Protective effect of beta-naphthoflavone against NO2 toxicity in mice with genetically inducible lung cytochrome P450.

abstract：:The phenylurea compound EDU (N-[2-(2-oxo-1-imidazolindinyl)ethyl]-N'-phenylurea) has been shown to protect plants from the damaging effects of ozone exposure. Models of rat lung injury, based on acute exposure to 2 ppm ozone for 3 hr and on exposure to 0.85 ppm ozone for 2 days, were used to determine whether EDU pret...

journal_title：Toxicology and applied pharmacology

authors： Bassett DJ,Elbon CL,Reichenbaugh SS,Boswell GA,Stevens TM,McGowan MC,Kerr JS

更新日期：1989-08-01 00:00:00

abstract：:The benzofurane derivative benzbromarone (BBR) previously has led to liver tumor formation after long-term treatment of rats, but no indications of genotoxicity were detected. The present studies were designed to elucidate the mechanism(s) possibly involved in liver tumor formation by BBR. Female Wistar rats were used...

journal_title：Toxicology and applied pharmacology

authors： Parzefall W,Schuppler J,Barthel G,Meyer-Rogge B,Schulte-Hermann R

更新日期：1990-12-01 00:00:00

abstract：:The InnoMed PredTox consortium was formed to evaluate whether conventional preclinical safety assessment can be significantly enhanced by incorporation of molecular profiling ("omics") technologies. In short-term toxicological studies in rats, transcriptomics, proteomics and metabolomics data were collected and analyz...

journal_title：Toxicology and applied pharmacology

authors： Ellinger-Ziegelbauer H,Adler M,Amberg A,Brandenburg A,Callanan JJ,Connor S,Fountoulakis M,Gmuender H,Gruhler A,Hewitt P,Hodson M,Matheis KA,McCarthy D,Raschke M,Riefke B,Schmitt CS,Sieber M,Sposny A,Suter L,Sweatman

更新日期：2011-04-15 00:00:00

abstract：:Breast cancer is the world's leading cause of death among women. This situation imposes an urgent development of more selective and less toxic agents. The use of natural molecular fingerprints as sources for new bioactive chemical entities has proven to be a quite promising and efficient method. Capsaicin, which is th...

journal_title：Toxicology and applied pharmacology

authors： de-Sá-Júnior PL,Pasqualoto KF,Ferreira AK,Tavares MT,Damião MC,de Azevedo RA,Câmara DA,Pereira A,de Souza DM,Parise Filho R

更新日期：2013-02-01 00:00:00

abstract：:Inflammation induced by chronic exposure to ultraviolet (UV) radiation has been implicated in various skin diseases. We formulated the hypothesis that a high-fat diet may influence the UV-induced inflammatory responses in the skin. C57BL/6 mice were fed a high-fat diet or control diet and exposed to UVB radiation (120...

journal_title：Toxicology and applied pharmacology

authors： Meeran SM,Singh T,Nagy TR,Katiyar SK

更新日期：2009-12-15 00:00:00

abstract：:Bisphenol A (BPA) is an important industrial chemical used in the manufacture of polycarbonate plastic products and epoxy resin-based food can liners. The presence of BPA metabolites in urine of >90% of Americans aged 6-60 suggests ubiquitous and frequent exposure in the range of 0.02-0.2μg/kgbw/d (25th-95th percentil...

journal_title：Toxicology and applied pharmacology

authors： Doerge DR,Twaddle NC,Vanlandingham M,Brown RP,Fisher JW

更新日期：2011-09-15 00:00:00

abstract：:The present investigation was undertaken to study if curcumin, which is recognized for its potential as an antineoplastic and immunopotentiating agent, can also influence the process of myelopoiesis in a tumor-bearing host. Administration of curcumin to tumor-bearing host augmented count of bone marrow cell (BMC) acco...

journal_title：Toxicology and applied pharmacology

authors： Vishvakarma NK,Kumar A,Kumar A,Kant S,Bharti AC,Singh SM

更新日期：2012-08-15 00:00:00

abstract：:Alcoholic liver disease (ALD) is a major complication of heavy alcohol (EtOH) drinking and is characterized by three progressive stages of pathology: steatosis, steatohepatitis, and fibrosis/cirrhosis. Alcoholic steatosis (AS) is the initial stage of ALD and consists of fat accumulation in the liver accompanied by min...

journal_title：Toxicology and applied pharmacology

authors： Apte UM,Banerjee A,McRee R,Wellberg E,Ramaiah SK

更新日期：2005-08-22 00:00:00

abstract：:Ethylnitrosourea (ENU) is a proven animal teratogen, although the mechanism of its developmental toxicity is unknown. The micromass rat embryo midbrain (CNS) and limb bud (LB) cultures were used in an effort to determine potential mechanisms by which ENU may exert its teratogenic effect. When cultured at high cell den...

journal_title：Toxicology and applied pharmacology

authors： Ribeiro PL,Faustman EM

更新日期：1990-06-15 00:00:00

abstract：:Carbon tetrachloride (CCl4) has been studied extensively for its hepatotoxic effects. There is a paucity of information, however, about its tissue deposition following administration by different routes and patterns of exposure. The specific objective of this study was to delineate the uptake, distribution, and elimin...

