Nickel-induced down-regulation of serpin by hypoxic signaling.

abstract：:To characterize modes of action of substances and their cytotoxic effects Bionas GmbH has developed a new screening system to allow the continuous recording of how an active substance can act (Bionas 2500 analyzing system). In the pharmaceutical industry it is important to acquire as much information as possible about...

journal_title：Toxicology and applied pharmacology

authors： Thedinga E,Kob A,Holst H,Keuer A,Drechsler S,Niendorf R,Baumann W,Freund I,Lehmann M,Ehret R

更新日期：2007-04-01 00:00:00

abstract：:Formic acid is the toxic metabolite in methanol poisoning. Permanent visual damage in methanol-intoxicated humans and non-human primates has been associated with prolonged exposures (> 24 hr) to blood formate concentrations in excess of 7 mM; however, little information is available on the toxicity associated with chr...

journal_title：Toxicology and applied pharmacology

authors： Eells JT,Salzman MM,Lewandowski MF,Murray TG

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Tiotropium bromide (TB) is a long acting muscarinic receptor antagonist used to manage chronic obstructive pulmonary disease (COPD). Recent meta-analyses suggest an increased risk of cardiovascular events with TB. Ca2+/calmodulin dependent kinase II (CaMKII) and L-type Ca2+ channels regulate Ca2+...

journal_title：Toxicology and applied pharmacology

authors： Cassambai S,Mee CJ,Renshaw D,Hussain A

更新日期：2019-12-01 00:00:00

abstract：:Application of global gene expression analysis in the study of mechanisms of toxicity could provide a more comprehensive interpretation of the molecular basis of drug action. WAY-144122 has pharmacological activity against several targets improving insulin responsiveness and favorably altering lipid profiles. Normal r...

journal_title：Toxicology and applied pharmacology

authors： Peterson RL,Casciotti L,Block L,Goad ME,Tong Z,Meehan JT,Jordan RA,Vinlove MP,Markiewicz VR,Weed CA,Dorner AJ

更新日期：2004-04-01 00:00:00

abstract：:Biochemical, functional and morphologic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the hearts of female rats were examined. Six days after the treatment of rats with TCDD, the blood pressures and resting heart rates were significantly less than in control animals. Treated animals were also less responsiv...

journal_title：Toxicology and applied pharmacology

authors： Hermansky SJ,Holcslaw TL,Murray WJ,Markin RS,Stohs SJ

更新日期：1988-09-15 00:00:00

abstract：:We evaluated the inhibition of striatal cholinesterase activity following intracerebral administration of paraoxon assaying activity either in tissue homogenates ex vivo or by substrate hydrolysis in situ. Artificial cerebrospinal fluid (aCSF) or paraoxon in aCSF was infused unilaterally (0.5 microl/min for 2 h) and i...

journal_title：Toxicology and applied pharmacology

authors： Ray A,Liu J,Karanth S,Gao Y,Brimijoin S,Pope C

更新日期：2009-05-01 00:00:00

abstract：:Inhalation of methyl chloride (CH3Cl) by male B6C3F1 mice resulted in a concentration-dependent depletion of glutathione (GSH) in liver, kidney, and brain. Exposure for 6 hr to 100 ppm CH3Cl decreased the concentration of GSH in mouse liver by 45%, while exposure to 2500 ppm for 6 hr lowered liver GSH to approximately...

journal_title：Toxicology and applied pharmacology

authors： Kornbrust DJ,Bus JS

更新日期：1984-03-15 00:00:00

abstract：:The aims of this study were to investigate whether several histamine receptor agonists and antagonists are subjected to receptor-independent ion trapping into acidic organelles, and whether this sequestration influences their pharmacological or toxicological properties. Vacuolar (V)-ATPase-dependent intracellular sequ...

journal_title：Toxicology and applied pharmacology

authors： Morissette G,Lodge R,Bouthillier J,Marceau F

更新日期：2008-06-15 00:00:00

abstract：:The cytotoxicity, genotoxicity, and mutagenicity of 1-chloro-2-hydroxy-3-butene (CHB), a known in vitro metabolite of the human carcinogen 1,3-butadiene, have not previously been investigated. Because CHB can be bioactivated by alcohol dehydrogenases to yield 1-chloro-3-buten-2-one (CBO), a bifunctional alkylating age...

journal_title：Toxicology and applied pharmacology

authors： Liu XJ,Zeng FM,An J,Yu YX,Zhang XY,Elfarra AA

更新日期：2013-08-15 00:00:00

abstract：:Acetylcholine and other neurotransmitters play unique trophic roles in brain development. Accordingly, drugs and environmental toxicants that promote or interfere with neurotransmitter function evoke neurodevelopmental abnormalities by disrupting the timing or intensity of neurotrophic actions. The current review disc...

