Coenzyme Q10 and alpha-tocopherol protect against amitriptyline toxicity.

abstract：:Arsenic ingestion has been linked to increasing global prevalence of and mortality from cardiovascular disease (CVD); arsenic can be removed from drinking water to reduce related health effects. Lactate dehydrogenase (LDH) is used for the evaluation of acute arsenic toxicity in vivo and in vitro, but it is not validat...

journal_title：Toxicology and applied pharmacology

authors： Liao YT,Chen CJ,Li WF,Hsu LI,Tsai LY,Huang YL,Sun CW,Chen WJ,Wang SL

更新日期：2012-08-01 00:00:00

abstract：:Toxic cardiovascular effects of allylamine and beta-aminopropionitrile were studied in adult male Sprague-Dawley rats given allylamine alone (AA), 100 mg/kg/day, beta-aminopropionitrile alone (beta APN), 1 g/kg/day, or both chemicals (AA + beta APN) by gavage. Rats were given a total of 10 doses in 11 days. Rats given...

journal_title：Toxicology and applied pharmacology

authors： Kumar D,Hysmith RM,Boor PJ

更新日期：1990-04-01 00:00:00

abstract：:It has been proposed [J. D. McKinney, J. Fawkes, S. Jordan, K. Chae, S. Oatley, R. E. Coleman, and W. Briner (1985). Environ. Health Perspect. 61, 41-53] that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) produces toxic responses through persistent occupancy of nuclear thyroxine (T4) receptors, and that maintenance of re...

journal_title：Toxicology and applied pharmacology

authors： Osborne R,Dold KM,Greenlee WF

更新日期：1987-09-30 00:00:00

abstract：:Most of the cytotoxicity induced by ionizing radiation is mediated by radical-induced DNA double-strand breaks. Cellular protection from free radicals can be stimulated several fold by sulforaphane-mediated activation of the transcription factor Nrf2 that regulates more than 50 genes involved in the detoxification of ...

journal_title：Toxicology and applied pharmacology

authors： Mathew ST,Bergström P,Hammarsten O

更新日期：2014-05-01 00:00:00

abstract：:The teleost swim bladder is assumed a homolog of the tetrapod lung. Both swim bladder and lung are developmental targets of persistent aryl hydrocarbon receptor (AHR(2)) agonists; in zebrafish (Danio rerio) the swim bladder fails to inflate with exposure to 3,3',4,4',5-pentachlorobiphenyl (PCB126). The mechanism for t...

journal_title：Toxicology and applied pharmacology

authors： Jönsson ME,Kubota A,Timme-Laragy AR,Woodin B,Stegeman JJ

更新日期：2012-12-01 00:00:00

abstract：:Experiments were conducted to study the acute and subacute effects of intramuscularly injected T-2 toxin in rats and rabbits. The LD50 values of T-2 toxin were 0.85 +/- 0.03 and 1.10 +/- 0.08 mg/kg body wt in rats and rabbits, respectively. The intoxication was characterized by a consistent decrease in serum alkaline ...

journal_title：Toxicology and applied pharmacology

authors： Chan PK,Gentry PA

更新日期：1984-05-01 00:00:00

abstract：:Acrylonitrile (VCN) is a heavily used monomer in plastic and fiber industries. Quantitatively, VCN-induced gastrointestinal hemorrhage is time and dose dependent and is not the result of a direct irritating action of VCN on gastric tissues. The effect of cytochrome P-450 enzymes inducers was studied. Pretreatment with...

journal_title：Toxicology and applied pharmacology

authors： Ghanayem BI,Ahmed AE

更新日期：1983-04-01 00:00:00

abstract：:Arsenic toxicity is a global health problem affecting millions of people. The objectives of this study were to determine if the toxic effects on primary cultured rat astroglia would be induced by different arsenicals. Based on alamarBlue assay and the single cell gel electrophoresis (SCGE, comet assay), the cell viabi...

journal_title：Toxicology and applied pharmacology

authors： Jin Y,Sun G,Li X,Li G,Lu C,Qu L

更新日期：2004-05-01 00:00:00

abstract：:Neonatal and adult rats (1, 2, 3, 6, and 12 weeks of age) were given five daily oral doses of di(2-ethylhexyl) phthalate (DEHP) (0, 10, 100, 1000, 2000 mg/kg) and histological changes in the testes were examined 24 hr after the last dose. Relative testis weights were reduced at doses of 1000 mg/kg in 1, 2, 3, and 6-we...

journal_title：Toxicology and applied pharmacology

authors： Dostal LA,Chapin RE,Stefanski SA,Harris MW,Schwetz BA

更新日期：1988-08-01 00:00:00

abstract：:The effects of air pollution on human health are a great concern, particularly in big cities with severe traffic problems such as Bangkok, Thailand. In this study, exposure to genotoxic compounds in ambient air was studied by analysis of particle-associated polycyclic aromatic hydrocarbons (PAHs) and benzene through d...

journal_title：Toxicology and applied pharmacology

authors： Ruchirawat M,Navasumrit P,Settachan D,Tuntaviroon J,Buthbumrung N,Sharma S

