Protective effect of bleomycin on 5-azacitidine induced cytotoxicity and apoptosis in mice hematopoietic stem cells via Bcl-2/Bax and HMGB1 signaling pathway.

abstract：:The effect of KCN on cytosolic Ca2+ levels was measured in PC12 cells using Quin II/AM, a fluorometric calcium indicator. The resting cytosolic Ca2+ concentration, 115.0 +/- 4.9 nm, increased gradually and steadily over a 30-min time period following addition of 10(-4), 10(-3), or 10(-2)M KCN to the cells. After 15 mi...

journal_title：Toxicology and applied pharmacology

authors： Johnson JD,Conroy WG,Isom GE

更新日期：1987-04-01 00:00:00

abstract：:Air pollution, especially fine particulate matter (PM2.5, particles <2.5 μm in size), induces adverse health effects on the respiratory system. Uncontrolled proliferation of bronchial epithelial cells, resulting from deregulated cell cycle progression, contributes to pulmonary homeostatic imbalance. Although dysregula...

journal_title：Toxicology and applied pharmacology

authors： Xiao T,Ling M,Xu H,Luo F,Xue J,Chen C,Bai J,Zhang Q,Wang Y,Bian Q,Liu Q

更新日期：2019-08-15 00:00:00

abstract：:Hepatotoxic doses of acetaminophen cause widespread alkylation of liver and early loss of cytosolic Ca2+ regulation. Although the precise location and target of lethal alkylation are not known, Ca2+ accumulation is viewed as a possible link between cell alkylation and cell death. We have recently shown that Ca2+ accum...

journal_title：Toxicology and applied pharmacology

authors： Shen W,Kamendulis LM,Ray SD,Corcoran GB

更新日期：1991-11-01 00:00:00

abstract：:To study the effect of cadmium exposure on maternal and fetal zinc metabolism, rats were exposed to 0, 5, 50, or 100 ppm Cd in the drinking water on Days 6 through 20 of pregnancy. In comparison to controls, fetal and maternal weights were slightly reduced in the 50- and 100-ppm groups, but not the 5-ppm group. Multip...

journal_title：Toxicology and applied pharmacology

authors： Sorell TL,Graziano JH

更新日期：1990-03-01 00:00:00

abstract：:Melittin is a cationic, hemolytic peptide that is the main toxic component in the venom of the honey bee (Apis mellifera). Melittin has multiple effects, including anti-bacterial, anti-viral and anti-inflammatory, in various cell types. However, the anti-apoptotic mechanisms of melittin have not been fully elucidated ...

journal_title：Toxicology and applied pharmacology

authors： Lee WR,Park JH,Kim KH,Park YY,Han SM,Park KK

更新日期：2011-10-15 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a highly toxic environmental pollutant and is well known for inducing thymic atrophy in mice, although the exact mechanism of its action remains unclear. Recent studies from our laboratory demonstrated that TCDD induces apoptosis in thymocytes and that Fas- mice (lpr/lpr) ...

journal_title：Toxicology and applied pharmacology

authors： Kamath AB,Nagarkatti PS,Nagarkatti M

更新日期：1998-05-01 00:00:00

abstract：:Energy metabolism and reproduction are closely linked and reciprocally regulated. The detrimental effect of underweight on reproduction complicates the safety evaluation of anti-obesity drugs, making it challenging to distinguish pathological changes mediated through the intended drug-induced weight loss from direct d...

journal_title：Toxicology and applied pharmacology

authors： Bolze F,Williams H,Bhuwania R,Egecioglu E,Bloem E,Paulsson JF,Pedersen MØ,Broadmeadow A,Chesher CJ,Moore EL,Skydsgaard M,Galle PS,Dalgaard M,Wulff BS,Tena-Sempere M,Andersen LW

更新日期：2020-10-01 00:00:00

abstract：:Age-dependent changes related to liver injury and regeneration were studied in rats aged 2, 12, and 30 months in a time period of 96 hr following a sublethal dose of thioacetamide (6.6 mmoles/kg body wt). Serum aspartate aminotransferase activity increased earlier in young rats, but the severity of injury was higher i...

journal_title：Toxicology and applied pharmacology

authors： Sanz N,Díez-Fernández C,Alvarez AM,Fernández-Simón L,Cascales M

更新日期：1999-01-01 00:00:00

abstract：:The effect of captopril, an angiotensin-converting enzyme inhibitor, on the progression of chronic renal disease was studied in rats subjected to partial nephrectomy. Following ablation of approximately 70% of their renal mass, rats were divided into three treatment groups: group I received a placebo treatment; group ...

journal_title：Toxicology and applied pharmacology

authors： Hall RL,Wilke WL,Fettman MJ

更新日期：1985-09-30 00:00:00

abstract：:Dietary consumption of phytoestrogens like genistein has been linked with lower incidence of prostate cancer. The estradiol-like benzopyran core of genistein confers estrogen receptor-β (ER-β) selectivity that imparts weak anti-proliferative activity against prostate cancer cells. DL-2-[4-(2-piperidinoethoxy)phenyl]-3...

