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Toward a systematic exploration of nano-bio interactions.

Abstract：

:Many studies of nanomaterials make non-systematic alterations of nanoparticle physicochemical properties. Given the immense size of the property space for nanomaterials, such approaches are not very useful in elucidating fundamental relationships between inherent physicochemical properties of these materials and their interactions with, and effects on, biological systems. Data driven artificial intelligence methods such as machine learning algorithms have proven highly effective in generating models with good predictivity and some degree of interpretability. They can provide a viable method of reducing or eliminating animal testing. However, careful experimental design with the modelling of the results in mind is a proven and efficient way of exploring large materials spaces. This approach, coupled with high speed automated experimental synthesis and characterization technologies now appearing, is the fastest route to developing models that regulatory bodies may find useful. We advocate greatly increased focus on systematic modification of physicochemical properties of nanoparticles combined with comprehensive biological evaluation and computational analysis. This is essential to obtain better mechanistic understanding of nano-bio interactions, and to derive quantitatively predictive and robust models for the properties of nanomaterials that have useful domains of applicability.

journal_name

Toxicol Appl Pharmacol

journal_title

Toxicology and applied pharmacology

authors

Bai X,Liu F,Liu Y,Li C,Wang S,Zhou H,Wang W,Zhu H,Winkler DA,Yan B

doi

10.1016/j.taap.2017.03.011

subject

Has Abstract

pub_date

2017-05-15 00:00:00

pages

66-73

eissn

0041-008X

issn

1096-0333

pii

S0041-008X(17)30115-1

journal_volume

323

pub_type

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