Study on the toxic effects induced by different arsenicals in primary cultured rat astroglia.

abstract：:Gallium arsenide (GaAs), indium arsenide (InAs), and aluminium gallium arsenide (AlGaAs) are semiconductor applications. Although the increased use of these materials has raised concerns about occupational exposure to them, there is little information regarding the adverse health effects to workers arising from exposu...

journal_title：Toxicology and applied pharmacology

authors： Tanaka A

更新日期：2004-08-01 00:00:00

abstract：:Gossypol, a polyphenolic compound isolated from cottonseeds, has been reported to possess many pharmacological activities, but whether it can influence inflammasome activation remains unclear. In this study, we found that in mouse macrophages, gossypol induced cell death characterized by rapid membrane rupture and rob...

journal_title：Toxicology and applied pharmacology

authors： Lin QR,Li CG,Zha QB,Xu LH,Pan H,Zhao GX,Ouyang DY,He XH

更新日期：2016-02-01 00:00:00

abstract：:The immunosuppressive synthetic methylated polycyclic aromatic hydrocarbon (PAH), 7,12-dimethylbenz[a]anthracene (DMBA), has been shown to cause both an immediate and a sustained elevation of free intracellular calcium (Ca2+) in human T cells. In the present studies, a series of anthracene- and pyrene-based PAHs were ...

journal_title：Toxicology and applied pharmacology

authors： Krieger JA,Born JL,Burchiel SW

更新日期：1994-08-01 00:00:00

abstract：:Dithiocarbamates have a wide spectrum of applications in industry, agriculture and medicine with new applications being actively investigated. One adverse effect of dithiocarbamates is the neurotoxicity observed in humans and experimental animals. Results from previous studies have suggested that dithiocarbamates elev...

journal_title：Toxicology and applied pharmacology

authors： Viquez OM,Valentine HL,Amarnath K,Milatovic D,Valentine WM

更新日期：2008-05-15 00:00:00

abstract：:1p4studied the effect of L-2-chloropropionic acid (L-CPA)-induced (250 mg/kg/po/day for 3 days) neurotoxicity, which results in an almost total destruction of cerebellar granule cells over 5 days, on forebrain and cerebellar neurochemistry. There was a reduction in cerebellar aspartate and glutamate concentrations of ...

journal_title：Toxicology and applied pharmacology

authors： Widdowson PS,Gyte A,Simpson MG,Wyatt I,Lock EA

更新日期：1996-01-01 00:00:00

abstract：:Acrylonitrile (VCN) is a heavily used monomer in plastic and fiber industries. Quantitatively, VCN-induced gastrointestinal hemorrhage is time and dose dependent and is not the result of a direct irritating action of VCN on gastric tissues. The effect of cytochrome P-450 enzymes inducers was studied. Pretreatment with...

journal_title：Toxicology and applied pharmacology

authors： Ghanayem BI,Ahmed AE

更新日期：1983-04-01 00:00:00

abstract：:The ability of brain tissue preparation to generate superoxide from xenobiotic interactions has been investigated. We showed that a significant superoxide production occurred with different molecules known to undergo a single electron reductive pathway of metabolism, both in a homogenate derived from neuronal and glia...

journal_title：Toxicology and applied pharmacology

authors： Ghersi-Egea JF,Livertoux MH,Minn A,Perrin R,Siest G

更新日期：1991-08-01 00:00:00

abstract：:Metabonomics is the evaluation of the multiparametric metabolic response of biological systems to pathophysiological stimuli. High-resolution nuclear magnetic resonance (NMR) spectroscopy of biofluids coupled with pattern recognition-based chemometric analysis is an emerging approach to the study of metabonomics and m...

journal_title：Toxicology and applied pharmacology

authors： Slim RM,Robertson DG,Albassam M,Reily MD,Robosky L,Dethloff LA

更新日期：2002-09-01 00:00:00

abstract：:Inhalation of sulfur mustard (SM), a bifunctional alkylating agent that causes severe lung damage, is a significant threat to both military and civilian populations. The mechanisms mediating its cytotoxic effects are unknown and were investigated in the present studies. Male rats Crl:CD(SD) were anesthetized, and then...

journal_title：Toxicology and applied pharmacology

authors： Malaviya R,Sunil VR,Cervelli J,Anderson DR,Holmes WW,Conti ML,Gordon RE,Laskin JD,Laskin DL

更新日期：2010-10-15 00:00:00

abstract：:This study was conducted to evaluate UDP-glucuronosyl-transferase (UDP-GT) activity, UDP-glucuronic acid (UDP-GA) concentration, and UDP-glucose (UDPG) concentration in the rat intestine and liver following oral administration of butylated hydroxyanisole (BHA), benzo[a]pyrene (BaP), 3-methylcholanthrene (3MC), phenoba...