journal_title：Toxicology and applied pharmacology

authors： Kumar R,Verma V,Sharma V,Jain A,Singh V,Sarswat A,Maikhuri JP,Sharma VL,Gupta G

更新日期：2015-03-15 00:00:00

abstract：:Oxidative damage to DNA induced by benzene is an important mechanism of its genotoxicity, which leads to chronic benzene poisoning (CBP). Therefore, genetic variation in DNA repair genes may contribute to susceptibility to CBP in the exposed population. We hypothesized that single nucleotide polymorphisms (SNPs) in hM...

journal_title：Toxicology and applied pharmacology

authors： Wu F,Zhang Z,Wan J,Gu S,Liu W,Jin X,Xia Z

更新日期：2008-12-15 00:00:00

abstract：:Calcium uptake in cells occurs through specific membrane channels. Since cadmium and mercury inhibit calcium uptake, this study examined whether the calcium channels may also be involved in the uptake of these metals. Primary cultures of rat hepatocytes were incubated with 3 microM CdCl2 or HgCl2 in the absence or pre...

journal_title：Toxicology and applied pharmacology

authors： Blazka ME,Shaikh ZA

更新日期：1991-09-01 00:00:00

abstract：:Nitrogen mustard (NM) is a toxic vesicant known to cause damage to the respiratory tract. Injury is associated with increased expression of inducible nitric oxide synthase (iNOS). In these studies we analyzed the effects of transient inhibition of iNOS using aminoguanidine (AG) on NM-induced pulmonary toxicity. Rats w...

journal_title：Toxicology and applied pharmacology

authors： Malaviya R,Venosa A,Hall L,Gow AJ,Sinko PJ,Laskin JD,Laskin DL

更新日期：2012-12-15 00:00:00

abstract：:CAsE-PE cells are an arsenic-transformed, human prostate epithelial line containing oncogenic mutations in KRAS compared to immortalized, normal KRAS parent cells, RWPE-1. We previously reported increased copy number of mutated KRAS in CAsE-PE cells, suggesting gene amplification. Here, KRAS flanking genomic and trans...

journal_title：Toxicology and applied pharmacology

authors： Merrick BA,Phadke DP,Bostrom MA,Shah RR,Wright GM,Wang X,Gordon O,Pelch KE,Auerbach SS,Paules RS,DeVito MJ,Waalkes MP,Tokar EJ

更新日期：2020-04-25 00:00:00

abstract：:The role of gamma-glutamyl transpeptidase (gamma-GTP) in the nephrotoxicity of hexachloro-1,3-butadiene (HCBD) was studied using male Sprague-Dawley rats pretreated with AT-125 (Acivicin; L-(alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid). Inhibition of gamma-GTP by more than 95% did not affect u...

journal_title：Toxicology and applied pharmacology

authors： Davis ME

更新日期：1988-08-01 00:00:00

abstract：:The epithelial-mesenchymal transition (EMT) is a critical stage during the development of silicosis fibrosis. In the current study, we hypothesized that the anti-fibrotic tetrapeptide, N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) may exert its anti-fibrotic effects via activation of the TGF-β1/ROCK1 pathway, leadin...

journal_title：Toxicology and applied pharmacology

authors： Deng H,Xu H,Zhang X,Sun Y,Wang R,Brann D,Yang F

更新日期：2016-03-01 00:00:00

abstract：:Motor neuron disease is a devastating neurodegenerative condition, with the majority of sporadic, non-familial cases being of unknown etiology. Several epidemiological studies have suggested that occupational exposure to chemicals may be associated with disease pathogenesis. We report the case of a patient developing ...

journal_title：Toxicology and applied pharmacology

authors： Kanavouras K,Tzatzarakis MN,Mastorodemos V,Plaitakis A,Tsatsakis AM

更新日期：2011-11-01 00:00:00

abstract：:Purified fetal bovine serum acetylcholinesterase (FBS AChE) and horse serum butyrylcholinesterase (BChE) were successfully used as single pretreatment drugs for the prevention of pinacolyl methylphosphonofluoridate (soman) toxicity in nonhuman primates. Eight rhesus monkeys, trained to perform Primate Equilibrium Plat...

journal_title：Toxicology and applied pharmacology

authors： Wolfe AD,Blick DW,Murphy MR,Miller SA,Gentry MK,Hartgraves SL,Doctor BP

更新日期：1992-12-01 00:00:00

abstract：:A new class of nitric oxide (NO•)-releasing nonsteroidal anti-inflammatory drugs (NONO-NSAIDs) were developed in recent years and have shown promising potential as NSAID substitutes due to their gentle nature on cardiovascular and gastrointestinal systems. Since nitric oxide plays a role in regulation of cell adhesion...

journal_title：Toxicology and applied pharmacology

authors： Cheng H,Mollica MY,Lee SH,Wang L,Velázquez-Martínez CA,Wu S

更新日期：2012-10-15 00:00:00

abstract：:The disposition of [3H]diisopropylfluorophosphate (DFP) and its metabolites was studied in mice after iv treatment. In addition, disposition of [3H]DFP in selected tissues was correlated with cholinesterase activity and spontaneous activity following DFP treatment. Within 1 min of administration [3H]DFP had penetrated...

