania R,Egecioglu E,Bloem E,Paulsson JF,Pedersen MØ,Broadmeadow A,Chesher CJ,Moore EL,Skydsgaard M,Galle PS,Dalgaard M,Wulff BS,Tena-Sempere M,Andersen LW

更新日期：2020-10-01 00:00:00

abstract：:Dietary phytochemicals are excellent ROS-modulating agents and have been shown to effectively enhance ROS levels beyond toxic threshold in cancer cells to ensure their selective killing while leaving normal cells unscathed. Here we demonstrate that hydroxychavicol (HC), extracted and purified from Piper betel leaves, ...

journal_title：Toxicology and applied pharmacology

authors： Gundala SR,Yang C,Mukkavilli R,Paranjpe R,Brahmbhatt M,Pannu V,Cheng A,Reid MD,Aneja R

更新日期：2014-10-01 00:00:00

abstract：:Melittin is a cationic, hemolytic peptide that is the main toxic component in the venom of the honey bee (Apis mellifera). Melittin has multiple effects, including anti-bacterial, anti-viral and anti-inflammatory, in various cell types. However, the anti-apoptotic mechanisms of melittin have not been fully elucidated ...

journal_title：Toxicology and applied pharmacology

authors： Lee WR,Park JH,Kim KH,Park YY,Han SM,Park KK

更新日期：2011-10-15 00:00:00

abstract：:Histone deacetylase inhibitors (HDI) have been shown to increase differentiation-related gene expression in several tumor-derived cell lines by hyperacetylating core histones. Effects of HDI on primary cultured cells, however, have hardly been investigated. In the present study, the ability of trichostatin A (TSA), a ...

journal_title：Toxicology and applied pharmacology

authors： Henkens T,Papeleu P,Elaut G,Vinken M,Rogiers V,Vanhaecke T

更新日期：2007-01-01 00:00:00

abstract：:Similarly to unleaded gasoline, 1,4-dichlorobenzene (1,4-DCB) administered for 2 years caused a dose-related increase in the incidence of renal tumors in male but not in female rats or in either sex of mice. Unleaded gasoline and 2,2,4-trimethylpentane (TMP), a component of unleaded gasoline, increased protein droplet...

journal_title：Toxicology and applied pharmacology

authors： Charbonneau M,Strasser J Jr,Lock EA,Turner MJ Jr,Swenberg JA

更新日期：1989-06-01 00:00:00

abstract：:In nonsmokers, ozone (O(3)) is removed primarily by the epithelial lining fluid (ELF) of the conducting airways. We hypothesized that cigarette smokers, whose ELF antioxidant capacity may be limited by smoking, would remove less O(3) from their conducting airways than nonsmokers. We recruited 29 nonsmokers (17M, 12F) ...

journal_title：Toxicology and applied pharmacology

authors： Bates ML,Brenza TM,Ben-Jebria A,Bascom R,Ultman JS

更新日期：2009-05-01 00:00:00

abstract：:The mechanism underlying glaucoma remains controversial, but apoptosis caused by increased levels of reactive oxygen species (ROS) is thought to play a role in its pathogenesis. We investigated the effects of compounds isolated from Psoralea corylifolia on oxidative stress-induced cell death in vitro and in vivo. Tran...

journal_title：Toxicology and applied pharmacology

authors： Kim KA,Shim SH,Ahn HR,Jung SH

更新日期：2013-06-01 00:00:00

abstract：:Brominated flame retardants (BFRs) are present in many consumer products ranging from fabrics to plastics and electronics. Wide use of flame retardants can pose an environmental hazard and it is of interest to determine the mechanism of their toxicity. Of all the BFRs, 3,3',5,5'-tetrabromobisphenol A (TBBPA) is produc...

journal_title：Toxicology and applied pharmacology

authors： Chignell CF,Han SK,Mouithys-Mickalad A,Sik RH,Stadler K,Kadiiska MB

更新日期：2008-07-01 00:00:00

abstract：:The role of lipid peroxidation in the cell death produced by the haloalkene cysteine conjugates S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine (PCBC), S-(1,2-dichlorovinyl)-L-cysteine (DCVC), S-(1,1,2,2-tetrafluoroethyl)-L-cysteine (TFEC), and S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine (CTFC) was investigated using ...

journal_title：Toxicology and applied pharmacology

authors： Groves CE,Lock EA,Schnellmann RG

更新日期：1991-01-01 00:00:00

abstract：:Female Sprague-Dawley rats were treated with a single ip dose of aflatoxin B1 (AFB1) (3 or 6 mg/kg). Twenty-four hours later and weekly until killed, some of the rats treated with AFB1 were given ethynylestradiol (EE) by gavage at the dose of 13 mg/kg. One, three, six, and nine months following the beginning of the ex...

journal_title：Toxicology and applied pharmacology

authors： Kamdem L,Magdalou J,Siest G,Ban M,Zissu D

更新日期：1983-01-01 00:00:00

abstract：:A cadmium-binding substance with a molecular weight even lower than that of metallothionein was demonstrated on Sephadex G-75 gel filtration chromatography of the soluble fractions from newborn human and adult rat liver homogenates and adult human hemolysate which were mixed with CdCl2 in vitro. This substance was pur...

journal_title：Toxicology and applied pharmacology

authors： Katoh M,Mizutani N,Keino H,Kashiwamata S

更新日期：1984-03-30 00:00:00

abstract：:Previous studies have demonstrated that mice lacking a functional folate binding protein 2 gene (Folbp2-/-) were significantly more sensitive to in utero arsenic exposure than were the wild-type mice similarly exposed. When these mice were fed a folate-deficient diet, the embryotoxic effect of arsenate was further exa...

journal_title：Toxicology and applied pharmacology

authors： Spiegelstein O,Gould A,Wlodarczyk B,Tsie M,Lu X,Le C,Troen A,Selhub J,Piedrahita JA,Salbaum JM,Kappen C,Melnyk S,James J,Finnell RH

更新日期：2005-02-15 00:00:00

abstract：:A number of methods have been developed to assess the impact of a xenobiotic on the various components of the immune system. For risk analysis, it is necessary to determine what degree of chemically induced immune perturbation translates into altered host resistance. Natural killer (NK) cells play a pivotal role in th...

journal_title：Toxicology and applied pharmacology

authors： Wilson SD,McCay JA,Butterworth LF,Munson AE,White KL Jr

更新日期：2001-12-15 00:00:00