journal_title：Toxicology and applied pharmacology

authors： Goon D,Klaassen CD

更新日期：1992-08-01 00:00:00

abstract：:1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin is a chemical inducer of Parkinson's disease (PD) whereas N-methylated beta-carbolines and isoquinolines are naturally occurring analogues of MPTP involved in PD. This research has studied the oxidation of MPTP by human CYP2D6 (CYP2D6*1 and CYP2D6*10 allel...

journal_title：Toxicology and applied pharmacology

authors： Herraiz T,Guillén H,Arán VJ,Idle JR,Gonzalez FJ

更新日期：2006-11-01 00:00:00

abstract：:Extensive destruction of primordial follicles by exposure to ovarian toxicants can cause early menopause in women. Primordial follicle destruction is known to result from dosing of mice and rats with three polycyclic aromatic hydrocarbons (PAHs), contaminants commonly found in cigarette smoke. Therefore, the purpose o...

journal_title：Toxicology and applied pharmacology

authors： Borman SM,Christian PJ,Sipes IG,Hoyer PB

更新日期：2000-09-15 00:00:00

abstract：:Gold compounds are used clinically in rheumatoid arthritis therapy. Acute renal toxicity is observed in some patients receiving chrysotherapy. The present study addresses morphofunctional and biochemical changes in rat kidneys during the first 8 days following a single ip injection of gold sodium thiomalate (AuTM), on...

journal_title：Toxicology and applied pharmacology

authors： Eiseman JL,Ribas JL,Knight E,Alvares AP

更新日期：1987-11-01 00:00:00

abstract：:Acute oral toxicity of Cd (as cadmium chloride) was enhanced in rats fasted 24 hr, as shown by a markedly decreased LD50. To examine the relationship among Cd toxicity, hepatic glutathione (GSH), and metallothionein (MT) during fasting, rats were administered 75 mg Cd/kg orally 24 hr after fasting and euthanized after...

journal_title：Toxicology and applied pharmacology

authors： Shimizu M,Morita S

更新日期：1990-03-15 00:00:00

abstract：:Recent studies with vinclozolin, a dicarboximide fungicide, demonstrate that perinatal exposure to 100 mg vinclozolin/kg/day from Gestational Day 14 through Postnatal Day 3 inhibits morphological sex differentiation. At 1 year, treated male rats exhibited hypospadias, cleft phallus, suprainguinal ectopic testes, a vag...

journal_title：Toxicology and applied pharmacology

authors： Kelce WR,Monosson E,Gamcsik MP,Laws SC,Gray LE Jr

更新日期：1994-06-01 00:00:00

abstract：:Technologies that generate information about the genome are being used to explore changes in gene expression and related proteins following exposure to chemicals. Conceptually, this information allows a greater understanding of genomic level mRNA expression (transcriptomics), cell and tissue protein expression (proteo...

journal_title：Toxicology and applied pharmacology

authors： Oberemm A,Onyon L,Gundert-Remy U

更新日期：2005-09-01 00:00:00

abstract：:Previous studies performed in this laboratory have shown that certain benzo(a)pyrene (BaP) metabolites, such as benzo(a)pyrene-7,8-dihydrodiol (BaP-7,8-diol) and benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE), were more effective in elevating intracellular Ca2+ in normal human peripheral blood mononuclear cell (HP...

journal_title：Toxicology and applied pharmacology

authors： Mounho BJ,Burchiel SW

更新日期：1998-03-01 00:00:00

abstract：:This study was designed to evaluate the developmental toxicity of nitrazepam (NZ) in Sprague-Dawley rats and ICR mice and to determine the metabolic factors which modulate susceptibility to the developmental effects of NZ. Rats were treated orally with a single dose of NZ at 300 mg/kg on Day 12 of gestation. Mice rece...

journal_title：Toxicology and applied pharmacology

authors： Takeno S,Hirano Y,Kitamura A,Sakai T

更新日期：1993-08-01 00:00:00

abstract：:The influence of carbon monoxide (CO) on the development of systemic hypertension was studied in Dahl rats selectively bred for susceptibility (DS) and resistance (DR) to NaCl-induced hypertension. This study was designed to examine the interactions among rat line (DS or DR), NaCl content of diet, and exposure to CO. ...

journal_title：Toxicology and applied pharmacology

authors： Shiotsuka RN,Drew RT,Wehner RW

更新日期：1984-11-01 00:00:00

abstract：:The physiologically based dosimetry description for acrylonitrile (ACN) and its mutagenic epoxide metabolite 2-cyanoethylene oxide (CEO) in F-344 rats (M. L. Gargas, M. E. Anderson, S.K.O. Teo, R. Batra, T. R. Fennell, and G. L. Kedderis, 1995, Toxicol. Appl. Pharmacol. 134, 185-194) has been refined to include a phys...