更新日期：2005-08-07 00:00:00

abstract：:A case study was conducted, using dibutyl phthalate (DBP), to explore an approach to using toxicogenomic data in risk assessment. The toxicity and toxicogenomic data sets relative to DBP-related male reproductive developmental outcomes were considered conjointly to derive information about mode and mechanism of action...

journal_title：Toxicology and applied pharmacology

authors： Makris SL,Euling SY,Gray LE Jr,Benson R,Foster P

更新日期：2013-09-15 00:00:00

abstract：:I-compounds are recently discovered, age-dependent covalent DNA modifications, which are detectable by 32P-postlabeling assay for DNA adducts. The effects of the catatoxic antiglucocorticoid, pregnenolone-16 alpha-carbonitrile (PCN), on hepatic and renal I-compound levels have been studied in male and female Sprague-D...

journal_title：Toxicology and applied pharmacology

authors： Moorthy B,van Golen KL,Randerath K

更新日期：1992-04-01 00:00:00

abstract：:Thiazacridine derivatives (ATZD) are a novel class of cytotoxic agents that combine an acridine and thiazolidine nucleus. In this study, the cytotoxic action of four ATZD were tested in human colon carcinoma HCT-8 cells: (5Z)-5-acridin-9-ylmethylene-3-(4-methylbenzyl)-thiazolidine-2,4-dione - AC-4; (5ZE)-5-acridin-9-y...

journal_title：Toxicology and applied pharmacology

authors： Barros FW,Bezerra DP,Ferreira PM,Cavalcanti BC,Silva TG,Pitta MG,de Lima Mdo C,Galdino SL,Pitta Ida R,Costa-Lotufo LV,Moraes MO,Burbano RR,Guecheva TN,Henriques JA,Pessoa C

更新日期：2013-04-01 00:00:00

abstract：:To characterize modes of action of substances and their cytotoxic effects Bionas GmbH has developed a new screening system to allow the continuous recording of how an active substance can act (Bionas 2500 analyzing system). In the pharmaceutical industry it is important to acquire as much information as possible about...

journal_title：Toxicology and applied pharmacology

authors： Thedinga E,Kob A,Holst H,Keuer A,Drechsler S,Niendorf R,Baumann W,Freund I,Lehmann M,Ehret R

更新日期：2007-04-01 00:00:00

abstract：:An in vitro model, the aggregating brain cell culture of fetal rat telencephalon, has been used to study the maturation-dependent sensitivity of brain cells to two organophosphorus pesticides (OPs), chlorpyrifos and parathion, and to their oxon derivatives. Immature (DIV 5-15) or differentiated (DIV 25-35) brain cells...

journal_title：Toxicology and applied pharmacology

authors： Monnet-Tschudi F,Zurich MG,Schilter B,Costa LG,Honegger P

更新日期：2000-06-15 00:00:00

abstract：:Therapy of seizure activity following exposure to the nerve agent soman (GD) includes treatment with the anticonvulsant diazepam (DZP), an allosteric modulator of γ-aminobutyric acid A (GABA(A)) receptors. However, seizure activity itself causes the endocytosis of GABA(A) receptors and diminishes the inhibitory effect...

journal_title：Toxicology and applied pharmacology

authors： Schultz MK,Wright LK,Stone MF,Schwartz JE,Kelley NR,Moffett MC,Lee RB,Lumley LA

更新日期：2012-03-15 00:00:00

abstract：:Arsenic had been reported to be associated with carotid atherosclerosis. However, there were few studies to evaluate the association between the susceptible gene of lipid metabolism and inflammation and carotid atherosclerosis among arsenic exposure residents. The aim of the study was to investigate the associations b...

journal_title：Toxicology and applied pharmacology

authors： Hsieh YC,Hsieh FI,Lien LM,Chou YL,Chiou HY,Chen CJ

更新日期：2008-02-15 00:00:00

abstract：:Cannabinoid receptor (CB) expression was characterized in immunological cell and tissue preparations. Northern analysis revealed approximately 6-kb transcripts for CB1 (brain-type) in mouse spleen and brain and in rat cerebellum. CB1 was not detected in mouse thymus or rat spleen RNA by Northern analysis. CB2 (periphe...

journal_title：Toxicology and applied pharmacology

authors： Schatz AR,Lee M,Condie RB,Pulaski JT,Kaminski NE

更新日期：1997-02-01 00:00:00

abstract：:The mechanisms of action of o,p'-DDD on adrenal steroidogenesis were investigated in vitro in rainbow trout (Oncorhynchus mykiss). Acute exposures to o,p'-DDD inhibited ACTH-stimulated cortisol secretion while cell viability decreased significantly only at the highest concentration tested (200 microM o,p'-DDD). Stimul...

journal_title：Toxicology and applied pharmacology

authors： Lacroix M,Hontela A

更新日期：2003-08-01 00:00:00

abstract：:In the monocrotaline (MCT) model of pulmonary hypertension, the pulmonary vascular endothelium is the likely early target of the reactive metabolite monocrotaline pyrrole (MCTP). Incubation of cultured bovine pulmonary arterial endothelial cells (BPAEC) with MCTP results in covalent binding to DNA, cell cycle arrest, ...