journal_title：Toxicology and applied pharmacology

authors： Martin BR

更新日期：1985-02-01 00:00:00

abstract：:Kinase activities were previously proposed to be central to germ cell apoptosis induced by ethylene glycol monomethyl ether (EGME) and its active metabolite methoxyacetic acid (MAA). We evaluated the role of tyrosine kinase pp60(c-src) in control and EGME-treated adult rat testis in vivo, as well as in vitro using cul...

journal_title：Toxicology and applied pharmacology

authors： Wang W,Wine RN,Chapin RE

更新日期：2000-03-01 00:00:00

abstract：:It has been proposed [J. D. McKinney, J. Fawkes, S. Jordan, K. Chae, S. Oatley, R. E. Coleman, and W. Briner (1985). Environ. Health Perspect. 61, 41-53] that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) produces toxic responses through persistent occupancy of nuclear thyroxine (T4) receptors, and that maintenance of re...

journal_title：Toxicology and applied pharmacology

authors： Osborne R,Dold KM,Greenlee WF

更新日期：1987-09-30 00:00:00

abstract：:Many cationic drugs are concentrated in acidic cell compartments due to low retro-diffusion of the protonated molecule (ion trapping), with an ensuing vacuolar and autophagic cytopathology. In solid tissues, there is evidence that phagocytic cells, e.g., histiocytes, preferentially concentrate cationic drugs. We hypot...

journal_title：Toxicology and applied pharmacology

authors： Roy C,Gagné V,Fernandes MJ,Marceau F

更新日期：2013-07-15 00:00:00

abstract：:Inhalation of sulfur mustard (SM), a bifunctional alkylating agent that causes severe lung damage, is a significant threat to both military and civilian populations. The mechanisms mediating its cytotoxic effects are unknown and were investigated in the present studies. Male rats Crl:CD(SD) were anesthetized, and then...

journal_title：Toxicology and applied pharmacology

authors： Malaviya R,Sunil VR,Cervelli J,Anderson DR,Holmes WW,Conti ML,Gordon RE,Laskin JD,Laskin DL

更新日期：2010-10-15 00:00:00

abstract：:Piperazine, a secondary amine widely used as an anthelmintic drug, nitrosates rapidly in vitro to form two N-nitrosamines. Anhydrous piperazine and a drug formulation were found to have a content of 0.2 to 20 micrograms of the suspected carcinogen N-mononitrosopiperazine per gram piperazine, but no detectable amounts ...

journal_title：Toxicology and applied pharmacology

authors： Bellander T,Osterdahl BG,Hagmar L

更新日期：1985-09-15 00:00:00

abstract：:The neurotoxicity of the dl and meso diastereomers of the gamma-diketone 3,4-dimethyl-2,5-hexanedione (DMHD) was studied to determine if the difference in rates of pyrrole derivatization would influence the clinical and morphological appearance of the neuropathy associated with these gamma-diketones. Two groups of rat...

journal_title：Toxicology and applied pharmacology

authors： Rosenberg CK,Genter MB,Szakál-Quin G,Anthony DC,Graham DG

更新日期：1987-02-01 00:00:00

abstract：:This study was undertaken to characterize the long-term toxic and carcinogenic potential of a polybrominated biphenyl (PBB) mixture in rats and mice of both sexes. Fischer 344 rats and B6C3F1 mice were given 125 po doses of PBB over a 6-month period at 0 (control), 0.1, 0.3, 1.0, 3.0, and 10.0 mg/kg body weight/day (5...

journal_title：Toxicology and applied pharmacology

authors： Gupta BN,McConnell EE,Moore JA,Haseman JK

更新日期：1983-03-30 00:00:00

abstract：:This study investigated the in vivo metabolism of di(2-ethylhexyl) phthalate (DEHP) and mono(2-ethylhexyl) phthalate (MEHP) in rats after multiple dosing, the metabolism of MEHP in primary rat hepatocyte cultures for periods of up to 3 days, and the biotransformation of some major metabolites of MEHP. Rats were orally...

journal_title：Toxicology and applied pharmacology

authors： Lhuguenot JC,Mitchell AM,Milner G,Lock EA,Elcombe CR

更新日期：1985-08-01 00:00:00

abstract：:In order to assess the effects of long-term exposure to cadmium (Cd) on the renal metabolism of eicosanoids, the urinary excretion of 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), prostaglandin E2 (PGE2), prostaglandin F2 alpha (PGF2 alpha), and thromboxane B2 (TXB2) was determined in 37 workers exposed to Cd and...

journal_title：Toxicology and applied pharmacology

authors： Cárdenas A,Ramis I,Hotter G,Roselló J,Gelpí E,Roels H,Bernard A,Lauwerys R

更新日期：1992-10-01 00:00:00

abstract：:The most commonly used chemical mixtures risk assessment methods involve simple notions of additivity and toxicological similarity. Newer methods are emerging in response to the complexities of chemical mixture exposures and effects. Factors based on both science and policy drive decisions regarding whether to conduct...

journal_title：Toxicology and applied pharmacology

authors： Teuschler LK

更新日期：2007-09-01 00:00:00