journal_title：Toxicology and applied pharmacology

authors： Slotkin TA

更新日期：2004-07-15 00:00:00

abstract：:The toxic milk mutation is an autosomal recessive mutation found in an inbred C57BL/6J strain of mice which results in an excessive hepatic accumulation of copper (Cu), mostly associated with metallothionein (MT). The possible toxicological significance of elevated levels of hepatic copper-metallothionein (Cu-MT) was ...

journal_title：Toxicology and applied pharmacology

authors： Stephenson GF,Chan HM,Cherian MG

更新日期：1994-03-01 00:00:00

abstract：:A BLU:Ha newborn mouse lung adenoma bioassay was employed to compare the tumorigenicity of selected mononitroarenes and unsubstituted parent compounds 6 months after initial treatment. The presence of a nitro group had a variable effect upon compound potency in which tumorigenicity was increased, abolished, or unchang...

journal_title：Toxicology and applied pharmacology

authors： Busby WF Jr,Stevens EK,Martin CN,Chow FL,Garner RC

更新日期：1989-07-01 00:00:00

abstract：:Catechol estrogens have been postulated to mediate estradiol-induced kidney tumorigenesis in Syrian hamsters. As part of an examination of this postulate, we studied the influence of quercetin, a polyphenolic flavonoid, on the incidence and severity of estrogen-induced kidney tumors, on the metabolic activation of est...

journal_title：Toxicology and applied pharmacology

authors： Zhu BT,Liehr JG

更新日期：1994-03-01 00:00:00

abstract：:The role of gamma-glutamyl transpeptidase (gamma-GTP) in the nephrotoxicity of hexachloro-1,3-butadiene (HCBD) was studied using male Sprague-Dawley rats pretreated with AT-125 (Acivicin; L-(alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid). Inhibition of gamma-GTP by more than 95% did not affect u...

journal_title：Toxicology and applied pharmacology

authors： Davis ME

更新日期：1988-08-01 00:00:00

abstract：:Chinese hamster cells (V79) were treated with ethylnitrosourea (ENU) and cis-diamminedichloroplatinum(II) (DDP) alone and in combination. Sister chromatid exchanges (SCEs) were quantified as measures of genotoxicity of the two agents. The combination experiment employed a factorial design in which cells were treated, ...

journal_title：Toxicology and applied pharmacology

authors： Solana RP,Chinchilli VM,Wilson J,Carter WH Jr,Carchman RA

更新日期：1986-09-15 00:00:00

abstract：:A single, intravenous administration of a low dose of monocrotaline pyrrole (MCTP), a derivative of the pyrrolizidine alkaloid monocrotaline (MCT), induces progressive pulmonary hypertension and right ventricular hypertrophy (RVH) in rats. The temporal relationship between morphologic alterations, biochemical markers ...

journal_title：Toxicology and applied pharmacology

authors： Reindel JF,Ganey PE,Wagner JG,Slocombe RF,Roth RA

更新日期：1990-11-01 00:00:00

abstract：:Inhalation of asbestos may activate the pulmonary endothelium to promote an inflammatory cell phenotype that participates in the development of pulmonary fibrosis. However, little is known about the effects of asbestos on endothelial cell function. Therefore, endothelial cells were exposed to chrysotile and crocidolit...

journal_title：Toxicology and applied pharmacology

authors： Treadwell MD,Mossman BT,Barchowsky A

更新日期：1996-07-01 00:00:00

abstract：:Mitochondrial oxidative stress plays important roles in aging and age-related degenerative disorders. The newly identified mitochondrial thioredoxin (mtTrx; Trx2) is a key component of the mitochondrial antioxidant system which is responsible for the clearance of reactive intermediates and repairs proteins with oxidat...

journal_title：Toxicology and applied pharmacology

authors： Chen Y,Yu M,Jones DP,Greenamyre JT,Cai J

更新日期：2006-10-15 00:00:00

abstract：:Targeting excessive production of reactive oxygen species (ROS) could be an effective therapeutic strategy to prevent oxidative stress-associated gastrointestinal inflammation. NADPH oxidase (NOX) and mitochondrial complexes (I and II) are the major sources of ROS production contributing to TNF-α/cycloheximide (CHX)-i...

journal_title：Toxicology and applied pharmacology

authors： Babu D,Leclercq G,Goossens V,Remijsen Q,Vandenabeele P,Motterlini R,Lefebvre RA

更新日期：2015-10-15 00:00:00

abstract：:The effects of the chemical species and concentration of selenium (Se) in diets on the concentrations of Se in hair, blood serum, red blood cells (RBCs), and urine were studied to gain an insight into the toxicological and nutritional significance of different chemical forms of Se. Male Wistar rats were fed an Se-defi...