journal_title：Toxicology and applied pharmacology

authors： Kedderis GL,Teo SK,Batra R,Held SD,Gargas ML

更新日期：1996-10-01 00:00:00

abstract：:The disposition of 2,3,4,7,8-pentachlorodibenzofuran (PeCDF), a highly toxic environmental contaminant which accumulates in human tissues, was examined in the male Fischer rat after iv and oral exposure. Greater than 70% of an oral dose of 0.1, 0.5, or 1.0 mumol PeCDF/kg body wt was absorbed by the gastrointestinal sy...

journal_title：Toxicology and applied pharmacology

authors： Brewster DW,Birnbaum LS

更新日期：1987-09-15 00:00:00

abstract：:Although piperonyl butoxide (PBO) is commonly used both in vivo and in vitro as an inhibitor of cytochrome P-450-dependent monooxygenase (MO) activity in a wide variety of species, the effect of PBO on the hepatic MO of fishes has never been characterized. The MO activity in hepatic microsomes from rainbow trout expos...

journal_title：Toxicology and applied pharmacology

authors： Erickson DA,Goodrich MS,Lech JJ

更新日期：1988-06-15 00:00:00

abstract：:Recent breakthroughs in stem cell biology, especially the development of the induced pluripotent stem cell techniques, have generated tremendous enthusiasm and efforts to explore the therapeutic potential of stem cells in regenerative medicine. Stem cell therapies are being considered for the treatment of degenerative...

journal_title：Toxicology and applied pharmacology

authors： Sharpe ME,Morton D,Rossi A

更新日期：2012-08-01 00:00:00

abstract：:We investigated the effects of JBP485 (an anti-inflammatory dipeptide and a substrate of OAT) on regulation of the expression and function of renal Oat1 and Oat3, which can accelerate the excretion of accumulated uremic toxins (e.g. indoxyl sulfate) in the kidney to improve gentamicin-induced ARF in rats. JBP485 cause...

journal_title：Toxicology and applied pharmacology

authors： Guo X,Meng Q,Liu Q,Wang C,Sun H,Peng J,Ma X,Kaku T,Liu K

更新日期：2013-09-01 00:00:00

abstract：:The effect of mucosal metallothionein (MT) preinduced by zinc (Zn) on tissue distribution of cadmium (Cd) after administration of Cd with several chelating agents was studied in rats. After Cd-cysteine (Cd-Cys) was incubated with intestinal Zn-MT in vitro, all the Cd dissociated from Cys and exchanged the Zn bound to ...

journal_title：Toxicology and applied pharmacology

authors： Min KS,Nakatsubo T,Kawamura S,Fujita Y,Onosaka S,Tanaka K

更新日期：1992-04-01 00:00:00

abstract：:Three major enzyme systems have been shown to metabolize epoxidized xenobiotics in vertebrate tissues, and this study demonstrates that these enzyme systems can be differentially induced. The cytosolic epoxide hydrolase activity was routinely monitored with trans-beta-ethylstyrene oxide, the microsomal epoxide hydrola...

journal_title：Toxicology and applied pharmacology

authors： Hammock BD,Ota K

更新日期：1983-11-01 00:00:00

abstract：:This pilot study was designed to assess whether a synthetic matrix metalloproteinase (MMP) inhibitor has anti-inflammatory properties in mild asthma. Tumor necrosis factor alpha (TNFalpha) has been shown to be an important cytokine in the pathogenesis of allergic airway inflammatory responses, and its release can be i...

journal_title：Toxicology and applied pharmacology

authors： Bruce C,Thomas PS

更新日期：2005-06-01 00:00:00

abstract：:A quantitative method based upon a stochastic model was used to estimate rates of initiation (alteration to express the ATPase-deficient phenotype) and of clonal growth of altered cells in an initiation promotion experiment in the livers of female Wistar rats. Diethylnitrosamine (DEN) was used as the initiating agent ...

journal_title：Toxicology and applied pharmacology

authors： Moolgavkar SH,Luebeck EG,Buchmann A,Bock KW

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND:The current COVID-19 pandemic is caused by SARS-CoV-2 which belongs to coronaviridae family. Despite the global prevalence, there are currently no vaccines or drugs. Dietary plant derived exosome-like vesicles are known as edible nanoparticles (ENPs). ENPs are filled with microRNAs (miRNAs), in bioavailable ...

journal_title：Toxicology and applied pharmacology

authors： Kalarikkal SP,Sundaram GM

更新日期：2021-01-28 00:00:00

abstract：:Epidemiological studies link arsenic exposure to increased risks of cancers of the skin, kidney, lung, bladder and liver. Additionally, a variety of non-cancerous conditions such as diabetes mellitus, hypertension, and cardiovascular disease have been associated with chronic ingestion of low levels of arsenic. However...

journal_title：Toxicology and applied pharmacology

authors： Pysher MD,Sollome JJ,Regan S,Cardinal TR,Hoying JB,Brooks HL,Vaillancourt RR

更新日期：2007-10-01 00:00:00