journal_title：Toxicology and applied pharmacology

authors： Thomas HC,Lamé MW,Dunston SK,Segall HJ,Wilson DW

更新日期：1998-08-01 00:00:00

abstract：:Inflammatory responses are accompanied by increased expression of hepatocyte-derived proteins collectively known as acute phase reactants (APR). B6C3F1 female mice were exposed intraperitoneally every 24 hr to either vehicle (PBS) or DMN (5 mg/kg) for up to six exposures. Following a single treatment (acute), liver ti...

journal_title：Toxicology and applied pharmacology

authors： Lockwood JF,Rutherford MS,Myers MJ,Schook LB

更新日期：1994-04-01 00:00:00

abstract：:Ammonium perfluorooctanoate (CAS Registry No. 3825-26-2) is used commercially in the aqueous polymerization of fluorinated monomers. Because the chemical exists as a fine white powder which can come in contact with skin, its dermal toxicology was studied in rabbits and rats. Dermal applications of 0.5 g for 24 hr prod...

journal_title：Toxicology and applied pharmacology

authors： Kennedy GL Jr

更新日期：1985-11-01 00:00:00

abstract：:Carcinogenic chromium (VI) compounds are persistent environmental contaminants with potential for human exposure through drinking water. One lesion associated with chromium (VI) exposure is the formation of DNA-protein crosslinks (DPC). In an attempt to develop markers of chromium exposure, the formation of DPC in lym...

journal_title：Toxicology and applied pharmacology

authors： Coogan TP,Motz J,Snyder CA,Squibb KS,Costa M

更新日期：1991-06-01 00:00:00

abstract：:The M2 subtype of muscarinic receptor is predominant in heart, and such receptors were reported to be located in muscles as well as in presynaptic cholinergic and adrenergic nerve terminals. Muscarinic receptors of rat heart were identified by the high affinity binding of the agonist (+)-[3H]cis-methyldioxolane ([3H]C...

journal_title：Toxicology and applied pharmacology

authors： Silveira CL,Eldefrawi AT,Eldefrawi ME

更新日期：1990-05-01 00:00:00

abstract：:Ochratoxin A (OTA) is a mycotoxin that is found in various food and feed products. The molecular mechanisms that are associated with OTA hepatotoxicity and teratogenicity have not been extensively elucidated in a developing organism. In this study, the transcriptomic profile of zebrafish embryos indicates that hemosta...

journal_title：Toxicology and applied pharmacology

authors： Wu TS,Lin YT,Huang YT,Cheng YC,Yu FY,Liu BH

更新日期：2018-02-01 00:00:00

abstract：:Though nanomaterials (NMs) are being utilized worldwide, increasing use of NMs have raised concerns over their safety to human health and environment. Iron oxide (Fe(2)O(3)) NMs have important applications. The aim of this study was to assess the genotoxicity of Fe(2)O(3)-30nm and Fe(2)O(3)-bulk in female Wistar rats....

journal_title：Toxicology and applied pharmacology

authors： Singh SP,Rahman MF,Murty US,Mahboob M,Grover P

更新日期：2013-01-01 00:00:00

abstract：:To examine the magnitude of human variability across the entire transcriptome after chemical challenge, we profiled gene expression responses to three different prototypic chemical inducers in primary human hepatocyte cultures from ten independent donors. Correlation between basal expression in any two hepatocyte dono...

journal_title：Toxicology and applied pharmacology

authors： Goyak KM,Johnson MC,Strom SC,Omiecinski CJ

更新日期：2008-09-01 00:00:00

abstract：:Nodularin is a natural toxin with multiple features, including inhibitor of protein phosphatases 1 and 2A as well as tumor initiator and promoter. One unique feature of nodularin is that this chemical is a hepatotoxin. It can accumulate into the liver after contact and lead to severe damage to hepatocyte, such as apop...

journal_title：Toxicology and applied pharmacology

authors： Feng G,Li Y,Bai Y

更新日期：2011-03-15 00:00:00

abstract：:Epidermal growth factor receptor antibody (EGFRAb) conjugated silica nanorattles (SNs) were synthesized and used to develop receptor mediated endocytosis for targeted drug delivery strategies for cancer therapy. The present study determined that the rate of internalization of silica nanorattles was found to be high in...

journal_title：Toxicology and applied pharmacology

authors： Sundarraj S,Thangam R,Sujitha MV,Vimala K,Kannan S

更新日期：2014-03-15 00:00:00

abstract：:The radioprotective effect of extracellular melanin, a naturally occurring pigment, isolated from the fungus Gliocephalotrichum simplex was examined in BALB/C mice, and the probable mechanism of action was established. At an effective dose of 50mg/kg body weight, melanin exhibited both prophylactic and mitigative acti...

journal_title：Toxicology and applied pharmacology

authors： Kunwar A,Adhikary B,Jayakumar S,Barik A,Chattopadhyay S,Raghukumar S,Priyadarsini KI

更新日期：2012-10-15 00:00:00