journal_title：Toxicology and applied pharmacology

authors： Shiobara Y,Yoshida T,Suzuki KT

更新日期：1998-10-01 00:00:00

abstract：:The differential effects of oral and dermal administration of single doses of 100 to 1000 mg/kg S,S,S-tri-n-butyl phosphorotrithioate (DEF) on nonspecific esterases and liver metabolism enzymes were investigated one day following administration. O,O-Diethyl O-(4-nitrophenyl) phosphorothioate (parathion) and tri-o-cres...

journal_title：Toxicology and applied pharmacology

authors： Lapadula DM,Carrington CD,Abou-Donia MB

更新日期：1984-04-01 00:00:00

abstract：:The purpose of this study was to characterize the induction of metallothionein (MT) by steroids in rat primary hepatocyte cultures. Comparison of the characteristics of MT induction by a steroid (dexamethasone) to that by metals (Zn and Cd), examination of the involvement of the glucocorticoid receptor in the steroid ...

journal_title：Toxicology and applied pharmacology

authors： Bracken WM,Klaassen CD

更新日期：1987-03-15 00:00:00

abstract：:While the effect that TCDD has on humoral immunity has been well documented for the mouse, it has not been for the rat. In this study, the effect that TCDD has on the antibody plaque-forming cell (PFC) response to sheep red blood cells (SRBC) in adult female B6C3F1 mice and F344 rats was compared. The effect that TCDD...

journal_title：Toxicology and applied pharmacology

authors： Smialowicz RJ,Riddle MM,Williams WC,Diliberto JJ

更新日期：1994-02-01 00:00:00

abstract：:Cadmium chloride (CdCl2) at a dose of 1 mg/kg of body weight was injected into male Wistar rats twice a day (12-hr intervals) for 7 consecutive days. A group of treated rats was maintained without any treatment for an additional period of 10 days and killed on the following day (on Day 18). Plasma aldosterone concentr...

journal_title：Toxicology and applied pharmacology

authors： Nishiyama S,Nakamura K

更新日期：1984-12-01 00:00:00

abstract：:The objective of this study was to evaluate an alternative mucosal irritation test using the slug Arion lusitanicus as test organism. The effect of 28 reference substances on the mucosal tissue of the slugs was determined by the amount of mucus produced, the reduction in body weight, and the release of proteins from t...

journal_title：Toxicology and applied pharmacology

authors： Adriaens E,Remon JP

更新日期：2002-07-15 00:00:00

abstract：:Endothelial-mesenchymal transition (EndMT) is a frequent event in endothelial dysfunction, which is associated with pulmonary arterial hypertension (PAH). MiR-181 family members exert diverse effects in multiple biological processes. However, the relationships between miR-181b-5p (miR-181b) and EndMT in PAH are not we...

journal_title：Toxicology and applied pharmacology

authors： Zhao H,Wang Y,Zhang X,Guo Y,Wang X

更新日期：2020-01-01 00:00:00

abstract：:An earlier study indicated that percutaneous absorption of a 40-nmol dose of TCDD decreased with aging in rats, suggesting that the potential for systemic exposure following dermal contact would be decreased in older age groups. In this study, maturational changes in potential for systemic exposure to TCDD following d...

journal_title：Toxicology and applied pharmacology

authors： Anderson YB,Jackson JA,Birnbaum LS

更新日期：1993-04-01 00:00:00

abstract：:Emerging evidence suggests that feeding a high-fat diet (HFD) to rodents affects the expression of genes involved in drug transport. However, gender-specific effects of HFD on drug transport are not known. The multidrug resistance-associated protein 2 (Mrp2, Abcc2) is a transporter highly expressed in the hepatocyte c...

journal_title：Toxicology and applied pharmacology

authors： Kong B,Csanaky IL,Aleksunes LM,Patni M,Chen Q,Ma X,Jaeschke H,Weir S,Broward M,Klaassen CD,Guo GL

更新日期：2012-06-01 00:00:00

abstract：:Nephrotoxicity is the main side effect of gentamicin (GENTA). Preconditioning (PC) refers to a situation in which an organ subjected to an injury responds less intensely when exposed to another injury. The aim of this study was to evaluate the effect of PC with GENTA on nephrotoxic acute kidney injury (AKI). GENTA gro...

journal_title：Toxicology and applied pharmacology

authors： Pessoa EA,Convento MB,Ribas OS,Tristão VR,Reis LA,Borges FT,Schor N

更新日期：2011-05-15 00:00:00

abstract：:Male Wistar rats exposed to a systemic organophosphorus insecticide, phorate [O,O-diethyl S-[(ethylthio) methyl] phosphorothioate] at varying oral doses of 0.046, 0.092 or 0.184mg phorate/kg bw for 14days, exhibited substantial oxidative stress, cellular DNA damage and activation of apoptosis-related p53, caspase 3 an...

journal_title：Toxicology and applied pharmacology

authors： Saquib Q,Attia SM,Siddiqui MA,Aboul-Soud MA,Al-Khedhairy AA,Giesy JP,Musarrat J

更新日期：2012-02-15 00:00:00