journal_title：Toxicology and applied pharmacology

authors： Sanzgiri UY,Srivatsan V,Muralidhara S,Dallas CE,Bruckner JV

更新日期：1997-03-01 00:00:00

abstract：:Vinylcyclohexene (VCH) is an industrial byproduct that is known to cause the destruction of ovarian follicles in mice. Its analog, 4-phenylcyclohexene (4PC), is a volatile product from latex-backed carpeting. These studies were undertaken to assess the structure-activity relationships of these compounds and the potent...

journal_title：Toxicology and applied pharmacology

authors： Hooser SB,Parola LR,Van Ert MD,Sipes IG

更新日期：1993-04-01 00:00:00

abstract：:The distribution of accumulated inorganic mercury deposits in the cortex of the calcarine sulcus of adult female Macaca fascicularis following long-term subclinical exposure to methyl-mercury (MeHg) and mercuric chloride (inorganic mercury-IHg) has been determined by autometallography. Four groups of monkeys were expo...

journal_title：Toxicology and applied pharmacology

authors： Charleston JS,Body RL,Mottet NK,Vahter ME,Burbacher TM

更新日期：1995-06-01 00:00:00

abstract：:Following a formulation change, a leather conditioner was involved in a 1992 nationwide outbreak of respiratory illness. We investigated the composition and toxicity of the conditioner produced before (previous product) and after (new product) the disease outbreak. The new product induced tachypnea, pulmonary edema, p...

journal_title：Toxicology and applied pharmacology

authors： Hubbs AF,Castranova V,Ma JY,Frazer DG,Siegel PD,Ducatman BS,Grote A,Schwegler-Berry D,Robinson VA,Van Dyke C,Barger M,Xiang J,Parker J

更新日期：1997-03-01 00:00:00

abstract：:Immobilization of nanoparticles on inorganic supports has been recently developed, resulting in the creation of nanocomposites. Concerning titanium dioxide nanoparticles (TiO2 NPs1), these have already been developed in conjugation with clays, but so far there are no available toxicological studies on these nanocompos...

journal_title：Toxicology and applied pharmacology

authors： Bessa MJ,Costa C,Reinosa J,Pereira C,Fraga S,Fernández J,Bañares MA,Teixeira JP

更新日期：2017-02-01 00:00:00

abstract：:As the main toxic component of aristolochic acid, aristolochic acid I (AAI) is primarily found in Aristolochiaceae plants such as Aristolochia, Aristolochia fangchi and Caulis aristolochiae manshuriensis. AAI has been proven to be carcinogenic, mutagenic and nephrotoxic. Although the role of AAI in testicular toxicity...

journal_title：Toxicology and applied pharmacology

authors： Cui Y,Han J,Ren J,Chen H,Xu B,Song N,Li H,Liang A,Shen G

更新日期：2019-06-15 00:00:00

abstract：:Nickel (Ni) carcinogenesis is thought to involve gene chip silencing by epigenetic mechanisms. Serpina3g, a member of the mouse serpin family, was among the most down-regulated genes (32-fold) in response to Ni exposure of mouse cells based on the Affymetrix gene chip. Serpina3g down-regulation was controlled by a hyp...

journal_title：Toxicology and applied pharmacology

authors： Zhao J,Yan Y,Salnikow K,Kluz T,Costa M

更新日期：2004-01-01 00:00:00

abstract：:Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the male reproductive system were investigated. Sexually mature (290 g) Sprague-Dawley rats were given single oral doses of TCDD sufficient to cause varying degrees of hypophagia and impaired body weight gain. The largest doses decreased plasma testosterone and ...

journal_title：Toxicology and applied pharmacology

authors： Moore RW,Potter CL,Theobald HM,Robinson JA,Peterson RE

更新日期：1985-06-15 00:00:00

abstract：:Arsenic is a toxicant found in ground water around the world, and human exposure mainly comes from drinking water or from crops grown in areas containing arsenic in soils or water. Epidemiological studies have shown that arsenic exposure during development decreased intellectual function, reduced birth weight, and alt...

journal_title：Toxicology and applied pharmacology

authors： Liu JT,Bain LJ

更新日期：2014-12-15 00:00:00

abstract：:This study sought to investigate the effects of environmentally relevant gestational followed by continued chronic exposure to the herbicide, atrazine, on motor function, cognition, and neurochemical indices of nigrostriatal dopamine (DA) activity in male rats. Dams were treated with 100 μg/kg atrazine, 10mg/kg atrazi...

journal_title：Toxicology and applied pharmacology

authors： Walters JL,Lansdell TA,Lookingland KJ,Baker LE

更新日期：2015-12-01 00:00:00

abstract：:The effect of age and sex on the elimination of theophylline in New Zealand White rabbits was investigated following exposure to 0.3 ppm of ozone (O3) for 3.75 hr/day over 5 consecutive days. Animals were given air alone 5 to 7 days before and after the 5 days of O3 exposure. The elimination half-life of theophylline ...

journal_title：Toxicology and applied pharmacology

authors： Canada AT,Calabrese EJ

更新日期：1985-10-01 00:00:00

abstract：:The differential effects of oral and dermal administration of single doses of 100 to 1000 mg/kg S,S,S-tri-n-butyl phosphorotrithioate (DEF) on nonspecific esterases and liver metabolism enzymes were investigated one day following administration. O,O-Diethyl O-(4-nitrophenyl) phosphorothioate (parathion) and tri-o-cres...

journal_title：Toxicology and applied pharmacology

authors： Lapadula DM,Carrington CD,Abou-Donia MB

更新日期：1984-04-01 00:00:00

abstract：:Propiconazole is a mouse hepatotumorigenic fungicide designed to inhibit CYP51, a key enzyme in the biosynthesis of ergosterol in fungi and is widely used in agriculture to prevent fungal growth. Metabolomic studies in mice revealed that propiconazole increased levels of hepatic cholesterol metabolites and bile acids,...

journal_title：Toxicology and applied pharmacology

authors： Murphy LA,Moore T,Nesnow S

更新日期：2012-04-15 00:00:00

abstract：:Inhalation of dust from hard metal (HM), a mixture of tungsten carbide, cobalt, and other metals, can cause interstitial alveolitis, fibrosis, and asthma in the workplace. Some effects of HM could occur after the metals dissolve in the lung. We examined whether chloride salts of metals in HM alloys can elicit response...

journal_title：Toxicology and applied pharmacology

authors： Fedan JS,Cutler D

更新日期：2001-08-01 00:00:00

abstract：:The subcellular location of aluminium is unknown, probably because of difficulties in investigating aluminium biochemistry and the use of varied experimental approaches of uncertain sensitivity. We have studied levels of uptake and the localization of gallium and of aluminium in cultured human neuroblastoma cells trea...

journal_title：Toxicology and applied pharmacology

authors： Dobson CB,Day JP,King SJ,Itzhaki RF

更新日期：1998-09-01 00:00:00

abstract：:The cDNA sequences for two dioxin-inducible cytochrome P450s in chicken, CYP1A4 and CYP1A5, have recently been reported which correspond to two dioxin-inducible forms of P450 previously designated as TCDDAHH and TCDDAA, respectively. The developmental expression of CYP1A4-associated aryl hydrocarbon (benzo[a]pyrene) h...

journal_title：Toxicology and applied pharmacology

authors： Bentivegna CS,Ihnat MA,Baptiste NS,Hamilton JW

更新日期：1998-07-01 00:00:00

abstract：:A previously developed PBPK model for ethylene glycol and glycolic acid was extended to include glyoxylic acid, oxalic acid, and the precipitation of calcium oxalate that is associated with kidney toxicity in rats and humans. The development and evaluation of the PBPK model was based upon previously published pharmaco...

journal_title：Toxicology and applied pharmacology

authors： Corley RA,Saghir SA,Bartels MJ,Hansen SC,Creim J,McMartin KE,Snellings WM

更新日期：2011-02-01 00:00:00

abstract：:The esters of the general structure, [CH(SH)COOR]2, i.e., Di-BDMS, R = CH2CH(CH3)2; Ds-BDMS, R = CH(CH3)CH2CH3; Di-ADMS, R = CH2CH2CH(CH3)2; and D3-ADMS, R = CH(CH2CH3)2 from the reaction of meso-2,3-dimercaptosuccinic acid with isobutyl, sec-butyl, isoamyl, and 3-amyl alcohols, respectively, have been prepared, chara...

journal_title：Toxicology and applied pharmacology

authors： Singh PK,Jones MM,Gale GR,Atkins LM,Smith AB

更新日期：1989-03-01 00:00:00

abstract：:Diurnal patterns of feeding, drinking, locomotor activity, and rearing in male Fischer-344 rats were examined for 2 weeks after a single oral dose of trimethyltin chloride (TMT) at 0, 3, 5, or 7 mg/kg. Body weights and feeding and drinking efficiency ratios (ratios of amount of food or water consumed per unit effort) ...

journal_title：Toxicology and applied pharmacology

authors： Bushnell PJ,Evans HL

更新日期：1985-06-15 00:00:00

abstract：:Recently, we described a family of non-targeting monomethylauristatin E (MMAE) antibody-drug conjugates (ADCs) whose pharmacokinetics could be tuned through incorporation of a short polyethylene glycol (PEG) moiety of up to twelve units into a drug-linker to render the ADC surface more hydrophilic. That work demonstra...

journal_title：Toxicology and applied pharmacology

authors： Simmons JK,Burke PJ,Cochran JH,Pittman PG,Lyon RP

更新日期：2020-04-01 00:00:00

abstract：:Deltamethrin, a widely used type II pyrethroid insecticide, is a relatively potent neurotoxicant. While the toxicity has been extensively examined, toxicokinetic studies of deltamethrin and most other pyrethroids are very limited. The aims of this study were to identify, characterize, and assess the relative contribut...

journal_title：Toxicology and applied pharmacology

authors： Anand SS,Bruckner JV,Haines WT,Muralidhara S,Fisher JW,Padilla S

更新日期：2006-04-15 00:00:00